Article
Nanoscience & Nanotechnology
Bao Le-Vinh, Christian Steinbring, Nguyet-Minh Nguyen Le, Barbara Matuszczak, Andreas Bernkop-Schnurch
Summary: Chitosan and its derivatives with high cell adhesion properties were designed and tested for their suitability as scaffold materials in tissue engineering. The attachment of a thiol group to chitosan significantly improved cell adhesion, with higher modification levels leading to better results. The resulting chitosan-based cryogels showed promise for 3D cell culture and tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli, Anika Singh
Summary: Recent advances in peptide delivery and nanotechnology have led to the development of non-parenteral administration routes, replacing subcutaneous injections. Thiolated biopolymers, a new material, are being explored to enhance mucoadhesivity and permeability for oral delivery. This study focuses on improving the mucoadhesivity of thiolated chitosans by activating them with mercaptonicotinic acid to create a novel thiomerized chitosan. Insulin nanoparticles encapsulated with this new material showed reduced size and increased cellular uptake, insulin transport, and permeability compared to nanoparticles encapsulated with unmodified chitosan and thiolated chitosan. The results suggest that MNA-TG-chitosan holds promise for improved peptide oral delivery.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Atida Selmani, Elisabeth Seibert, Carolin Tetyczka, Doris Kuehnelt, Ivan Vidakovic, Karin Kornmueller, Markus Absenger-Novak, Borna Radatovic, Ivana Vinkovic Vrcek, Gerd Leitinger, Eleonore Frohlich, Andreas Bernkop-Schnurch, Eva Roblegg, Ruth Prassl
Summary: This study aimed to design a hybrid oral liposomal delivery system for selenium nanoparticles to improve the bioavailability of selenium. Thiolated chitosan was used for surface functionalization of the liposomal nanoparticles. The thiolated liposomal nanoparticles showed good mucoadhesive properties and were stable in a simulated microenvironment of the small intestine. This study provides a promising solution for oral selenium delivery.
Article
Biochemistry & Molecular Biology
Dong Jin Choi, Kyoung Choi, Sang Jun Park, Young-Jin Kim, Seok Chung, Chun-Ho Kim
Summary: By adding biodegradable suture fibers into gelatin biomaterial ink, the printability, mechanical strength, and dimensional stability of 3D printed scaffolds can be significantly improved. This method enhances printing accuracy, increases mechanical strength, and controls the degradation rate of 3D printed scaffolds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yanhuizhi Feng, Huai-Ling Gao, Di Wu, Yu-Teng Weng, Ze-Yu Wang, Shu-Hong Yu, Zuolin Wang
Summary: The bio-inspired lamellar chitosan scaffold (LCS), manufactured through a bidirectional freezing method, shows excellent mechanical properties in the hydrated state and accelerates vessel formation and soft tissue regeneration in vivo, as well as inducing macrophage differentiation to M2 macrophages.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Paper & Wood
Gabriela Melo Rodriguez, Donata Trueb, Joachim Koser, Joachim Schoelkopf, Maurizio Gullo
Summary: This work describes the manufacturing of cellulosic scaffolds with a 3D origami crease pattern for cardiac tissue engineering. Cotton linters were chosen as the most suitable material for cardiomyocytes, with high biocompatibility and mechanical properties. Different methods were investigated to achieve fiber alignment, and origami-inspired crease patterns were applied to introduce directional flexibility for cardiac contraction.
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Amit Kumar Singh, Krishna Pramanik, Amit Biswas
Summary: In this study, a SA/CH/GE tri-polymer complex was used as a bioink to fabricate a scaffold suitable for bone-tissue regeneration through 3D printing. The addition of gelatin improved the mechanical properties, structural stability, protein adsorption, and cellular adhesion of the scaffold. It also exhibited desirable degradation rate and controlled swelling properties.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Polymer Science
Amit Kumar Singh, Krishna Pramanik
Summary: This study reports 3D-printed scaffolds made of natural biopolymers, sodium alginate (SA) and chitosan (CH). The scaffolds possess open pore microstructures with desired pore size, favorable for cell attachment and bone regeneration. Among the compositions, SA/CH: 60/40 scaffold shows superior biological properties and bioactivity, making it a suitable matrix for future bone tissue regeneration applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Ceramics
Patricia Ros-Tarraga, Carlos M. Martinez, Miguel A. Rodriguez, Piedad N. De Aza
Summary: The elderly population is increasing, leading to an increase in bone and joint problems. Scaffold for bone tissue regeneration can solve these problems, and material selection is crucial for satisfactory results. This study designed a three-dimensional porous ceramic scaffold and analyzed its biocompatibility and osteoinductive capacity. The results suggest that it has potential applications as bone substitutes.
CERAMICS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Ihn Han, Juie Nahushkumar Rana, Ji-Hye Kim, Eun Ha Choi, Youngsun Kim
Summary: This study evaluated the osteogenic potential of non-thermal biocompatible plasma (NBP)-treated chitosan scaffolds. The results showed that NBP-treated chitosan scaffolds demonstrated significant improvements in cell viability and differentiation.
Article
Pharmacology & Pharmacy
Fabrizio Ricci, Giuseppe Francesco Racaniello, Nunzio Denora, Luigi Gentile, Antonio Lopalco, Annalisa Cutrignelli, Massimo Franco, Rosa Maria Iacobazzi, Valentino Laquintana, Angela Lopedota
Summary: In recent years, researchers have studied mucoadhesive in situ gelling formulations to improve bladder cancer treatment. In this study, a Pluronic F127-based thermoresponsive gel was prepared using two mucoadhesive derivatives of glycol chitosan. The gel was loaded with a combination of Gemcitabine and Celecoxib, and the solubility of Celecoxib was increased by forming an inclusion complex with 2-Hydroxypropyl-β-cyclodextrin. The rheological properties of the gel were evaluated, and the selected system demonstrated enhanced retention and sustained drug release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Devanand Kamnoore, Dhrubojyoti Mukherjee, Damodar Nayak Ammunje, Pavadai Parasuraman, Banala Venkatesh Teja, M. Radhika
Summary: A polymer hybrid scaffold functionalized with hydroxyapatite nanoparticles was developed in this study using the freeze-thawing technique. FTIR and XRD studies confirmed the polymeric interlinking in the scaffold, while SEM and micro-CT analysis indicated a spongy structure of the nanocomposite scaffold with controlled pore intensity. In silico and in vivo evaluations suggested that the nanocomposite scaffold may be a suitable material for tissue engineering through controlled actions of epidermal growth factor and glycogen synthase kinase.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Andrea Fuerst, Gergely Kali, Nuri Ari Efiana, Zeynep Burcu Akkus-Dagdeviren, Soheil Haddadzadegan, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to compare the mucoadhesive properties of nonionic, negatively, and positively charged thiolated cyclodextrins. The structure of thiolated cyclodextrins was confirmed via 1H NMR. A high degree of thiolation and the introduction of cationic charges were found to be mainly responsible for the high mucoadhesive properties of cyclodextrins.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Sobia Noreen, Andreas Bernkop-Schnuerch
Summary: Thiolation of poly- and oligosaccharides introduces various favorable properties for tissue engineering and wound healing, including stable 3D networks, enhanced cell adhesion and signaling, and controlled release of active ingredients.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Environmental Sciences
Isadora C. Carvalho, Fernanda G. L. Medeiros Borsagli, Alexandra A. P. Mansur, Claudia L. Caldeira, Dionei J. Haas, Andrey P. Lage, Virginia S. T. Ciminelli, Herman S. Mansur
Summary: This study developed three-dimensional porous hydrogel sponges for dye removal and antibacterial applications, with high adsorption capacity and antibacterial activity demonstrated through comprehensive characterization.
ENVIRONMENTAL TECHNOLOGY
(2021)
Article
Chemistry, Physical
Christiane L. Salgado, Alexandra A. P. Mansur, Herman S. Mansur, Fernando J. M. Monteiro
Summary: The novel functionalized hybrid semiconductor bioconjugates made of fluorescent quantum dots with chitosan surface and OPS chemical modification showed promising biocompatibility with human cell sources. The particles preferentially accumulated in human bone mesenchymal stromal cells, exhibiting stable photoluminescence emission. Additionally, the OPS-modified nanoparticles had intense intracellular trafficking in HBMSCs, promoting a late-osteoblast phenotype with increased extracellular matrix mineralization.
Article
Biochemistry & Molecular Biology
Fernanda G. L. Medeiros Borsagli, Jordane S. Rodrigues, Rafaella A. Aguiar, Aislan Esmeraldo Paiva, Jhonattan Frank Baez Vasquez, Welyson Tiano do Santos Ramos, Paulo Allibrandini, Elem Patricia Alves Rocha, Max P. Goncalves, Fidel Edson de Souza
Summary: This study introduces a novel 3D scaffold technology utilizing thiolated chitosans for luminescence, to be used in vertebral disc regeneration/theragnostic. Through various characterization methods, the scaffolds demonstrated advantages in terms of cytocompatibility and mechanical properties, opening up new possibilities for tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Aislan Esmeraldo Paiva, Jhonattan Frank Baez Vasquez, Tatiana S. Perova, Fernanda G. L. Medeiros Borsagli, Michael Morris
Summary: This research focused on the selective metal infiltration of a pyridine-containing block copolymer in a liquid-phase setting. The study found that metal cations interact differently with the poly(2-vinylpyridine) component, and that the oxidation state and type of cation are crucial for the infiltration process, which is also influenced by the solvent used. While silver did not effectively infiltrate, nickel and chromium were able to reproduce the pattern of the block copolymer. These differences can be attributed to the coordination of pyridinic nitrogen and the metal, as well as p-interactions. Additionally, the presence of oxyanions enhanced the infiltration of chromium and facilitated the formation of a highly faithful ordered metal oxide layer.
Article
Nanoscience & Nanotechnology
Aislan Esmeraldo Paiva, Jhonattan Frank Baez Vasquez, Andrew Selkirk, Nadezda Prochukhan, Fernanda G. L. Medeiros Borsagli, Michael Morris
Summary: A facile and versatile strategy was developed to produce highly ordered porous metal oxide structures using block copolymer lithography. The effects of various parameters on the ordering of the structures were analyzed, and the strategy can be applied to create different inorganic nanostructures for various applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Alexandra A. P. Mansur, Sandhra M. Carvalho, Luiz Carlos A. Oliveira, Elaine Maria Souza-Fagundes, Zelia I. P. Lobato, Maria F. Leite, Herman S. Mansur
Summary: In this study, a novel hybrid nanomaterial composed of gold nanoparticles as the oxidase-like nanozyme and cobalt-doped superparamagnetic iron oxide nanoparticles as the peroxidase-like nanozyme was synthesized. These nanomaterials, functionalized with a carboxymethylcellulose biopolymer organic shell, demonstrated the ability to trigger a biocatalytic cascade reaction in the cancer tumor microenvironment for combined magnetothermal-chemodynamic therapy.
Article
Engineering, Environmental
Aislan Esmeraldo Paiva, Jhimli Paul Guin, Jhonattan Frank Baez Vasquez, K. Ravindranathan Thampi, James A. Sullivan, Fernanda G. L. Medeiros Borsagli, Michael A. Morris
Summary: Porous iron oxide structures were produced on glass substrates using block copolymer templating. XRD and XPS studies revealed the coexistence of FeIII/FeII. Vertically aligned PS cylinders with pore sizes of 35, 45 and 400 nm were obtained by varying the annealing time. The iron oxide-covered glass substrates showed efficient degradation of levofloxacin solution through a photo-Fenton process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Sandhra M. Carvalho, Alexandra A. P. Mansur, Izabela B. da Silveira, Thaisa F. S. Pires, Henrique F. V. Victoria, Klaus Krambrock, M. Fatima Leite, Herman S. Mansur
Summary: Glioblastoma (GBM) is a common primary brain cancer in adults. Nanotechnology has emerged as an innovative strategy for developing nanomaterials, such as nanozymes, for cancer nanomedicine. This study reports the design and synthesis of non-toxic bioengineered nanotherapeutics, called nanozymes, which can kill GBM cancer cells by producing reactive oxygen species. Furthermore, the use of 3D spheroid models demonstrated the effectiveness of these nanozymes in inhibiting tumor growth and accurately simulating the tumor microenvironment.
Article
Polymer Science
Nadia Sueli Vieira Capanema, Alexandra Ancelmo Piscitelli Mansur, Isadora Cota Carvalho, Sandhra Maria Carvalho, Herman Sander Mansur
Summary: The study reports the synthesis and characterization of hybrid hydrogels for wound dressings using a water-responsive system. These hydrogels demonstrated tunable physicochemical properties and were produced through an eco-friendly process. The hydrogels showed high absorbency and cytocompatibility, making them suitable for chronic wound healing and skin tissue engineering applications.
Review
Polymer Science
Jordane Silva Rodrigues, Carla Jeany Teixeira Silva, Nathalia da Cunha Silva, Rafaella Azevedo Aguiar, Micheli de Souza Bernardes, Carlos Mateus Soares, Jhonatan do Amparo Madureira, Fernanda G. L. Medeiros Borsagli
Summary: Life expectancy continues to improve, but changes in lifestyle have led to overweight and related health problems. Carbohydrate hydrogels, with their diverse properties and characteristics, have great potential in tissue regeneration, drug delivery, and antibacterial activity. Despite numerous publications on carbohydrate hydrogels, there is still a significant gap in biomedical areas such as theragnostic, biosensors, and antibacterial activity.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
A. A. P. Mansur, M. A. Rodrigues, N. S. V. Capanema, S. M. Carvalho, D. A. Gomes, H. S. Mansur
Summary: This study reports the design, development, and synthesis of chemically biofunctionalized hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked by citric acid. These hydrogels show suitable physicochemical properties, cytocompatibility, and hemocompatibility, making them potential smart wound dressings for skin tissue engineering. The biofunctionalization of the hydrogels with L-arginine and RGD peptide promotes bioadhesion of fibroblast and keratinocyte cells, offering potential enhancements for wound healing and skin tissue engineering applications.
Article
Chemistry, Multidisciplinary
Alexandra A. P. Mansur, Sandhra C. Carvalho, Elaine M. S. Dorneles, Andrey P. Lage, Zelia I. P. Lobato, Herman S. Mansur
Summary: Among different types of cancer, glioma is one of the most common malignant tumors in the central nervous system. Glioblastoma is considered to be one of the deadliest brain cancers and poses a challenge for oncologists. This research focuses on the design and synthesis of novel nanoconjugates composed of photoluminescent ZnS quantum dots biofunctionalized with polypeptides, which can be used for bioimaging and antibacterial activity against glioblastoma cancer cells.
Article
Engineering, Environmental
Ana Julia M. Souza, Cristiane T. Lima, Max P. Goncalves, Patricia N. da C. Souza, Silas S. Santana, Sandhra M. Carvalho, Andressa Franca, Poliane Chagas, Aislan Esmeraldo Paiva, Jhonattan Frank Baez Vasquez, Michael Morris, Fernanda G. L. Medeiros Borsagli
Summary: Understanding the relationship between material properties, characteristics, and biosafety/toxicity responses is crucial. This study extracts natural materials from Calotropis procera seeds using two different routes and evaluates their biosafety/toxicity using in vitro assays. The extracted materials were extensively characterized, and their cytotoxicity against different cell lines was evaluated. The results show that the natural extract behaves differently depending on the cell line and that the extraction routes significantly affect the composition of the extract. Furthermore, the difference in toxicity/biosafety among the cells suggests that these materials have potential applications in sustainability.
JOURNAL OF HAZARDOUS MATERIALS ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Anderson J. Caires, Herman S. Mansur, Alexandra A. P. Mansur, Isadora C. Carvalho, Sandhra C. Carvalho
Summary: Despite the challenges in treating brain cancer, hybrid nanostructures of gold nanoparticles and zinc sulfide semiconductor synthesized using a green nanomedicine approach show potential in combating GBM cancer cells. These nanohybrids, combining excitonic activity and plasmonic properties, demonstrate a novel approach to cancer treatment by integrating diagnosis and therapy simultaneously.
Article
Engineering, Environmental
Fernanda G. L. Medeiros Borsagli, Aislan E. Paiva
Summary: This research presents new ecofriendly luminescent ZnO nanoconjugates based on different thiol ligands, which significantly improve the environmental photocatalytic activity of pure ZnO nanoparticles. The morphology, size, and photoluminescent properties of the ZnO nanoconjugates were influenced by the thiol ligands, leading to enhanced photocatalytic efficiency for dye degradation. The novel ZnO nanoconjugates demonstrated promising potential as ecologically friendly photocatalytic materials for wastewater treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
