期刊
GASTROINTESTINAL ENDOSCOPY
卷 81, 期 3, 页码 583-595出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.gie.2014.07.034
关键词
-
资金
- Grants-in-Aid for Scientific Research [26460956] Funding Source: KAKEN
Background: EMR and endoscopic submucosal dissection (ESD) are used frequently to remove colon neoplasms. However, the predominance of these procedures has not yet been thoroughly explored. Objective: To compare the efficacy and adverse events related to EMR with those related to ESD for colon neoplasms. Design: A meta-analysis of 8 studies published between 2005 and 2013. Setting: Multicenter review. Patients: Patients from 8 studies yielding 2299 lesions. Interventions: EMR or ESD. Main Outcome Measurements: En bloc resection, curative resection, recurrence, and adverse events. Results: The pooled odds ratios (OR) (OR [95% confidence interval]) for the tumor size, length of the procedure, en bloc resection, curative resection, recurrence, additional surgery, delayed bleeding, and perforation by ESD versus EMR were 7.38 (6.42-8.34), 58.07 (36.27-79.88), 6.84 (3.30-14.18), 4.26 (3.77-6.57), 0.08 (0.04-0.17), 2.16 (1.16-4.03), 0.85 (0.45-1.60), and 4.96 (2.79-8.85), respectively. Limitations: This analysis included only nonrandomized studies. Conclusion: The size of the tumor and rate of en bloc resection and curative resection were higher, and the rate of recurrence was lower in the ESD group versus the EMR group. However, in the ESD group, the procedure was longer, and the rate of additional surgery and perforation was higher, suggesting that the indications for ESD should therefore be rigorously determined in order to avoid such problems.
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