Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yi Qin, Milad Ashrafizadeh, Vera Mongiardini, Benedetto Grimaldi, Francesco Crea, Katja Rietdorf, Balazs Gyorffy, Daniel J. Klionsky, Jun Ren, Wei Zhang, Xianbin Zhang
Summary: The emergence of drug resistance is a major challenge for oncologists. Autophagy plays a complex physio-pathological role in cancer drug resistance, either promoting cell survival or contributing to cell death. Understanding the regulation and modulation of autophagy can lead to potential therapeutic strategies for cancer treatment.
Article
Biochemistry & Molecular Biology
Laura Mosca, Martina Pagano, Annalisa Pecoraro, Luigi Borzacchiello, Luigi Mele, Giovanna Cacciapuoti, Marina Porcelli, Giulia Russo, Annapina Russo
Summary: This study demonstrated that S-adenosyl-l-methionine can overcome drug resistance in colon cancer cells lacking p53 through multiple mechanisms, including cell cycle arrest, autophagy inhibition, reactive oxygen species augmentation, and apoptosis induction. The results suggest that S-adenosyl-l-methionine may hold promise as a potential agent for cancer therapy by examining p53 and uL3 profiles in tumors to improve clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jianran Hu, Ping Li, Baozhong Shi, Jun Tie
Summary: Saikosaponin D (SSD) can enhance cisplatin sensitivity of gastric cancer cells by inducing apoptosis and autophagy, and inhibiting the IKK beta/NF-κB signaling pathway.
Article
Cell Biology
Zhifu Gui, Zhenguo Zhao, Qi Sun, Guoyi Shao, Jianming Huang, Wei Zhao, Yuting Kuang
Summary: Long non-coding RNA FEZF1-AS1 is upregulated in gastric cancer tissues and cell lines, and is associated with chemoresistance. High expression of FEZF1-AS1 is an independent predictor for poor overall survival in gastric cancer patients, potentially regulating multi-drug resistance through modulating autophagy in gastric cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Milad Ashrafizadeh, Sepideh Mirzaei, Kiavash Hushmandi, Vahid Rahmanian, Amirhossein Zabolian, Mehdi Raei, Mahdi Vasheghani Farahani, Mohammad Ali Sheikh Beig Goharrizi, Haroon Khan, Ali Zarrabi, Saeed Samarghandian
Summary: Lung cancer is a major cause of death worldwide, with various risk factors such as genetics, epigenetics, and environmental factors playing a role in its development. The AMP-activated protein kinase (AMPK) signaling pathway is crucial in lung cancer progression, influencing metastasis, proliferation, and response to treatments like chemotherapy and radiotherapy. AMPK activation can both enhance and suppress lung cancer progression, indicating its complex and dual role in cancer cells.
Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Article
Oncology
Haifeng Xu, Bing Xu, Jiayu Hu, Jun Xia, Le Tong, Ping Zhang, Lei Yang, Lusheng Tang, Sufeng Chen, Jing Du, Ying Wang, Yanchun Li
Summary: This study developed a prognostic model based on the specific role of autophagy-related genes (ATGs) in gastric cancer (GC), which improved the prediction of GC outcomes and could help with individualized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Seog Young Kang, Dongwon Hwang, Soyoung Shin, Jinju Park, Myoungchan Kim, MD. Hasanur Rahman, Md. Ataur Rahman, Seong-Gyu Ko, Bonglee Kim
Summary: Bioactive food components from natural products play a crucial role in gastric cancer prevention and treatment, with potential mechanisms including suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Administering these natural bioactive food components may enhance the efficacy of gastric chemotherapy and minimize adverse effects, offering potential novel treatment strategies for gastric cancer management.
Review
Cell Biology
Asha Tonkin-Reeves, Charlett M. Giuliani, John T. Price
Summary: The process of macroautophagy is essential for degrading unnecessary and damaged proteins and organelles, which are then reused by the cells. Autophagy is crucial for normal cells to survive various stressors, but it is often upregulated in cancer cells, promoting their aggressive behavior and resistance to treatment. This review provides a comprehensive summary of the role of autophagy in therapeutic resistance and the limitations of current autophagic inhibitors in cancer treatment. It emphasizes the urgent need to explore new inhibitors that can work synergistically with existing therapies to improve patient outcomes. Advancing research in this field is critical for developing more effective treatments and enhancing the lives of cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Suyun Zhang, Rui Feng, Fang Yuan, Qiong Luo, Xiangqi Chen, Nan Li, Sheng Yang
Summary: Dihydroartemisinin (DHA) has therapeutic effects on cisplatin-resistant gastric cancer cells by enhancing autophagy, inducing apoptosis, and increasing cisplatin sensitivity.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoping Pan, Xiaolv Hong, Sumei Li, Ping Meng, Feng Xiao
Summary: This study identified the METTL3/miR-221-3p/HIPK2/Che-1 axis as a potential mechanism for breast cancer cell resistance to adriamycin. Knockdown of METTL3 resulted in reduced expression of miR-221-3p, leading to decreased drug resistance and increased apoptosis in ADR-resistant MCF-7 cells.These findings suggest that targeting the METTL3/miR-221-3p/HIPK2/Che-1 axis may improve chemotherapy efficacy in breast cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao
Summary: The study elucidates the potential role of Sestrin2 in regulating the sensitivity of osteosarcoma to chemotherapy, demonstrating that Sestrin2 activates autophagy by inhibiting the mTOR pathway and decreases apoptosis via Bcl-2, ultimately slowing down tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Annie Cristhine Moraes Sousa-Squiavinato, Diego Alfonso Arregui Ramos, Monica Silveira Wagner, Josiane Weber Tessmann, Julio Cesar Madureira de-Freitas-Junior, Jose Andres Morgado-Diaz
Summary: A long-term drug-resistant colorectal cancer model was established to explore the cellular events underlying 5-fluorouracil (5FU) resistance. The study identified various cellular events and molecular changes associated with 5FU resistance, as well as specific genes that could predict poor outcomes in colorectal cancer patients. The findings highlight the importance of identifying promising targets involved in multiple cellular events to overcome drug resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Chenghao Li, Jiawei Li, Yan Li, Ling Li, Yali Luo, Junjie Li, Yiming Zhang, Yanru Wang, Xiuzhu Liu, Xiaotian Zhou, Hongxia Gong, Xiaojie Jin, Yongqi Liu
Summary: Isorhamnetin (ISO), a chemical substance derived from plants, has been found to have antitumor effects. In a hypoxic environment, ISO can significantly inhibit gastric cancer cell autophagy by targeting PI3K and blocking the PI3K-AKT-mTOR signaling pathway, as well as promote cell apoptosis, making it a promising candidate for the treatment of gastric cancer.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Yaqing Wei, Jun He, Jie Zhang, Mingyang Ou, Yanpeng Guo, Jiajun Chen, Cheng Zeng, Jia Xu, Jiantao Han, Tianyou Zhai, Huiqiao Li
Summary: This study proposes a seamless integration strategy by merging the voltage and capacity of phosphorus and antimony into a solid solution alloy. Experimental results show that this alloy exhibits superior cycle stability, rate performance, and even delivers high capacity at low temperature.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Engineering, Manufacturing
Lin Deng, Tianle Lv, Yongbing Li, Wayne Cai, Amberlee S. Haselhuhn, Blair E. Carlson, Michael P. Balogh, Daad Haddad
Summary: This study investigates the effect of sheet surface condition, electrode surface morphology, electrode material, weld schedule, and electrode tip condition on asymmetric nugget growth, as well as the resulting weld microstructure and coach peel strength in resistance spot welding of aluminum alloys. It was found that asymmetric nugget growth was most influenced by sheet surface conditions and electrode materials at the positive polarity electrode side, leading to reduced weld mechanical strength and toughness.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Cardiac & Cardiovascular Systems
Jiao Wang, Adrian Campos, Miguel E. Renteria, Lin Xu
Summary: Using two-sample Mendelian randomization, this study found a causal relationship between sleep apnea (SA) and snoring with cardiovascular diseases (CVDs), which could be partly driven by body mass index (BMI).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Genetics & Heredity
Xiaotong Jing, Linlin Xu, Xinjia Huai, Hong Zhang, Fengli Zhao, Yushan Qiao
Summary: In this study, the AGO, DCL, and RDR gene families were identified and characterized in Fragaria vesca and Fragaria x ananassa. The expression patterns of these genes in different tissues and developmental stages were studied, as well as their response to hormone stresses. This study provides important genomic information and insights into the evolution of strawberries.
Article
Veterinary Sciences
Xiaohui Yao, Qiangqiang Song, Wei Zhu, Jianchao Wei, Donghua Shao, Ke Liu, Zongjie Li, Yafeng Qiu, Zhiyong Ma, Lining Xia, Beibei Li
Summary: The resistance profiles of Actinobacillus pleuropneumoniae and Pasteurella multocida isolates from swine in China were examined. High resistance rates of florfenicol, tetracycline, and trimethoprim-sulfamethoxazole were observed in both bacteria. The presence of the floR gene in florfenicol-resistant isolates indicated clonal expansion, and the genetic basis of this resistance was identified as plasmids. Horizontal transfer of plasmids was found to be important for dissemination of the floR gene in these bacterial pathogens. Further studies on florfenicol resistance and transfer vectors in Pasteurellaceae bacteria are needed.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Analytical
Qiao Lin, Chunwang Meng, Jie Liu, Fei Liu, Qinmei Zhou, Juan Liu, Cheng Peng, Liang Xiong
Summary: With the development of NMR spectrometers and probes, 2D qNMR technology has become increasingly accessible for quantitation of complex mixtures. However, the need for a long relaxation recovery time makes it difficult for 2D qNMR to achieve high quantitative accuracy and data acquisition efficiency. By using relaxation optimization and nonuniform sampling, we successfully established an optimized 2D qNMR strategy for accurate quantitation of diester-type C-19-diterpenoid alkaloids.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shoulin Zhang, Xue Zhou, Guangyao Zhou, Bin He, Huan Pang, Lin Xu, Yawen Tang
Summary: This study proposes a reliable self-sacrificial template-engaged approach to synthesize O-doped CoP microflowers with enhanced catalytic performance. The optimized O-CoP microflowers show remarkable HER property with small overpotential, low Tafel slope, and long-term durability under alkaline electrolyte. This work provides valuable insights for the design of low-cost and effective electrocatalysts in energy conversion and storage systems.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Ecology
Liujun Xiao, Guocheng Wang, Jinfeng Chang, Yaoyao Chen, Xiaowei Guo, Xiali Mao, Mingming Wang, Shuai Zhang, Zhou Shi, Yiqi Luo, Lei Cheng, Kailiang Yu, Fei Mo, Zhongkui Luo
Summary: The aim of this study was to understand the distribution of belowground net primary productivity (BNPP) in soil depths down to 2m across the globe and analyze the environmental factors affecting it. Global datasets on net primary production, root biomass, and soil profiles were used to map the depth-resolved BNPP at a resolution of 1km. It was found that temperature, precipitation, and soil properties play a crucial role in regulating BNPP and its depth distribution.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Article
Chemistry, Physical
Qiu Zhang, Yuekun Zhang, Fengyan Li, Tingting Zhang, Lin Xu
Summary: The Cu2WS4/[Me2NH2]11[CeIII(PW11O39)2] (CWS/CeIII(PW11)2) composite was synthesized and used as a counter electrode material in CdS/CdSe/ZnS-sensitized quantum dot sensitized solar cell (QDSSCs). The CWS has more redox active sites than Cu2S due to the co-existence of copper and tungsten in different valence states. The CWS-4 CE showed the highest electrocatalytic activity and improved cell performance by generating shallow electron traps and inhibiting charge recombination.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Xiaohong Liu, Xingtao Xu, Xiaoxu Xuan, Wei Xia, Guilin Feng, Shuaihua Zhang, Zhen-Guo Wu, Benhe Zhong, Xiaodong Guo, Keyu Xie, Yusuke Yamauchi
Summary: In this study, a yolk-shell nanoarchitecture of NASICON-structured NTP/C materials (ys-NTP@C) was developed using a metal-organic framework@ covalent organic polymer (MOF@COP) as a sacrificial template and space-confined nanoreactor. ys-NTP@C exhibited good CDI performance with high salt adsorption capacities (SACs) and good cycling stability. This study provides a new synthetic paradigm for preparing yolk-shell structured materials and highlights the potential use of yolk-shell nanoarchitectures for electrochemical desalination.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Yaya Liu, Jinliang Zhang, Min Xiao, Jiandong Zha, Yanqiu Fu, Changyu Wei, Jun Tang
Summary: The aim of this study was to investigate the effect of Golgi membrane protein 1 (GOLM1) on the proliferation, migration, and invasion of esophageal squamous cell carcinoma (ESCC) cells and its underlying oncogenic mechanism. The expression level of GOLM1 in EC tissues was significantly higher, and its mRNA expression in ESCC was significantly higher than adjacent tissues. GOLM1 silencing can reduce the proliferation, migration, and invasion of ESCC cells by inhibiting the Wnt/β-catenin signaling pathway.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Yi-Ming Zhang, Tian-Yan Lan, Shuai Zhang, Shao-Qiu Xiao
Summary: In order to suppress coupling among patch antenna arrays and reduce out-of-band spurious, this paper proposes a feeding-decoupling network with harmonic suppression. The decoupling method is achieved by generating two decoupling paths between the feeding of an antenna and the radiating patch of an adjacent antenna. The results show that the proposed decoupling structure effectively suppresses coupling and out-of-band spurious.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Chemistry, Multidisciplinary
Xue Zhuan, Mu Zhonglin, He Runhe, Li Yongbing, Zhang Xingxiang
Summary: To improve the electrochemical performance of lithium sulfur batteries, aminated carbon nanotubes (MWCNT-NH2) were used to enhance the cathode properties. MWCNT-NH2 was synthesized through Diels-Alder (D-A) reaction, and a series of specimens were obtained by varying the reaction time. The samples were analyzed and characterized using thermogravimetric analyzer, Raman spectrometer, and infrared spectrometer. The results demonstrated that the amino content of MWCNT-NH2 increased with the prolonged D-A reaction time, reaching a grafting rate of 10.02 mmol/g at 16 hours. Electrochemical performance analysis of four cells assembled using MWCNT-NH2 composites with different amino content revealed that a higher amino content led to better electrochemical performance. The cathode material with the highest amino content (SPAN/MWCNTs-NH2-16) exhibited initial discharge specific capacities of 943.3 and 887.1 mA·h/g (composite) at 0.2C and 1.0C, respectively. After 200 cycles at 0.2C, the reversible specific capacity was 716.4 mA·h/g (composite), with an increased capacity retention rate.
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2023)
Article
Chemistry, Multidisciplinary
Zhenya Hu, Niuwa Yang, Yongjun Feng, Lin Xu, Chaoquan Hu, Hui Liu, Shaonan Tian, Jun Yang
Summary: By adjusting the amount of Se precursors, orthorhombic PdSe2, cubic Pd17Se15, and monoclinic Pd7Se2 nanoparticles were synthesized, exhibiting phase-dependent electrocatalysis for ethanol oxidation reaction. This study advances the controlled synthesis of transition metal selenides and inspires their applications in electrocatalysis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mohan Li, Libo Wang, Fengyan Li, Lin Xu
Summary: Photocatalytic nitrogen fixation using Zn-doped Co3O4 nanopolyhedrons as the semiconductor material was investigated in this study. The Zn doping resulted in abundant oxygen vacancies on the surface of the Co3O4 polyhedron, which improved both the nitrogen adsorption and activation as well as the separation ability of photocarriers, leading to enhanced efficiency in photocatalytic nitrogen fixation.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)