期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 113, 期 -, 页码 971-975出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.02.104
关键词
Polysaccharide; Oxidative damage; Ulva pertusa
资金
- National Natural Science Foundation of China [41206129/D0609]
- Natural Science Foundation of Shandong Province [ZR2012DL13]
- Development of Medical Science and Technology Project of Shandong Province [2016WS0665]
- Shandong Province Higher Educational Science and Technology Program [J12LM51]
- Weifang Science and Technology Program [201301027]
Several studies have reported that ulvan from the alga Ulva pertusa (Chlorophyta) exhibits substantial antioxidant and antihyperlipidemic activities; however, which group of heteropolysaccharides play roles in these activities remains unknown. In this study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAE-Sepharose fast-flow column. The antioxidant activity was detected via the model of hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3, which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%) as well as the lowest average molecular weight (83,094 Da), exhibited the stronger antioxidant activity than other examples. It significantly decreased MDA (29.2%; P<0.05), increased SOD (36.4%; P<0.05) and CAT (43.6%; P<0.05) compared with hyperlipidemia group. In conclusion, PU3 may be potential sources of natural antioxidant to protecting against the liver damage of oxidative stress induced by cholesterol-rich diet. (C) 2018 Elsevier B.V. All rights reserved.
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