Review
Biochemistry & Molecular Biology
Haruki Usuda, Takayuki Okamoto, Koichiro Wada
Summary: The intestinal tract acts as a barrier preventing harmful molecules from invading mucosal tissue, with intestinal permeability serving as an index for intestinal barrier integrity. Increased intestinal permeability is associated with various diseases, and chronic increase leads to 'leaky gut,' observed in patients and animal models. Nutrients play a key role in influencing intestinal permeability and the microbiome for a better understanding of leaky gut and its potential mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Angelica Cruz-Lebron, Ramona Johnson, Claire Mazahery, Zach Troyer, Samira Joussef-Pina, Miguel E. Quinones-Mateu, Christopher M. Strauch, Stanley L. Hazen, Alan D. Levine
Summary: Chronic opioid use leads to dysbiosis in the gut microbiome, resulting in compromised intestinal barrier integrity and reduced levels of short-chain fatty acids. The study shows that metabolites produced by Akkermansia muciniphila can modulate intestinal barrier integrity, offering potential therapeutic benefits. Therefore, enhancing the therapeutic potential of A. muciniphila and developing new clinical strategies to normalize the gut microbiome may provide effective treatment for individuals affected by chronic opioid use.
Article
Nutrition & Dietetics
Diego Taladrid, Dolores Gonzalez de Llano, Irene Zorraquin-Pena, Alba Tamargo, Mariana Silva, Natalia Molinero, M. Victoria Moreno-Arribas, Begona Bartolome
Summary: This study investigated the impact of grape pomace extract on intestinal barrier functionality, showing that the intestinal-digested extract significantly reduced paracellular transport while the colonic-digested extract did not. Colonic fermentation of the extract led to the production of short-chain fatty acids and phenolic metabolites, affecting bacteria abundance and paracellular permeability. Further research is needed to confirm these initial trends on the effects of grape pomace extract.
Article
Biochemistry & Molecular Biology
Keila Rodrigues Zanardi, Mariana Grancieri, Caroline Woelffel Silva, Leonardo Oliveira Trivillin, Mirelle Lomar Viana, Andre Gustavo Vasconcelos Costa, Neuza Maria Brunoro Costa
Summary: The functional effects of yacon and kefir, administered separately or in combination, were evaluated in rats with colorectal cancer. Yacon increased acetate levels, reduced pH, and decreased carcinogenic neoplastic lesions, while kefir increased macroscopic neoplastic lesions and the abundance of certain bacteria. The combination of yacon and kefir increased the number of carcinogenic lesions, despite reducing pH and the prevalence of beneficial bacteria.
Article
Biochemistry & Molecular Biology
Keila Rodrigues Zanardi, Mariana Grancieri, Caroline Woelffel Silva, Leonardo Oliveira Trivillin, Mirelle Lomar Viana, Andre Gustavo Vasconcelos Costa, Neuza Maria Brunoro Costa
Summary: The functional effects of yacon and kefir in rats with colorectal cancer were evaluated in this study. Yacon reduced pH and carcinogenic neoplastic lesions, increased acetate levels, and promoted the abundance of beneficial bacteria. Kefir, on the other hand, increased macroscopic neoplastic lesions and the abundance of certain harmful bacteria. The combination of yacon and kefir increased the number of carcinogenic lesions despite a reduction in pH and beneficial bacteria prevalence.
Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Paula Lopes Armond Carvalho, Maria Emilia Rabelo Andrade, Luisa Martins Trindade, Paola Caroline Lacerda Leocadio, Jacqueline Isaura Alvarez-Leite, Diego Carlos dos Reis, Geovanni Dantas Cassali, Ericka Lorenna de Sales Souza e Melo, Flaviano dos Santos Martins, Simone Odilia Antunes Fernandes, Maria do Carmo Gouveia Peluzio, Simone de Vasconcelos Generoso, Valbert Nascimento Cardoso
Summary: Prebiotic fructo-oligosaccharides (FOS) have beneficial effects in preventing and treating intestinal mucositis, with total treatment with FOS being more effective than pre-treatment alone.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Carolina Pellegrini, Matteo Fornai, Vanessa D'Antongiovanni, Luca Antonioli, Nunzia Bernardini, Pascal Derkinderen
Summary: The intestinal barrier, consisting of a mucus layer, an epithelial barrier, and a gut vascular barrier, plays a crucial role in health and disease by facilitating nutrient absorption and preventing pathogen entry. Growing evidence suggests that the intestinal barrier is compromised not only in digestive disorders, but also in central nervous system (CNS) disorders such as Parkinson's disease, autism spectrum disorder, depression, multiple sclerosis, and Alzheimer's disease. This article provides an overview of the structure and functions of the intestinal barrier, reviews existing preclinical and clinical studies supporting intestinal barrier dysfunction in neurological, neurodevelopmental, and psychiatric disorders, and discusses the potential impact of evaluating enteric barriers on clinical practice.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alina Kondrashina, Andre Brodkorb, Linda Giblin
Summary: This study found that by treating mature cell monolayers with sodium butyrate, a model of the infant intestinal barrier with characteristics of infant gut can be developed. This treatment is not cytotoxic, but can increase permeability and stability of the intestinal barrier.
Article
Biochemistry & Molecular Biology
Zhi-Yuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Wan Jin, Hong-Mei Ren, Sheng-Yao Kuang, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Xiao-Qiu Zhou
Summary: This study focused on the protective effects of dietary mannoligosaccharides (MOS) supplementation on the intestinal structural integrity of grass carp. The results showed that dietary MOS supplementation protected the microvillus of the intestine, reduced mucosal permeability, and maintained intestinal structural integrity through the inhibition of MLCK and RhoA/ROCK signaling pathways. These findings highlight the positive impact of dietary MOS supplementation on intestinal health.
Article
Biochemistry & Molecular Biology
Marika Lanza, Alessia Filippone, Giovanna Casili, Letterio Giuffre, Sarah Adriana Scuderi, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: The study found that short-chain fatty acids (SCFAs) sodium propionate (SP) and sodium butyrate (SB) can alleviate pain, reduce intestinal tissue damage, restore intestinal permeability, and regulate the composition of microbiota in a mouse model of migraine. These results suggest the potential use of SCFAs as novel supportive therapies for intestinal dysfunction associated with migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Fusheng Liu, Jin Liu, Yinuo Liu, Yin Zhang, Xia Ding
Summary: The study demonstrated that SFD significantly reduced mortality, prevented intestinal and liver damage, relieved sepsis-induced intestinal permeability and inflammation, and ameliorated the condition of sepsis-induced impaired intestinal permeability by regulating tight junction proteins and p-VASP.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fang Li, Zhuoran Kang, Xiaojuan Wu, Wei Wu
Summary: Dietary protein plays a crucial role in body growth and shaping the gut microbiota. This study found that oxidation of rice bran protein (RBP) altered the composition of the gut microbiota, improved intestinal barrier function, but had limited effects on short-chain fatty acid production.
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Food Science & Technology
Ningning Huang, Miaomiao Wang, Jian Peng, Hongkui Wei
Summary: ARA plays a significant role in growth and development, while its release can lead to the production of eicosanoids, which have various physiological functions.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Chao Wang, Ze-Xue Liu, Ying-Hui Wu, Hong-Kui Wei, Jian Peng
Summary: This study aimed to establish a feasible model for analysing factors affecting piglet litter performance at birth. The results showed that MLM is superior to GLM and can replace MPM in analysing discrete data with hierarchical structure in pig production. Additionally, other potential influencing factors of litter performance at birth can be analysed using the established MLM in the future.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Chemistry, Applied
Xiong Xia, Hongkui Wei, Lingling Hu, Jian Peng
Summary: The combination of xanthan gum and guar gum enhances swelling and water-binding capacities during in vitro fermentation, leading to higher degradation rates and promotion of beneficial microbiota growth.
CARBOHYDRATE POLYMERS
(2021)
Correction
Food Science & Technology
Zhao Deng, Huichao Yu, Zhipeng Yang, Lingling Hu, Yanan Wang, Qi Liu, Hong-Kui Wei, Jian Peng
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Chenbin Cui, Qi Liu, Bingbing Duan, Xiangchen Liu, Hongkui Wei, Jian Peng
Summary: This study found that a bioactive triple peptide (BTP) can alleviate intestinal injuries and inflammation caused by Salmonella typhimurium, inhibit bacteria translocation, and exhibit antibacterial and anti-inflammatory activities. BTP also significantly inhibited the adhesion and invasion of S. typhimurium to cells.
Letter
Oncology
Zhao Deng, Zhipeng Yang, Chenbin Cui, Hongkui Wei, Lijia Wang, Dean Tian, Fang Xiao, Jian Peng
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Miaomiao Wang, Zhaoyu Wang, Yueyue Miao, Hongkui Wei, Jian Peng, Yuanfei Zhou
Summary: This study found that hydrogen sulfide (H2S) can serve as an important signaling molecule to regulate placental angiogenesis and improve reproductive performance in maternal obesity. Treatment with the H2S donor diallyl trisulfide (DATS) promoted placental angiogenesis by regulating lipid metabolism and alleviating inflammatory responses in obese pregnant mice.
Article
Agriculture, Dairy & Animal Science
Yanan Wang, Zhipeng Yang, Yuanfei Zhou, Jiajian Tan, Haiqing Sun, Defa Sun, Yuyun Mu, Jian Peng, Hongkui Wei
Summary: The study reveals that high AA level and dietary supplementation with CB can improve the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity, thereby alleviating diarrhea symptoms and improving feed conversion ratio.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Fangrui Zuo, Hongkui Wei, Jian Peng, Shengqing Li, Yuanfei Zhou
Summary: The study found that L-Met and DL-HMTBA have significant effects on methionine metabolism, especially on transmethylation, suggesting that DL-HMTBA has the potential to influence the intestinal barrier function of animals through epigenetic processes.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jianwei Gao, Chuanhui Xu, Mengdi Zhang, Jianhua Liu, Xiaoyu Wu, Chenbin Cui, Hongkui Wei, Jian Peng, Rong Zheng
Summary: The combination of functional fiber (FF) and every-other-day fasting (EODF) can improve insulin sensitivity and curb weight gain by regulating the composition of gut microbiota. In the study, 6% FF-EODF significantly improved insulin sensitivity in obese mice and increased satiety, energy consumption, weight, and adipose loss during a normal chow diet phase. Additionally, FF supplementation increased the abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium in the intestine, which was correlated with decreased adiposity and insulin resistance.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Mengdi Zhang, Jianhua Liu, Chen Li, Jianwei Gao, Chuanhui Xu, Xiaoyu Wu, Tiesheng Xu, Chenbin Cui, Hongkui Wei, Jian Peng, Rong Zheng
Summary: This study found that a synthetic functional fiber can alleviate obesity and metabolic syndrome by modulating intestinal microbiota and metabolites, leading to improvements in gut health.
Review
Immunology
Zhipeng Yang, Xiangchen Liu, Yanting Wu, Jian Peng, Hongkui Wei
Summary: This review explores the significance of early-life microbial colonization and the development of intestinal innate immunity, as well as discusses two main methods of early-life intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ningning Huang, Xiangchen Liu, Xiaoqi Pei, Jian Peng, Hongkui Wei
Summary: This study analyzed the concentrations of oxylipins in feces of suckling piglets and identified the importance of ARA-derived oxylipins in the physiological changes of the piglets. The results provide new information on the physiological changes during the suckling period.
Article
Spectroscopy
Yang Cao, Yinghui Wu, Zihui Liu, Qinshu Kang, Hongkui Wei, Jian Peng, Shengqing Li
Summary: Trace elements play a crucial role in the spermatogenesis, maturation, and fertilization of sperm. In this study, a simple method using time resolved inductively coupled plasma mass spectrometry (ICP-MS) was developed to accurately determine trace elements in single boar's sperm cells. The method provides valuable information for evaluating the quality of boar semen and has potential applications in studying sperm signal transduction and relevant physiological topics.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Article
Nutrition & Dietetics
Zhipeng Yang, Yanting Wu, Xiangchen Liu, Mei Zhang, Jian Peng, Hongkui Wei
Summary: This study found that early intervention with Saccharomyces boulardii improved growth performance and gut microbiome in early-weaned rats. It also enhanced gut mucosal barrier function and suppressed inflammatory response while promoting anti-inflammatory response.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)