Article
Immunology
Lihui Lin, Ying Li, Gaoshi Zhou, Ying Wang, Li Li, Jing Han, Minhu Chen, Yao He, Shenghong Zhang
Summary: This study aimed to analyze the impact of a Western-style diet (WSD) on experimental colitis susceptibility and its underlying mechanism using transcriptomics and metabolomics. The results showed that WSD induced more severe inflammation in experimental colitis and identified differential genes and metabolites related to the diet. Integrating transcriptomic and metabolomic data revealed major co-expression networks through which WSD promoted experimental IBD susceptibility.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Food Science & Technology
Meztli Ramos-Garcia, Jorge Luis Ble-Castillo, Carlos Garcia-Vazquez, Carlos Alfonso Tovilla-Zarate, Isela Esther Juarez-Rojop, Viridiana Olvera-Hernandez, Alma Delia Genis-Mendoza, Ruben Cordova-Uscanga, Carlos Alfonso Alvarez-Gonzalez, Juan Cuauhtemoc Diaz-Zagoya
Summary: According to this study, recommended doses of NNS do not alter feeding behavior, body weight, or glycemic tolerance in healthy and with altered glycemic rats.
Article
Nutrition & Dietetics
Louise M. Burke, Rebecca Hall, Ida A. Heikura, Megan L. Ross, Nicolin Tee, Georgina L. Kent, Jamie Whitfield, Sara F. Forbes, Avish P. Sharma, Andrew M. Jones, Peter Peeling, Jamie R. Blackwell, Inigo Mujika, Karen Mackay, Marta Kozior, Brent Vallance, Alannah K. A. McKay
Summary: The study explored two strategies for race walkers, one involving beetroot juice and the other involving a multi-faceted approach including high carbohydrate diet and acute CHO loading. Results showed an increase in exogenous CHO use during exercise and elite athletes had optimized intestinal CHO absorption through habitual practices.
Article
Multidisciplinary Sciences
Daniel Laubitz, Michael A. Gurney, Monica Midura-Kiela, Christy Clutter, David G. Besselsen, Hao Chen, Fayez K. Ghishan, Pawel R. Kiela
Summary: Dysregulation of NHE3 expression in colorectal cancer is associated with poorer survival and leads to increased tumor numbers, enhanced DNA damage, increased cell proliferation, and decreased apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Marija Petrusic, Zorica Stojic-Vukanic, Ivan Pilipovic, Dusko Kosec, Ivana Prijic, Gordana Leposavic
Summary: The study found that thymic involution impairs the susceptibility of AO rats to clinical EAE, while the development of EAE contributes to the progression of thymic involution. The results suggest that thymic involution promotes the differentiation of CD8+ T cells into IL-17-producing cells and leads to the accumulation of CD28-T cells in the peripheral blood and target organs. Furthermore, the development of EAE decreases the thymic output of T cells, including Tregs, contributing to the progression and maintenance of clinical EAE.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Gastroenterology & Hepatology
Katayoun Khoshbin, Lehar Khanna, Daniel Maselli, Jessica Atieh, Margaret Breen-Lyles, Kayla Arndt, Deborah Rhoten, Roy B. Dyer, Ravinder J. Singh, Sunita Nayar, Sandra Bjerkness, William S. Harmsen, Irene Busciglio, Michael Camilleri
Summary: This study aimed to obtain normative data on small intestinal and colonic permeability. Results showed that C-13-mannitol is the preferred probe for small intestinal permeability, while C-12-mannitol is not suitable for use.
Article
Nutrition & Dietetics
Minchun Zhang, Jie Chen, Minglan Yang, Cheng Qian, Yu Liu, Yicheng Qi, Rilu Feng, Mei Yang, Wei Liu, Jing Ma
Summary: This study investigated the effects of lower doses of sucralose on fecal microbiota in obesity and found that 0.54 mM and 0.78 mM sucralose can affect beneficial bacteria. Different dosages of sucralose may alter the compositions of fecal microbiota.
FRONTIERS IN NUTRITION
(2021)
Article
Immunology
Hannah E. Maier, Guillermina Kuan, Lionel Gresh, Roger Lopez, Nery Sanchez, Amy Schiller, Sergio Ojeda, Eva Harris, Angel Balmaseda, Aubree Gordon
Summary: The study conducted in Nicaragua found that obesity is associated with increased susceptibility to symptomatic H1N1pdm infection among adults, particularly middle-aged and older women. However, obesity was not associated with increased susceptibility or symptoms related to H3N2 infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Qing Wang, Mengmeng Jia, Mingyue Jiang, Yanlin Cao, Peixi Dai, Jiao Yang, Xiaokun Yang, Yunshao Xu, Weizhong Yang, Luzhao Feng
Summary: This study quantitatively estimated the dynamics and cumulative susceptibility to influenza infections after the lifting of COVID-19 public health measures. The results showed that the length of the 2022-2023 influenza season was significantly shorter in southern China, northern China, and the United States compared to previous seasons without strong social distancing interventions. This led to an increase in the scale of influenza infections and population susceptibility to influenza.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Environmental Sciences
Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey, H. Troy Nagle
Summary: The purpose of this study was to determine the toxicological and pharmacokinetic properties of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. It was found that sucralose-6-acetate is genotoxic and raises significant health concerns regarding the safety and regulatory status of sucralose itself. Sucralose-6-acetate also impairs intestinal barrier integrity and inhibits members of the cytochrome P450 family.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Article
Infectious Diseases
Zhiyuan Wu, Yufeng Liang, Yunlong Zuo, Yufen Xu, Hanran Mai, Lei Pi, Di Che, Xiaoqiong Gu
Summary: This study found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China, especially in children under 60 months old, male, and with sepsis. Further multicenter studies are needed to confirm these findings.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Johanne Brooks-Warburton, Dezso Modos, Padhmanand Sudhakar, Matthew Madgwick, John P. Thomas, Balazs Bohar, David Fazekas, Azedine Zoufir, Orsolya Kapuy, Mate Szalay-Beko, Bram Verstockt, Lindsay J. Hall, Alastair Watson, Mark Tremelling, Miles Parkes, Severine Vermeire, Andreas Bender, Simon R. Carding, Tamas Korcsmaros
Summary: This study introduces a precision medicine workflow called integrated single nucleotide polymorphism network platform (iSNP), aiming to uncover patient-specific pathways affected in complex diseases by combining genomics and network biology approaches.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen
Summary: This study identified SERPINA3 as a potential biomarker and drug target for ulcerative colitis (UC) through analysis of gene expression profiles and previous research. Further investigations revealed its role in the pathogenesis of UC and its potential therapeutic implications.
Article
Plant Sciences
Chang-Shun Liu, Yin-Xia Hu, Zhen-Ye Luo, Chuan-Wei Qiu, Xiang-Hua Deng, Fei-Long Chen
Summary: The study suggests that Xianglian pill (XLP) treats ulcerative colitis (UC) by regulating gut microbiota, specifically through the gut microbiota-succinate-Treg differentiation axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Liu, Shuangyu Li, Hongjia Yang, Yaru Chen, Dong Fan
Summary: This study identified and analyzed 12 carboxylesterase sequences from the oriental armyworm, finding that different insecticide treatments impact their expression levels. RNA interference successfully inhibited their expression, indicating a potential new method to increase insect susceptibility to insecticides.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)