MAIT cells and microbial immunity

Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells

(2018) Nadine Hartmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

(2018) Lauren J. Howson et al.   Nature Communications

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation

(2017) Martin Solders et al.   Scientific Reports

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

(2017) Christopher R. Shaler et al.   PLOS BIOLOGY

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets

(2017) Ayako Kurioka et al.   Frontiers in Immunology

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

(2017) Rosângela Salerno-Goncalves et al.   Frontiers in Immunology

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis

(2016) Eric Gracey et al.   ANNALS OF THE RHEUMATIC DISEASES

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

(2016) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

(2016) Nicholas A. Gherardin et al.   IMMUNITY

MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection

(2016) Anda I. Meierovics et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis

(2016) Keiichi Haga et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling

(2016) Anna Rita Liuzzi et al.   JOURNAL OF IMMUNOLOGY

Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis

(2016) E. Hayashi et al.   JOURNAL OF RHEUMATOLOGY

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation

(2016) A Gibbs et al.   Mucosal Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

(2016) J M Greene et al.   Mucosal Immunology

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

(2016) Z Chen et al.   Mucosal Immunology

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1

(2016) Hamish E G McWilliam et al.   NATURE IMMUNOLOGY

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

(2016) Erin W. Meermeier et al.   Nature Communications

Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

(2016) Jing Jiang et al.   Scientific Reports

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus

(2016) Seung-Ji Kang et al.   PLoS Neglected Tropical Diseases

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells

(2016) Melanie J. Harriff et al.   PLoS Pathogens

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

(2015) Prabhat K. Sharma et al.   IMMUNOLOGY

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites

(2015) Isaac G. Sakala et al.   JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells

(2015) Claire Soudais et al.   JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity

(2015) Yong-Soo Kwon et al.   TUBERCULOSIS

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

(2015) Edwin Leeansyah et al.   PLoS Pathogens

Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection

(2015) Jayaum S. Booth et al.   Frontiers in Immunology

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

(2014) Marielle C. Gold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of Invariant T Cells by Next-Generation Sequencing of the Human TCR α-Chain Repertoire

(2014) Barbera van Schaik et al.   JOURNAL OF IMMUNOLOGY

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Reduced Mucosal Associated Invariant T-Cells Are Associated with Increased Disease Severity and Pseudomonas aeruginosa Infection in Cystic Fibrosis

(2014) Daniel J. Smith et al.   PLoS One

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

(2014) Edwin Leeansyah et al.   Nature Communications

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses

(2014) Daniel T. Leung et al.   PLoS Neglected Tropical Diseases

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

(2014) Juandy Jo et al.   PLoS Pathogens

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections

(2013) David Grimaldi et al.   INTENSIVE CARE MEDICINE

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

(2013) X.-Z. Tang et al.   JOURNAL OF IMMUNOLOGY

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination

(2012) Hui Yee Greenaway et al.   IMMUNOBIOLOGY

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

(2012) Wei-Jen Chua et al.   INFECTION AND IMMUNITY

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress

(2012) M C Gold et al.   Mucosal Immunology

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells

(2011) W.-J. Chua et al.   JOURNAL OF IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE