Review
Genetics & Heredity
Li Liu, Zhenglong Zhai, Danyang Wang, Yun Ding, Xiaoqing Chen, Qiqi Wang, Zheyue Shu, Minglan Wu, Lei Chen, Xuelin He, Dazhi Fan, Faming Pan, Meiyuan Xing
Summary: This meta-analysis revealed significant associations between IL-1α rs3783553, IL-1 β + 31C/T, IL-1 β + 511C/T, and IL-1RN VNTR with colorectal cancer (CRC) susceptibility based on data from 18 independent studies.
Review
Immunology
Xian-Ling Cao, Xuan-You Zhou, Nai-Xin Xu, Song-Chang Chen, Chen-Ming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between IL-4 and IL-10 gene polymorphisms and preterm birth (PTB). The findings suggest that the over-dominant gene model AA + GG vs. AG of IL-10-1082A/G (rs1800896) polymorphism may be associated with genetic susceptibility to PTB and may have a protective function against PTB risk. However, no clear association was found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), and IL-10-819T/C (rs1800871) polymorphisms and PTB. Further research is needed to confirm these findings due to the limitations of the included studies and the risk of publication bias.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qiuchen Jin, Fangjun Teng, Zhigang Cheng
Summary: Functional polymorphisms of IL-1 alpha (C-889T), IL-1 beta (C+3954T, C-511T) and the composite genotype of IL-1 can serve as predictive markers for peri-implant disease, while the TNF alpha G-308A polymorphism is not associated with peri-implant disease.
Article
Behavioral Sciences
Fan Cheng, Xiao-Min Si, Gong-Li Yang, Lan Zhou
Summary: This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.
BRAIN AND BEHAVIOR
(2021)
Review
Genetics & Heredity
Jiangang Jiang, Xinmin Chen, Chengwei Li, Xiaoma Du, Huadong Zhou
Summary: This study systematically reviewed the literature on TRIB1 gene polymorphisms and susceptibility to coronary atherosclerotic heart disease (CAD) and stroke. It found that the rs2954029 genetic polymorphism significantly increased the risk of CAD and stroke, while the rs17321515 polymorphism was not associated with the risk of CAD and stroke.
Review
Geriatrics & Gerontology
Ranran Duan, Na Wang, Yanan Shang, Hengfen Li, Qian Liu, Li Li, Xiaofeng Zhao
Summary: This study found a correlation between TNF-alpha rs1800629 polymorphism, increased levels of TNF-alpha, and decreased levels of IGF-1 with the etiology of ischemic stroke (IS).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Xuelun Zou, Le Zhang, Leiyun Wang, Sai Wang, Yi Zeng
Summary: Through a two-stage genetic study, we found a causal relationship between type I diabetes and small vessel stroke, but no causal relationship with other subtypes of stroke. Further research is needed to understand the underlying biological mechanisms.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Multidisciplinary Sciences
Juan Jiao, Zhaoping Wang, Yanfei Guo, Jie Liu, Xiuqing Huang, Xiaolin Ni, Danni Gao, Liang Sun, Xiaoquan Zhu, Qi Zhou, Ze Yang, Huiping Yuan
Summary: The IL-1RN2* allele and IL-1RN2*2* homozygous polymorphism are strongly associated with an increased risk of T2DM, while the IL-1B (-511) T allele polymorphism is associated with a decreased risk of T2DM in the East Asian subgroup.
Review
Clinical Neurology
Jie Chai, Xian-Ling Cao, Feng Lu
Summary: This meta-analysis found no significant association between IL-6 -174G/C(rs1800795) polymorphism and ischemic stroke (IS), but subgroup analysis showed that the relationship varied significantly according to ethnicity and geography.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Guanglu Che, Fang Liu, Li Chang, Yongmei Jiang
Summary: The study found no significant association between IL-10 -819C/T, -592A/C polymorphisms and the risk of preeclampsia, but did show a significant association with preeclampsia susceptibility in Asian and Caucasian populations.
Article
Immunology
Qianqian Liu, Wenzhang Li, Yunfeng Chen
Summary: The meta-analysis did not find a significant association between IL-4 rs2243250 polymorphism and TB risk overall, but indicated a potential increase in TB risk in the European population with the recessive genetic model. Additional research is needed to clarify the ethnic differences in genetic association studies.
MICROBIAL PATHOGENESIS
(2021)
Article
Endocrinology & Metabolism
Jinjing Wei, Bing Yang, Ruxin Wang, Haowen Ye, Ying Wang, Lihong Wang, Xiaofang Zhang
Summary: GLP-1RA therapy reduces the risk of stroke in patients with type 2 diabetes, especially ischemic stroke.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Etrat Javadirad, Masoud Sadeghi, Pembe Oltulu, Sepehr Sadafi
Summary: This meta-analysis examined the associations between IL-4 and IL-17 polymorphisms and colorectal cancer risk. The results showed that IL-17A rs2275913 and IL-17F rs763780 polymorphisms may be associated with an increased risk of colorectal cancer, while the association between IL-4 and IL-4R polymorphisms and colorectal cancer risk remains unclear. Ethnicity, genotyping method, sample size, control group, and publication year were identified as factors affecting the results.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Review
Genetics & Heredity
Jiachen Liu, Yunxia Chen, Xiuqi Shan, Huan Wang
Summary: This meta-analysis found significant associations between CILP (1184T > C) polymorphism and phenotype-dependent radiologic IDD, while the associations between IL-1 alpha (+889C/T) polymorphism and RIDD and SIDH were less credible.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Fatima Cano-Cano, Laura Gomez-Jaramillo, Pablo Ramos-Garcia, Ana I. Arroba, Manuel Aguilar-Diosdado
Summary: This study conducted a systematic review and meta-analysis on the chronic inflammation in the progression of Type 1 Diabetes Mellitus (T1DM), and found that the peripheral levels of interleukin-1 beta (IL-1 beta) were significantly elevated in T1DM patients, especially in patients under 18 years old and those with high levels of glycated hemoglobin. The levels of IL-1 beta may be associated with the management status and early stage of T1DM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.