Article
Chemistry, Inorganic & Nuclear
Aarti Upadhyay, Paramita Kundu, Vanitha Ramu, Paturu Kondaiah, Akhil R. Chakravarty
Summary: Three compounds were synthesized and characterized, and their anticancer activities were studied. They generated singlet oxygen under red light and showed photocytotoxicity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Aarti Upadhyay, Amrita Nepalia, Arpan Bera, Deepak Kumar Saini, Akhil R. Chakravarty
Summary: In this study, two platinum(II) complexes and their photodynamic therapy (PDT) activity were synthesized and characterized. Among them, complex 2 exhibited strong absorption and fluorescence properties under red light, and could generate singlet oxygen. The cytotoxicity of this complex was significantly enhanced against lung cancer and breast cancer cells under light exposure, and it also showed anti-metastasis properties.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Hui Chong, Chuan Tan, Siyu Fang, Xichen Chen, Qi Tao, Xiaohui Yuan, Jinzhi Li, Cunhui Zhai, Chengxin Fei, Di Yang, Hongying Fan, Hongxia Shao, Aijian Qin, Guoxiu Wang, Zhonghua Shi, Ting Z'hang, Hang Yao, Hualing Li, Chengyin Wang
Summary: Two novel BODIPY-bearing complexes with pyridine and pyrimidine motifs showed stronger interactions with DNA compared to cisplatin. They exhibited improved anti-chemoresistance capabilities and significantly decreased lifespan and body length in a cisplatin-resistant model. Upregulation of certain genes related to chemoresistance was observed upon exposure to cisplatin, but not to the synthesized Pt(II) complexes.
INORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Ziqi Zhou, Yan Zhang, Simin Xia, Xi Chen
Summary: This study introduces a photoactivatable antitumor immunosuppressant that can be activated to induce tumor cell apoptosis by deep-red light illumination. By integrating it with another photosensitizer, a red-light-activatable AND Boolean logic gate is established through a mechanism of synergetic apoptotic induction.
Article
Biochemistry & Molecular Biology
Arpan Bera, Srishti Gautam, Somarupa Sahoo, Apurba Kumar Pal, Paturu Kondaiah, Akhil R. Chakravarty
Summary: A cisplatin-based platinum(iv) prodrug with a red-light active boron-dipyrromethene (BODIPY) pendant was synthesized and studied for its potential application in chemo-photodynamic therapy. The prodrug showed strong absorption and emission properties in the red-light range and demonstrated the ability to generate singlet oxygen when irradiated with red light. It exhibited high stability in the dark but rapid activation in a reducing environment. The prodrug displayed remarkable apoptotic photocytotoxicity in cancer cells with minimal cytotoxicity in non-cancerous cells.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Isabel Wen Badon, Jun-Pil Jee, Temmy Pegarro Vales, Chanwoo Kim, Seungbin Lee, Jaesung Yang, Si Kyung Yang, Ho-Joong Kim
Summary: The straightforward synthesis of three cationic boron-dipyrromethene (BODIPY) derivatives and their mitochondria-targeting and photodynamic therapeutic (PDT) capabilities are reported. The halogenated BODIPY dyes exhibit lower fluorescence quantum yields and enable the efficient production of singlet oxygen species. The synthesized dyes displayed good PDT capabilities against cancer cell lines, with low cytotoxicity in the dark, demonstrating the potential of cationic BODIPY-based dyes as therapeutic drugs for anticancer photodynamic therapy.
Article
Engineering, Biomedical
Shuaishuai Bian, Xiuli Zheng, Weimin Liu, Jihao Li, Zekun Gao, Haohui Ren, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang
Summary: In this study, a highly-stable and bright aggregation induced emission (AIE) fluorophore (PTPE3 NP) was developed for dynamic fluorescence (FL) imaging of vascular dysfunction beyond the 1300 nm window during vascular-targeted photodynamic therapy (V-PDT). The PTPE3 NP showed excellent brightness and high resolution, enabling clear images of vasculature and real-time tracking of blood circulation. Furthermore, the PTPE3 NP allowed visualization of mesenteric and tumor vascular dysfunction and real-time monitoring of blood flow velocity (BFV) during V-PDT, providing a powerful approach to assess vascular responses and evaluate the efficacy of V-PDT.
Article
Chemistry, Multidisciplinary
Ezel Ozturk Gunduz, Berkan Tasasiz, M. Emre Gedik, Gurcan Gunaydin, Elif Okutan
Summary: Three multifunctional targeted NI-BODIPYs and GO nanocarriers were fabricated for specific recognition of cancer cells and efficient singlet oxygen production. Detailed characterization, photophysical/ photochemical properties, and interactions with GO were studied. Formation of nanohybrids with GO promoted singlet oxygen formation and showed no dark toxicity, as evaluated with human chronic myelogenous leukemia cells.
Article
Medicine, Research & Experimental
Martin Porubsky, Sona Gurska, Jarmila Stankova, Marian Hajduch, Petr Dzubak, Jan Hlavac
Summary: The study introduces two concepts of drug delivery using small-molecule drug conjugates for specific targeting and drug release monitoring via ratiometric fluorescence. The results demonstrate efficient thiol-mediated cleavage of the fluorescent reporter and subsequent drug liberation in a test tube. Furthermore, the conjugate with c(RGDfK) is able to penetrate cells and release drugs, which can be monitored inside the cells.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Elif Yildiz Gul, Elanur Aydin Karatas, Hatice Aydin Dogan, Omer Faruk Karatas, Buenyemin Cosut, Esra Tanriverdi Ecik
Summary: In this study, smart photosensitizers containing BODIPY, erlotinib, and hydrophilic units were prepared and their physicochemical properties and PDT effects were investigated. The halogenated derivatives showed lower fluorescence and good ROS generation ability under red light. In vitro experiments demonstrated the potent activity of the halogenated conjugates on cancer cell viability and their low dark toxicity.
Article
Chemistry, Multidisciplinary
Alexandra Egyed, Krisztina Nemeth, Tibor A. Molnar, Mihaly Kallay, Peter Kele, Marton Bojtar
Summary: Here, we introduce a method for synthesizing water-soluble, low-molecular-weight photocages derived from xanthenium, enabling light-controlled cargo release in the green to red range. These new photocages allow for installation of various payloads through ester, carbamate, or carbonate linkages during the final stages of synthesis. Efficient uncaging of payloads was achieved using green, orange, or red light, resulting in the release of carboxylic acids, phenols, and amines. The application of these photocages in light-controlled drug release, specifically using the chemotherapeutic drug SN38 derived from camptothecin, showed significant potential for clinical use.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Liting Tang, Dan Lin, Noreen Rehmat, Manlin Lu, Zafar Mahmood, Hui Liang, Ming-de Li, Zujin Zhao, Yanping Huo, Shaomin Ji
Summary: In this study, a series of n-conjugated selenophene-substituted boron dipyrromethene dyes were synthesized and their excited state properties were investigated. It was found that although these dyes have nearly identical molecular profiles, their photophysical properties and excited state dynamics are significantly different. These dyes showed excellent J-aggregation capabilities and NIR emission, and also exhibited potential in triplet fusion upconversion.
Article
Biochemistry & Molecular Biology
Ana F. Amendoeira, Andre Luz, Ruben Valente, Catarina Roma-Rodrigues, Hasrat Ali, Johan E. van Lier, Fernanda Marques, Pedro V. Baptista, Alexandra R. Fernandes
Summary: This study evaluated the cell uptake of Estradiol-BODIPY, 19-nortestosterone-BODIPY, and testosterone-BODIPY in breast cancer and prostate cancer cells, as well as in normal dermal fibroblasts. The results showed that the highest internalization occurred in cells expressing specific receptors for the compounds. Blocking experiments also revealed differences in non-specific cell uptake between cancer and normal cells, possibly due to differences in lipophilicity. The internalization process was energy-dependent and mediated by clathrin- and caveolae-endocytosis. Co-culture studies demonstrated that the compounds exhibited selectivity towards cancer cells. Furthermore, the compounds showed non-toxicity towards cancer and/or normal cells, and visible light irradiation induced cell death, indicating their potential use as PDT agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Somarupa Sahoo, Sanmoy Pathak, Arun Kumar, Dipankar Nandi, Akhil R. Chakravarty
Summary: To overcome the limitations of current chemotherapeutic and porphyrin-based photodynamic therapy (PDT) agents, BODIPY scaffold has been used to design new photosensitizers for cellular imaging. However, their organic form has poor cell permeability and solubility in water, which hinders their in-vitro application. To address this issue, metal-BODIPY conjugates with improved stability and therapeutic efficacy have been developed. Two iron(III)-BODIPY conjugates, derived from benzyl-dipicolylamine and its glycosylated analogue along with a BODIPY-tagged catecholate, showed strong absorption bands and demonstrated apoptotic PDT activity when exposed to red light. These complexes exhibited high cytotoxicity in cancer cells with low dosage requirement and minimal cytotoxic effects in non-cancerous cells, making them promising potential drugs for ROS mediated red light photocytotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Arnab Bhattacharyya, Aida Jameei, Aditya Garai, Rupak Saha, Anjali A. Karande, Akhil R. Chakravarty
DALTON TRANSACTIONS
(2018)
Article
Chemistry, Inorganic & Nuclear
Somarupa Sahoo, Santosh Podder, Aditya Garai, Shamik Majumdar, Nandini Mukherjee, Uttara Basu, Dipankar Nandi, Akhil R. Chakravarty
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Avishek Jana, Brijesh K. Verma, Aditya Garai, Paturu Kondaiah, Akhil R. Chakravarty
INORGANICA CHIMICA ACTA
(2018)
Correction
Chemistry, Inorganic & Nuclear
Avishek Jana, Brijesh K. Verma, Aditya Garai, Paturu Kondaiah, Akhil R. Chakravarty
INORGANICA CHIMICA ACTA
(2019)
Correction
Chemistry, Inorganic & Nuclear
Utso Bhattacharyya, Brijesh Kumar, Aditya Garai, Arnab Bhattacharyya, Arun Kumar, Samya Banerjee, Paturu Kondaiah, Akhil R. Chakravarty
INORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Arun Kumar, Akanksha Dixit, Somarupa Sahoo, Samya Banerjee, Arnab Bhattacharyya, Aditya Garai, Anjali A. Karande, Akhil R. Chakravarty
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Subhadeep Paul, Paramita Kundu, Utso Bhattacharyya, Aditya Garai, Ram Chandra Maji, Paturu Kondaiah, Akhil R. Chakravarty
INORGANIC CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Aditya Garai, Pascale Delangle
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Catherine A. J. Hooper, Lucia Cardo, James S. Craig, Lazaros Melidis, Aditya Garai, Ross T. Egan, Viktoriia Sadovnikova, Florian Burkert, Louise Male, Nikolas J. Hodges, Douglas F. Browning, Roselyne Rosas, Fengbo Liu, Fillipe Rocha, Mauro A. Lima, Simin Liu, David Bardelang, Michael J. Hannon
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Lazaros Melidis, Harriet J. Hill, Nicholas J. Coltman, Scott P. Davies, Kinga Winczura, Tasha Chauhan, James S. Craig, Aditya Garai, Catherine A. J. Hooper, Ross T. Egan, Jane A. McKeating, Nikolas J. Hodges, Zania Stamataki, Pawel Grzechnik, Michael J. Hannon
Summary: Researchers have successfully constructed 3D models of the untranslated regions of the SARS-CoV-2 genome and found that metallo-supramolecular helicates can suppress viral replication, highlighting their potential as novel anti-viral agents.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Vanitha Ramu, Paramita Kundu, Paturu Kondaiah, Akhil R. Chakravarty
Summary: Maloplatin-B is a novel near-infrared light organelle-targeting photodynamic therapy agent that induces effective apoptosis in lung and cervical cancer cells by generating reactive oxygen species within cells. Fluorescence experiments show that this complex has a high fluorescence quantum yield under red light excitation and localizes primarily in mitochondria.
INORGANIC CHEMISTRY
(2021)
Article
Polymer Science
Hari Sharan Adhikari, Aditya Garai, Machchhendra Thapa, Rameshwar Adhikari, Paras Nath Yadav
Summary: Chitosan, a polyfunctional biomaterial, can be chemically modified to produce derivatives with remarkable anticancer activity. This study successfully functionalized low and high molecular weight chitosan, established their copper(II) complexes, and tested their anticancer activity using MTT assay, finding that the complexes exhibited higher activity than the corresponding ligands.
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Arnab Bhattacharyya, Aida Jameei, Rupak Saha, Aditya Garai, Anjali A. Karande, Akhil R. Chakravarty
Summary: The study describes the preparation and characterization of dipicolylamine-based cis-dichlorido zinc(ii) complexes, with potential photocytotoxicity for cancer cells. The designed zinc-BODIPY hybrids show enhanced aqueous solubility, mito-DNA targeting propensity, and organelle-selective apoptotic photocytotoxicity at nanomolar concentrations.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Aditya Garai, Armin Gandhi, Vanitha Ramu, Md Kausar Raza, Paturu Kondaiah, Akhil R. Chakravarty