期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 107, 期 -, 页码 105-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.08.141
关键词
Thiosemicarbazone; Palladium (II); Anti-bacterial activity; Amoxicillin
Steroidal Pd (II) metal complexes were synthesized by the reaction of steroidal thiosemicarbazones with [Pd (DMSO)(2) Cl-2]. The steroidal thiosemicarbazones coordinate to palladium through the azomethine nitrogen and thionic sulfur. The thiosemicarbazone derivatives were obtained by the reaction of thiosemicarbazide with steroidal ketones. The identity of steroidal thiosemicarbazones and their Pd(II) metal complexes were elucidated by IR, H-1,C-13 NMR, FAB mass spectroscopic methods, elemental analysis and TGA analysis. The antibacterial activity of these compounds were tested in vitro by disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that the Pd(II) complexes are better growth inhibitors than steroidal thiosemicarbazones of both types of the bacteria (gram-positive and gram-negative). The compound 2a {[Pd(C35H54N3SCl)Cl-2]} is a as good as antibacterial agent as compared to amoxicillin. (C) 2017 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据