Article
Biochemistry & Molecular Biology
Wanwen Kang, Jiacheng Liang, Ting Liu, Hui Long, Langhuan Huang, Qingshan Shi, Jingxian Zhang, Suiping Deng, Shaozao Tan
Summary: A temperature-sensitive antibacterial hydrogel, NIPAM-CG/GM, was synthesized and its critical solution temperature and mechanical properties can be controlled by adjusting the composition. This hydrogel shows excellent biocompatibility and antibacterial effects, with high drug loading and drug release at a physiological temperature of 37 degrees Celsius.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Norhazirah Rosli, Wan Zaireen Nisa Yahya, Mohd Dzul Hakim Wirzal
Summary: Nanostructure adsorbents, specifically nanofiber membranes made of chitosan/PVA blend, were successfully synthesized through electrospinning and functionalization methods to act as potential bio-sorbents for heavy metal ions removal. The synthesized adsorbent showed excellent performance in removing Pb(II) ions from pure heavy metal ions solutions, with a high adsorption capacity and compatibility with the Freundlich isotherm and pseudo-second-order kinetic models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Wei-Ting Du, Esam A. Orabi, Mohamed Gamal Mohamed, Shiao-Wei Kuo
Summary: Two isomeric hydroxyphenylmaleimide (HPMI) monomers were synthesized and copolymerized with styrene to form two near-perfect alternating copolymers. Characterization using various techniques revealed differences in hydrogen bonding interactions between oHPMI and PVP compared to pHPMI, leading to weaker interactions between oHPMI and PVP.
Article
Chemistry, Multidisciplinary
Yong Wang, Xiaorong Lan, Shuyin Zuo, Yafeng Zou, Sai Li, Zhonglan Tang, Yunbing Wang
Summary: A star-shaped PLLA oligomer with photoreactive groups at the terminal was synthesized, and a photopolymerizable resin was prepared by incorporating NVP and FAME. The resulting network showed high mechanical properties in the dry state and good flexibility in the wet state, with both cytocompatibility and anti-adhesion properties. The material holds potential for applications in anti-adhesion barrier materials and biological anti-fouling materials with customization requirements, enabled by Digital Light Processing (DLP) technology.
Article
Engineering, Environmental
Fan Yang, Liangpeng Xu, Dajun Kuang, Yao Ge, Gaoyang Guo, Yunbing Wang
Summary: This study developed a new method to copolymerize zwitterionic monomer and methacrylated porcine pericardium for the fabrication of TAV leaflets with robust antithrombotic and anticalcification properties. The experimental results showed that this new hybrid material has lower thrombogenicity and can effectively inhibit the calcification of valve leaflets, promising to extend the lifespan of TAV.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Mehtap Tanyol, Gulben Torgut
Summary: A new graft copolymer was synthesized and used as an adsorbent for the rapid removal of tetracycline from aqueous solutions, showing excellent adsorption capacity and environmental friendliness. The study also examined the kinetics, isotherms, and thermodynamics of adsorption, with thermodynamic parameters indicating that the adsorption process was exothermic and spontaneous.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Miguel Angel Pacha-Olivenza, Leire Ruiz-Rubio, Oihane Gartziandia, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: Different polymeric antibacterial coatings were developed and analyzed for Ti6Al4V surface covering in this study, showing good cytocompatibility and antibacterial properties, which confirms their effectiveness against bacterial infections for future applications in protecting biomedical implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Nooraddein A. Ekrayem, Almahdi A. Alhwaige, Wael Elhrari, Mohamed Amer
Summary: The study developed eco-friendly polymeric spheres derived from crosslinking of chitosan (CTS) with different polyesters. The spheres showed enhanced structure and stability in aqueous media, with decreased hydrophilicity, and were effective in adsorbing lead ions (Pb2+) from aqueous solutions. The experimental data was fitted well with the Freundlich isotherm model, showing the best fit for the adsorption process.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Polymer Science
Nikoletta Roka, Olga Kokkorogianni, Philippos Kontoes-Georgoudakis, Ioannis Choinopoulos, Marinos Pitsikalis
Summary: Recent advances in the controlled RAFT polymerization of complex macromolecular architectures based on PNVP are summarized in this review, with a focus on the synthesis of statistical copolymers, block copolymers, star polymers and copolymers, graft copolymers, and more complex architectures. The advantages and limitations of the synthetic methodologies are discussed in detail.
Article
Polymer Science
Wafa A. A. Bawazir, Qana A. A. Alsulami, Sherif M. A. S. Keshk
Summary: In this study, the proton conductivity of poly(vinyl alcohol) (PVA) was enhanced by crosslinking polyvinyl pyrrolidone (PVP) with PVA, forming polyvinyl ketal (PVKL), without using any crosslinkers. Characterization techniques such as FT-IR, H-1-NMR, XRD, and TGA were employed. The PVKL film exhibited excellent water uptake ability and a proton conductivity of 100 mS cm(-1) at 110 degrees C. The increased proton conductivity of the PVKL film was attributed to the larger charge carrier concentration due to ketal ring formation. These findings suggest that the PVKL film has a longer lifespan and excellent proton conductivity, making it potentially useful in various optoelectronic applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Kheira Zanoune Dellali, Mohammed Dellali, Delia Mihaela Rata, Anca Niculina Cadinoiu, Leonard Ionut Atanase, Marcel Popa, Mihaela-Claudia Spataru, Carmen Solcan
Summary: Drug delivery is a critical aspect of nanomedicine, aimed at targeting specific active substances to desired sites of action. This study focuses on the synthesis of nanocapsules using chitosan and poly(N-vinyl pyrrolidone-alt-itaconic anhydride) and investigates their behavior and properties. In vivo experiments demonstrate the biocompatibility of nanocapsules and their ability to stimulate the monocytic macrophage system without causing inflammation. The study also emphasizes the importance of the administration route and the interaction with organ cells in determining the behavior of nanocapsules.
Article
Chemistry, Applied
M. R. El-Aassar, Omar M. Ibrahim, Moustafa M. G. Fouda, Hala Fakhry, Jamaan Ajarem, Saleh N. Maodaa, Ahmed A. Allam, Elsayed E. Hafez
Summary: The wound dressing made of chitosan, gelatin, polyvinyl pyrmlidone, and embedded silver nanoparticles showed strong antibacterial activity against pathogenic bacteria and reduced the expression of antibiotic resistance genes. This cost-effective membrane has a promising application in treating severe diabetic and burn wound infections.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Jun-Hee Cho, Young-Je Kwark
Summary: Poly (N-vinyl pyrrolidone) was synthesized successfully via photo-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. The photolysis of the chain transfer agent (CTA) was effectively prevented by using a light emitting diode with narrow-band emission at approximately 410 nm. The polymerization reaction showed a linear relationship between ln ([M]0/[M]) vs. time and molecular weight vs. conversion. Furthermore, the system was perfectly controlled by light as confirmed by a light on/off switching test, and the syndiotacticity of the polymer could be increased by polymerizing with fluoroalcohol at low temperature.
Article
Chemistry, Applied
Jheng-Yu Wu, Chien Wei Ooi, Cher Pin Song, Chi-Yun Wang, Bing-Lan Liu, Guan-Yu Lin, Chen-Yaw Chiu, Yu-Kaung Chang
Summary: HTCC, a chitosan derivative with quaternary ammonium groups, shows higher antibacterial activity but is unsuitable for electrospinning due to its hydrophilic nature. Adding PVA enhances its electrospinnability. Crosslinking PVA/HTCC/BI nanofiber membranes improves stability and antibacterial efficacy, making it a promising material for food packaging and wound dressing.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Amr M. Emara, Emad M. Elsharma, Islam M. Abdelmonem
Summary: To remove radioactive cesium ions from wastewater, researchers synthesized graft copolymer of chitosan-g-poly(acrylic acid/N-vinylcaprolactam) [CTS-P(AA/VC)]. The copolymer's shape, thermal stability, and structure were characterized using SEM, TGA, and FT-IR. Batch sorption experiments were conducted to evaluate the effects of various parameters on the adsorption process. Kinetics data were analyzed using different models, and the Langmuir and Freundlich equations were used for isotherm modeling. The copolymer showed promising potential in treating cesium-134 ions-containing liquids.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)