Article
Genetics & Heredity
Bing Song, Chao Wang, Yujie Chen, Guanjian Li, Yang Gao, Fuxi Zhu, Huan Wu, Mingrong Lv, Ping Zhou, Zhaolian Wei, Xiaojin He, Yunxia Cao
Summary: The study found that DNA methylation of different genes is associated with sperm DNA integrity status, with imprinting genes having a higher proportion of differentially methylated CpG sites compared to non-imprinting genes. Further research is needed to investigate the specific mechanisms leading to epigenetic modifications.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Oncology
Huanhuan Chen, Lei Zhang, Li Meng, Linlin Liang, Cuilian Zhang
Summary: Cryopreservation is an important aspect of assisted reproductive technology. The vitrification method has been widely used and has shown improved outcomes in terms of cell survival rate, preimplantation development rate, and pregnancy outcomes. However, the use of high-concentration cryoprotectants and ultra-rapid cooling in vitrification may cause adverse effects on gametes, embryos, and tissue cells. Imprinted genes, which are regulated by epigenetic modifications, play a crucial role in placenta, fetal development, and offspring health. The impact of cryopreservation techniques, especially vitrification, on imprinted genes has been found in animal studies but has limited evidence in humans.
CLINICAL EPIGENETICS
(2022)
Article
Endocrinology & Metabolism
Bing Song, Yujie Chen, Chao Wang, Guanjian Li, Zhaolian Wei, Xiaojin He, Yunxia Cao
Summary: This study suggests that abnormal DNA methylation of certain CpG sites of imprinted genes is associated with poor sperm quality and severe sperm DNA damage.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Oncology
Yingxin Han, Liyan Ji, Yanfang Guan, Mengya Ma, Pansong Li, Yinge Xue, Yinxin Zhang, Wanqiu Huang, Yuhua Gong, Li Jiang, Xipeng Wang, Hong Xie, Boping Zhou, Jiayin Wang, Junwen Wang, Jinghua Han, Yuliang Deng, Xin Yi, Fei Gao, Jian Huang
Summary: Cervical cancer is the second leading cause of cancer death among women globally. Epigenetic dysregulation through DNA methylation and hydroxymethylation plays a crucial role in tumorigenesis. This study found genome-wide hypo-methylation and hypo-hydroxymethylation in CC, along with local hyper-methylation and hyper-hydroxymethylation. Additionally, novel differentially methylated/hydroxymethylated-associated genes were identified as potential epigenetic biomarkers for CC prognosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Chiara Herzog, Karin Sundstrom, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner, Martin Widschwendter
Summary: This study developed an automatable triage test for cervical screening that is highly sensitive and specific in predicting the risk of progression to CIN3+ in HPV+ patients. The test demonstrated a sensitivity of 100% for detecting invasive cancer and 78% for detecting CIN3, with a specificity of 90%. It also identified 52% of women aged 30 and above with a negative cytology index sample who were later diagnosed with CIN3 within 1-4 years.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Xiao Han, Fang Fang, Weiwei Cui, Ya Liu, Yuxin Liu
Summary: This study investigates the effect of alcohol consumption on cervical cancer by examining the methylation status of cervical cancer cells. The results suggest that ethanol can affect the expression of DNMT by inducing methyl donor consumption, leading to genome-wide hypomethylation in cervical cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Halimatou Diop-Ndiaye, Xavier Sastre-Garau, Aboubacry Drame, Birama Dembele, Nafissatou N. Ba, Oumy Diop-Diongue, Madeleine Mbow, Mba E. B. Diakhaby, Gisele Woto-Gaye, Coumba Toure Kane, Mamadou Diop
Summary: This study analyzed viral epidemiology of cervical neoplasia in Senegal and found that most HPV-positive cases were associated with viral genotypes covered by the 9-valent HPV vaccine, while 14.1% of cases remained HPV negative. Prophylactic vaccination using a 9-valent vaccine should reduce the incidence of HPV-associated neoplasia, but detection and treatment of CIN are still necessary for optimal prevention of cervical cancer.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Divika Sapehia, Aatish Mahajan, Parampal Singh, Jyotdeep Kaur
Summary: This study investigates the effects of dietary vitamin B12 and folic acid on fetal and placental epigenetics. It finds that deficiency in vitamin B12 and high folate levels have a significant impact on the gene expression of MEST and PHLDA2. The study also reveals that DNA methylation changes occur in both generations, while altered histone modifications primarily regulate gene expression in the F1 generation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Genetics & Heredity
Christopher Rt Hillyar, Shivani S. Kanabar, Kamil R. Pufal, Alexander W. Lawson, Joshua Li Saw Hee, Kathrine S. Rallis, Anjan Nibber, Michail Sideris
Summary: This study reviewed the literature on the ability of HPV methylation biomarkers to screen for cervical precancerous and cancerous lesions and found that methylation biomarkers with high diagnostic ability have the potential to serve as independent screening tests.
Article
Multidisciplinary Sciences
Chenchen Ren, Xianxu Zeng, Zhongna Shi, Chunyan Wang, Huifen Wang, Xiuqin Wang, Baoping Zhang, Zhaoning Jiang, Huan Ma, Hao Hu, Haozhe Piao, Xiaoan Zhang, Baojin Wang
Summary: This study evaluated the diagnostic value of OCT in detecting cervical precancerous lesions and cancer, showing that OCT has good diagnostic accuracy and consistency, making it a potential cervical diagnosis method.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Alexandros Daponte, George Michail, Athina-Ioanna Daponte, Nikoletta Daponte, George Valasoulis
Summary: Despite significant advancements in cervical cancer prevention, many women still miss the opportunity for early detection. Self-sampling HPV modalities have shown promise in addressing this issue and are considered a feasible alternative strategy with enhanced population coverage.
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Oncology
Liye Shi, Xue Yang, Ling He, Chunying Zheng, Zhen Ren, Juweria Abdisamad Warsame, Suye Suye, Lei Yan, Haiyi Cai, Xiao Xiao, Chun Fu
Summary: This study investigated the diagnostic value of methylation biomarkers of six tumor suppressor genes in cervical precancerous lesions and cervical cancer. The results showed a positive correlation between methylation score and lesion severity, and the GynTect (R) assay was found to be valuable in detecting CIN2 + and CIN3 +.
Article
Biology
Mansour A. Alghamdi, Laith N. AL-Eitan, Amneh H. Tarkhan, Firas A. Al-Qarqaz
Summary: The study revealed that HPV-induced warts lead to significant and unique epigenetic alterations to the host genome, with distinct patterns of methylation differences.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Zhiqing Huang, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, Ikuo Konishi, Shingo Fujii, Andrew Berchuck, Susan K. Murphy
Summary: Spheroids exhibit drug resistance and slow proliferation, which may be due to increased expression of mitochondrial pathway genes. The protein kinase C inhibitor UCN-01 has shown efficacy against spheroids, while conventional chemotherapies like cisplatin and paclitaxel were not effective. Ovarian cancer recurrence may be prevented by targeting genes involved in mitochondrial function in spheroids.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pediatrics
Rachel L. Maguire, John S. House, Dillon T. Lloyd, Harlyn G. Skinner, Terrence K. Allen, Asifa Mohamed Raffi, David A. Skaar, Sarah S. Park, Lauren E. McCullough, Scott H. Kollins, Staci D. Bilbo, David N. Collier, Susan K. Murphy, Bernard F. Fuemmeler, Kymberly M. Gowdy, Cathrine Hoyo
Summary: This study found that pre-pregnancy obesity is associated with increased concentrations of TNF-alpha and IFN-gamma in maternal plasma, and the related inflammation may increase the risk of childhood obesity, especially in African Americans.
Article
Oncology
Sanaz Keyhan, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, David L. Corcoran, Adelheid Soubry, Catherine Hoyo, Susan K. Murphy
Summary: Male obesity is associated with altered sperm DNA methylation profiles that appear to affect reprogramming fidelity in a subset of sperm, suggestive of an influence on the spermatogonia. Further work is required to determine the potential heritability of these DNA methylation alterations. If heritable, these changes have the potential to impede normal development.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Zachary R. Visco, Gregory Sfakianos, Carole Grenier, Marie-Helene Boudreau, Sabrina Simpson, Isabel Rodriguez, Regina Whitaker, Derek Y. Yao, Andrew Berchuck, Susan K. Murphy, Zhiqing Huang
Summary: The study found a stronger correlation between Claudin-1 (CLDN1) expression and methylation in recurrent and primary ovarian cancer. This inverse correlation was more prominent in short-term survivors and recurrent tumors, indicating its potential predictive value for disease prognosis. The relationship between CLDN1 methylation and expression plays a crucial role in ovarian cancer aggressiveness and recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Candice L. Alick, Rachel L. Maguire, Susan K. Murphy, Bernard F. Fuemmeler, Cathrine Hoyo, John S. House
Summary: This study found that maternal periconceptional diets with high glycemic loading are associated with offspring temperament, with variations in behavior observed between male and female offspring.
Article
Genetics & Heredity
Rashmi Joglekar, Carole Grenier, Cathrine Hoyo, Kate Hoffman, Susan K. Murphy
Summary: Maternal smoke exposure during pregnancy can impact the methylation of metastable epialleles (MEs). This exposure is associated with reduced micronutrients and increased DNA methylation at the PAX8 gene. Further research is needed to understand the consequences of these changes on smoking-related disease risk.
ENVIRONMENTAL EPIGENETICS
(2022)
Article
Oncology
Alexandra Bukowski, Cathrine Hoyo, Michael G. Hudgens, Wendy R. Brewster, Fidel Valea, Rex C. Bentley, Adriana C. Vidal, Rachel L. Maguire, John W. Schmitt, Susan K. Murphy, Kari E. North, Jennifer S. Smith
Summary: This study assessed the role of different HPV genotypes in the progression of high-grade cervical intraepithelial neoplasia (CIN2+). The results showed that non-16/18 HPV types are associated with differential rates of CIN2+ progression, with HPV16, 33, and 58 exhibiting the highest risks.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Neurosciences
Rashmi Joglekar, Marty Cauley, Taylor Lipsich, David L. Corcoran, Heather B. Patisaul, Edward D. Levin, Joel N. Meyer, Margaret M. McCarthy, Susan K. Murphy
Summary: Nicotine exposure during development may affect the sexual differentiation of the developing brain, potentially influencing adult sexual behavior in rodents. This study found that developmental nicotine exposure had an impact on the sexual differentiation of the preoptic area (POA) in rats, with the normal sex differences in male sexual behavior and POA area eliminated in nicotine-treated animals. In neonates, nicotine exposure also induced changes in gene expression and DNA methylation levels at sexually-dimorphic regions, suggesting the involvement of epigenetic mechanisms in the masculinization of the rat POA.
Article
Public, Environmental & Occupational Health
Carrie A. Miller, Sunny Jung Kim, Rochelle D. Schwartz-Bloom, Paul N. Bloom, Susan K. Murphy, Bernard F. Fuemmeler
Summary: This study evaluated the effectiveness of health messages disseminated through Facebook Ads in reducing tobacco smoke exposure during pregnancy. The static infographic was more engaging and reached a larger audience compared to the video version.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2022)
Article
Andrology
Rose Schrott, Katherine W. Greeson, Dillon King, Krista M. Symosko Crow, Charles A. Easley, Susan K. Murphy
Summary: Cannabis use is increasing in the United States, especially among men at their peak reproductive years. Research has shown that cannabis exposure can lead to widespread changes in sperm DNA methylation, affecting important genes in neurodevelopment. In this study, an in vitro human spermatogenesis model was used to replicate chronic cannabis use and assess DNA methylation at imprinted and autism spectrum disorder (ASD) candidate genes. The results support previous findings in human cohorts and provide a new tool to understand the mechanistic link between paternal cannabis use and the risk of ASD in offspring.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dillon T. Lloyd, Harlyn G. Skinner, Rachel Maguire, Susan K. Murphy, Alison A. Motsinger-Reif, Cathrine Hoyo, John S. House
Summary: Children conceived with assisted reproductive technology (ART) have an increased risk of adverse outcomes due to altered methylation of imprint control regions (ICRs), which is associated with cardiovascular disease, metabolic and behavioral outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Christine E. Crute, Chelsea D. Landon, Angela Garner, Samantha M. Hall, Jeffery Everitt, Sharon Zhang, Bevin Blake, Didrik Olofsson, Henry Chen, Heather M. Stapleton, Susan K. Murphy, Liping Feng
Summary: The study found that gestational exposure to PFBS may lead to adverse maternal and fetal health outcomes, including renal injury, hypertension, restricted fetal growth, and abnormal placenta function. These findings raise concerns about pregnant women's exposure to PFBS and pregnancy outcomes.
TOXICOLOGICAL SCIENCES
(2023)
Review
Genetics & Heredity
Jamie O. Lo, Rahul J. D'Mello, Lester Watch, Danny J. Schust, Susan K. Murphy
Summary: The rate of substance use is increasing, especially among reproductive-age individuals. Paternal pre-conception and maternal prenatal substance use may alter offspring epigenetic regulation and outcomes later in life. More research is needed in this area to provide public health warnings and healthcare provider counseling for individuals or couples in the pre-conception and prenatal periods to mitigate long-term offspring morbidity and mortality.
Article
Substance Abuse
David C. Wheeler, Joseph Boyle, D. Jeremy Barsell, Rachel L. Maguire, Junfeng Zhang, Jason A. Oliver, Shawn Jones, Bassam Dahman, Susan K. Murphy, Cathrine Hoyo, Chris D. Baggett, Joseph McClernon, Bernard F. Fuemmeler
Summary: The study found a significant positive association between TRO exposure and cotinine levels, with secondhand smoke exposure playing a significant role in low cotinine levels and active smoking associated with neighborhood deprivation index (NDI). Additionally, individual factors such as race, education, and marital status also influenced cotinine levels.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
Albert J. Ksinan, Yaou Sheng, Elizabeth K. Do, Julia C. Schechter, Junfeng (Jim) Zhang, Rachel L. Maguire, Cathrine Hoyo, Susan K. Murphy, Scott H. Kollins, Bruce Rubin, Bernard F. Fuemmeler
Summary: A data-driven approach was used to identify and validate two items that may serve as a screening tool for quickly and accurately assessing children at risk for secondhand smoke exposure.
NICOTINE & TOBACCO RESEARCH
(2021)