期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 106, 期 -, 页码 1235-1239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.08.123
关键词
Sulfated galactan; Cellular senescence; Antioxidant activities
资金
- Zhejiang Provincial Natural Science Foundation of China [LQ16D060005]
- National Natural Science Foundation of China [31700307, 81771520, 31201040]
- Science Technology Department of Zhejiang Province [2016C34002]
- Health Bureau of Zhejiang Province [2015DTA001, 2013KYA003]
Porphyran sulfated galactan extracted from red algae Porphyra haitanensis is a sulfated polysaccharide, which possesses excellent activities. In the present study, WI-38 cells were treated with H2O2 to induce premature senescence and then the protection of porphyran against aging in vitro and associated molecular mechanisms were investigated. The protection occurred in a dose-dependent manner, offering an optimal efficacy starting at 10 mu g/mL. The proportion of SA-beta-gal positive cells in porphyran group decreases from 53% to 23% in the cultures at 30 PDs. Porphyran has been detected specifically reducing SAHF-like foci formation in senescent cells. In addition, porphyran significantly affected the p53-p21 pathways in H2O2-treated WI-38 cells. Our data suggest the promising role of porphyran as an attractive and bio-safe agent with the potential to retard senescence and attenuate senescence-related diseases. (C) 2017 Published by Elsevier B.V.
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