Article
Multidisciplinary Sciences
Masoud Hamidi, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, Davide Palmieri, Cedric Delattre, Guillaume Pierre, Mahta Mirzaei, Lei Nie, Hadi Samadian, Amin Shavandi
Summary: This study characterized and evaluated the biological properties of exopolysaccharides (EPS) produced by the yeast Papiliotrema terrestris PT22AV. The EPS showed potential antibacterial activity and wound healing capacity, making it a promising material for skin wound healing.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Luyao Xiao, Yao Yang, Shuo Han, Xin Rui, Kai Ma, Changliang Zhang, Guangxian Wang, Wei Li
Summary: The study analyzed the structure of exo-polysaccharides (EPS) from Lacticaseibacillus paracasei S-NB and demonstrated the importance of genes associated with EPS biosynthesis in strain surface characteristics and cell-host interaction. The results showed that the genes S-NB_2176 and S-NB_2175 played a significant role in strain surface characteristics and host cell interaction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Teng-Gen Hu, Feng-Xiang Tan, Lu Li, Ke-Jing An, Bo Zou, Jing Wen, Ji-Jun Wu, Geng-Sheng Xiao, Yuan-Shan Yu, Yu-Juan Xu
Summary: Litchi polysaccharide Lzp2-2 promotes EPS production by Weissella confusa and improves the viscosity, texture, mouthfeel, and flavor of yoghurt.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Xiaoyin Yang, Joseph G. Sebranek, Xin Luo, Wangang Zhang, Mengmeng Zhang, Baochen Xu, Yimin Zhang, Rongrong Liang
Summary: This study investigated the impacts of adding different concentrations of CaCl2 and CaLac on the physicochemical properties of cured beef sausages. The results showed that both calcium salts resulted in deteriorative color and texture properties, as well as promoted pH decline, cooking loss, and lipid oxidation of the sausages. However, increased calcium salt addition led to a reduction in residual nitrite.
Article
Chemistry, Applied
Tristan Rath, Broder Ruehmann, Jochen Schmid, Volker Sieber
Summary: The study focused on the production of exopolysaccharides (EPS) by Gluconacetobacter sp., with glycerol as a beneficial carbon source compared to glucose, and crude glycerol as a potential substitute. Optimal parameters resulted in a high EPS titer and productivity, with varying peptone concentrations leading to changes in monomer ratios and molecular size distribution. Multiple polysaccharides were identified, with the main one composed of glucose, galactose, mannose, and glucuronic acid, and a minor one of galactose, mannose, and ribose.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Hui Jin, Jiwon Park, Rui Li, Geun Eog Ji, Tony V. Johnston, Deokyeong Choe, Se -Ho Park, Myeong Soo Park, Seockmo Ku
Summary: This study investigated the effect of consuming exopolysaccharide-enriched VP30 fermented milk on functional constipation. The results showed that the EPS-enriched VP30 fermented milk was more effective in increasing defecation frequency, volume, and fecal type. However, it did not significantly change symptoms such as flatulence, pain, and bloating. Gut microbiome analysis revealed slight changes in bacterial proportions. This study is the first to demonstrate the functional effect of EPS produced by Weissella strain in reducing functional constipation through human clinical studies.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Xuefei Shao, Miaomiao Zhu, Ziye Zhang, Pan Huang, Baocai Xu, Conggui Chen, Peijun Li
Summary: The study demonstrated that Lactobacillus pentosus R3 effectively reduces N-nitrosodimethylamine (NDMA) content in fermented sausages through various mechanisms, including direct degradation, indirect reduction of precursors, weakened oxidation, and decrease in non-haem iron content. This is achieved by inoculating the sausages with L. pentosus, which also improves microbial quality and inhibits NDMA formation.
Article
Chemistry, Applied
Bao Xing, Xiushi Yang, Liang Zou, Jingke Liu, Yongqiang Liang, Mengzhuo Li, Zhuo Zhang, Nuo Wang, Guixing Ren, Lizhen Zhang, Peiyou Qin
Summary: The distribution of starch chain lengths is important for controlling the texture and physicochemical properties of cereal products. This study investigated the texture and physicochemical properties of cooked foxtail millet and their correlation with starch chain length distributions in eight varieties of foxtail millet. The average chain lengths of amylopectin and amylose ranged from DP 24-25 and DP 878-1128, respectively. The percentage of short amylopectin chains was negatively correlated with hardness but positively correlated with adhesiveness and cohesion. On the other hand, the amount of amylose intermediate chains was positively correlated with hardness but negatively correlated with adhesiveness and cohesion. The findings of this study can be useful for breeders and food scientists in selecting foxtail millet varieties with improved quality properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Patricia Concordio-Reis, Joao R. Pereira, Vitor D. Alves, Ana R. Nabais, Luisa A. Neves, Ana C. Marques, Elvira Fortunato, Xavier Moppert, Jean Guezennec, Maria A. M. Reis, Filomena Freitas
Summary: This study assessed the film-forming capacity of exopolysaccharides (EPS) produced by six Alteromonas strains isolated from marine environments in French Polynesia. The films showed transparency and had minimal color alterations when applied over colored surfaces. Scanning electron microscopy revealed that the EPS films were dense, compact, and had smooth surfaces. The films also had high water vapor permeabilities, characteristic of hydrophilic polysaccharide films, and demonstrated different mechanical properties under tensile tests.
Article
Environmental Sciences
Tianran Ye, Ao Yang, Yulai Wang, Na Song, Ping Wang, Huacheng Xu
Summary: This study investigates the response of extracellular polymeric substances (EPS) in Microcystis aeruginosa to microplastics (MPs). The results show that MPs can inhibit the growth of Microcystis, but enhance the secretion of EPS. The organic composition in EPS varies differently in response to MP exposure, leading to changes in the dominant components and potential ecotoxicological risk. These findings contribute to our understanding of the interaction between phytoplankton and MPs in aquatic environments.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Applied
Chuang Li, Jiyong Shi, Zhou Chenguang, Xiaowei Huang, Xiaodong Zhai, Zhikun Yang, Zhihua Li, Xuetao Hu, Yanxiao Li, Jianbo Xiao, Xiaobo Zou
Summary: In this study, the effects of different low-sodium salt substitutes on the properties, texture, sensory attributes, volatile compounds, microstructure, and safety of cured and aged beef were investigated. The results showed that substituting sodium chloride with potassium chloride maintained acceptable sensory and safety profiles for beef consumption.
Article
Chemistry, Applied
Maggie P. Wear, Audra A. Hargett, John E. Kelly, Scott A. McConnell, Conor J. Crawford, Daron I. Freedberg, Ruth E. Stark, Arturo Casadevall
Summary: The physicochemical properties of Cryptococcus neoformans exopolysaccharide (EPS) are significantly affected by lyophilization. Lyophilization leads to the attenuation of the EPS signals in solution 1H Nuclear Magnetic Resonance (NMR) and the broadening of the resonances. Observation through 1H solid-state Nuclear Magnetic Resonance (ssNMR), dynamic light scattering, and transmission electron microscopy suggests that lyophilized and resuspended EPS becomes disordered and contains larger dense aggregates. Additionally, lyophilized EPS shows weaker binding to monoclonal antibodies (mAbs) compared to native EPS.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Kuenchan Na-Nakorn, Bruce R. Hamaker, Sunanta Tongta
Summary: The study found that substituting with 20% soy protein isolate increased the hardness and stickiness of cooked rice, while reducing peak viscosity, delaying starch gelatinization. Additionally, cooked rice with 20% SPI had a longer lag phase in human gastric emptying, potentially leading to a feeling of fullness.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Pervaiz Ali, Daniel Fucich, Aamer Ali Shah, Fariha Hasan, Feng Chen
Summary: In this study, EPS extracted from a glacier bacterium was used as a cryoprotective agent for the cryopreservation of three unicellular cyanobacteria and two eukaryotic microalgae. The highest concentration (20%) of EPS yielded the best growth recovery for the algal strains tested, outperforming the commonly used cryoprotectants DMSO and glycerol.
Article
Food Science & Technology
Yalin Zhang, Youyou Lu, Fusheng Chen
Summary: This study analyzed the relationship between chemical composition change, volatile flavor compounds (VFCs), and microbial structural distribution in Chinese-style (CFS) and Salami fermented sausages (WFS) during their fermentation processes. The results showed that CFS had higher pH, acid, and peroxide values compared to WFS throughout the fermentation process. Moisture contents of CFS were higher than WFS in the initial stage, but lower in the later stage. Nitrite contents were higher in WFS, while total free-amino acid contents were lower in CFS. The main VFCs in both sausages were aldehydes, acids, alcohols, esters, ketones, and hydrocarbons, with higher ketone content in CFS. The bacterial abundance increased gradually in CFS, but initially increased and then decreased in WFS. Fungal abundances and diversities were higher in WFS. In conclusion, microbial structural distribution significantly influenced the chemical composition quality of fermented sausages, providing data support for the production improvement of CFS and WFS.
Article
Chemistry, Organic
Mounir Cherfi, Tarik Harit, Meryem Idrissi Yahyaoui, Abdeslam Asehraou, Fouad Malek
Summary: Novel symmetrical tetrapodal ligands with flexible lateral arms and two bidentate chelating pyrazole-tetrazole subunits were synthesized. The copper catalysis reaction yield was optimized using Cu(NO3)(2) in DMF solvent, resulting in a high yield of 96%. The antibacterial activity test showed a moderate activity of these molecules compared to the reference compound gentamicin.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Food Science & Technology
Imane Ziani, Hamza Bouakline, Meryem Idrissi Yahyaoui, Yousra Belbachir, Marie-Laure Fauconnier, Abdeslam Asehraou, Abdesselam Tahani, Abdelmonaem Talhaoui, Ali El Bachiri
Summary: This study aimed to investigate the effect of ethanol/water concentration on the extraction yield, chemical composition, antioxidant, and antimicrobial activities of solid residues of Rosmarinus tournefortii de Noe. The results showed that ethanol/water concentration had significant effects on the phenolic composition, antioxidant activity, and antifungal activity. However, only a slight difference was observed for the antibacterial activity. HPLC analysis revealed the preferential extraction of specific phenolic compounds at different ethanol concentrations.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Agronomy
Samir Aydi, Sameh Sassi Aydi, Rami Rahmani, Faten Bouaziz, Jean Pierre Souchard, Othmane Merah, Chedly Abdelly
Summary: This study compared the effects of local farm resources, date-palm waste, as culture substrate to coconut fiber on melon plant growth and chemical properties. The results showed that date-palm waste-based substrates can improve the vegetative growth and fruit yield of melon, and could be a promising alternative to coconut fiber substrates commonly used in soilless cultures.
Article
Energy & Fuels
Hassan Erraji, Abdeslam Asehraou, Anas Tallou, Yahya Rokni
Summary: Morocco, located in northwestern Africa, is one of the Mediterranean countries facing the threat of increasing organic waste. Through the use of anaerobic digestion, this study successfully treated cattle dung to produce biogas and digestate. The application of the digestate as biofertilizer for maize crop resulted in higher yield compared to NPK fertilizer and the control group. These findings have the potential to promote biogas technology in Morocco and similar countries.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Plant Sciences
Sameh Sassi Aydi, Samir Aydi, Talel Ben Khadher, Naourez Ktari, Othmane Merah, Jalloul Bouajila
Summary: By studying the characteristics of polysaccharides extracted from Moringa leaves (MLWSP) and evaluating its antioxidant activities, cytotoxic effects, and wound healing effects, it is found that MLWSP has great potential for wound dressing materials.
Article
Agronomy
Khawla Hadj Mohamed, Sameh Sassi Aydi, Samir Aydi, Rami Rahmani, Mansour Haddad, Anna Lante, Federica Tinello, Stefania BIenvenuti, Habib Bousnina
Summary: The physico-chemical properties of soil affect both the quality and quantity of medicinal plant production. Soil amendments have been shown to have an impact on plant production. This study aimed to determine the effects of different soil amendments on soil properties and their influence on the growth, yield, and quality of Matricaria recutita. The results showed that the different fertilization systems affected chamomile yield and improved its essential oil quality and composition.
COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS
(2023)
Article
Chemistry, Applied
N. Ghabbour, Y. Rokni, H. Abouloifa, R. Bellaouchia, I. Hasnaoui, S. Gaamouche, N. Houmy, M. El Yamani, R. Ben Salahg, N. Ktari, E. Saalaoui, A. Asehraou
Summary: This study investigates the controlled fermentation of heat-shocked, unsalted and inoculated green olives. The results show that heat-shock treatment at 70 and 80 degrees Celsius effectively reduces indigenous Enterobacteria and improves the acidification of olives compared to 60 degrees Celsius. Inoculation with L.p-FSO175 and addition of CFS of C.p-L18 enhance the fermentation and preservation of unsalted green olives, leading to decreased pH, increased free acidity, and complete disappearance of Enterobacteria. The best reduction in bitterness and favorable color changes are achieved by heat-shock treatment at 80 degrees Celsius, inoculation with L.p-FSO175, and addition of CFS of C.p-L18. This sequential method improves the sensory characteristics, lowers spoilage incidence, and reduces fermentation time, making it suitable for controlling fermentation of Moroccan picholine green olives.
Article
Biochemistry & Molecular Biology
Sabir Ouahhoud, Mohamed Marghich, Hanane Makrane, Ahmed Karim, Amine Khoulati, Samira Mamri, Mohamed Addi, Christophe Hano, Redouane Benabbes, Mohammed Aziz, Abdeslam Asehraou, Ennouamane Saalaoui
Summary: The study evaluated the myorelaxant and antispasmodic activities of the byproducts (tepals and leaves) of Crocus sativus and compared them with the stigma of the plant. The results showed that the extracts had moderate myorelaxant and inhibitory effects on contractions, suggesting potential use in treating bowel spasms.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Chaymae Bourhou, Hind Benouda, Reda Bellaouchi, Mohammed Merzouki, Elmehdi Fraj, Tarik Harit, Allal Challioui, Abdeslam Asehraou, Rachid Touzani, Ismail Ozdemir, Boufelja Bouammali
Summary: This study involves the synthesis of novel Bis(arylidene-2-[(tetrazol-5-yl)]alkane derivatives and their evaluation for antibacterial and antifungal activities. The compounds showed moderate yields and their structures were determined through spectroscopic analyses. In vitro testing revealed antimicrobial properties against various bacterial and fungal strains. Docking study further confirmed the interactions of the compounds with the active site in Staphylococcus aureus.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Multidisciplinary Sciences
Ahlem Dab, Ismail Hasnaoui, Sondes Mechri, Fawzi Allala, Khelifa Bouacem, Alexandre Noiriel, Amel Bouanane-Darenfed, Ennouamane Saalaoui, Abdeslam Asehraou, Fanghua Wang, Abdelkarim Abousalham, Bassem Jaouadi
Summary: This study describes a newly isolated extracellular lipolytic carboxylester hydrolase called FAL from a filamentous fungus. FAL exhibited lipase and PLA(1) activities, and showed high tolerance to various organic solvents, surfactants, and oxidants. It also demonstrated effective oil-stain removal in laundry detergents, suggesting potential applications in the detergent industry.
Article
Plant Sciences
Samir Aydi, Sameh Sassi Aydi, Asma Marsit, Nadia El Abed, Rami Rahmani, Jalloul Bouajila, Othmane Merah, Chedly Abdelly
Summary: This study found that using local organic farm resources as substrates can enhance tomato growth and quality. In a hydroponics system, coconut fiber as a growing substrate can be replaced by organic agricultural waste, reducing costs and increasing tomato yield and nutritional value.
Article
Multidisciplinary Sciences
Amine Khoulati, Sabir Ouahhoud, Ismail Channouf, Khalid Channouf, Amal Azdimousa, Samira Mamri, Anas Ziani, Sanae Baddaoui, Abderrahmane Hadini, Abdeslam Asehraou, Ennouamane Saalaoui
Summary: This study aims to use saffron by-products as biostimulants in agriculture to replace chemical products. Different treatments of aqueous extract from saffron stigmas, tepals, and stamens were applied to eggplant plants in greenhouse conditions. The results show that using 2 g/L of tepal extract and 1 g/L of saffron can improve the main secondary metabolites of fruits under greenhouse conditions.
SCIENTIFIC AFRICAN
(2023)
Article
Plant Sciences
Samir Aydi, Sameh S. A. S. S. Aydi, Ghada Ben Salah, Amani Dekhil, Rami Rahmani, Abdelhakim Bouajila, Niveen A. Mohamed, Chedly Abdelly
Summary: This study aims to investigate the potential of selected native plants to accumulate and tolerate chemical pollutants in contaminated sites. The results showed that the selected plants, Bassia indica and Chenopodium album, exceeded normal ranges and phytotoxic levels for cadmium, lead, copper, zinc, and fluorine. Based on bioconcentration, translocation, and biological accumulation factors, the plants were classified as excluders, indicators, and accumulators for each element. This suggests that these native plants have significant potential for phytoremediation and can be used as biomonitors in contaminated soils.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2023)
Article
Chemistry, Multidisciplinary
Salima Haddou, Kadi Mounime, El Hassania Loukili, Douaae Ou-yahia, Asmae Hbika, Meryem Yahyaoui Idrissi, Abdelkhaleq Legssyer, Hassane Lgaz, Abdeslam Asehraou, Rachid Touzani, Belkheir Hammouti, Abdelkrim Chahine
Summary: The bioactive potential of the organic and aqueous extracts derived from Moroccan Ketama hemp seeds was assessed in this study, with a focus on antioxidant, antimicrobial, and anti-inflammatory activities. The ethanolic extract showed excellent antioxidant activity, while the organic and hexane extracts exhibited strong antimicrobial effects. All extracts demonstrated potential therapeutic value in inhibiting heat/hypotonia-induced erythrocyte haemolysis, indicating their anti-inflammatory properties.
MOROCCAN JOURNAL OF CHEMISTRY
(2023)
Article
Food Science & Technology
Ismail Hasnaoui, Houssam Abouloifa, Yahya Rokni, Reda Bellaouchi, Meryem Idrissi Yahyaoui, Ennouamane Saalaoui, Alexandre Noiriel, Abdelkarim Abousalham, Kamal Essifi, Abdesselam Tahani, Bassem Jaouadi, Abdeslam Asehraou
Summary: Biological preservatives are increasingly sought after due to health and environmental concerns. Lactic acid bacteria isolated from fermented olives showed significant antimicrobial activity against pathogenic bacteria and yeast involved in foodborne diseases and food spoilage. Specific strains of Levilactobacillus brevis, Lactiplantibacillus pentosus, and Lactiplantibacillus plantarum exhibited strong antimicrobial effects and can be used as potential bio-preservatives in various food products.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
