期刊
GENE
卷 554, 期 2, 页码 196-204出版社
ELSEVIER
DOI: 10.1016/j.gene.2014.10.047
关键词
Apolipoprotein C1; Bone morphogenetic proteins; Retinoic acid; Embryonic development
资金
- National Major Basic Research Program [2010CB126301]
- National 863 High Technology Research Program [2012AA092201-3]
- Ministry of Agriculture of China within the special Fund for Agro-scientific Research in the Public Interest [200903045]
- National Natural Science Foundation of China [30971414]
Apolipoproteins, the major components of lipoproteins, play physiological roles in lipoprotein metabolism. Contrary to the well-documented effects on plasma lipid, little is known about the function and regulation of Apolipoproteins during embryonic development. Here we have shown that apolipoprotein Cl (apoc1) gene is highly expressed in the yolk syncytial layer, a structure implicated in embryonic and larval nutrition. The apoc1 transcripts are also observed in the deep cell layer at the ventral and lateral region during gastrulation, and in the tail paraxial mesoderm during somitogenesis. By whole-mount in situ hybridization and quantified RT-RCR, we further demonstrate that apoc1 expression is induced by bone morphogenetic proteins (BMPs) signaling, while retinoic acid (RA) signaling suppresses the expression of BMP ligands and inhibits the BMP effect in this process. (C) 2014 Elsevier B.V. All rights reserved.
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