Review
Biochemistry & Molecular Biology
Yingchao Wang, Hongbin Liu, Xingxiang Ji, Qiang Wang, Zhongjian Tian, Pedram Fatehi
Summary: Nowadays, there is an urgent need for nanocellulose production processes that are green, eco-friendly, and cost-effective. Acidic deep eutectic solvents (ADES) have been widely used in the preparation of nanocellulose due to their unique advantages. Several studies have explored the effectiveness of ADESs, particularly those based on choline chloride (ChCl) and carboxylic acids. This review comprehensively summarizes the latest progress of these ADESs and discusses the challenges and outlooks of implementing ChCl/carboxylic acids-based DESs in nanocellulose fabrication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Norafiqah Ismail, Jun Pan, Mahmoud Rahmati, Qian Wang, Denis Bouyer, Mohamed Khayet, Zhaoliang Cui, Naser Tavajohi
Summary: In this study, a new family of non-ionic deep eutectic solvents (NIDES) is proposed for membrane preparation, and high-performance PVDF membranes are efficiently prepared by dissolving PVDF polymer.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Energy & Fuels
Arash Abbasi, Farzaneh Feyzi
Summary: The synthesis of carboxylic-based deep eutectic solvents (DESs) for extractive catalytic oxidative desulfurization (ECODS) resulted in high sulfur removal efficiency, reaching up to 99.67% under optimal conditions. The Taguchi experimental design method was employed to determine critical parameters affecting the experiments, highlighting the importance of temperature, fuel to DES volume ratio, and oxidant to sulfur molar ratio.
PETROLEUM SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Yu Chen, Di Zhao, Yue Bai, Yaoting Duan, Cong Liu, Jiaming Gu, Xin Wang, Xuanchao Sun, Yuting Li, Lijuan Zhang
Summary: This study systematically investigates the refractive index of typical deep eutectic solvents (DESs) and analyzes the effects of hydrogen-bonding donor, hydrogen-bonding acceptor, mole ratio, and temperature. The results show that these factors have a significant impact on the refractive index, and the presence of water decreases the refractive index of all DESs studied.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Karzan A. Omar, Rahmat Sadeghi
Summary: The study found that hydrogen bond donors that interact strongly with choline chloride and form deep eutectic solvents exhibit positive deviation from semi-ideal behavior, while hydrogen bond donors that do not interact with the hydrogen bond acceptor and cannot form deep eutectic solvents show negative deviation from semi-ideal behavior.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Aditi Prabhune, Ranjan Dey
Summary: Deep Eutectic Solvents (DESs) have emerged as potential alternatives to conventional solvents in many industrial applications due to their safety, greenness, ease of preparation and wide range of applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Guoxuan Li, Chengmin Gui, Chengna Dai, Gangqiang Yu, Zhigang Lei
Summary: Three SO2 absorption strategies based on DESs are studied, with simulated results validated against experimental data; molecular insights into interactions and separation mechanisms are provided through MD simulation results; a modeling method for SO2 absorption and DES recovery is established using Aspen Plus.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Engineering, Environmental
Fernando Bergua, Miguel Castro, Jose Munoz-Embid, Carlos Lafuente, Manuela Artal
Summary: The study investigated the removal of drugs in aqueous ecosystems through liquid-liquid extraction, exploring new eco-sustainable procedures and finding the most efficient extraction method using solvent mixtures. Results showed varying levels of hydrophobicity among the drugs, highlighting the risks associated with drug contamination in water ecosystems.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Paper & Wood
Xuerong Bi, Jiansheng Guo, Jin Wen, Chongwen Yu
Summary: Clean energy and green solvents, such as deep eutectic solvents (DES), have attracted attention for their non-toxic and recyclable properties. This study compares different carboxylic acid DESs for the preparation of cellulose nanocrystals (CNCs) and finds that oxalic acid (OA) DESs have higher yield and crystalline index. The presence of crystal water molecules in DESs enhances the reaction activity. Molecular dynamics simulations and quantum chemical calculations reveal strong non-covalent interactions between DESs and cellulose, which are further enhanced by crystal waters. Computational simulations show that OA is more reactive with cellulose in esterification and acidolysis reactions, confirming the beneficial effects of OA DESs in CNC production.
Article
Materials Science, Paper & Wood
Xuerong Bi, Jiansheng Guo, Jin Wen, Chongwen Yu
Summary: Clean energy and green solvents, such as deep eutectic solvent (DES), have attracted attention for their non-toxic and recyclable properties. Experimental and computational studies have shown that oxalic acid (OA) DESs have advantages in the formation of cellulose nanocrystals (CNCs) compared to citric acid DESs. The interactions between DESs and cellulose, as well as the reaction pathways, have been investigated to understand the formation mechanism of CNCs.
Article
Environmental Sciences
Usman Saeed, Asim Laeeq Khan, Mazhar Amjad Gilani, Muhammad Aslam, Asad Ullah Khan
Summary: Betaine-based natural deep eutectic solvents (NADESs) were immobilized into a porous polyvinylidene fluoride (PVDF) support for the separation of CO(2) from CO2/N(2) and CO2/CH(4) mixtures. The gas permeation results showed improved performance with NADES-SLMs compared to imidazolium-based-supported ionic liquid membranes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Chemical
Guokai Cui, Kang Jiang, Huayan Liu, Ying Zhou, Zekai Zhang, Ruina Zhang, Hanfeng Lu
Summary: A series of active cuprous-based ternary deep eutectic solvents were designed and prepared for capturing carbon monoxide in hydrogen gas, and the efficiency and mechanism of CO capture at different molar ratios were analyzed. The presence of Cu(I) was found to be crucial for efficient CO capture by these DESs, and Delta H was identified as the main driving force for CO capture.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bin Li, Ting Xiao, Shiqi Guo, Yan Wu, Rongrong Lai, Ziyi Liu, Weixuan Luo, Yuehong Xu
Summary: The study aimed to synthesize deep eutectic solvents (DESs) based on oxymatrine (OMT) and fatty acids with various alkyl chain lengths (LCFAs) as novel vehicles, to enhance the percutaneous penetration of water-insoluble drugs. The results showed that DESs could effectively solubilize drugs and exhibit different sustained release behavior. Additionally, DESs enhanced the skin permeation of OMT and quercetin (QUE), with DESs based on lauric acid (LA) showing the highest enhancing effect. Cell viability tests confirmed the good safety of DESs on the skin. Overall, OMT-LCFA DESs hold promise as penetration enhancers for transdermal drug delivery and provide guidance for the design of new DESs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Hala B. El-Nassan, Sally S. El-Mosallamy, Amr M. Mahmoud
Summary: This study reports the unexpected formation of xanthene-1,8-diones during the attempted Biginelli reaction. The reaction was carried out using cyclohexanedione, thiourea, and different aldehydes under electrochemical conditions with ethanol or deep eutectic solvents, and Amberlyst-15 & REG; was used as a catalyst. The formation of the expected Biginelli reaction product, hexahydroquinazoline-5-one, was not observed under various reaction conditions, suggesting a different mechanistic pathway leading to xanthene-1,8-dione formation. The mechanism was elucidated through cyclic voltammetry.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Review
Chemistry, Physical
Md Sajjadur Rahman, Ranen Roy, Balawanthrao Jadhav, Md Nayeem Hossain, Mohammad A. Halim, Douglas E. Raynie
Summary: Deep eutectic solvents (DESs) are versatile alternatives in the design of greener chemicals, with therapeutic DES (THEDES) and amino acid-based DES (AADES) being reviewed as emerging and unconventional types. THEDES are primarily developed to enhance drug efficacy, while AADES have various applications in pharmaceuticals and other areas.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemical Research Methods
Jean-Baptiste Chagnoleau, Ines L. D. Ryan, Ryan Khedher, Joao AP Coutinho, Thomas Michel, Xavier Fernandez, Nicolas Papaiconomou
Summary: A study was conducted on ternary biphasic systems composed of heptane, 1-butanol or ethyl acetate, and type III or type V deep eutectic solvents based on levulinic acid and choline chloride or thymol. The binodal curves, densities, and phase compositions of the equilibrium phases were determined for seven systems. The partition coefficients of six natural compounds were measured in these systems. Based on the results, a system composed of heptane, 1-butanol, and the deep eutectic solvent choline chloride:levulinic acid at a molar ratio of 1:3 was selected for centrifugal partition chromatography and showed good separation of apigenin, coumarin, beta-ionone, and alpha-tocopherol.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Multidisciplinary
Henrique Bastos, Nicolas Schaeffer, Jennifer M. M. Pringle, Joao A. P. Coutinho, Cristina Pozo-Gonzalo
Summary: The study investigates the use of dilute HCl solutions in hydroxylated solvents for dissolving Co, Ni, and Mn oxides in spent lithium-ion batteries. The findings present a simple and greener alternative to current leaching processes, reducing acid consumption and enhancing dissolution efficiency.
Article
Engineering, Chemical
Sergio M. Vilas-Boas, Isabella W. Cordova, Dinis O. Abranches, Joao A. . P. Coutinho, Olga Ferreira, Simao P. Pinho
Summary: In this study, the Abraham and NRTL-SAC semi-predictive models were used to represent the solubility of different solutes in water and organic solvents. The models were calibrated using measured and literature data, and their predictive capabilities were tested on independent solvents. The results showed that NRTL-SAC performed better in the correlation/prediction approach, while COSMO-RS could produce satisfactory predictions even without experimental data.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Sergio M. Vilas-Boas, Aline Zambom Coelho, Monia A. R. Martins, Joao A. P. Coutinho, Olga Ferreira, Simao P. Pinho
Summary: In this study, the potential use of ionic liquids (ILs) and their mixtures as separation agents in the fractionation of essential oils was investigated. Experimental and modeling approaches showed that chloride-based ILs are effective in fractionating essential oils containing hydrogen-bond donor monoterpenoids.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Physical
Mehriban Aliyeva, Paula Brandao, Joao A. P. Coutinho, Olga Ferreira, Simao P. Pinho
Summary: This study investigates the impact of chaotropic anions (thiocyanate and tosylate) on the solubility of glycine, L-leucine, L-phenylalanine, and L-aspartic acid in aqueous solutions. The experiments reveal that thiocyanate salts and sodium tosylate generally enhance solubility, while glycine shows different behavior. The order of anion effects on solubility for the other amino acids follows the Hofmeister series, except for glycine in aqueous nitrate solutions.
JOURNAL OF SOLUTION CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bruna P. Soares, Ana M. Ferreira, Marina Justi, Luiz Gustavo Goncalves Rodrigues, J. Vladimir Oliveira, Simao P. Pinho, Joao A. P. Coutinho
Summary: Anthocyanins from jucara fruits were extracted using biobased solvents, 1,2-alkanediols and glycerol ethers, through either pressurized liquid extraction (PLE) or ultrasound-assisted extraction (UAE). The optimized PLE conditions resulted in 23.1 mg(anthocyanins)center dot g(dry biomass)(-1), while the UAE conditions with 1,2-propanediol yielded 50 mg(anthocyanins)center dot g(dry biomass)(-1). The biobased solvent solutions exhibited higher anthocyanin yields and antioxidant capacity compared to water and ethanolic extracts.
Article
Biochemistry & Molecular Biology
Aline Zambom, Sergio M. Vilas-Boas, Liliana P. Silva, Monia A. R. Martins, Olga Ferreira, Simao P. Pinho
Summary: The potential of methylimidazolium-based ionic liquids (ILs) as solvents for terpene fractionation and fuel processing was studied. The results showed that ILs with long alkyl chains as cations can enhance the capacity, while the selectivity depends on the solute polarity.
Article
Engineering, Environmental
Ana R. F. Carreira, Andre Nogueira, Anna P. S. Crema, Helena Passos, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: Recycling spent lithium-ion batteries is crucial for resource recovery and environmental protection. An integrated process for the leaching and separation of metals from spent cathode powder has been developed. By using a hydrophobic deep eutectic solvent, the cathodes can be efficiently leached and specific metals can be precipitated simultaneously. The proposed leaching process can extract cobalt, manganese, and copper completely from the spent batteries, while only extracting a small amount of nickel. Nickel can be easily recovered with high purity through appropriate manipulation. This system shows better atom economy and provides a new mild approach for the simultaneous leaching and separation of metals from lithium-ion batteries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Thomas Brouwer, Emanuel A. Crespo, Antoon ten Kate, Joao A. P. Coutinho, Sascha R. A. Kersten, Gerrald Bargeman, Boelo Schuur
Summary: This study systematically assessed the feasibility of determining vapor-liquid equilibrium (VLE) data based on excess molar enthalpy (h(E)) results. Twelve cubic Equation of State (cEoS) models combined with eight mixing rules and the Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT) were evaluated. The results showed that the developed h(E)-cEoS-VLE methodology can accurately predict VLE data for systems with unavailable binary interaction parameters, and the h(E)-PC-SAFT-VLE model can accurately predict VLE data for highly nonideal and associating systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Filipe H. B. Sosa, Pedro J. Carvalho, Joao A. P. Coutinho
Summary: Ionic liquids (ILs) have great potential as solvents and catalysts in the chemical industry, but the lack of efficient and economically viable recycling and purification processes hinders their practical application. This study focuses on understanding the separation of ILs from aqueous solution using membranes, a widely used technique in industry.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Andre F. M. Nogueira, Ana R. F. Carreira, Silvia J. R. Vargas, Helena Passos, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: In this study, precipitation processes using hydrophilic quaternary ammonium salts were demonstrated as a simple and economical alternative for the recovery of critical metals from ores and electronic wastes. The addition of tetrabutylammonium-based salts resulted in the recovery of over 90% of gold from synthetic solutions. The selectivity of gold precipitation was attributed to the formation of size selective apolar cavity between the cation and anion.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jean -Baptiste Chagnoleau, Nicolas Papaiconomou, Xavier Fernandez, Joao A. P. Coutinho
Summary: This study evaluates the potential of the conductor-like screening model for designing biphasic systems for natural compound separation. The model accurately predicts binodal curves and phases composition and shows excellent agreement with experimental data for partition coefficients of natural compounds. The model is able to capture the influence of changes in system composition on partition coefficients.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Jordana Benfica, Afonso C. Martins, German Perez-Sanchez, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: The impact of sodium salt anions on the hydrotropic dissolution of syringic acid was studied. Different sodium salts were found to have opposite effects on the solubility, due to pH buffering and anion exchange.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Jordana Benfica, Afonso C. Martins, German Perez-Sanchez, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: The impact of sodium salt anions on the hydrotropic dissolution of syringic acid using an ionic liquid as a hydrotrope was studied. The presence of different sodium salts had different effects on the solubility of syringic acid, with Na[N(CN)2] increasing solubility and Na[SCN] decreasing solubility.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)