Article
Chemistry, Multidisciplinary
Sunyoung Woo, Soojin Kim, Hyunhong Kim, Young Woo Cheon, Seokjoo Yoon, Jung-Hwa Oh, Jongnam Park
Summary: The study synthesized three differently charged IONPs with high colloidal stability via RAFT polymerization and ligand exchange. These IONPs showed no significant cytotoxicity in human cell lines or acute toxicity in mice, indicating their potential for bio-applications.
Article
Materials Science, Multidisciplinary
Khushboo Jani, Neeraj Kaushal, Mostafa Sadoqi, Gen Long, Zhe-Sheng Chen, Emilio Squillante
Summary: The study aimed to fabricate polymeric nanoparticles with magnetic property, successfully preparing oleic acid magnetic nanoparticles. The nanoparticles were dispersed within a polymeric matrix, and superior efficacy in U-138 cells was observed in the presence of an external magnetic field.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Dong Han, Baolin Zhang, Jianghui Dong, Boning Yang, Yuntao Peng, Junfeng Wang, Liping Wang
Summary: DMPC-modified SPIONs have advantages in faster transport to the brain and easier cellular uptake, with potential applications in drug delivery and activation of neuronal membrane channels.
Article
Biophysics
Huiyan Wang, Jie Li, Han Liang, Xinrong Huang, Na Meng, Ninglin Zhou
Summary: In this study, a method was explored to prepare an effective antibacterial nanocomposite of silver nanoparticles/graphene oxide-sulfobutylether-beta-cyclodextrin (AgNPs/GO-SBE-beta-CD). Dopamine was used as a green and mild reductant to directly reduce silver nitrate on SBE-beta-CD modified graphene oxide. The synthesized nanocomposite showed uniform distribution of silver nanoparticles and exhibited strong antibacterial properties against gram-negative and gram-positive bacteria. It also demonstrated good biocompatibility, making it a promising material for preventing bacterial infection and wound healing applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Toxicology
Lin Wu, Wen Wen, Xiaofeng Wang, Danhua Huang, Jin Cao, Xueyong Qi, Song Shen
Summary: The study found that ultrasmall Fe3O4 nanoparticles have high toxicity, especially on the heart. The toxicity is related to both the iron element and particle size, providing new insights into the toxicology of ultrasmall Fe3O4 nanoparticles.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Crystallography
Xing Zhong, Qiaozhulin Yuan, Qiang Wang, Caixia Hu, Kai Guo, Jinbo Ouyang, Mingyang Chen
Summary: In this study, maleic anhydride-beta-cyclodextrin functionalized magnetic iron oxide nanoparticles were prepared and their adsorption behavior for uranium (VI) was investigated. The results showed that the maleic anhydride-beta-cyclodextrin-coated iron oxide nanoparticles had significantly improved adsorption capacity for uranium (VI) and can be easily separated by magnetic separation technique. The adsorption process followed pseudo-second-order kinetic model and Langmuir model, indicating a chemisorption process.
Article
Biochemistry & Molecular Biology
Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Luedtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries
Summary: In this study, the impact of MPI optimized dextran-coated SPIONs on monocytic cells was investigated. It was found that SPIONs were rapidly taken up by monocytes and did not affect cell viability. However, SPION uptake hindered monocyte differentiation into macrophages and led to changes in cytokine secretion.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Amandeep Kaur, Poonam Khullar, Mandeep Singh Bakshi
Summary: In this study, cyclodextrin-stabilized magnetic nanoparticles were used to extract Au/Ag nanoparticles as nanometallic pollutants from water. The extraction process relied on the host-guest interactions between the surfactants used for stabilizing the Au/Ag nanoparticles and the CD cavity of the functionalized magnetic nanoparticles. Stronger host-guest interactions were found to be necessary for effective extraction.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Abdurahman Hajinur Hirad, Siddique Akber Ansari, Mohamed Abdellatif Eltayeb Ali, Mohamed Ali Egeh
Summary: In this study, iron oxide nanoparticles (IONPs) were synthesized using Ocimum tenuiflorum leaf extract and characterized. The results showed that IONPs exhibited excellent photocatalytic and antimicrobial properties, and higher toxicity towards cancer cells with higher biocompatibility towards normal cells.
PROCESS BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Alexandre Fromain, Jose Efrain Perez, Aurore van de Walle, Yoann Lalatonne, Claire Wilhelm
Summary: This study demonstrates that photothermia at the nanoscale can trigger the degradation of magnetic nanoparticles, leading to the release of Fe(II) and enabling photothermo-ferroptotic therapy. The temperature acts as an accelerator for nanoparticle degradation and can be remotely triggered by laser-mediated photothermal conversion. The efficacy of this treatment method has been confirmed in in vitro experiments.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Samia Aboushoushah, Wafa Alshammari, Reem Darwesh, Nihal Elbaily
Summary: The study suggests that curcumin-coated iron oxide nanoparticles (Cur-IONPs) exhibit good safety and non-toxicity in a mouse model. Cur-IONPs primarily accumulate in the liver, spleen, and brain, with minimal presence in the kidney, and can be completely cleared after a certain period of time.
Article
Pharmacology & Pharmacy
Hanyi Li, Erwin Peng, Feng Zhao, Jun Li, Junmin Xue
Summary: Supramolecular polymers formed through host-guest complexation have inspired the development of functional materials for biological and biomedical applications. A novel non-viral gene delivery system composed of a cationic star polymer forming supramolecular complexes with superparamagnetic iron oxide nanoparticles (SPIONs) was designed for magnetically enhanced delivery of DNA into mammalian cells. The study demonstrated a facile two-in-one method to make the SPIONs water-soluble and functionalized for enhanced magnetofection.
Article
Toxicology
Linn Voss, Elisa Hoche, Valerie Stock, Linda Boehmert, Albert Braeuning, Andreas F. Thuenemann, Holger Sieg
Summary: Iron oxide nanoparticles are receiving increasing attention for their industrial use, but their effects on human cells are still being investigated. This study found that the nanoparticles did not dissolve during gastrointestinal passage, had minor uptake in intestinal cells, and showed varying effects on different cell types. Case-by-case assessment of iron oxide nanoparticles is necessary due to the lack of correlation between particle characteristics and cellular effects.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina A. Petrova, Natallia V. Dubashynskaya, Iosif V. Gofman, Alexey S. Golovkin, Alexander I. Mishanin, Arthur D. Aquino, Daria V. Mukhametdinova, Alexandra L. Nikolaeva, Elena M. Ivan'kova, Alexander E. Baranchikov, Alexander V. Yakimansky, Vladimir K. Ivanov, Yury A. Skorik
Summary: Polymeric nanocomposite materials have the potential to enhance tissue-engineered scaffolds by influencing the structure and properties of polymeric materials and regulating cell behavior. In this study, cerium oxide nanoparticles were incorporated into a chitosan film to promote the proliferation of mesenchymal stem cells. The resulting CS-CeONP films exhibited good biocompatibility and regenerative potential in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Iris Garrido-Cano, Vicente Candela-Noguera, Guadalupe Herrera, Juan Miguel Cejalvo, Ana Lluch, M. Dolores Marcos, Felix Sancenon, Pilar Eroles, Ramon Martinez-Manez
Summary: Mesoporous silica nanoparticles (MSNs) are efficiently internalized by human cells, with uptake mechanisms differing among cell types and particles. These biocompatible materials do not induce ROS/RNS production, nor affect mitochondrial membrane potential or cell cycle within cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Cell Biology
Divya Desai, Aparna Khanna, Prasad Pethe
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Chemistry, Analytical
Priyal Chikhaliwala, Sudeshna Chandra
Article
Chemistry, Organic
Mangesh Sakhalkar, Sharad V. Lande, Sudeshna Chandra
Summary: This paper presents a method for the benzylation of naphthalene using a chloroaluminate ionic liquid as a catalyst. The method offers a highly active catalyst, low temperature and pressure reaction conditions, and high selectivity, making it significant for the synthesis of mono-benzylated naphthalenes.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Analytical
Gita Singh, Sudeshna Chandra
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Cell & Tissue Engineering
Ruchita Shelat, Lokesh Kumar Bhatt, Bhawan Paunipagar, Thomas Kurian, Aparna Khanna, Sudeshna Chandra
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Materials Science, Multidisciplinary
Priyal Chikhaliwala, Wayne Schlegel, Heinrich Lang, Sudeshna Chandra
Summary: Inkjet printing technology shows great potential in fabricating biosensor devices, with the challenge lying in stabilizing ink suspensions. Nanoparticles are believed to enable miniaturization of biosensing devices. By synthesizing stable nanoparticle ink dispersion of PAMAM@Fe3O4, uniform printed patterns were successfully achieved on graphene paper.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Mangesh Sakhalkar, Rudra Prosad Choudhury, Vishnupriya Bhakthavatsalam, Sharad Lande, Jeevan Pradhan, Sudeshna Chandra
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Chemistry, Multidisciplinary
Jayprakash Rao, Amar Nath Chandrani, Anil Powar, Sudeshna Chandra
Summary: Polyurea microcapsules containing oxyfluorfen herbicide were synthesized using interfacial polymerization reaction, with varying core to shell ratios and emulsifying agents. The study found that encapsulation efficiency decreased with increasing core to shell ratio, release kinetics were influenced by stirring rate and medium pH, and particle size distribution was affected by agitation speed. Different molecular weight Kraft lignins were used, showing slow release with high molecular weight lignin. Safety study on paddy crop indicated these capsules were safe for use compared to commercially available oxyfluorfen.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2021)
Article
Chemistry, Physical
Meenakshi Shukla, K. C. Barick, H. G. Salunke, Sudeshna Chandra
Summary: Heterogeneous catalysts, specifically the chiral Ni-Schiff base derived catalyst immobilized in mesoporous silica, exhibit high catalytic activity and enantioselectivity up to 99% in the asymmetric transfer hydrogenation of various ketones. The developed catalyst can be recovered and reused for multiple consecutive runs without loss of enantioselectivity, showing promising potential in the synthesis of enantiomerically pure drug intermediates such as Montelukast.
MOLECULAR CATALYSIS
(2021)
Article
Chemistry, Physical
Jayprakash Rao, Amar Nath Chandrani, Anil Powar, Sudeshna Chandra
Summary: This study reports the preparation of capsule suspension formulation for the herbicide oxyfluorfen and investigates the effect of surfactants on the stability of the formulation. The study found that the nature of surfactant influences the properties of the formulation. The synthesized microcapsules were characterized and tested on rice crop, demonstrating their safety and potential as an alternative to oxyfluorfen EC.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shirish K. Phanse, Shriya Sawant, Harinder Singh, Sudeshna Chandra
Summary: This paper reports on the encapsulation of Dhavana oil in a modified starch matrix using a spray-drying technique. The study evaluates the physico-chemical properties, stability, release mechanism, and antimicrobial efficacy of the encapsulated oil. The findings provide valuable information for cosmetic formulation and potential applications in the perfumery, food, and cosmetic industries.
Review
Cell Biology
Aishwarya Shetty, Priyal Chikhaliwala, Jui Suryawanshi, Sudeshna Chandra
Summary: Dendrimers serve as versatile tools for delivery of nucleic acids, drugs, and vaccines for different diseases through various administration routes by enhancing systemic blood circulation time, biocompatibility, and reducing toxicity. Non-covalent interactions improve drug solubility, while electrostatic interactions with charged molecules encourage endosomal escape. Covalent associations through physiologically labile bonds or cleavable linkers enable controlled release and targeted delivery of therapeutic moieties.
CURRENT PATHOBIOLOGY REPORTS
(2021)
Article
Chemistry, Multidisciplinary
A. Shetty, S. Chandra
MATERIALS TODAY CHEMISTRY
(2020)
Article
Oncology
Divya Desai, Aparna Khanna, Prasad Pethe
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Polymer Science
Jayprakash Rao, Amar Nath Chandrani, Anil Powar, Sudeshna Chandra
DESIGNED MONOMERS AND POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)