Article
Infectious Diseases
Cong Su, Ting Wu, Bao Meng, Chengcheng Yue, Yating Sun, Lingling He, Tingting Bian, Yanyan Liu, Ying Huang, Yanhu Lan, Jiabin Li
Summary: In Anhui province, there is a high prevalence of hyper virulent Klebsiella pneumoniae (HvKP) infections, especially in intensive care units and respiratory and critical care departments. The most common capsular serotype is K2, followed by K1. Most HvKP strains are carbapenem resistant, with the majority harboring KPC.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Mohamed Sabry Abd Elraheam Elsayed, Samah Mahmoud Eldsouky, Tamer Roshdy, Lamia Said, Nahed Thabet, Tamer Allam, A. B. Abeer Mohammed, Ghada M. Nasr, Mohamed S. M. Basiouny, Behairy A. Akl, Maha M. Nader, Al Shaimaa Hasan, Ahmed Salah
Summary: Pasteurella multocida isolates recovered from apparently healthy and diseased cattle and humans in Egypt showed diverse capsular types and virulence gene combinations, exhibiting high levels of antimicrobial resistance. Detection of resistance genes co-occurrence led to multiple drug-resistant phenotypes, highlighting the potential risk to livestock and humans.
Article
Multidisciplinary Sciences
Keming Ning, Rushun Zhou, Manxiang Li
Summary: This study analyzed the capsular polysaccharides, molecular typing, and antibiotic resistance characteristics of Staphylococcus aureus isolates from raw milk of dairy farms in Hunan Province, China. The results revealed the presence of CP5 (42.10%) and CP8 (57.89%) genes in the isolates. The isolates showed a multiple antimicrobial resistance rate of 26.75%, with the highest resistance rate to penicillin (82.89%). Molecular typing identified 22 sequence types (ST) and 20 spa types, with t796-ST7 being the most prevalent, possibly indicating the major epidemic strain of multidrug-resistant S. aureus.
Article
Microbiology
Liting Wu, Hongduo Bao, Zhengquan Yang, Tao He, Yuan Tian, Yan Zhou, Maoda Pang, Ran Wang, Hui Zhang
Summary: The study found that Listeria isolates from meat processing environments exhibited high antimicrobial resistance, with a majority of isolates showing resistance to multiple antibiotics and carrying various resistance genes. Multilocus sequence typing revealed that specific ST types dominated in processing plants, demonstrating high invasion characteristics.
Article
Microbiology
Wei Wang, Hui Li, Menghan Li, Yinping Dong, Yao Bai, Fengqin Li, Jing Xiao
Summary: This study analyzed the antimicrobial resistance, biofilm formation, and genomic characteristics of ST88 MRSA collected from various foods in China and compared them with publicly available ST88 genomes worldwide. The results showed differences between ST88 MRSA in China and Africa and suggested a more recent clonal evolution in China. The molecular mechanisms of the global spread of ST88 MRSA remain unclear.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Nikoletta Argyro Theocharidi, Iliana Balta, Dimitra Houhoula, Andreas G. Tsantes, George P. Lalliotis, Angeliki C. Polydera, Haralambos Stamatis, Panagiotis Halvatsiotis
Summary: The study revealed a high frequency of foodborne Klebsiella pneumoniae in Greece, with most strains carrying both resistance and virulence genes, indicating a significant risk to human health.
Article
Microbiology
Haiyan Long, Ya Hu, Yu Feng, Zhiyong Zong
Summary: The Klebsiella oxytoca complex consists of nine closely related species that cause human infections, with K. oxytoca and Klebsiella michiganensis being more commonly associated with human infections and carrying more virulence genes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Jiakang Li, Lei Yang, Xuelin Huang, Yiping Wen, Qin Zhao, Xiaobo Huang, Jing Xia, Yong Huang, Sanjie Cao, Senyan Du, Rui Wu, Likou Zou, Qigui Yan, Xinfeng Han
Summary: This study revealed a high prevalence of multidrug-resistant Enterococcus faecalis in ducks, with the potential for transmission to humans due to the presence of various resistance and virulence genes. The findings highlight the importance of monitoring antimicrobial resistance in poultry to prevent the spread of potentially harmful pathogens.
Article
Infectious Diseases
Othman M. Alzahrani, Mahmoud Fayez, Amal S. Alswat, Mohamed Alkafafy, Samy F. Mahmoud, Theeb Al-Marri, Ahmed Almuslem, Hassan Ashfaq, Shaymaa Yusuf
Summary: This study investigated the diversity of Enterococcus in healthy backyard birds and identified the occurrence of multidrug resistance, sequence types, virulence genes, and biofilm formation. The results showed that healthy backyard chickens could act as reservoirs for multidrug-resistant and virulent Enterococcus. Effective antimicrobial stewardship programs and One Health approach are necessary to investigate the transmission of antimicrobial resistance from backyard chickens to humans.
Article
Microbiology
Fangyou Yu, Astrid Cienfuegos-Gallet, Marcus H. Cunningham, Ye Jin, Bingjie Wang, Barry N. Kreiswirth, Liang Chen
Summary: Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) sequence type 9 (ST9) has emerged and disseminated in Asia, with evidence of direct transmission of animal-adapted strains to human hosts. Genetic analysis suggests that ST9 originated from human-adapted strains and evolved through genetic events to adapt to animal hosts, acquiring animal-specific virulent factors and multidrug resistance genes. The rapid clonal expansion of multidrug-resistant ST9 strains in mainland China and Taiwan underscores the need for effective surveillance of antibiotic consumption in animal husbandry to control antimicrobial resistance spread.
Article
Microbiology
Fabrizio Bertelloni, Giulia Cagnoli, Valentina Virginia Ebani
Summary: Dogs can harbor different species of Staphylococcus and can develop various clinical forms caused by these bacteria. Most of the clinical Staphylococcus isolates cultured from sick dogs were Staphylococcus pseudointermedius, with common characteristics including gelatinase, biofilm, and slime production, as well as high levels of multi-drug resistance.
Review
Biochemistry & Molecular Biology
Giovanni Stelitano, Mario Cocorullo, Matteo Mori, Stefania Villa, Fiorella Meneghetti, Laurent Roberto Chiarelli
Summary: The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections is a crucial challenge in the scientific community. This review discusses innovative strategies to hinder iron acquisition in bacteria, including interesting targets and chemical entities that interfere with their function. The mechanism of action, pharmacodynamics, pharmacokinetics, and toxicological properties of each drug candidate are also reviewed. Comprehensive knowledge in this area may lead to the discovery of newer antibiotics to combat antimicrobial resistance effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Simone de Fatima Rauber Wurfel, Denise da Fontoura Prates, Natalie Rauber Kleinubing, Joline Dalla Vecchia, Cristiane Vaniel, Louise Haubert, Odir Antonio Dellagostin, Wladimir Padilha da Silva
Summary: The study found high antimicrobial resistance and genetic diversity in Campylobacter isolates from broiler meat products in southern Brazil. Multidrug-resistant Campylobacter, especially in C. jejuni, was prevalent. Data analysis revealed that antimicrobial resistance and virulence profiles were not species-specific.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Infectious Diseases
Mykhailo Savin, Gabriele Bierbaum, Nico T. Mutters, Ricarda Maria Schmithausen, Judith Kreyenschmidt, Isidro Garcia-Menino, Silvia Schmoger, Annemarie Kaesbohrer, Jens Andre Hammerl
Summary: This study characterizes carbapenem-resistant Klebsiella spp. in wastewater and surface water in Germany. The isolates showed resistance to multiple antibiotics and a high diversity of antibiotic-resistance genes. Virulence factors were also present in most isolates. The findings suggest the possible dissemination of resistant bacteria in the environment and the risk of colonization and infection in humans, livestock, and wildlife.
Article
Multidisciplinary Sciences
Xiaojuan Wang, Xiaoling Xu, Shaojun Zhang, Na Chen, Yunfeng Sun, Kuifen Ma, Dongsheng Hong, Lu Li, Yongzhong Du, Xiaoyang Lu, Saiping Jiang
Summary: The article describes the design of a nanorod drug delivery system that overcomes Klebsiella pneumonia resistance to tigecycline by increasing drug accumulation, inhibiting efflux pumps, and targeting bacteria, thus enhancing the drug's antibacterial activity.
NATURE COMMUNICATIONS
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
