Article
Cell Biology
Xing-Chi Hu, Jian Chu, Yong Zhou, Chang-Chun Li, Guang-Jun Zhou, Guo-Qin Jiang
Summary: The study revealed that UXT is elevated in breast cancer and associated with poor prognosis. HOXD9 upregulated UXT via transcriptional activation, and UXT promoted malignant phenotypes of breast cancer cells by suppressing RND3. Furthermore, UXT facilitated tumorigenesis and metastasis of breast cancer cells in vivo.
CELLULAR SIGNALLING
(2022)
Review
Oncology
Stefano Zoroddu, Irene Marchesi, Luigi Bagella
Summary: Muscle differentiation failure may involve epigenetic systems and the PRC2 complex. Research has shown that EZH2 is often deregulated in rhabdomyosarcoma and is associated with tumor malignancy.
CLINICAL EPIGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Fei Li, Yuting Xia, Shijie Yuan, Xiaorong Xie, Lin Li, Yuan Luo, Qiuyang Du, Yuqi Yuan, Ran He
Summary: In this study, the non-proteinogenic amino acid AABA was found to inhibit M1 macrophage polarization and function, resulting in prolonged survival in septic mice and reduced disease severity in colitis mice. Mechanistically, AABA promoted oxidative phosphorylation and glutamine and arginine metabolism while inhibiting glycolysis. Moreover, AABA increased the occupancy of trimethylation of histone H3K27 at the promoter regions of M1 macrophage-associated inflammatory genes, contributing to the inhibition of M1 macrophage polarization. These findings suggest that AABA may have therapeutic potential for inflammatory diseases through metabolic and epigenetic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini, Anna Meyfour, Maryam Shahhoseini, Mohamadreza Baghaban Eslaminejad
Summary: In this study, the effect of Curcumin on the expression of EZH2 in osteoblast differentiation was investigated. The results demonstrated that Curcumin could enhance osteogenic differentiation by downregulating the expression of EZH2.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Multidisciplinary Sciences
Suresh Chava, Suresh Bugide, Parmanand Malvi, Romi Gupta
Summary: CDC7 is overexpressed in melanoma and patients with higher expression have shorter survival. Inhibition of CDC7 can inhibit melanoma tumor growth and metastasis. Combination of CDC7 inhibitor with EZH2 or BRPF1/2/3 inhibitors shows stronger growth inhibition effect on melanoma.
Article
Oncology
Manvi Sharma, Trygve O. Tollefsbol
Summary: Dietary phytochemicals have the ability to prevent cancer by regulating the epigenome. Some natural botanicals, when combined at optimal concentrations, can synergistically decrease cellular viability and inhibit tumor growth in breast cancer cell lines. These combinations also down-regulate the levels of enzymes involved in epigenetic modifications and induce global changes in chromatin modifications. This study suggests that combined use of these dietary compounds may have implications in breast cancer therapy.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Food Science & Technology
Lujing Wang, Ahmad Abdel Fat Shannar, Renyi Wu, Pochung Chou, Md Shahid Sarwar, Hsiao-chen Kuo, Rebecca Mary Peter, Yujue Wang, Xiaoyang Su, Ah-Ng Kong
Summary: Butyrate regulates the expression of cancer markers through modulating CpG methylation, activates the mitochondrial TCA cycle, and inhibits methionine metabolism, thereby exerting cancer-preventive/anticancer effects in colorectal cancer cell model.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Neurosciences
Craig T. Werner, Rachel D. Altshuler, Yavin Shaham, Xuan Li
Summary: A growing body of evidence over the past 15 years implicates epigenetic mechanisms in the behavioral effects of addictive drugs, focusing on psychomotor sensitization and drug reinforcement. Studies have shown long-lasting changes in epigenetic enzymes and molecules after prolonged abstinence, inspiring further research on relapse mechanisms.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Agriculture, Dairy & Animal Science
Qiufang Zong, Huan Qu, Yahui Zhao, Haoyu Liu, Shenglong Wu, Shuai Wang, Wenbin Bao, Demin Cai
Summary: This study aims to investigate whether a histone deacetylase inhibitor, sodium butyrate (NaBu), can protect the porcine liver from deoxynivalenol (DON) exposure by modulating cholesterol metabolism. The results showed that NaBu effectively restored parameters associated with liver injury, cholesterol content, and key genes involved in the cholesterol biosynthesis pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Oncology
Simon Leonhard April-Monn, Valentina Andreasi, Marco Schiavo Lena, Martin Carl Sadowski, Corina Kim-Fuchs, Michelle Claudine Buri, Avanee Ketkar, Renaud Maire, Annunziata Di Domenico, Joerg Schrader, Francesca Muffatti, Claudio Doglioni, Stefano Partelli, Massimo Falconi, Aurel Perren, Ilaria Marinoni
Summary: Pancreatic neuroendocrine neoplasms are driven by epigenetic factors, with high EZH2 expression associated with higher tumor grade, distant metastases, and shorter disease-free survival. Inhibition of EZH2 reduces cell viability and proliferation in PanNEN cell lines and patient-derived tumoroids, as well as decreases tumor burden in mouse models. Targeting EZH2 could be a valuable epigenetic treatment option for patients with PanNEN.
Review
Biochemistry & Molecular Biology
Soomin Jeong, Anil K. K. Chokkalla, Charles K. K. Davis, Raghu Vemuganti
Summary: Epigenetic and epitranscriptomic modifications have therapeutic potential for neurological diseases. Gut microbiota and its metabolites can modulate epigenetic and epitranscriptomic pathways, which are implicated in the pathogenesis of stroke and depression. This review focuses on the interaction between gut microbiota and these pathways in post-stroke depression, highlighting specific candidate genes.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Violina Kakoty, K. C. Sarathlal, Chih-Hao Yang, Sunil Kumar Dubey, Rajeev Taliyan
Summary: This study investigates the role of fibroblast growth factor 21 (FGF21) in insulin resistance (IR) associated with Parkinson's disease (PD). The findings suggest that a combination treatment with metformin (MF) and sodium butyrate (NaB) can potentially ameliorate the pathology of IR-associated PD in rats.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Allergy
Ying Song, Zhen-Zhen Wang, Lixin Wang, Paul Faybusovich, Kamal Srivastava, Changda Liu, Jody Tversky, David Dunkin, Paula Busse, Xianqing Ren, Rachel Miller, Mingsan Miao, Xiu-Min Li
Summary: ASHMI can modulate the production of IL-5 and IL-10 in PBMCs from asthmatic patients, leading to an increased IL-10/IL-5 ratio and positive immunomodulatory effects. The active ingredient SF-F2 in Sophora flavescens can enhance IL-10 production, while SF-F4 can suppress IL-5 production.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Immunology
Smita S. Ghare, Paula M. Chilton, Aakarsha V. Rao, Swati Joshi-Barve, Paula Peyrani, Andrea Reyes Vega, Craig J. McClain, Kendall Bryant, Robert L. Cook, Mathew Freiberg, Shirish Barve
Summary: This study demonstrates that HIV infection leads to enhanced FasL expression and increased susceptibility to activation-induced cell death in CD4(+) T cells. The epigenetic mechanisms involving histone modifications play a crucial role in regulating FasL expression and the susceptibility of CD4(+) T cells to apoptosis in people living with HIV-1 infection.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Review
Biochemistry & Molecular Biology
Maryam Al-Khannaq, Jonathan Lytton
Summary: Potassium-dependent sodium-calcium exchangers (NCKX) play a crucial role in regulating calcium signaling and homeostasis, especially in cells and tissues with fluctuating ion concentrations. NCKX transporters can be modulated through various mechanisms, including changes in cellular location, protein expression, genetic alterations, substrate concentration, and post-translational modifications. Understanding the regulation of NCKX has the potential to provide valuable insights into transporter function and the treatment of dysregulated calcium homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yizhuo Zhao, Wei Peng, Muhammad Abbas, Meiqi Shi, Yiqun Tang, Li Wang, Huiying Yan
Summary: This case report describes a rare occurrence of anaphylactic shock in a patient following atezolizumab treatment, with prompt intervention leading to successful recovery and discharge. Anaphylactic shock, although rare, is a severe complication of immunotherapy that requires swift detection and intervention for survival.
INVESTIGATIONAL NEW DRUGS
(2022)
Review
Nutrition & Dietetics
Kassim Said Abasse, Eno E. Essien, Muhammad Abbas, Xiaojin Yu, Weihua Xie, Jinfang Sun, Laboni Akter, Andre Cote
Summary: This study provides evidence of varying associations between dietary intakes of nitrate and nitrite and site-specific cancer risks. Higher nitrite intakes are associated with an increased risk of glioma, bladder cancer, and stomach cancer, while lower risk of pancreatic cancer. Higher nitrate intakes are associated with an increased risk of thyroid cancer and a lower risk of kidney cancer.
Article
Chemistry, Applied
Meng-Ya Guo, Lu-Gang Wei, Jia-Wen Shen, Xiao-Jing Liu, Muhammad Abbas, Yu-Shun Yang, Chen Xu, Bao-Zhong Wang, Hai-Liang Zhu
Summary: This study presents a novel benzofuranone fluorescent probe, BFO-SFT, for monitoring sulfite in living cells and mice. The probe operates over a wide pH range and exhibits a red-shifted emission maximum. The response of the probe is relatively rapid and shows a good linear correlation with the sulfite concentration.
Review
Chemistry, Inorganic & Nuclear
Gul Rehman Elmi, Kalsoom Saleem, Mirza Muhammad Faran Ashraf Baig, Muhammad Naeem Aamir, Minglian Wang, Xiuli Gao, Muhammad Abbas, Masood Ur Rehman
Summary: Magnetic gold nanoparticles (mGNP) have attracted significant attention in biomedical applications due to their magnetic and plasmonic properties. This critical review summarizes recent developments in the synthesis and surface modification of mGNP, as well as their applications in drug and gene delivery, bioimaging, biosensing, and neuro-regeneration.
Article
Pharmacology & Pharmacy
Umair Ilyas, Muhammad Asif, Minglian Wang, Reem Altaf, Hajra Zafar, Mirza Muhammad Faran Ashraf Baig, Ana Claudia Paiva-Santos, Muhammad Abbas
Summary: Pioglitazone (PGZ) is utilized as a therapeutic agent in the management of type 2 diabetes. This study aimed to develop and optimize PGZ-containing nanostructured lipid carriers (NLCs) as a drug delivery system. The optimized PGZ-NLCs showed excellent physical and chemical properties, and significantly extended release compared to unformulated PGZ.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Tao Huang, Bisma Nazir, Reem Altaf, Bolun Zang, Hajra Zafar, Ana Claudia Paiva-Santos, Nabeela Niaz, Muhammad Imran, Yongtao Duan, Muhammad Abbas, Umair Ilyas
Summary: This study aimed to identify potential biomarkers of type 2 diabetes mellitus (DM) using a systems biology approach and R programming. Through differential expression analysis, several differentially expressed genes were identified as key markers for DM. The study also revealed the functional relationship between these genes and other proteins involved in the progression of DM, highlighting their potential as new targets for DM management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yongfang Yao, Murad Habib, Hajra Fazeelat Bajwa, Anina Qureshi, Rameesha Fareed, Reem Altaf, Umair Ilyas, Yongtao Duan, Muhammad Abbas
Summary: The gastrointestinal tract and liver are crucial organs for human survival. In order to maintain their health, it is important to tackle common issues such as diarrhea, stomach ache, and constipation. Herbal medicines have been used for centuries to treat such ailments, but further research is needed to evaluate their effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Umair Ilyas, Bisma Nazir, Reem Altaf, Syed Aun Muhammad, Hajra Zafar, Ana Claudia Paiva-Santos, Muhammad Abbas, Yongtao Duan
Summary: This study investigated the anti-diabetic potential of synthesized dihydropyrimidinone derivatives by conducting in vitro assays and molecular docking analysis. The results showed significant inhibition of alpha-glucosidase by a specific compound, indicating its potential as a new target for treating type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Mirza Muhammad Faran Ashraf Baig, Xiuli Gao, Awais Farid, Abdul Wasy Zia, Muhammad Abbas, Hongkai Wu
Summary: The development of DNA nanotechnology has allowed for the synthesis of materials with controllable sizes and uniform geometries at the nano- and micro-scales. In this study, we proposed a method using double-crossover, antiparallel, and half-turns perimeter tiles to create large 2D DNA micro-assemblies. By adjusting the inter-tile distances and the number of half-turns in the connections, we were able to achieve stable lattices with different twisting patterns. The results showed that the inter-tile connections and the number of half-turns greatly influenced the coiling and twisting forces in the DNA helix, as well as the overall structure and geometry of the DNA lattices.
APPLIED NANOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Qin Han, Yina Ding, Huihui Zhou, Zhipeng Chen, Jingjing Wang, Jiaxin Xiang, Zhengbo Song, Muhammad Abbas, Liyun Shi
Summary: Cancer development is a prolonged process, in which macrophages have a crucial role. It is hypothesized that intra-tumoral macrophages can acquire stem cell-like properties and memory-like activity, promoting cancer development. This study reveals a distinct subpopulation of macrophages with hybrid characteristics of stem cells and memory cells, and identifies a regulatory mechanism that integrates transcriptional, epigenetic, and metabolic pathways to enhance long-lasting anti-tumor immunity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Gul Rehman Elmi, Kamil Anum, Kalsoom Saleem, Rameesha Fareed, Sobia Noreen, Haiyan Wei, Yongxing Chen, Avirup Chakraborty, Masood Ur Rehman, Shi Liyuan, Muhammad Abbas, Yongtao Duan
Summary: Diabetes mellitus (DM) is a global metabolic disorder that causes 6.7 million deaths annually. Current treatments have common side effects, making ethnomedicine an attractive option. Ethnomedicine works by inhibiting glucose absorption and production while promoting uptake and insulin secretion. Despite numerous plant-based clinical trials, few have been approved for use. This study evaluates these trials, highlighting major limitations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Hafiz Muhammad Zubair, Muhammad Arslan Khan, Faisal Gulzar, Musaed Alkholief, Abdul Malik, Suhail Akhtar, Ali Sharif, Muhammad Furqan Akhtar, Muhammad Abbas
Summary: This study aims to explore the experiences of NSCLC patients receiving palliative chemotherapy and their adaptation to post-chemotherapy life, beliefs, and quality of life. Through face-to-face interviews, the patients' experiences were categorized into five themes, revealing the importance of shared decision-making between clinicians and patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Surgery
Murad Habib, Hajra Fazeelat Bajwa, Muhammad Abbas, Muhammad Amjad Chaudhary
Summary: This article reports a case of a newborn with diphallia and anorectal malformation. The patient underwent surgery and a sigmoid colostomy was performed. The article emphasizes that diphallia is a rare congenital anomaly that requires a multidisciplinary approach.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Chemistry, Analytical
Shang-Ming-Zhu Zeng, Qing Zhang, Qin Li, Liang-Chao Yuan, Muhammad Abbas, Zhen-Xiang He, Hai-Liang Zhu, Zhong-Chang Wang
Summary: In this study, a highly selective Cys fluorescent probe ZS-C1 based on quinoline was reported, which can monitor and image Cys levels in real time, providing critical information for early diagnosis and treatment of GBM.
Review
Environmental Sciences
Eno E. Essien, Kassim Said Abasse, Andre Cote, Kassim Said Mohamed, Mirza Muhammad Faran Ashraf Baig, Murad Habib, Muhammad Naveed, Xiaojin Yu, Weihua Xie, Sun Jinfang, Muhammad Abbas
Summary: This study found an association between nitrate intake from drinking water and a specific type of cancer in humans. Controlling nitrate concentrations in drinking water is crucial for preventing pollution.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2022)