Article
Biochemistry & Molecular Biology
Celine Abueva, Hyun Seok Ryu, Jun Won Min, Phil Sang Chung, Hyeon Sook You, Myung Suk Yang, Seung Hoon Woo
Summary: The study synthesized a quaternary ammonium chitosan derivative, which when complexed with povidone-iodine showed increased effectiveness against multidrug-resistant bacteria and fungi, with no cytotoxic effects and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Neda Akhlaghi, Ghasem Najafpour-Darzi
Summary: In this study, a thermosensitive injectable hydrogel based on chitosan-integrated hydroxyapatite nanoparticles was developed for the treatment of orthopedic implant-associated infections. The hydrogel, containing vancomycin and quercetin-loaded in F127 micelles, demonstrated pH-sensitive drug release and showed complete inhibition of Staphylococcus aureus growth for 14 days. Additionally, it exhibited strong antioxidant activities and 95.88% eradication of S. aureus biofilm. Due to its high degradation stability, gelation within 10 minutes at 37 degrees Celsius, and easy injectability, this hydrogel could be a promising local drug delivery system for implant-related infections.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Gozde Bayer, Silvia Grasselli, Annalisa Malchiodi, Ilker S. Bayer
Summary: An alternative approach of fabricating soy lecithin/alginate gels without solvents was demonstrated, successfully encapsulating the antiseptic drug PVPI. The composite gels exhibited minimal drug loss and slow drug release, showing potential in disinfecting aqueous media.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Medicine, General & Internal
Gerard P. Slobogean, Sheila Sprague, Jeffrey L. Wells, Lehana Thabane, C. Daniel Mullins, Anthony D. Harris, Amber Wood Msn, Roman M. Natoli, Todd O. McKinley, William Obremskey, Phillip M. Mitchell, Jennifer E. Hagen, Marissa Pazik, Stephen J. Warner, Joshua L. Gary, Herman Johal, Jodi L. Gallant, Kyle J. Jeray, Stephanie L. Tanner, Justin Fowler, Sarah N. Pierrie, Robert O'Toole, Andrea L. Howe, Michael J. Prayson, Jennifer Jerele, Christina L. Boulton, Jason Lowe, Niloofar Dehghan, Michael D. McKee, Saam Morshed, Meir T. Marmor, Ernesto Guerra-Farfan, Yaiza Garcia-Sanchez, Francesc Marcano-Fernandez, Laia Martinez-Carreres, Nathan N. O'Hara, Shannon Dodds, David Pogorzelski, Sofia Bzovsky, Diane Heels-Ansdell, Olivia Paige Szasz, Gregory J. Della Rocca, Robert D. Zura, Lucas S. Marchand, Joan N. Hebden, Joseph T. Patterson, Christopher Lee, Lyndsay M. O'Hara, Debra Marvel, Jana E. Palmer, I. Leah Gitajn, Jean-Claude G. D'alleyrand, Jessica C. Rivera, Franca Mossuto, Manjari Joshi, Jeff Friedrich, Gordon Guyatt, P. J. Devereaux, Mohit Bhandari
Summary: This study compared the effect of aqueous 10% povidone-iodine and aqueous 4% chlorhexidine gluconate on the risk of surgical site infection in patients with open fractures requiring surgery. The results showed no significant difference between the two groups. Either aqueous 10% povidone-iodine or aqueous 4% chlorhexidine gluconate can be selected for skin antisepsis in patients with open fractures based on availability, contraindications, or cost.
Article
Chemistry, Multidisciplinary
Xiaodong Hu, Jiaqi Zhong, Haiyong Ao, Xinhui Wu, Yujiong Chen, Zhaoxiang Peng
Summary: This study presents a novel approach to mitigating bacterial infections and antibiotic resistance in medical implants through iodine-doping and 3D printing techniques. The integration of iodine and titanium alloy on 3D-printed implants was confirmed through various analyses. In vitro studies demonstrated the implants' strong antimicrobial properties against E. coli and S. aureus, suggesting promising clinical applications.
Article
Medicine, General & Internal
Veronica Romano, Donato Di Gennaro, Anna Maria Sacco, Enrico Festa, Emanuela Roscetto, Morena Anna Basso, Tiziana Ascione, Giovanni Balato
Summary: This study evaluated the cytotoxicity of solutions containing povidone-iodine (PI) and hydrogen peroxide (H2O2), alone or in combination. The results showed that the toxicity of all tested solutions increased as exposure time increased, except for 0.3% PI solution, which exhibited the lowest toxicity. The combined solutions had lower cellular killing at 3 and 5 min compared to equal concentrations of H2O2, similar to PI solutions.
Review
Ophthalmology
Andrzej Grzybowski, Hiroyuki Shimada, Hiroyuki Nakashizuka, Jagger Koerner
Summary: Endophthalmitis following intraocular surgery is rare with current antiseptic techniques, but challenges such as increased multidrug-resistant bacterial endophthalmitis and low rate of endophthalmitis caused by typical bacteria still exist. Recent findings show that povidone-iodine is widely available and repetitively applying diluted povidone-iodine can effectively sterilize the ocular surface.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Zhang Hui-min, Jiang Hong-rui, Chen Dai-jie, Shen Zi-liang, Mao Yong-jiang, Liang Yu-sheng, Juan J. Loor, Yang Zhang-ping
Summary: The study evaluated the efficacy of a barrier teat dip containing povidone-iodine and chitosan for the prevention of mastitis. Results showed that the barrier teat dip with 1.0% chitosan and 4.0% povidone-iodine was more effective in reducing subclinical mastitis infection prevalence compared to the nonbarrier product containing 10% povidone-iodine.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Public, Environmental & Occupational Health
Phat Tran, Jonathan Kopel, Keaton Luth, Huy Dong, Ameesh Dev, Dilip Mehta, Kelly Mitchell, Keith W. Moeller, Cameron D. Moeller, Ted Reid
Summary: This study aimed to determine if the combination of 5% betadine solution and silver colloidal gel is more effective than either substance alone in inhibiting the growth of gram-negative and gram-positive bacteria. The results showed that silver gel had complete inhibition on all the bacteria species examined except for the Klebsiella pneumoniae clinical isolate strain, while 5% betadine solution did not completely kill any of the tested bacteria. However, when 5% betadine solution and silver gel were used together, they were able to completely eliminate K. pneumoniae. The study concluded that the combination of 5% betadine solution and silver gel was superior at eliminating all tested bacteria.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Pharmacology & Pharmacy
Shaydier Argel, Melissa Castano, Daiver Estiven Jimenez, Sebastian Rodriguez, Maria Jose Vallejo, Cristina Isabel Castro, Marlon Andres Osorio
Summary: In this study, bioactive wound dressings were successfully developed by loading the antibacterial povidone-iodine and anti-inflammatory acetylsalicylic acid into bacterial nanocellulose (BNC). The structure and mechanical properties of the dressings were characterized by scanning electron microscopy and mechanical tests. The release assays and histology confirmed the diffusion of the bioactive compounds in porcine skin. Antimicrobial experiments and protein denaturation tests further confirmed the antibacterial and anti-inflammatory properties of the dressings.
Article
Medicine, General & Internal
Summary: A trial conducted in low-income and middle-income countries did not demonstrate benefits of 2% alcoholic chlorhexidine skin preparation compared with povidone-iodine, or triclosan-coated sutures compared with non-coated sutures, in preventing surgical site infections in cleancontaminated or contaminated or dirty surgical wounds. Both interventions are more costly than alternatives, and these results do not endorse routine use.
Article
Biology
Anne Steins, Christina Carroll, Fui Jiun Choong, Amee J. George, Jin-Shu He, Kate M. Parsons, Shouya Feng, Si Ming Man, Cathelijne Kam, Lex M. van Loon, Perlita Poh, Rita Ferreira, Graham J. Mann, Russell L. Gruen, Katherine M. Hannan, Ross Hannan, Klaus-Martin Schulte
Summary: The safety of Povidone-iodine (PVP-I) is controversial, and its toxicity is mainly caused by diatomic iodine (I2). The higher the concentration and duration of PVP-I, the greater the toxicity to cells. Additionally, PVP-I can disrupt cell membranes and lipid rafts, leading to cellular dysfunction. Therefore, a reevaluation of PVP-I in clinical practice is necessary to avoid unnecessary toxicity.
LIFE SCIENCE ALLIANCE
(2023)
Review
Dermatology
Dunyao Bai, Fan Zhou, Liuting Wu
Summary: Surgical site infections (SSIs) have a significant impact on patient health and healthcare costs. This meta-analysis examines the effectiveness of antiseptics, chlorhexidine and povidone-iodine, in reducing SSIs and concludes that chlorhexidine is more effective than povidone-iodine.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Bruna Costa, Guillermo Martinez-de-Tejada, Paula A. C. Gomes, M. Cristina L. Martins, Fabiola Costa
Summary: The prevention of orthopedic implant-related infections is a major medical challenge, and antimicrobial peptides (AMPs) are considered promising alternatives to conventional antibiotics due to their broad-spectrum activity and low propensity for resistance. Research strategies involving AMP-releasing and immobilization onto surfaces show potential for preventing infections, with a focus needed on clinical validation and translation efforts.
Article
Chemistry, Applied
Zeliang Zhu, Yi Yuan, Jingke Guo, Xiaolin Luo, Shutao Liu, Song Miao
Summary: The study developed chitosan-coated alginate gel particles (CS/SA) and chitosan-coated alginate-shellac gel particles (CS/SA/Lac) as potential oral delivery systems for enhanced stability and activity of superoxide dismutase (SOD). The encapsulation efficiency, enzyme activity retention ratio, particle structure, SOD release behavior, and the effect of shellac were evaluated. The optimal formula for CS/SA was determined, and the addition of shellac improved SOD stability in gastric conditions. CS/SA released SOD in stimulated intestinal fluid, while CS/SA/Lac released SOD in stimulated colonic fluid. These findings suggest that CS/SA and CS/SA/Lac are excellent candidates for SOD oral administration in developing functional products.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)