Article
Oncology
Elisabeth F. P. Peterse, Reinier G. S. Meester, Lucie de Jonge, Amir-Houshang Omidvari, Fernando Alarid-Escudero, Amy B. Knudsen, Ann G. Zauber, Iris Lansdorp-Vogelaar
Summary: The study found that among alternative screening methods, computed tomographic colonography every 5 years, annual mSEPT9, and annual multi-target stool DNA screening are the most cost-effective choices. However, these alternative tests are not cost-effective compared to FIT and colonoscopy.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Nutrition & Dietetics
James Ashcroft, Aminder Anthony Singh, Bhavna Ramachandran, Amir Habeeb, Victoria Hudson, Jeremy Meyer, Constantinos Simillis, Richard Justin Davies
Summary: This network meta-analysis identified early feeding as the most efficacious therapeutic intervention to reduce post-operative ileus in patients undergoing colorectal surgery, in addition to highlighting other therapies that require further investigation by high quality study. In patients undergoing colorectal surgery, emphasis should be placed on early feeding as soon as can be appropriately initiated to support the return of gastrointestinal motility.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Soumitri Chattopadhyay, Pawan Kumar Singh, Muhammad Fazal Ijaz, SeongKi Kim, Ram Sarkar
Summary: Colorectal cancer, the third most common cancer type, can be diagnosed early through an automated computer-aided detection framework based on deep learning. This framework utilizes histological slide images for predictions and achieves high accuracy and F1-Score through feature extraction and dimensionality reduction using Particle Swarm Optimization. The proposed method outperforms existing state-of-the-art methods on a colorectal cancer histology dataset, providing visual explanations and justifying the use of CAD framework in screening.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Johanna C. Maedge, Andreas Stallmach, Lisa Kleebusch, Peter Schlattmann
Summary: Aspirin can improve the survival of patients with colorectal cancer, and PIK3CA mutation and high expression of PTGS2 are associated with longer survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Douglas J. Robertson, Jason A. Dominitz, Alexander Beed, Kathy D. Boardman, Barbara J. Del Curto, Peter D. Guarino, Thomas F. Imperiale, Andrew LaCasse, Meaghan F. Larson, Samir Gupta, David Lieberman, Beata Planeta, Aasma Shaukat, Shanaz Sultan, Stacy B. Menees, Sameer D. Saini, Philip Schoenfeld, Stephan Goebel, Erik C. von Rosenvinge, Gyorgy Baffy, Ildiko Halasz, Marcos C. Pedrosa, Lyn Sue Kahng, Riaz Cassim, Katarina B. Greer, Margaret F. Kinnard, Divya B. Bhatt, Kerry B. Dunbar, William V. Harford, John A. Mengshol, Jed E. Olson, Swati G. Patel, Fadi Antaki, Deborah A. Fisher, Brian A. Sullivan, Christopher Lenza, Devang N. Prajapati, Helen Wong, Rebecca Beyth, John G. Lieb, Joseph Manlolo, Fernando V. Ona, Rhonda A. Cole, Natalia Khalaf, Charles J. Kahi, Divyanshoo Rai Kohli, Tarun Rai, Prateek Sharma, Jiannis Anastasiou, Curt Hagedorn, Ronald S. Fernando, Christian S. Jackson, M. Mazen Jamal, Robert H. Lee, Farrukh Merchant, Folasade P. May, Joseph R. Pisegna, Endashaw Omer, Dipendra Parajuli, Adnan Said, Toan D. Nguyen, Claudio Ruben Tombazzi, Paul A. Feldman, Leslie Jacob, Rachel N. Koppelman, Kyle P. Lehenbauer, Deepak S. Desai, Mohammad F. Madhoun, William M. Tierney, Minh Q. Ho, Heather J. Hockman, Christopher Lopez, Emily Carter Paulson, Martin Tobi, Hugo L. Pinillos, Michele Young, Nancy C. Ho, Ranjan Mascarenhas, Kirrichai Promrat, Pritesh R. Mutha, William M. Pandak, Tilak Shah, Mitchell Schubert, Frank S. Pancotto, Andrew J. Gawron, Amelia E. Underwood, Samuel B. Ho, Priscilla Magno-Pagatzaurtundua, Doris H. Toro, Charles H. Beymer, Andrew M. Kaz, Jill Elwing, Jeffrey A. Gill, Susan F. Goldsmith, Michael D. Yao, Petr Protiva, Heiko Pohl, Tassos Kyriakides
Summary: The CONFIRM study aimed to compare the mortality outcomes of colorectal cancer among individuals who underwent colonoscopy with those who took annual fecal immunochemical tests (FIT). The study found a growing preference for FIT among individuals declining colonoscopy, particularly in the western US.
Review
Oncology
Senshuang Zheng, Jelle J. A. Schrijvers, Marcel J. W. Greuter, Guersah Kats-Ugurlu, Wenli Lu, Geertruida H. de Bock
Summary: Based on large-scale randomized control trials and model studies, biennial FIT/gFOBT, single and 5-yearly FS, and 10-yearly colonoscopy screenings significantly reduce CRC-specific mortality. The effectiveness of screening increases at younger screening initiation ages and higher adherences.
Article
Oncology
Zhixiao Liao, Yueyang Deng, Jingxu Zhou, Jinli Zhu, Rui Xia
Summary: This study compares the clinical characteristics and survival differences between early-onset colorectal cancer (EOCRC) patients and late-onset colorectal cancer (LOCRC) patients, and identifies the risk factors for cancer-specific mortality (CSM) in LOCRC patients. A mortality risk assessment nomogram is constructed. The results show differences in the distribution of multiple clinical features between EOCRC and LOCRC patients. Age, tumor size, histological type, grading, stage, surgery, radiotherapy, chemotherapy, neural invasion, and CEA level are independent factors influencing the CSM rate in LOCRC patients. The nomogram has acceptable predictive performance for LOCRC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Jing Zhao, Yun Zhu, Meizhi Du, Yu Wang, Jillian Vallis, Patrick S. Parfrey, John R. Mclaughlin, Xiuying Qi, Peizhong Peter Wang
Summary: High dietary fiber intake is associated with improved survival among colorectal cancer patients, reducing the risk of all-cause mortality and CRC-specific mortality.
Review
Oncology
Minghao Cai, Zhongyan Gao, Junyi Liao, Yuanping Jiang, Yong He
Summary: The study found that regardless of differences in frailty screening and treatment approaches, outcomes for frailty patients were less favorable in all studies. Compared with the non-frail group, the frail group had higher mortality, more serious complications, more postoperative blood transfusions and delirium, and more support outside the home.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nursing
Charlene H. L. Wong, William K. W. Cheung, Claire C. W. Zhong, Eng-kiong Yeoh, Chi Tim Hung, Benjamin H. K. Yip, Eliza L. Y. Wong, Samuel Y. S. Wong, Vincent C. H. Chung
Summary: The study showed that nurse-led peri-discharge interventions did not significantly differ from usual care in reducing all-cause 30-day hospital readmissions. Simple interventions were found to be just as effective as more complex ones.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Cell Biology
Christos Athanasiou, Fehmi Hafiz, Alexia Tsigka, James Hernon, Adam Stearns
Summary: This study compares different techniques to improve lymph node yield in colorectal cancer specimens and evaluates their effectiveness. The combination of methylene blue and fat clearing (MBFC) was found to have the highest lymph node yield and is among the most effective methods.
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Manuel Zorzi, Jessica Battagello, Anna Rita Fiore, Laura Memo, Carlo Senore, Massimo Rugge
Summary: Limited endoscopy capacity is a main barrier to extending screening for colorectal cancer to individuals over 70 years old, due to the high positivity rate in this age group. A study assessing CRC incidence and mortality among 70-year-olds with negative fecal immunochemical tests (FIT) found that those with previous negative FIT results had lower 10-year cumulative rates of cancer incidence and mortality compared to those who had not participated in screening or had positive FIT results. Therefore, optimizing resources by targeting screening efforts towards individuals aged 70 to 74 with no previous negative FIT results may be a more efficient approach.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Public, Environmental & Occupational Health
Kazem Rahmani, Rasoul Shavaleh, Mahtab Forouhi, Hamideh Feiz Disfani, Mostafa Kamandi, Rozita Khatamian Oskooi, Molood Foogerdi, Moslem Soltani, Maryam Rahchamani, Mohammad Mohaddespour, Mostafa Dianatinasab
Summary: This meta-analysis study evaluated the effectiveness of COVID-19 vaccines in reducing the incidence, hospitalization, and mortality from COVID-19. The results showed that vaccination with BNT162b2 mRNA, mRNA-1273, and ChAdOx1 was associated with a favorable effectiveness against SARS-CoV2 in different populations, particularly in the second dose.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Fasiha Kanwal, Saira Khaderi, Amit G. Singal, Jorge A. Marrero, Nicole Loo, Sumeet K. Asrani, Christopher Amos, Aaron P. Thrift, Xiangjun Gu, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Hashem B. El-Serag
Summary: This study investigated the risk of developing HCC in patients with cirrhosis and found that the incidence rate of HCC was lower than previously reported. The risk of HCC varied depending on the etiology, with higher risk in patients with cured HCV and lower risk in those with NAFLD. Current smoking and overweight/obesity were also associated with increased HCC risk.
Article
Gastroenterology & Hepatology
Nikita Sandeep Wagle, Sulki Park, David Washburn, Robert L. Ohsfeldt, Nicole E. Rich, Amit G. Singal, Hye-Chung Kum
Summary: This study found that treatment delays are prevalent in patients with hepatocellular carcinoma (HCC) and are associated with worse survival. Treatment delays varied across different treatment modalities and were more likely to occur in Black patients and those living in high poverty neighborhoods. The results highlight the importance of interventions to improve time-to-treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Sandi L. Pruitt, Anna Tavakkoli, Hong Zhu, Daniel F. Heitjan, David E. Gerber, Amit G. Singal, Ethan A. Halm, Muhammad Shaalan Beg, Bhumika Maddineni, Ankit J. Kansagra, Caitlin C. Murphy
Summary: Pancreas cancer patients who have previously had another cancer have similar survival rates to those without previous cancer, suggesting that cancer survivors should be considered for inclusion in pancreas cancer clinical trials.
Article
Oncology
Andrew M. Brown, Ihab Kassab, Marco Massani, Whitney Townsend, Amit G. Singal, Cigdem Soydal, Laura Moreno-Luna, Lewis R. Roberts, Vincent L. Chen, Neehar D. Parikh
Summary: This study conducted an overall and individual patient data (IPD) meta-analysis of transarterial radioembolization (TARE) and transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). The results showed that TARE had a significantly longer time to progression (TTP) compared to TACE, but there was no significant difference in overall survival (OS) between the two modalities. The limitations of the current data include inconsistent length of follow-up and response criteria. Therefore, prospective studies comparing these treatments are needed.
Article
Public, Environmental & Occupational Health
Caitlin C. Murphy, Piera M. Cirillo, Nickilou Y. Krigbaum, Amit G. Singal, Dean P. Jones, Timothy Zaki, Barbara A. Cohn
Summary: This study examined the association between in-utero exposure to antibiotics and the risk of colorectal cancer (CRC) in adult offspring. The findings suggest that in-utero exposure to long-acting sulfonamides is associated with an increased risk of CRC in adulthood.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Computer Science, Information Systems
Philip D. Barrison, Allen Flynn, Rachel Richesson, Marisa Conte, Zach Landis-Lewis, Peter Boisvert, Charles P. Friedman
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Aaron P. Thrift, Fasiha Kanwal, Yanhong Liu, Saira Khaderi, Amit G. Singal, Jorge A. Marrero, Nicole Loo, Sumeet K. Asrani, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Spiridon Tsavachidis, Xiangjun Gu, Christopher I. Amos, Hashem B. El-Serag
Summary: This study found that polygenic risk scores can be used to predict the risk of hepatocellular cancer in contemporary U.S. cirrhosis patients and can improve the predictive ability of traditional risk factor models.
Article
Medicine, General & Internal
Deborah A. Levine, Bingxin Chen, Andrzej T. Galecki, Alden L. Gross, Emily M. Briceno, Rachael T. Whitney, Robert J. Ploutz-Snyder, Bruno J. Giordani, Jeremy B. Sussman, James F. Burke, Ronald M. Lazar, Virginia J. Howard, Hugo J. Aparicio, Alexa S. Beiser, Mitchell S. V. Elkind, Rebecca F. Gottesman, Silvia Koton, Sarah T. Pendlebury, Anu Sharma, Mellanie V. Springer, Sudha Seshadri, Jose R. Romero, Rodney A. Hayward
Summary: The association between poststroke vascular risk factor levels and cognitive decline is uncertain. This study found that higher poststroke glucose levels were associated with faster global cognitive decline, but poststroke LDL cholesterol and SBP levels did not show any association with cognitive decline.
Article
Multidisciplinary Sciences
Noa Kopplin, Angie Garcia, Annika Reczek, Kate Wilkinson, Sruthi Yekkaluri, Caitlin C. Murphy, Jasmin Tiro, Alagar R. Muthukumar, Andrew Masica, Amit G. Singal
Summary: This study investigated the natural history and sequelae symptoms of mild COVID-19 infection. More than one in five patients reported persistent symptoms during follow-up. Levels of anti-nucleocapsid and anti-spike antibodies decreased within six months following infection and vaccination.
Article
Health Care Sciences & Services
Allison Ranusch, Ying-Jen Lin, Michael P. Dorsch, Arthur L. Allen, Patrick Spoutz, F. Jacob Seagull, Jeremy B. Sussman, Geoffrey Barnes
Summary: This study examined the impact of individual clinician authority on the implementation success of an EHR DOAC Dashboard for safe medication prescribing. The results showed that a high level of individual clinician authority was associated with key facilitators for effective use of the DOAC Dashboard, while a lack of individual authority was often associated with barriers to effective use.
JMIR HUMAN FACTORS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sang Gune Yoo, Justine Davies, Jen Manne-Goehler, Pascal Geldsetzer, David Guwatudde, Mark Huffman, Sahar Saeedi Moghaddam, Kavita Singh, Jeremy Sussman, David Flood
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Correction
Neurosciences
Deborah A. Levine, Alden L. Gross, Emily M. Briceno, Nicholas Tilton, Rachael Whitney, Dehua Han, Bruno J. Giordani, Jeremy B. Sussman, Rodney A. Hayward, James F. Burke, Mitchell S. V. Elkind, Andrew E. Moran, Sarah Tom, Rebecca F. Gottesman, Darrell J. Gaskin, Stephen Sidney, Kristine Yaffe, Ralph L. Sacco, Susan R. Heckbert, Timothy M. Hughes, Oscar L. Lopez, Norrina Bai Allen, Andrzej T. Galecki
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Kerry A. Ryan, Jason K. Hou, Jessica A. Baker, Christopher Krenz, Raymond De Vries, Akbar K. Waljee
Meeting Abstract
Gastroenterology & Hepatology
Jessica L. Sheehan, LaVana Greene-Higgs, Jeffrey Berinstein, John Piette, Kenneth Resnicow, Akbar K. Waljee, Peter D. Higgins, Shirley Cohen-Mekelburg
Meeting Abstract
Gastroenterology & Hepatology
Shirley Cohen-Mekelburg, Tony Van, Jeffrey Berinstein, Xianshi Yu, Deena Costa, Beth I. Wallace, Sameer D. Saini, Andrew J. Admon, Peter D. Higgins, Ji Zhu, Akbar K. Waljee
