Review
Medicine, General & Internal
Ye Tian, Lie Wang, Zhongtian Wang, Lizhong Ding, Lina Wei, Lei Guo, Xiaozhou Sun, Lei Wang, Fushuang Yang, Liping Sun
Summary: Recurrent respiratory tract infections are common respiratory ailments in children that can have a significant impact on their physical and mental health. This study aims to evaluate the efficacy and safety of Tuina massage in treating RRTIs.
Article
Medicine, General & Internal
Changqing Cao, Jinghua Wang, Yuning Li, Yumei Li, Liyan Ma, Mohamed E. A. Abdelrahim, Yi Zhu
Summary: OM-85 consumption is significantly associated with a lower frequency, total duration, incidence, number of antibiotic courses, and antibiotic use in respiratory tract infections. However, it is not significantly related to adverse events or wheezing attacks frequency. This indicates that OM-85 could be a valuable tool to improve immunity against recurrent respiratory tract infections, especially in critical situations like the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Immunology
Felix Bergmann, Lena Pracher, Rebecca Sawodny, Amelie Blaschke, Georg Gelbenegger, Christine Radtke, Markus Zeitlinger, Anselm Jorda
Summary: The study showed that adjunctive systemic corticosteroid therapy in adult patients hospitalized with community-acquired pneumonia was associated with a reduction in all-cause mortality by day 30, without increasing the risk of adverse events.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Reproductive Biology
Chunmei Zhang, Wancheng Zhao
Summary: Angiogenesis inhibitors have shown efficacy and safety in the treatment of recurrent ovarian cancer, improving overall survival, progression-free survival, and objective response rate. However, they may increase the risk of grade >= 3 adverse events.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yanan Xu, Haijing Guan, Kefu Yu, Nan Ji, Zhigang Zhao
Summary: This study compared the efficacy and safety of treatments for patients with recurrent high-grade gliomas. The results showed that regorafenib and bevacizumab plus lomustine (90 mg/m(2)) improved overall survival, but had lower objective response rates in these patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pediatrics
Lu Zhang, Xuqiong Wang, Dong Wang, Yinling Guo, Xinying Zhou, Haiyan Yu
Summary: This study demonstrated that adjuvant YPFG therapy can improve clinical response rate and increase serum immunoglobulin levels while decreasing TNF-alpha level in children with recurrent respiratory tract infections.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Maria Wilma R. Turalde-Mapili, Jerahmeel Aleson L. Mapili, Christian Wilson R. Turalde, Marimel R. Pagcatipunan
Summary: This study aims to determine the efficacy and safety of nirsevimab in preventing RSV infection among infants through a review of relevant clinical trials. The two included studies showed that nirsevimab given before the RSV season significantly reduced the risk of medically attended RSV-related infection and hospitalization due to RSV infection among infants, without significant adverse events. However, studies on the cost-effectiveness of nirsevimab are lacking.
FRONTIERS IN PEDIATRICS
(2023)
Review
Neurosciences
Ashna Talwar, Emily Estes, Rajender Aparasu, Doodipala Samba Reddy
Summary: This study evaluated the clinical potential of oral CBD in treating refractory epilepsy through a systematic review and meta-analysis. The results suggest that CBD treatment is more effective than placebo in reducing seizures in patients with refractory epilepsy, although it is associated with increased adverse events. CBD shows promise as a standalone or adjunct therapy for controlling seizures, but further investigation and guidelines are needed.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Tingting Shu, Huaqiao Chen, Lu Wang, Wuwan Wang, Panpan Feng, Rui Xiang, Li Wen, Wei Huang
Summary: Pulmonary vasodilators significantly decrease mortality, improve respiratory and hemodynamic parameters, and reduce mechanical ventilation duration in pediatric pulmonary hypertension patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pediatrics
Li Lai, Xuan Yue
Summary: The meta-analysis compared the efficacy of antimicrobial-impregnated catheters with conventional catheters in preventing CRBSI. Findings suggest that there are similar rates of CRBSI and catheter colonization between the two types of catheters in the pediatric and neonatal populations. Larger scale RCTs are needed for further confirmation due to existing heterogeneity and limited sample sizes in current studies.
FRONTIERS IN PEDIATRICS
(2021)
Article
Emergency Medicine
Xue Heng, Peng Cai, Zhiqiang Yuan, Yizhi Peng, Gaoxing Luo, Haisheng Li
Summary: Respiratory and circulatory dysfunction are common complications and leading causes of death among burn patients. This study aimed to comprehensively evaluate the efficacy and safety of extracorporeal membrane oxygenation (ECMO) in burn patients. The study found that ECMO can be an appropriate rescue therapy for burn patients despite relatively high mortality and complication rates.
Review
Clinical Neurology
Jisun Hwang, Hee Mang Yoon, Beom Hee Lee, Pyeong Hwa Kim, Kyung Won Kim
Summary: This study systematically evaluated the efficacy and safety of selumetinib in children with neurofibromatosis type 1 (NF1). The results suggest that selumetinib is an effective and safe treatment for pediatric patients with symptomatic, inoperable plexiform neurofibromas.
Article
Pharmacology & Pharmacy
Suying Lu, Ye Hong, Huimou Chen, Liuhong Wu, Feifei Sun, Juan Wang, Jia Zhu, Yi Que, Lian Zhang, Zijun Zhen, Xiaofei Sun, Junting Huang, Yizhuo Zhang
Summary: This study evaluated the efficacy and safety of anlotinib in pediatric patients with refractory or recurrent solid tumors. The results showed that anlotinib monotherapy and its combination with chemotherapy may be effective treatment options with tolerable adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Fengyun Wang, Yiming Li, Bingqing Wang, Jianguo Li, Zhiyong Peng
Summary: This study conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of mesenchymal stromal cells (MSC) in acute respiratory distress syndrome (ARDS). The results showed that MSC treatment was as safe as standard treatment and could reduce the mortality rate of ARDS. However, more high-quality and large-scale clinical trials are needed to further confirm these findings.
Review
Medicine, General & Internal
Surjit Singh, Daisy Khera, Ankita Chugh, Pushpinder Singh Khera, Vinay Kumar Chugh
Summary: The study found that remdesivir did not reduce mortality in the treatment of COVID-19, but it did improve clinical improvement rate and shorten time to clinical improvement, while also reducing the risk of serious adverse events, but did not have a significant impact on the risk of respiratory failure.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)