Review
Medicine, General & Internal
Andrew Xanthopoulos, Grigorios Giamouzis, Apostolos Dimos, Evangelia Skoularigki, Randall C. Starling, John Skoularigis, Filippos Triposkiadis
Summary: This study discusses the role and predictive value of red blood cell distribution width (RDW) in heart failure, explores the possible mechanisms of RDW increase, and its prognostic role in heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Minkwan Kim, Chan Joo Lee, Hye-Jin Kang, Nak-Hoon Son, SungA Bae, Jiwon Seo, Jaewon Oh, Se-Joong Rim, In Hyun Jung, Eui-Young Choi, Seok-Min Kang
Summary: This study aimed to evaluate the impact of red cell distribution width (RDW) on the prognosis of patients with heart failure. The results showed that elevated RDW at the time of diagnosis was associated with poor prognosis in patients with heart failure, independent of clinical risk factors and echocardiographic parameters. RDW may have important implications in the management of patients with heart failure.
Article
Cardiac & Cardiovascular Systems
Fang Gu, Han Wu, Xiaoli Jin, Cheng Kong, Wenyan Zhao
Summary: In recent years, red cell distribution width (RDW) has been found to be associated with the prognosis of patients with heart failure (HF) in Western countries. However, evidence from Asia is limited. This study aimed to investigate the relationship between RDW and the risk of 3-month readmission in hospitalized Chinese HF patients. The findings indicate that a higher RDW value is significantly associated with a greater risk of 3-month readmission in hospitalized patients with HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Zongjie Wei, Fan Zhang, Xin Ma, Weiyang He, Xin Gou, Xu Zhang, Yongpeng Xie
Summary: This study explored the prognostic value of preoperative red blood cell distribution width (RDW) in patients with metastatic renal cell carcinoma (mRCC). The results showed that higher RDW levels were associated with worse progression-free survival (PFS) and overall survival (OS). Multivariate analysis revealed that RDW was an independent risk factor for PFS and OS in mRCC patients after cytoreductive nephrectomy.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Eldad Rahamim, Donna R. Zwas, Andre Keren, Gabby Elbaz-Greener, Mahsati Ibrahimli, Offer Amir, Israel Gotsman
Summary: This study evaluated the predictive value of the Hb/RDW ratio on clinical outcomes in patients with HF. The results showed that patients with a lower Hb/RDW ratio were more likely to experience mortality and cardiovascular hospitalizations, and decreasing Hb/RDW ratio was associated with reduced survival rates. Therefore, the Hb/RDW ratio is an important prognostic tool for predicting clinical outcomes in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xiaojiong Jia, Si Cheng, Long Zhang, Yuan Zheng, Hua Zou, Shifeng Huang, Hongxu Wang, Juan Lu, Dijiao Tang
Summary: This study found that patients with elevated RDW levels three months post hematopoietic stem cell transplantation had poorer clinical outcomes and shorter progression-free survival. RDW may serve as an important predictive biomarker for risk stratification in HSCT patients. Further prospective studies are needed to confirm its prognostic value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ke-Hang Xie, Ling-Ling Liu, Yun-Ru Liang, Chu-Yin Su, Hua Li, Run-Ni Liu, Qing-Qing Chen, Jia-Sheng He, Yong-Kun Ruan, Wang-Kai He
Summary: The study found that red blood cell distribution width (RDW) can predict subsequent stroke in patients with transient ischaemic attack (TIA). The RDW values of patients with ischaemic stroke (IS) and haemorrhagic stroke (HS) after TIA were significantly higher than patients with TIA. RDW was independently associated with stroke, especially ischaemic stroke, after TIA.
ANNALS OF MEDICINE
(2022)
Article
Medical Laboratory Technology
Qingwei Ni, Xue Wang, Jie Wang, Peng Chen
Summary: High levels of RAR are associated with increased short- and long-term mortality in patients with heart failure, as well as increased risk of sepsis and requirement for renal replacement therapy. RAR is a promising biomarker that is easy to obtain and readily predicts mortality in heart failure patients.
CLINICA CHIMICA ACTA
(2022)
Article
Geriatrics & Gerontology
Kyoung Min Kim, Ridhima Nerlekar, Gregory J. Tranah, Warren S. Browner, Steven R. Cummings
Summary: This study investigated the relationship between red cell distribution width (RDW) and prognosis in hospitalized patients over 60 years old. The results showed that greater variability of RBC size, as indicated by a higher RDW value, was significantly associated with worse outcomes, including higher mortality, increased risk of re-admission, and longer hospital stay. Therefore, RDW value should be considered in risk stratification strategies for hospitalized elderly patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Oncology
Hiroaki Saito, Shota Shimizu, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoshiyuki Fujiwara
Summary: PDW and RDW can serve as independent prognostic indicators in gastric cancer, and their combination can further enhance the accuracy of predicting patient outcomes.
Review
Medicine, General & Internal
Angelo Zinellu, Arduino A. Mangoni
Summary: The study suggests that the red cell distribution width (RDW) may serve as a useful parameter for the diagnosis and risk stratification of patients with chronic obstructive pulmonary disease (COPD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xinyu Zhang, Yi Wang, Naiyi Chen, Yan Liu, Jie Xiao, Zongwei Lin, Huixia Lu, Xiaoping Ji
Summary: This study suggests that red cell distribution width (RDW) is independently associated with short-term mortality in critically ill patients with heart failure, particularly stronger correlations were found in male patients and those with normal renal function. Further large prospective research and longer follow-up time are needed to validate these findings.
Review
Agriculture, Dairy & Animal Science
Arianna Miglio, Carlotta Valente, Carlo Guglielmini
Summary: Red blood cell distribution width (RDW) is a laboratory parameter that reflects the variation in erythrocyte size and can be used as a diagnostic and prognostic biomarker in various human disorders. This narrative review summarizes the studies investigating the relationship between RDW and various canine disorders.
Article
Agriculture, Dairy & Animal Science
Carlo Guglielmini, Chiara Martina Valentini, Barbara Contiero, Carlotta Valente, Helen Poser
Summary: Red cell distribution width (RDW) is an important parameter reflecting red blood cell size differences, and has been associated with negative prognosis in cardiovascular diseases. In dogs, RDW may serve as an independent prognostic marker for myxomatous mitral valve disease (MMVD).
Article
Oncology
Kung-Chuan Cheng, Yueh-Ming Lin, Chin-Chen Liu, Kuen-Lin Wu, Ko-Chao Lee
Summary: Red blood cell distribution width (RDW) is associated with the prognosis of colorectal cancer patients. High RDW is a negative predictor for overall survival, disease-free survival, and cancer-specific survival, and is also related to age, tumor stage, abnormal blood parameters, and comorbidities.
Article
Cardiac & Cardiovascular Systems
C. Pelosi, R. M. Kauling, J. A. A. E. Cuypers, A. E. van den Bosch, W. A. Helbing, E. M. W. J. Utens, J. S. Legerstee, J. W. Roos-Hesselink
Summary: Nowadays, a large number of adults with congenital heart disease (CHD) have attained adulthood, but there is limited knowledge about their psychosocial functioning. This longitudinal cohort study followed 204 patients who underwent surgery for CHD during childhood and found that despite lower education and employment rates, CHD patients had better health-related quality of life and emotional functioning compared to the general population.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Engineering, Biomedical
Amira Assaf, Dominic A. M. J. Theuns, Michelle Michels, Jolien Roos-Hesselink, Tamas Szili-Torok, Sing-Chien Yap
Summary: The 2018 ESC Syncope guidelines expanded the indications for an insertable cardiac monitor (ICM) to include patients with unexplained syncope and primary cardiomyopathy or inheritable arrhythmogenic disorders. This review article discusses the clinical evidence for using an ICM for risk stratification in different patient populations, including various cardiac conditions. The experts suggest that while there is limited data on the usefulness of ICMs in these populations, most studies demonstrate its early detection of clinically relevant arrhythmias. However, the impact of ICMs on prognosis is difficult to demonstrate in populations with rare diseases.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Hematology
Annette von Drygalski, Esteban Gomez, Adam Giermasz, Giancarlo Castaman, Nigel S. Key, Susan U. Lattimore, Frank W. G. Leebeek, Wolfgang A. Miesbach, Michael Recht, Robert Gut, Ricardo Dolmetsch, Paul E. Monahan, Sandra Le Quellec, Steven W. Pipe
Summary: This study reports the 3-year outcomes of using Etranacogene dezaparvovec in the treatment of adults with hemophilia B. The results show that Etranacogene dezaparvovec significantly increases FIX activity, reduces bleeding frequency, improves joint health, and has no major adverse events over the 3-year period.
Review
Cardiac & Cardiovascular Systems
F. Meccanici, J. W. C. de Bruijn, J. S. Dommisse, J. J. M. Takkenberg, A. E. van den Bosch, J. W. Roos-Hesselink
Summary: This study aimed to systematically review the prevalence of aortic disease among women with Turner syndrome (TS). The results showed that ascending aortic dilatation is common in adult TS women, and there is an increased risk of aortic dissection.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Article
Hematology
Marieke J. A. Verhagen, Waander L. van Heerde, Johanna G. van der Bom, Erik A. M. Beckers, Nicole M. A. Blijlevens, Michiel Coppens, Samantha C. Gouw, Joop H. Jansen, Frank W. G. Leebeek, Lize F. D. van Vulpen, Danielle Meijer, Saskia E. M. Schols
Summary: The association between clinical bleeding phenotype and thrombin generation and plasmin generation profiles in patients with hemophilia was investigated. The study found that thrombin generation and plasmin generation parameters differed between patients with hemophilia and healthy individuals, and a decreased thrombin generation profile was associated with a severe clinical bleeding phenotype.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Feyza Memis, Carlijn G. E. Thijssen, Arjen L. Gokalp, Maximiliaan L. Notenboom, Frederike Meccanici, Mohammad Mostafa Mokhles, Roland R. J. van Kimmenade, Kevin M. Veen, Guillaume S. C. Geuzebroek, Jelena Sjatskig, Franciscus J. ter Woorst, Jos A. Bekkers, Johanna J. M. Takkenberg, Jolien W. Roos-Hesselink
Summary: This study aims to evaluate patient and procedural characteristics and compare the outcomes and mortality after surgery between elderly and non-elderly patients with ascending aortic aneurysm. The study found that elderly patients had larger aortic diameters and more cardiovascular risk factors. Short-term mortality was comparable between elderly and non-elderly patients, but the five-year survival rate was lower in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
J. A. van der Zande, G. Wander, K. P. Ramlakhan, J. W. Roos-Hesselink, M. R. Johnson
Summary: Due to improved survival rates in individuals with CHD, considering their reproductive health is important. This paper discusses fertility, sexuality, assisted reproductive technology (ART), and contraception in adults with CHD. The expert opinion suggests that timely counseling is necessary, and ART decisions are typically based on expert opinion with follow-up in an expert center recommended. Further research is needed to fill gaps in knowledge on the risks and frequency of complications of ART in adults with CHD, as well as differentiate relative risks in different types of CHD.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Article
Hematology
Roger E. G. Schutgens, Victor Jimenez-Yuste, Miguel Escobar, Anna Falanga, Bruna Gigante, Robert Klamroth, Riitta Lassila, Frank W. G. Leebeek, Michael Makris, Tarek Owaidah, Michelle Sholzberg, Andreas Tiede, David J. Werring, H. Bart van der Worp, Jerzy Windyga, Giancarlo Castaman
Summary: Cardiovascular disease is becoming more common in patients with hemophilia, and managing the delicate balance between thrombosis and hemostasis in these patients requires careful consideration. Specific recommendations are lacking for patients with very low clotting factor levels, and treatment strategies are mainly based on anecdotal evidence. For patients with higher clotting factor levels, antithrombotic therapy can be used with careful monitoring.
Article
Hematology
Martijn R. Brands, Lotte Haverman, Jelmer J. Muis, Mariette H. E. Driessens, Felix J. M. van der Meer, Geertje Goedhart, Stephan Meijer, Marianne de Jong, Johanna G. van der Bom, Marjon H. Cnossen, Karin Fijnvandraat, Samantha C. Gouw
Summary: This study examined the satisfaction of hemophilia patients in the Netherlands with their care and found high levels of satisfaction, but also identified areas for improvement such as better information provision and care coordination, with the potential use of digital health tools. These findings are important for further enhancing the care of hemophilia patients.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Sjoerd F. Koopman, Tine M. H. J. Goedhart, Laura H. Bukkems, Trevor M. Mulders, Frank W. G. Leebeek, Karin Fijnvandraat, Michiel Coppens, Mary Mathias, Peter W. Collins, R. Campbell Tait, Catherine N. Bagot, Nicola Curry, Jeanette Payne, Pratima Chowdary, Marjon H. Cnossen, Ron A. A. Mathot
Summary: This study evaluated the predictive performance of a population pharmacokinetic (PK) model for a recombinant factor IX Fc fusion protein (rFIX-Fc) and developed a new model using real-world data. The published model significantly underpredicted FIX activity levels, while the new model better described rFIX-Fc PK, especially for children aged <12 years.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Gurleen Wander, Johanna A. van der Zande, Roshni R. Patel, Mark R. Johnson, Jolien Roos-Hesselink
Summary: This article provides an overview of common scenarios and management strategies for congenital heart disease (CHD) during pregnancy, including preconception counseling, antenatal management, and strategies to prevent maternal and fetal complications. Preconception counseling should start early and be offered to both men and women, addressing contraception choices, lifestyle modifications, cardiac optimization, chances of inherited cardiac lesions in the child, risks to the mother, and long-term prognosis. Pregnancy induces cardiovascular changes that may result in cardiac complications, and risk stratification is based on the underlying cardiac disease and data from studies. Women with lower-risk CHDs can be managed in secondary care, while complex CHD cases require expert counseling in tertiary centers. Those with high-risk conditions should avoid pregnancy, use effective contraception, and seek tertiary center management if pregnancy does occur.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Article
Hematology
Maurice Swinkels, Sophie Hordijk, Petra E. Buergisser, Johan A. Slotman, Tom Carter, Frank W. G. Leebeek, A. J. Gerard Jansen, Jan Voorberg, Ruben Bierings
Summary: This study investigated the release of VWF and VWFpp from individual alpha-granules in response to different physiological stimuli. The results showed that the secretion of alpha-granule cargo increased in a dose-dependent manner upon activation of PAR-1 and GPVI signaling pathways. However, there were differential release patterns for VWF and VWFpp.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Maria Teresa Pagliari, Ulrich Budde, Luciano Baronciani, Peyman Eshghi, Minoo Ahmadinejad, Zahra Badiee, Mohammad-Reza Baghaipour, Olga Benitez Hidalgo, Eugenia Biguzzi, Imre Bodo, Giancarlo Castaman, Jenny Goudemand, Mehran Karimi, Bijan Keikhaei, Riitta Lassila, Frank W. G. Leebeek, Maria Fernanda Lopez Fernandez, Renato Marino, Johannes Oldenburg, Ian Peake, Cristina Santoro, Reinhard Schneppenheim, Andreas Tiede, Gholamreza Toogeh, Alberto Tosetto, Marc Trossaert, Hamideh Yadegari, Eva M. K. Zetterberg, Pier Mannuccio Mannucci, Augusto B. Federici, Jeroen Eikenboom, Flora Peyvandi
Summary: The prevalence of anti-von Willebrand factor (VWF) antibodies was assessed in patients with type 3 von Willebrand disease (VWD). The study found that 8.4% of the subjects tested positive for anti-VWF antibodies, while 6% had neutralizing VWF inhibitors. These inhibitors were mainly found in patients homozygous for VWF null alleles.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Eva K. Kempers, Calvin B. van Kwawegen, Joke de Meris, Manon C. W. Spaander, Saskia E. M. Schols, Paula F. Ypma, Floor C. J. I. Heubel-Moenen, Lize F. D. van Vulpen, Michiel Coppens, Johanna G. van der Bom, Karin Fijnvandraat, Karina Meijer, Jeroen Eikenboom, Samantha C. Gouw, Frank W. G. Leebeek, Marieke J. H. A. Kruip
Summary: The study evaluates the performance of FIT in patients with Von Willebrand disease (VWD) or hemophilia. The false-positive rate of FIT is higher in these patients compared to the general population. However, the detection rate of colorectal cancer (CRC) and/or advanced adenoma (AA) is high in hemophilia patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Viola J. F. Strijbis, Lorenzo G. R. Romano, Ka Lei Cheung, Jeroen Eikenboom, Ying Poi Liu, Andrew C. McCreary, Frank W. G. Leebeek, Mettine H. A. Bos
Summary: This study aimed to evaluate the efficacy of FIX-FIAV in plasma from HA patients. The results showed that FIX-FIAV could increase the FVIII-equivalent activity and coagulation activity in HA patient plasma, mitigating the HA phenotype. Therefore, FIX-FIAV could serve as a potential treatment for HA patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)