Article
Medicine, General & Internal
Takashi Sasaki, Shuntaro Yoshida, Hiroyuki Isayama, Akiko Narita, Tomonori Yamada, Toshiyuki Enomoto, Yorinobu Sumida, Rika Kyo, Toshio Kuwai, Masafumi Tomita, Rintaro Moroi, Mamoru Shimada, Nobuto Hirata, Yoshihisa Saida
Summary: The study confirmed that endoscopic placement of self-expandable metal stents with low axial force for malignant colorectal obstruction management showed high technical and clinical success rates, and safety with no colonic perforation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Sigrid Skov Bennedsgaard, Lene Hjerrild Iversen
Summary: Histopathology plays a crucial role in the diagnosis and treatment guidance of colorectal cancer. The study found limited evidence on the necessity of biopsy sampling during acute SEMS placement, highlighting the need for prospective studies to determine the real risk of hemorrhage associated with biopsy during the procedure.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shuya Shimizu, Itaru Naitoh, Fumihiro Okumura, Atsuyuki Hirano, Katsuyuki Miyabe, Yuji Nishi, Hiroki Takada, Kenichi Haneda, Kaiki Anbe, Michihiro Yoshida, Hiromu Kondo, Hitoshi Sano, Kazuki Hayashi, Hiromi Kataoka
Summary: This study compared one-step and two-step transpapillary covered self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction. The main outcome of time to recurrent biliary obstruction (TRBO) did not differ significantly between the two groups, but SEMS migration was significantly more frequent in the two-step group. Additionally, the total costs were significantly lower in the one-step SEMS group.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Tae-Geun Gweon, Chul-Hyun Lim, Jinsu Kim, Dong Hoon Kang, Bo In Lee, Young-Seok Cho
Summary: An ultrathin endoscope (UTE) was used as a rescue method for guidewire insertion in patients with malignant colorectal obstruction (MCO) when conventional SEMS insertion failed. This technique improved the overall success rate of SEMS placement.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Rei Ishibashi, Takashi Sasaki, Hiroyuki Isayama, Takeaki Matsuzawa, Toshio Kuwai, Tomonori Yamada, Shuji Saito, Masafumi Tomita, Toshiyasu Shiratori, Satoshi Ikeda, Hideki Kanazawa, Mitsuhiro Fujishiro, Iruru Maetani, Yoshihisa Saida
Summary: This study demonstrates that endoscopic colorectal stenting using high axial force SEMS is an effective and safe procedure for palliating malignant colorectal obstruction. However, caution should be taken to avoid stent edge perforation when using a long SEMS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kentaro Yamao, Masayuki Kitano, Yasutaka Chiba, Takeshi Ogura, Takaaki Eguchi, Ichiro Moriyama, Yukitaka Yamashita, Hironari Kato, Takahisa Kayahara, Noriyuki Hoki, Yoshinobu Okabe, Hideyuki Shiomi, Yoshitaka Nakai, Yoshinori Kushiyama, Yoshifumi Fujimoto, Shiro Hayashi, Shigeki Bamba, Yasushi Kudo, Nobuaki Azemoto, Toshiharu Ueki, Norimitsu Uza, Masanori Asada, Kazuya Matsumoto, Hiroko Nebiki, Hiroshi Takihara, Chisio Noguchi, Hideki Kamada, Kojiro Nakase, Daisuke Goto, Tsuyoshi Sanuki, Tetsuya Koga, Shinichi Hashimoto, Hidefumi Nishikiori, Masahiro Serikawa, Keiji Hanada, Ken Hirao, Masaya Ohana, Imakiire Kazuyuki, Takao Kato, Motoyuki Yoshida, Hirofumi Kawamoto
Summary: In patients with mGOO, although overall survival rates are low, there is no significant difference in survival between covered and uncovered stents. However, the proportion of stent dysfunction is significantly higher in uncovered stents, especially in patients with extrinsic tumors. Subgroup analysis suggests using covered stents for intrinsic tumors and uncovered stents for extrinsic malignancies.
Article
Surgery
Takeshi Okamoto, Takashi Sasaki, Toshiyuki Yoshio, Chinatsu Mori, Takafumi Mie, Takaaki Furukawa, Yuto Yamada, Tsuyoshi Takeda, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Junko Fujisaki, Naoki Sasahira
Summary: This study compared the outcomes of partially covered and uncovered self-expandable metal stents (SEMS) placement after recurrent duodenal obstruction (RDO) in patients with malignant duodenal obstruction. The results showed that there was a risk of stent migration after partially covered stent placement, and the choice of SEMS did not affect the time to re-recurrent obstruction or overall survival. Chemotherapy after the second stenting was associated with longer overall survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Hyung-Hoon Oh, Sung-Bum Cho, Ji-Yun Hong, Dong-Hyun Kim, Hee-Chan Yang, Sang-Wook Kim, Jun Lee, Seong-Jung Kim, Yeom-Dong Han, Geom-Seok Seo, Gun-Young Hong, Ho-Dong Kim, Dae-Seong Myung, Hyun-Soo Kim, Young-Eun Joo
Summary: This study compared the efficacy of palliative SEMS placement in left-sided and right-sided malignant colorectal obstructions and investigated predictive factors for clinical success and risk factors for complications. The study found that palliative SEMS placement in right-sided MCO had a higher clinical success rate compared to left-sided MCO, and the use of uncovered stents resulted in better outcomes.
Article
Medicine, General & Internal
Yang Bai, Ke Zhan, Jing Chi, JinYue Jiang, Shuang Li, Yuting Yin, Yishi Li, Shuliang Guo
Summary: This study investigated the effect of self-expanding metallic stent (SEMS) on palliative treatment for patients with malignant central airway obstruction (CAO) or tracheoesophageal fistula (TEF), and explored the prognostic factors associated with 3-month survival. The results showed significant improvement in symptoms for CAO patients after SEMS placement, while the survival rate for TEF patients was lower, possibly due to aspiration pneumonitis and malnutrition. The authors recommended more aggressive treatment modalities for TEF patients and emphasized the need for further studies on prognostic factors.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Atsuko Izumi, Toshiyuki Yoshio, Takashi Sasaki, Mitsuaki Ishioka, Atsuko Kizawa, Yohei Ikenoyama, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Keisho Chin, Mariko Ogura, Naoki Sasahira, Junko Fujisaki
Summary: This retrospective study investigated the efficacy and safety of self-expandable metallic stent (SEMS) placement for malignant esophageal fistulas. The results showed that most patients were able to resume oral intake with a low rate of major adverse events after SEMS placement, indicating that SEMS placement is a reasonable palliative treatment option.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Zhaofei Zeng, Yang Liu, Ketong Wu, Dan Li, Haiyang Lai, Bo Zhang
Summary: This study aimed to investigate the long-term outcomes of self-expandable metallic stent (SEMS) insertion in patients with malignant colorectal obstruction and identify the risk factors for complications. The results showed that SEMS under fluoroscopic guidance is a safe and effective treatment. For resectable colorectal cancer (CRC), stent placement can serve as a bridge to surgery, and adjuvant chemotherapy between SEMS and surgery does not increase complications. For patients with recurrent CRC, stent placement can relieve symptoms and improve quality of life.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, General & Internal
Chinatsu Yonekura, Takashi Sasaki, Takafumi Mie, Takeshi Okamoto, Tsuyoshi Takeda, Takaaki Furukawa, Yuto Yamada, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Naoki Sasahira
Summary: Malignant afferent loop obstruction is a rare and challenging condition. Endoscopic transluminal treatment and self-expandable metal stent placement are both safe and effective options for patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Dao-Jian Gao, Jian-Feng Yang, Shu-Ren Ma, Jun Wu, Tian-Tian Wang, Hang-Bin Jin, Ming-Xing Xia, Ying-Chun Zhang, Hong-Zhang Shen, Xin Ye, Xiao-Feng Zhang, Bing Hu
Summary: Additional RFA may improve overall survival and quality of life in patients with inoperable primary extrahepatic biliary cancer compared to stent placement alone.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Namyoung Park, Min Kyu Jung, Eui Joo Kim, Woo Hyun Paik, Jae Hee Cho
Summary: This study evaluates the efficacy of in-stent radiofrequency ablation (IS-RFA) followed by uncovered self-expandable metal stent (SEMS) placement for the management of occluded SEMSs. The results show that the median time to recurrent biliary obstruction was longer in the IS-RFA group compared to the control group, but there were no significant differences in overall survival between the two groups. IS-RFA followed by uncovered SEMS placement is a safe and feasible option for treating occluded SEMSs in patients with pancreatobiliary cancer.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Massimo Conio, Maria Flavia Savarese, Rosa Angela Filiberti, Todd Huntley Baron, Angelo Caruso, Raffaele Manta, Mario Marini, Luca De Luca, Antonella De Ceglie
Summary: The study found that using a fully covered SEMS with an anti-migration system is a safe and effective treatment for malignant dysphagia. Although the overall migration rate was reduced, it remained high in strictures located in the upper esophagus and when the stent was placed across the esophago-gastric junction.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Oncology
Akira Ishikawa, Kazuya Kuraoka, Junichi Zaitsu, Akihisa Saito, Toshio Kuwai, Yosuke Shimizu, Takeshi Sudo, Hirotaka Tashiro, Kiyomi Taniyama, Wataru Yasui
Summary: This study examined the expression of ANXA10 in SBA for the first time, finding that ANXA10 expression is associated with poor prognosis and could be a new prognostic biomarker for SBA.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Naoki Yorita, Ryo Yuge, Hidehiko Takigawa, Atsushi Ono, Toshio Kuwai, Kazuya Kuraoka, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama
Summary: This study found that the combination of anti-PD-1 antibody and imatinib has an anti-tumor effect on excluded-type tumors in colorectal cancer. The combination therapy suppressed stromal reaction and increased the number of CD8-positive T cells in the tumor nest, suggesting potential efficacy for CRC cases resistant to anti-PD-1 monotherapy.
Review
Gastroenterology & Hepatology
Atsushi Yamaguchi, Takuro Hamada, Kaoru Wada, Riho Moriuchi, Kanae Tao, Hirona Konishi, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, Kohei Ishiyama, Naoto Hadano, Takeshi Sudo, Naoyuki Toyota, Junichi Zaitsu, Kazuya Kuraoka, Hiroshi Kohno
Summary: Intraductal tubulopapillary neoplasm (ITPN) is a new disease concept with a relatively good prognosis. ITPNs localized in branch ducts (BD) are rare and difficult to diagnose before surgery. The round shape and low fluid content in this case may be distinctive characteristics differentiating it from branch duct type IPMN and raising suspicion of ITPN in BD.
BMC GASTROENTEROLOGY
(2021)
Article
Oncology
Toshikatsu Naito, Ryo Yuge, Yasuhiko Kitadai, Hidehiko Takigawa, Yukihito Higashi, Toshio Kuwai, Kazuya Kuraoka, Shinji Tanaka, Kazuaki Chayama
Summary: The study found that SPARC expression in CRC cells is associated with tumor severity, lymph node metastasis, staging, and poor prognosis. SPARC may play a role in the tumor microenvironment by inducing epithelial-mesenchymal transition and promoting stromal formation.
Article
Surgery
Yuki Okamoto, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Seiji Onogawa, Takeshi Mizumoto, Hideharu Okanobu, Morihisa Akagi, Kazuaki Chayama
Summary: This study investigated the clinical outcomes of hybrid ESD for colorectal tumors that met the 30 mm lesion size criterion. The salvage group had a higher perforation rate overall, but a lower rate during snaring. During the second period compared to the first, there were significantly higher complete en bloc resection rates and experienced operator rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Toshio Kuwai, Yuzuru Tamaru, Ryusaku Kusunoki, Shuntaro Yoshida, Takeaki Matsuzawa, Hiroyuki Isayama, Iruru Maetani, Mamoru Shimada, Tomonori Yamada, Shuji Saito, Masafumi Tomita, Koichi Koizumi, Toshiyasu Shiratori, Toshiyuki Enomoto, Yoshihisa Saida
Summary: This study investigated the long-term outcomes of bridge-to-surgery colonic stenting using a standardized SEMS insertion method. The results showed high technical success and low perforation rates, with satisfactory overall survival and relapse-free survival rates in patients. However, perforation was identified as an independent factor affecting relapse-free survival.
DIGESTIVE ENDOSCOPY
(2022)
Letter
Gastroenterology & Hepatology
Sauid Ishaq, Keith Siau, Toshio Kuwai, Chris J. Mulder, Helmut Neumann
Article
Medicine, General & Internal
Kaoru Wada, Toshio Kuwai, Syuhei Sugata, Takuro Hamada, Riho Moriuchi, Yuzuru Tamaru, Ryusaku Kusunoki, Atsushi Yamaguchi, Hirotaka Kouno, Sauid Ishaq, Hiroshi Kohno
Summary: This study evaluated the efficacy and safety of a newly developed proximal release-type colonic stent in treating malignant colorectal obstructions. The results showed that the stent was highly effective in treating lesions near the anal verge, but caution should be exercised when considering the indications for rectosigmoid colon lesions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Akihiro Miyakawa, Toshio Kuwai, Yukie Sakuma, Manabu Kubota, Akira Nakamura, Ei Itobayashi, Haruhisa Shimura, Yoshio Suzuki, Kenji Shimura
Article
Gastroenterology & Hepatology
Yuzuru Tamaru, Toshio Kuwai, Akihiro Miyakawa, Noriyoshi Kanazawa, Ryusaku Kusunoki, Haruhisa Shimura, Shiori Uchiyama, Sauid Ishaq, Hiroshi Kohno
Summary: The use of a traction device in colorectal endoscopic submucosal dissection (ESD) can hasten the resection speed, especially in the proximal colon. It may also have potential benefits in the resection of large tumors.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Toshio Kuwai, Takeshi Mizumoto, Yuzuru Tamaru, Ryusaku Kusunoki, Sauid Ishaq
DIGESTIVE ENDOSCOPY
(2022)
Article
Medicine, General & Internal
Atsushi Yamaguchi, Naohiro Kato, Shuhei Sugata, Takuro Hamada, Nao Furuya, Takeshi Mizumoto, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, Naoyuki Toyota, Takeshi Sudo, Kazuya Kuraoka, Hiroshi Kohno
Summary: This study evaluated the efficacy of abdominal ultrasonography as a diagnostic tool for pancreatic cancer (PC) in asymptomatic individuals. The results showed that the prognosis of PC patients diagnosed through ultrasonography during medical checkups was better than those diagnosed through symptomatic presentations.
Article
Medicine, General & Internal
Rei Ishibashi, Takashi Sasaki, Hiroyuki Isayama, Takeaki Matsuzawa, Toshio Kuwai, Tomonori Yamada, Shuji Saito, Masafumi Tomita, Toshiyasu Shiratori, Satoshi Ikeda, Hideki Kanazawa, Mitsuhiro Fujishiro, Iruru Maetani, Yoshihisa Saida
Summary: This study demonstrates that endoscopic colorectal stenting using high axial force SEMS is an effective and safe procedure for palliating malignant colorectal obstruction. However, caution should be taken to avoid stent edge perforation when using a long SEMS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Atsushi Yamaguchi, Naohiro Kato, Syuhei Sugata, Takuro Hamada, Nao Furuya, Takeshi Mizumoto, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, Hiroshi Kohno
Summary: This study investigated the usefulness of the UMIDAS NB stent for biliary drainage in cases of accidental nasobiliary drainage (NBD) tube removal. The results showed that the UMIDAS NB stent was effective and safe for biliary drainage in patients at high risk of self-removal of the NBD tube.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yuki Kamigaichi, Shiro Oka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Akira Furudoi, Seiji Onogawa, Hideharu Okanobu, Takeshi Mizumoto, Tomohiro Miwata, Shiro Okamoto, Hidenori Tanaka, Ken Yamashita, Yuki Ninomiya, Shinji Tanaka
GASTROINTESTINAL ENDOSCOPY
(2021)