Article
Chemistry, Multidisciplinary
Jeremiah Y. Kim, Matthew G. Rosenberger, Siquan Chen, K. M. I. P. Carman, Azadeh Bahmani, Qing Chen, Jinjing Shen, Yifeng Tang, Andrew Wang, Emma Kenna, Minjun Son, Savas Tay, Andrew L. Ferguson, Aaron P. Esser-Kahn
Summary: Stimulation of the innate immune system is crucial for vaccinations and immunotherapies. Small molecule immunomodulators can improve adjuvant activity by modulating signaling activity, allowing customization of innate responses. These modulators have various applications, ranging from prophylactics to immunotherapy enhancement.
ACS CENTRAL SCIENCE
(2023)
Article
Oncology
Niranjan Kumar, Akanksha Vyas, Saurabh Kumar Agnihotri, Naibedya Chattopadhyay, Monika Sachdev
Summary: Small secretory proteins of immune cells, such as cytokines and chemokines, play a crucial role in modulating immune response and controlling the movement and location of immune cells. They have been extensively studied for their potential in cancer therapy, including gynecological malignancies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alexander A. Andreev-Andrievskiy, Roman A. Zinovkin, Mikhail A. Mashkin, Olga Yu Frolova, Yuriy G. Kazaishvili, Victoria S. Scherbakova, Boris A. Rudoy, Vladimir G. Nesterenko
Summary: Kagocel is a synthetic compound that treats flu and other viral infections by enhancing interferon production. The study found that Kagocel upregulates genes involved in inflammatory responses, antiviral defense, and lymphocyte survival and proliferation in Peyer's patches lymphocytes. Additionally, pattern recognition receptors, TLRs, and dectin-1 are identified as key mediators of Kagocel's immunomodulatory action, possibly involving an interferon autocrine loop.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Taishi Yamamoto, Masashi Sada, Ryo Miyake, Yoshitomo Tsutsui, Ryohei Nishimura, Takayuki Toyohara, Yuki Ikeda, Yoko Shojima, Hiroko Deguchi Miyamoto, Tomonori Tadokoro, Masataka Ikeda, Kohtaro Abe, Tomomi Ide, Shintaro Kinugawa, Hiroyuki Tsutsui
Summary: This study reveals that ZBP1 knockdown exacerbates mtDNA-induced inflammation in cardiomyocytes by increasing RIPK3, NF-kappa B, NLRP3, IL-1 beta, and IL-6 expression. In mouse models of myocardial infarction and heart failure, ZBP1 knockout worsens left ventricular dilatation and dysfunction, accompanied by increased expression of RIPK3, NF-kappa B, NLRP3, IL-1 beta, and IL-6. This suggests that ZBP1 acts as an endogenous suppressor of mtDNA-induced myocardial inflammation and plays a protective role against cardiac remodeling.
CIRCULATION RESEARCH
(2023)
Review
Multidisciplinary Sciences
S. M. Neamul Kabir Zihad, Nazifa Sifat, Mohammad Ashraful Islam, A. S. M. Monjur-Al-Hossain, K. M. Yasif Kayes Sikdar, Md Moklesur Rahman Sarker, Jamil A. Shilpi, Shaikh Jamal Uddin
Summary: This review summarizes the role of pattern recognition receptors in host immune cells in recognizing Mycobacterium tuberculosis and initiating signaling pathways, providing molecular insight into the interaction between specific Mtb ligands and specific PRRs. This information can aid in identifying novel drug targets and developing new drugs and adjuvants.
Article
Fisheries
Fang Li, Xiaohong Liu, Hailong Ge, Jing Huang, Yaoguang Zhang, Zhijian Wang
Summary: A study was conducted to analyze the immune response of Chinese sucker to Aeromonas hydrophila infection at the molecular level. Various immune-related genes were found to be involved in the antibacterial immune response.
Article
Multidisciplinary Sciences
Xiaohui Mu, Zimin Lin, Yu Sun, Lu Chen, Qingqiao Lv, Cejuan Ji, Xiaoyuan Kuang, Weiyi Li, Zhengling Shang, Jinzhi Cheng, Ying Nie, Zhiqiang Li, Jiahong Wu
Summary: The immunomodulatory protein, Ae. albopictus ADA, is involved in mosquito blood feeding and may modulate the transmission of dengue virus through macrophage or monocyte-driven immune response.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lucian G. Scurtu, Olga Simionescu
Summary: The soluble factors in skin innate immunity, including pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines, play a crucial role in sensing threats and inducing inflammation. Recent interest in modulating these factors has increased due to their involvement in various skin inflammatory, infectious, and neoplastic disorders. Cytokine inhibitors have revolutionized the treatment of moderate to severe psoriasis and atopic dermatitis.
Article
Biochemistry & Molecular Biology
Li Liu, Wen Song, Shijia Huang, Kai Jiang, Yoshitaka Moriwaki, Yichuan Wang, Yongfan Men, Dan Zhang, Xing Wen, Zhifu Han, Jijie Chai, Hongwei Guo
Summary: This study reveals that plant cell-surface peptide-receptor complexes can function as extracellular pH sensors, regulating plant growth and immunity. Acidic environment inhibits root meristem growth, while alkaline environment promotes immune response.
Article
Immunology
Manasa Suresh, Bin Li, Xu Huang, Kyle E. Korolowicz, Marta G. Murreddu, Severin O. Gudima, Stephan Menne
Summary: Recent research has shown an increasing interest in immune modulation for the treatment of chronic hepatitis B, with compounds designed for targeting host pattern recognition receptors. These agonistic molecules activate receptor signaling pathways to trigger an innate immune response, shaping adaptive immunity to control chronic HBV infection. Studies have explored various viral RNA sensing receptors and investigated the antiviral potential of viral DNA sensing receptors, showing promising results in animal models of CHB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Briana L. Hickey, Junyi Chen, Yunfan Zou, Adam D. Gill, Wenwan Zhong, Jocelyn G. Millar, Richard J. Hooley
Summary: An arrayed combination of water-soluble deep cavitands and cationic dyes has been shown to optically sense insect pheromones at micromolar concentration in water. Machine learning approaches were used to optimize the most effective array components, which allows differentiation between small structural differences in targets, including between different diastereomers, even though the pheromones have no innate chromophore. When combined with chiral additives, enantiodiscrimination is possible, dependent on the size and shape of the pheromone.
CHEMICAL COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Erika Huijser, Marjan A. Versnel
Summary: Primary Sjogren's syndrome (pSS) is a systemic autoimmune rheumatic disease characterized by dryness of the eyes and mucous membranes, with majority of patients exhibiting persistent systemic activation of the type I interferon (IFN) system. Dysregulated detection of endogenous nucleic acids (NAs) is widely implicated in the pathogenesis of systemic autoimmune diseases. Stimulation of endosomal Toll-like receptors by NA-containing immune complexes contributes to the systemic type I IFN activation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Boris Ryabchenko, Irina Soldatova, Vojtech Sroller, Jitka Forstova, Sandra Huerfano
Summary: This study elucidated the roles of p204 and cGAS sensors in MPyV infection, demonstrating that p204 is responsible for sensing viral genomes in the nucleus, while cGAS is responsible for sensing leaked viral DNA and micronucleus-like bodies in the cytoplasm.
Review
Fisheries
Zhiwei Liao, Jianguo Su
Summary: This review summarizes the research progress on TLRs/RLRs/NLRs in teleost, including their expression profiles, signaling transductions, and functions. Research shows that TLRs in teleost can sense different pathogens by forming various types of dimers, and the activity of endolysosomal TLRs is also influenced by proteolytic cleavage and pH levels.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ali Bishani, Elena L. Chernolovskaya
Summary: Nucleic acid-based therapeutics have shown promise in treating tumor and viral diseases, but challenges remain in delivering therapeutic acids to target cells and achieving specific therapeutic effects. The issue of minimizing excessive secretion of inflammatory cytokines also needs to be addressed in order to fully realize the potential of immunostimulatory nucleic acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Hirawati Deval, Kalichamy Alagarasu, Neha Srivastava, Rupali Bachal, Mahima Mittal, Apoorv Agrawal, Minal Bote, Aniket Gondhalekar, Vijay P. Bondre, Rajni Kant
Summary: The study investigated the association of SNPs in CD209, MMP9, TNFA, and IFNG genes with susceptibility to Japanese encephalitis in 238 JE cases and 405 healthy controls. Results showed higher frequencies of certain genotypes in JE cases, indicating a potential genetic influence on susceptibility to JE.
Article
Virology
Shilpa Jagatram Tomar, Kalichamy Alagarasu, Ashwini More, Manasi Nadkarni, Rupali Bachal, Minal Bote, Jayashri Patil, Vasanthy Venkatesh, Deepti Parashar, Babasaheb Vishwanath Tandale
Summary: This study investigates the decadal change in chikungunya virus infection in Pune City from 2009 to 2019. It finds a fivefold increase in seroprevalence over the decade, with higher seroprevalence observed among older age groups. Modeling analysis suggests that the age-stratified seroprevalence data from 2019 coincide with a recent outbreak in 2016.
Article
Immunology
Kalichamy Alagarasu, Poonam Patil, Meenakshi Kaushik, Deepika Chowdhury, Rajesh K. Joshi, Harsha V. Hegde, Mahadeo B. Kakade, Sugeerappa Laxmanappa Hoti, Sarah Cherian, Deepti Parashar
Summary: This study conducted in vitro antiviral screening of plant extracts and purified compounds for their activities against dengue and chikungunya viruses. The extracts from Plumeria alba, Ancistrocladus heyneanus, Bacopa monnieri, and Cucurbita maxima showed activity against both viruses, while the extract from Vitex negundo only showed activity against dengue virus. Among the purified compounds, anacardic acid, chloroquinone, and methyl gallate showed activity against dengue virus, and only methyl gallate had activity against chikungunya virus. These findings provide potential candidates for the development of phytopharmaceutical drugs against dengue and chikungunya.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Naiju Thomas, Poonam Patil, Anjana Sharma, Sandeep Kumar, Vikas Kumar Singh, Kalichamy Alagarasu, Deepti Parashar, Suman Tapryal
Summary: Chebulinic acid (CA) has been shown to inhibit HSV-2 and DENV-2 infection by blocking viral-host cell attachment. However, it does not have a significant inhibitory effect on CHIKV infection.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian
Summary: This study utilized transcriptomics-based bioinformatics approach to identify drugs with significant anti-DENV activity. The results showed that these drugs can interact with multiple protein targets of DENV and decrease virus production.
Article
Multidisciplinary Sciences
Nitin Motilal Atre, Kalichamy Alagarasu, Pratip Shil
Summary: This study developed a database of antigenic proteins from arboviruses, named ArVirInd, which includes sequences from arboviruses isolated from countries in the Indian subcontinent. The database provides information on the country and year of outbreak or origin of the viral strain for each sequence. Researchers can use this database for immune informatics, diagnostics, and vaccinology research on arboviruses.
Article
Biochemistry & Molecular Biology
Rajesh Kumar Joshi, Shivankar Agarwal, Poonam Patil, Kalichamy Alagarasu, Kingshuk Panda, Sarah Cherian, Deepti Parashar, Subarna Roy
Summary: The lipophilic fraction of the stem of Ocimum basilicum (LFOB) showed antiviral activity against dengue virus (DENV) but not against chikungunya virus (CHIKV). Analysis of LFOB identified 26 compounds, with beta-sitosterol, stigmasterol, and campesterol being the most abundant. LFOB demonstrated significant inhibition of DENV replication but had no effect on CHIKV, indicating its potential as a prophylactic/therapeutic agent against DENV-2.
Letter
Chemistry, Medicinal
Kalichamy Alagarasu, Madhura Punekar, Poonam Patil, Bhagyashri Kasabe, Mahadeo Kakade, Kusuma Sai Davuluri, Sarah Cherian, Deepti Parashar
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Rajarshee Tagore, Kalichamy Alagarasu, Poonam Patil, Suneela Pyreddy, Shakil Ahmed Polash, Mahadeo Kakade, Ravi Shukla, Deepti Parashar
Summary: In this study, carbonated ZIF (ZIF-C) was used as a carrier to successfully deliver siRNAs against CHIKV, resulting in a reduction in viral replication and infectivity. The results indicate that delivery of siRNA through ZIF-C enhances the antiviral activity against CHIKV.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
P. Patil, K. Alagarasu, D. Chowdhury, M. Kakade, S. Cherian, S. Kaushik, J. P. Yadav, D. Parashar
Summary: This study demonstrates the antiviral activity of commercially available Carica papaya leaves extract (CPLE) based products and CPLE prepared in different formulations against dengue virus type 2 (DENV-2) and chikungunya virus (CHIKV) in an in-vitro system. Effective formulations were found under different treatment conditions. The results suggest the potential of CPLE formulations as treatments for dengue and chikungunya, but further validation in in-vivo models is needed.
Article
Plant Sciences
Rajesh K. Joshi, Shivankar Agarwal, Poonam Patil, Kalichamy Alagarasu, Kingshuk Panda, Cherish Prashar, Mahadeo Kakade, Kusuma S. Davuluri, Sarah Cherian, Deepti Parashar, Kailash C. Pandey, Subarna Roy
Summary: This study aimed to explore the activities of the lipophilic fraction of S. androgynus leaves against dengue, chikungunya viruses, and malaria parasite. The results showed that the lipophilic fraction of S. androgynus leaves can inhibit dengue virus infection and may be a potential prophylactic/therapeutic agent against dengue.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Virology
Shridhar Shukla, Santosh M. Jadhav, Yogesh K. Gurav, Deepti Parashar, Kalichamy Alagarasu
Summary: This study evaluated the association between serum ferritin levels and severe dengue, as well as its utility as a biomarker of disease severity. The analysis included 18 studies and found that serum ferritin levels were higher in severe dengue cases compared to non-severe cases.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Immunology
Bhagyashri Kasabe, Gunwant Ahire, Poonam Patil, Madhura Punekar, Kusuma Sai Davuluri, Mahadeo Kakade, Kalichamy Alagarasu, Deepti Parashar, Sarah Cherian
Summary: In this study, the anti-CHIKV activity of 14 FDA-approved drugs was investigated through in vitro and in silico approaches. The findings revealed that nine drugs exhibited anti-chikungunya activity. In addition, molecular docking studies showed that these drugs could bind to specific structural and non-structural proteins of CHIKV. Overall, these drugs have the potential to suppress infection and replication of CHIKV, but further in vivo studies and clinical trials are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Gabriel Luz Wallau
LANCET GLOBAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kalichamy Alagarasu, Shilpa Tomar, Jayashri Patil, Rupali Bachal, Reva More, Minal Bote, Mahadeo Kakade, Vasanthy Venkatesh, Deepti Parashar, Babasaheb Tandale
Summary: This study investigated the seroprevalence of dengue in Pune City, India, and found a significant increase in the intensity of dengue virus transmission over the past decade. The results indicate that over 85% of participants above nine years of age had exposure to the dengue virus by 2019, suggesting that dengue vaccine introduction can be considered.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
