Article
Nanoscience & Nanotechnology
Wen Ren, Victoria Messerschmidt, Michael Tsipursky, Joseph Irudayaraj
Summary: In this study, an oxygen nanobubbles-embedded hydrogel (ONB-G) with carbopol was proposed for oxygenation of wounds to accelerate wound healing. ONB-G, prepared by integrating carbopol, hydrogel, and dextran-based oxygen nanobubbles (ONBs), can hold and release oxygen to promote wound healing. Experimental results showed that ONB-G could encapsulate oxygen for up to 34 days and maintain high oxygen levels for up to 4 weeks. HDFa cell-based studies demonstrated the potential of ONB-G in enhancing cell viability, proliferation, and wound closure. Histological evaluation using a pig model also indicated improved healing with ONB-G treatment compared to control groups. Overall, dextran-shell ONBs embedded in a gel exhibit promising potential in accelerating wound healing.
ACS APPLIED NANO MATERIALS
(2023)
Article
Polymer Science
Zhenghua Sun, Hao Xiong, Tengfei Lou, Weixuan Liu, Yi Xu, Shiyang Yu, Hui Wang, Wanjun Liu, Liang Yang, Chao Zhou, Cunyi Fan
Summary: Treating chronic wounds, especially in diabetes mellitus cases, is challenging due to prolonged inflammatory responses. Macrophage polarization and the use of Quercetin (QCT) have shown potential in promoting wound healing and inhibiting inflammation. However, the limited solubility of QCT restricts its applicability. Small intestinal submucosa (SIS) has been studied as a carrier for tissue regeneration and wound healing. Researchers have developed a biosafe hydrogel dressing with self-healing, water-absorbable, and immunomodulatory properties by combining SIS and QCT. In in vivo experiments, the hydrogels significantly increased wound repair rate and showed promising results in promoting wound healing.
Article
Nanoscience & Nanotechnology
Reena Badhwar, Bharti Mangla, Yub Raj Neupane, Kushagra Khanna, Harvinder Popli
Summary: The study successfully developed QCT-AgNPs hydrogel as a synergistic treatment for diabetic wounds, demonstrating superior therapeutic efficacy in both in vitro and in vivo studies, thus showing potential for the treatment of diabetic wounds.
Article
Biochemistry & Molecular Biology
Saeed Ali Alsareii, Javed Ahmad, Ahmad Umar, Mohammad Zaki Ahmad, Ibrahim Ahmed Shaikh
Summary: Researchers are currently focused on exploring natural or herbal bioactive compounds for therapeutic intervention. This study investigated the wound healing potential of a piperine hydrogel formulation, which showed promising results in improving wound healing.
Article
Biochemistry & Molecular Biology
Lanlan Wang, Jinhua Dong, Ziqiang Zhao, Dawei Li, Wenhao Dong, Yingke Lu, Bingqi Jin, Haoxuan Li, Qingsheng Liu, Bingyao Deng
Summary: Antibiotic abuse has become a burden on patients and healthcare systems, leading to a need for non-antibiotic wound dressings. However, hydrogel wound dressings with good recoverability, toughness, and excellent antibacterial properties still face obstacles. In this study, a series of semi-interpenetrating network (semi-IPN) hydrogels were developed using quaternized chitosan (QCS) and polyacrylamide (PAM) through a one-pot method, which showed exceptional mechanical performance and remarkable antibacterial activity. The integration of quercetin (QT) further enhanced the antibacterial properties against S. aureus and E. coli. These high-elastic hydrogels have potential applications in wound dressing, tissue repair, chronic wound care, and other biomedical fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Nahideh Asadi, Hamidreza Pazoki-Toroudi, Azizeh Rahmani Del Bakhshayesh, Abolfazl Akbarzadeh, Soodabeh Davaran, Nasim Annabi
Summary: Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix and ability to provide a moist environment. However, lack of multifunctionality and low mechanical properties may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures is an emerging approach to develop multifunctional hydrogels for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Yanan Jiang, Xin Zhang, Wei Zhang, Menghao Wang, Liwei Yan, Kefeng Wang, Lu Han, Xiong Lu
Summary: A skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy is presented. The hydrogel exhibits a thermoresponsive network and can be activated upon contact with warm skin, while painless detachment can be achieved by placing an ice bag on the surface. The hydrogel also has immunomodulatory performance and can prevent irritation and allergic reactions during long-period contact with the skin.
Article
Chemistry, Multidisciplinary
Wenda Wang, Zicheng Zeng, Li Xiang, Cong Liu, Diana Diaz-Dussan, Zunguo Du, Anika B. Asha, Wenshuai Yang, Yi-Yang Peng, Mingfei Pan, Ravin Narain, Jifang Liu, Hongbo Zeng
Summary: An injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly has been developed for gastric perforation healing. The hydrogel dressing possesses sensitive thermo-responsibility, injectability, antibiofouling property, simplifying surgical procedures, reducing postoperative complications, and enhancing the healing process. This work provides valuable insights for the development of biological environment-adaptive functional materials for biomedical applications.
Article
Materials Science, Multidisciplinary
Cheng Zhao, Jiahui Guo, Han Zhang, Min Nie, Caihong Yang, Yujuan Zhu, Yuanjin Zhao, Liping Zhong
Summary: In this study, bamboo-inspired gasotransmitter microfibres were generated using microfluidic spinning, allowing for precise control of bubble size and morphology. The microfibres promoted wound healing through the dual effects of drugs and gas, and the addition of responsive materials enabled controlled drug release for continuous effects.
ADVANCED FIBER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zhicong Lin, Donghao Fan, Guojiao Li, Liming He, Xianyan Qin, Bin Zhao, Qin Wang, Wenlang Liang
Summary: This study developed a hydrogel with tissue adhesivity, conductivity, and antibacterial function, which showed promising results in promoting diabetic wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste
Summary: High-mobility group box 1 (HMGB1) released during wounding delays skin regeneration. We discovered that dissolving glycyrrhizin in water forms a hydrogel with remarkable rheological properties. Glycyrrhizin-based hydrogels accelerate the closure of cutaneous wounds in normoglycemic and diabetic mice by influencing keratinocyte migration.
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Shikha Srivastava, Deependra Singh, Satish Patel, Manju R. Singh
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Review
Pharmacology & Pharmacy
Shikha Srivastava, Deependra Singh, Satish Patel, Arun K. S. Parihar, Manju R. Singh
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2017)
Review
Pharmacology & Pharmacy
Madhulika Pradhan, Shikha Srivastava, Deependra Singh, Shailendra Saraf, Swarnlata Saraf, Manju Rawat Singh
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
(2018)
Article
Biochemistry & Molecular Biology
Satish Patel, Shikha Srivastava, Manju Rawat Singh, Deependra Singh
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Review
Biochemistry & Molecular Biology
Krishna Yadav, Deependra Singh, Manju Rawat Singh
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Chemistry, Medicinal
Shikha Srivastava, Deependra Singh, Manju R. Singh
JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Review
Medicine, Research & Experimental
Madhulika Pradhan, Amit Alexander, Manju Rawat Singh, Deependra Singh, Swarnlata Saraf, Shailendra Saraf, Ajazuddin
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Review
Medicine, Research & Experimental
Satish Patel, Shikha Srivastava, Manju Rawat Singh, Deependra Singh
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Public, Environmental & Occupational Health
Meenu Sharma, Shikha Srivastava, Abhijit Pathak
Summary: Family psychoeducation (FPE) was found to have a significant positive impact on improving the psychological well-being of caregivers and the effective management of patients with schizophrenia.
INDIAN JOURNAL OF COMMUNITY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)