Article
Chemistry, Applied
Farnaz Azadikhah, Ali Reza Karimi
Summary: This study developed injectable and photosensitizing supramolecular hydrogels with interconnected porous morphology. The hydrogels exhibited mechanical strength, injectability, self-healing and shear-thinning capabilities, as well as antioxidant and antibacterial properties. They also showed excellent biocompatibility and potential for biomedical applications.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Sudan Liu, Diansen Li, Yu Wang, Guoqiang Zhou, Kun Ge, Lei Jiang
Summary: A double crosslinked hydrogel was prepared using carboxylated polyvinyl alcohol (PC) and chitosan (CS)/Fe3+, which showed excellent swelling ratio, biodegradability, mechanical strength, and adhesion properties. It also demonstrated antibacterial activity, hemostatic capacity, and promoted skin healing by angiogenesis and collagen deposition. Therefore, the double crosslinked hydrogel is a promising dressing for dynamic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hyun-Ho Roh, Hyun-Seung Kim, Chunggoo Kim, Kuen-Yong Lee
Summary: Three-dimensional bioprinting technology has been utilized for tissue and organ regeneration, especially with the self-healing properties of hydrogels composed of oxidized hyaluronate, glycol chitosan, and adipic acid dihydrazide. The addition of alginate in the hydrogels enhances their structural stability while maintaining self-healing capability, making them suitable for various tissue engineering applications. The potential application of these hydrogels in cartilage regeneration through 3D bioprinting has also been investigated.
Article
Biochemistry & Molecular Biology
Shuang Sun, Yizhe Xu, Xieraili Maimaitiyiming
Summary: A simple method to prepare tough polyvinyl alcohol (PVA) and gelatin hydrogel with high mechanical strength and flexibility was proposed in this study. The PVA-gelatin-Fe3+ hydrogel exhibited high strength, toughness, and excellent sensing properties, making it a promising material for flexible sensors. Furthermore, an ionic immersion strategy can be used to impart multiple functions to hydrogel sensor materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Hao Lv, Yaobo Liu, Duyi Lu, Yuanrui Wang
Summary: In this study, a novel nonprotein small molecule called kartogenin (KGN) was combined with polyvinyl alcohol/nano-hydroxyapatite (PVA/n-HA) composite hydrogel for tendon-bone healing after anterior cruciate ligament (ACL) reconstruction. The results showed that KGN/PVA/n-HA composite hydrogel promoted ACL growth and collagen fiber formation. Furthermore, new bone formation was observed in the presence of KGN/PVA/n-HA scaffolds. These findings suggest that KGN/PVA/n-HA scaffolds have potential as novel biomaterials in cartilage tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Chemistry, Applied
Lin Ma, Chunxiao Chai, Wenna Wu, Ping Qi, Xingcen Liu, Jingcheng Hao
Summary: Hydrogels, a class of hydrophilic polymers, have extensive water content and three-dimensional crosslinked networks. They have been widely used as plant culture substrates to overcome the drawbacks of hydroponics and soil. Many polysaccharide hydrogels with exceptional stability, high clarity, and low cost can be employed as plant substrates. However, the existing hydrogel-based plant growth substrates have not benefited much from the developments of gels in the past few decades. Prospects for future development include the creation of new conduction techniques, the development of potential new hydrogels, and the functionalization of hydrogels as plant culture substrates.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Mohamed A. Elblbesy, Taha A. Hanafy, Mamdouh M. Shawki
Summary: This study improved the drawbacks of pure PVA hydrogel by cross-linking with gum Arabic, increasing its swelling ratio and reducing cytotoxicity. Experimental results showed a gradual decrease in the wound area with increasing gum Arabic concentration. Therefore, gum Arabic enhances the biological applications of PVA hydrogel.
Article
Polymer Science
Hamide Hemati, Fateme Haghiralsadat, Mahdie Hemati, Ghasem Sargazi, Nastaran Razi
Summary: In this study, a nanoliposome-loaded hydrogel scaffold system was proposed for treating skin injuries. The system exhibited high drug entrapment efficiency and gradual drug release characteristics, with low toxicity to human cells, suggesting its potential in wound healing.
Article
Chemistry, Multidisciplinary
Xiaoliang Qi, Yijing Huang, Shengye You, Yajing Xiang, Erya Cai, Ruiting Mao, Wenhao Pan, Xianqin Tong, Wei Dong, Fangfu Ye, Jianliang Shen
Summary: Polydopamine (PDA) nanoparticles are biomimetic photothermal agents with potential applications in photothermal antibacterial therapy. This study successfully synthesized PDA@Ag nanoparticles with high photothermal conversion efficiency and encapsulated them into a cationic guar gum hydrogel network, demonstrating excellent antibacterial efficacy.
Article
Nanoscience & Nanotechnology
Neelima Varshney, Ajay Kumar Sahi, Suruchi Poddar, Niraj K. Vishwakarma, Gauri Kavimandan, Archisha Prakash, Sanjeev Kumar Mahto
Summary: In this study, scaffolds based on polyvinyl alcohol (PVA) and soy protein isolate (SPI) were prepared using the freeze-thaw method. The properties of the scaffolds were investigated, and it was found that the concentration of soy protein isolate significantly influenced the properties of the scaffolds. In vitro tests showed that the fabricated hydrogels had good compatibility and water vapor transmission rate suitable for wound dressing. The results demonstrated that the fabricated scaffolds had excellent biocompatibility, mechanical strength, porosity, stability, and degradation rate, indicating their potential for tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Gabriela Rivera-Hernandez, Marilena Antunes-Ricardo, Patricia Martinez-Morales, Mirna L. Sanchez
Summary: Polyvinyl alcohol (PVA) is a biodegradable synthetic polymer with high biocompatibility and non-toxicity, widely used in biomedical and pharmaceutical applications. Utilizing PVA to prepare hydrogels, microparticles, or nanoparticles for cancer treatment shows promising results in improving drug solubility, targeted drug delivery, and reducing toxicity and side effects. The combination of PVA with copolymers has emerged as a viable strategy for building novel functional composites for drug delivery systems in cancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Dongling Qiao, Wenjuan Shi, Man Luo, Fatang Jiang, Binjia Zhang
Summary: This study reveals the effect of polyvinyl alcohol (PVA) on the practical features of agar/konjac glucomannan (KGM) system. Incorporating 6% PVA enhances the chain entanglements of the ternary solution, leading to increased viscosity, tensile strength, and hydrophobicity of the resulting film.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Yongyan Yang, Lifeng Xu, Jingfei Wang, Qingye Meng, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Hydrogels are polymer materials with three-dimensional networks that can absorb a large amount of water and biological fluids. Self-healing hydrogels, due to their good biocompatibility and biodegradability, have great potential applications in tissue engineering, wound dressings, drug delivery, and other fields.
CARBOHYDRATE POLYMERS
(2022)
Article
Agricultural Engineering
Jing Wang, Tianyi Dai, Yankun Lin, Hongbing Jia, Qingmin Ji, Guoliang Yuan
Summary: In this study, intelligent ionic hydrogels based on oxide sodium alginate, poly (acrylamide-co-acrylic acid), and FeCl3 were synthesized. The hydrogels showed excellent elongation at break, strong tensile strength, and high self-healing efficiency. They also demonstrated accurate and stable detection of human movement and physiological stimuli.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Applied
Parichehr Foroughi, Narjes Koupaei
Summary: In this study, a novel polymeric hydrogel network consisting of polyvinyl alcohol (PVA)/chitosan (CS)/gum tragacanth (GT) loaded with vitamin E (VE) was developed using the freeze-thaw approach for wound healing applications. The characteristics of the prepared samples were investigated through Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) analyses. The addition of CS and GT to PVA improved the swelling ratio, gel fraction, water vapor transmission rate (WVTR), and elongation of the hydrogel films. Moreover, the cytocompatibility of the PVA/CS/GT hydrogel films was confirmed, and the film containing GT and CS exhibited the highest antibacterial activity.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2023)
Article
Polymer Science
Mohammad Sabzi, Masoud Babaahmadi, Navid Samadi, Gholam Reza Mahdavinia, Mohsen Keramati, Nasser Nikfarjam
POLYMER INTERNATIONAL
(2017)
Article
Biochemistry & Molecular Biology
Gholam Reza Mandavinia, Amirabbas Mosallanezhad, Moslem Soleymani, Mohammad Sabzi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Polymer Science
Soroush Aziz, Mohammad Sabzi, Ali Fattahi, Elham Arkan
JOURNAL OF POLYMER RESEARCH
(2017)
Review
Materials Science, Biomaterials
Mohammad Sabzi, Navid Samadi, Farhang Abbasi, Gholam Reza Mandavinia, Masoud Babaahmadi
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Gholam Reza Mandavinia, Moslem Soleymani, Hossein Etemadi, Mohammad Sabzi, Ziba Atlasi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Polymer Science
Mohammad Sabzi, Marziyeh Ranjbar-Mohammadi, Qiwei Zhang, Saeid Kargozar, Jinsong Leng, Tahereh Akhtari, Robabeh Abbasi
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Polymer Science
Nima Shafagh, Mohammad Sabzi, Mohammad Javad Afshari
JOURNAL OF POLYMER RESEARCH
(2018)
Article
Polymer Science
Mohammad Sabzi, Nima Shafagh, Mohsen Mohammadi
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Engineering, Environmental
Mohammad Sabzi, Amirhossein Ghafelebashi, Mohammadjavad Miri, Gholam Reza Mahdavinia
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2020)
Article
Chemistry, Applied
Amir Mokhtari, Mohammad Sabzi, Hamidreza Azimi
Summary: Porous ionically crosslinked biofoams were prepared as efficient adsorbents for Eriochrome black-T dye, exhibiting outstanding adsorption performance and stability at various pH conditions. The bioadsorbents presented a 3D interconnected porous structure, facilitating dye adsorption, and demonstrated repeated dye removal capability after multiple adsorption cycles.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Mostafa Ahmadi, Farhad Panahi, Naeimeh Bahri-Laleh, Mohammad Sabzi, Gerard Pareras, Bruno N. Falcone, Albert Poater
Summary: PDCA ligands have good coordination ability in synthetic hydrogels, with better coordination ability to Co2+/3+ and Ni2+ compared to Fe3+ and Zn2+. Rheological and spectroscopic studies provide evidence to support this conclusion.
CHEMISTRY OF MATERIALS
(2022)
Article
Polymer Science
Ehsan Alikhani, Mohsen Mohammadi, Mohammad Sabzi
Summary: A compound of SEBS and SR has been developed via melt blending and curing. The results show that the addition of SR increases the crosslinking and cure rate of the blends, and the presence of SEBS enhances the mechanical properties of SR. In addition, SR exhibits better thermal stability compared to SEBS.
Article
Engineering, Environmental
Gholam Reza Mahdavinia, Moslem Soleymani, Mohammad Sabzi, Hamidreza Azimi, Ziba Atlasi
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2017)
Article
Nanoscience & Nanotechnology
Mohammad Sabzi, Masoud Babaahmadi, Mohammadreza Rahnama
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)