Article
Gastroenterology & Hepatology
Carolin Lackner, Rudolf E. Stauber, Susan Davies, Helmut Denk, Hans Peter Dienes, Viviane Gnemmi, Maria Guido, Rosa Miquel, Valerie Paradis, Peter Schirmacher, Luigi Terracciano, Andrea Berghold, Gudrun Pregartner, Lukas Binder, Philipp Douschan, Florian Rainer, Stephan Sygulla, Marion Jager, Pierre-Emmanuel Rautou, Andreea Bumbu, Adelina Horhat, Ioana Rusu, Horia Stefanescu, Sonke Detlefsen, Aleksander Krag, Maja Thiele, Helena Cortez-Pinto, Christophe Moreno, Annette S. H. Gouw, Dina G. Tiniakos
Summary: The SALVE Histopathology Group developed and validated a grading and staging system for alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. The system showed significant associations with disease activity and fibrosis stage, impacting both long-term and short-term outcomes in ALD patients.
JOURNAL OF HEPATOLOGY
(2021)
Article
Pediatrics
Kanwar Saini, Rishi Bolia, Nowneet Kumar Bhat
Summary: Sepsis-associated liver injury (SALI) occurs as a result of systemic and microcirculatory changes caused by sepsis. This study found an association between SALI occurrence and higher pSOFA scores, and SALI development increases the risk of mortality in children with sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Jiaxu Zhang, Yi Luo, Mingxuan Feng, Qiang Xia
Summary: Biliary atresia is strongly associated with immune response, with differentially expressed immune-related genes and cell types identified in the liver. Further correlation analysis suggests potential markers for fibrosis and inflammation in BA liver.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Jeremy S. Nayagam, Deepak Joshi, Richard J. Thompson, Anil Dhawan, Nedim Hadzic, Claudia Mestre-Alagarda, Maesha Deheragoda, Marianne Samyn
Summary: This study retrospectively reviewed 104 pediatric patients with autoimmune liver disease (AILD) at our institution from 1999 to 2018. The results showed that elevated hepatic dry copper weight is common in pediatric AILD, and it is not associated with cholestasis but is related to the need for liver transplantation. Close monitoring is recommended for patients with elevated copper levels.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Li Wang, Yi-Ling Qiu, Hong-Mei Xu, Jing Zhu, Shuang-Jie Li, Wen-Xian OuYang, Yong-Feng Yang, Yi Lu, Xin-Bao Xie, Qing-He Xing, Jian-She Wang
Summary: The phenotype of MYO5B deficiency is associated with MYO5B genotypes, particularly null variants or affected domains. The severity of intestinal manifestation and cholestasis in FIC patients is correlated with specific variants of the MYO5B gene. Missense/in-frame variants affecting non-motor regions and IQ motifs in MYO5B are more common in FIC patients compared to MVID patients.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Shunsuke Fukui, Kohei Ikeda, Mayu Kobayashi, Keigo Nishida, Keita Yamada, Shotaro Horie, Yasuaki Shimada, Hiroto Miki, Hiroki Goto, Koken Hayashi, Yuuichi Nakazawa, Hiroki Mizutani, Toshitaka Kamon, Yusuke Tanigaito, Shuji Kodama, Takashi Kato, Yuuki Nishiura, Daisuke Suga, Toshikazu Terashima, Yuhuko Ichikawa, Isao Moritani, Akitaka Yamamoto, Kei Takaba, Kouji Yasumoto, Hideo Wada, Katsuya Shiraki
Summary: The present study aimed to identify useful biomarkers to predict deterioration in patients with COVID-19. Several blood markers, including CRP, PSP, LDH, and AST, were found to be reliable indicators for predicting the prognosis of non-severe cases. However, no blood biomarkers were able to predict the outcome in severe cases.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Peripheral Vascular Disease
Julie K. K. Vishram-Nielsen, Anna M. Dyrvig Kristensen, Manan Pareek, Stephane Laurent, Peter M. Nilsson, Allan Linneberg, Sara Greve, Luigi Palmieri, Simona Giampaoli, Chiara Donfrancesco, Frank Kee, Giuseppe Mancia, Giancarlo Cesana, Giovanni Veronesi, Guido Grassi, Kari Kuulasmaa, Veikko Salomaa, Tarja Palosaari, Susana Sans, Jean Ferrieres, Jean Dallongeville, Stefan Soderberg, Marie Moitry, Wojciech Drygas, Abdonas Tamosiunas, Annette Peters, Hermann Brenner, Sameline Grimsgaard, Matti Savallampi, Michael H. Olsen
Summary: The study found a positive association between age and systolic blood pressure, with a more pronounced effect in individuals over 50 years old. Systolic blood pressure and mean blood pressure were significantly associated with the cardiovascular endpoint, regardless of age group. Diastolic blood pressure showed independent predictive value in the younger age group.
Article
Endocrinology & Metabolism
Jiang Deng, Yonghong Zhang, Limei Bu, Haitao Shi, Hailing Tang, Shenhao Wang, Qian Wang, Shuangsuo Dang, Ming Li, Zhiyi Han, Xiaolan Lu
Summary: The study found that the prevalence of non-obese fatty liver disease is high and rapidly increasing in Karamay. Triglycerides are the best predictor of non-obese fatty liver in non-obese individuals undergoing physical examinations. An increase in body mass index is associated with an increased risk of non-obese fatty liver disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lauren G. Poole, Anna-Katherine Fournier, Holly M. Cline-Fedewa, Anna K. Kopec, James P. Luyendyk, Dafna J. Groeneveld
Summary: VWF plays different roles in experimental acute and chronic ANIT-induced cholestatic liver injury.
Article
Gastroenterology & Hepatology
Paul Wasuwanich, Hassan Choudry, Joshua M. So, Sarah Lowry, Wikrom Karnsakul
Summary: This study collected 59 cases of Vanishing bile duct syndrome (VBDS) and drug-induced liver injury (DILI) case reports, finding that antibiotics were the most common offending agents and higher bilirubin levels were associated with poor outcomes.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Immunology
Wagdi Almishri, Liam A. Swain, Charlotte D'Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Summary: Increased expression of ADAM17 is observed in cholestatic liver diseases. Inhibition of ADAM17 activity improves liver injury and associated sickness behavior development, suggesting that ADAM17 inhibition may be a potential therapeutic approach for patients with cholestatic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yojiro Arinobu, Yusuke Kashiwado, Kohta Miyawaki, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Toshihiro Miyamoto, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro
Summary: The study revealed that the prognosis was poor in patients with MDS-associated AIMs, with the presence of AIMs and higher-risk disease being independent risk factors for increased mortality. Treatment strategies for patients with MDS-associated AIMs should be reconsidered.
Article
Gastroenterology & Hepatology
Ranya Selim, Joseph Ahn
Summary: Pruritus associated with chronic liver disease has a complex and not fully understood pathophysiology. For patients whose quality of life is affected by severe itching, liver transplantation may be considered if medical therapy fails to provide relief. Further research is needed to fully understand the pathophysiology of pruritus in chronic liver disease, which would help in developing more effective treatments for this condition.
CLINICS IN LIVER DISEASE
(2023)
Article
Plant Sciences
Chunlei Wei, Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu, Fang Liu
Summary: This review summarizes the effective single and compound traditional Chinese medicines (TCMs) for the treatment of cholestatic liver disease (CLD). Based on the different clinical stages of CLD, the pharmacological effects and mechanisms of five promising TCM examples, including Yin Chen, Chi Shao, Fu Ling, Huang Qi Decoction (HQD), and Yin Chen Hao Decoction (YCHD), are discussed. The findings suggest that TCMs can effectively control the development of CLD and personalized treatment measures can slow down the progression of the disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Immunology
Rui Wang, Ruqi Tang, Bo Li, Xiong Ma, Bernd Schnabl, Herbert Tilg
Summary: The delicate interaction between the gut microbiota and liver is crucial in preventing accidental immune activation against harmless antigens, also aiding in understanding and treating various liver diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rozanne C. de Veer, Maria C. van Hooff, Christophe Corpechot, Douglas Thorburn, Pietro Invernizzi, Willem J. Lammers, Harry L. A. Janssen, Pier M. Battezzati, Frederik Nevens, Keith D. Lindor, Annarosa Floreani, Cyriel Y. Ponsioen, Marlyn J. Mayo, Albert Pares, Andrew L. Mason, Kris V. Kowdley, Palak J. Trivedi, Gideon M. Hirschfield, Jorn C. Goet, Tony Bruns, George N. Dalekos, Nikolaos K. Gatselis, Xavier Verhelst, Bettina E. Hansen, Maren H. Harms, Adriaan J. van der Meer, Global PBC Study Grp
Summary: A study found an association between changes in the GLOBE score in patients with primary biliary cholangitis (PBC) treated with ursodeoxycholic acid (UDCA) and LT-free survival. The study assessed the risk of LT or death in UDCA-treated PBC patients based on changes in the GLOBE score.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Carla F. Murillo Perez, Alessio Gerussi, Palak J. Trivedi, Christophe Corpechot, Adriaan J. van der Meer, Pier Maria Battezzati, Keith D. Lindor, Frederik Nevens, Kris V. Kowdley, Tony Bruns, Nora Cazzagon, Annarosa Floreani, Atsushi Tanaka, Xiong Ma, Andrew L. Mason, Aliya Gulamhusein, Cyriel Y. Ponsioen, Marco Carbone, Ana Lleo, Marlyn J. Mayo, George N. Dalekos, Nikolaos K. Gatselis, Douglas Thorburn, Xavier Verhelst, Albert Pares, Harry L. A. Janssen, Gideon M. Hirschfield, Bettina E. Hansen, Pietro Invernizzi, Willem J. Lammers
Summary: This study investigates whether clinical outcomes of PBC patients in Western Europe differ according to geographical regions. The results show that patients from North Europe have higher biochemical markers and higher rates of poor outcomes (decompensation and liver transplantation) compared to those from South Europe.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Maryam Ebadi, Elora Rider, Catherine Tsai, Sarah Wang, Ellina Lytvyak, Andrew Mason, Aldo J. Montano-Loza
Summary: This study aimed to investigate the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). The results showed that severe vitamin D deficiency was related to an increased risk of hepatobiliary malignancies, and a severe deficiency at diagnosis and persistent deficiencies over time were independently associated with poor clinical liver outcomes.
Review
Oncology
Flavio Milana, Michela Anna Polidoro, Simone Famularo, Ana Lleo, Renzo Boldorini, Matteo Donadon, Guido Torzilli
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and both liver resection and liver transplantation are considered potentially curative options. The management of HCC recurrence is still not well defined, but surgery remains a curative option for selected patients. This study aimed to summarize the patterns and histopathological characteristics of HCC recurrence, their prognostic value, and the main surgical strategies for dealing with HCC relapse.
Article
Oncology
Teru Kumagi, Takashi Terao, Taira Kuroda, Mitsuhito Koizumi, Yoshiki Imamura, Yoshinori Ohno, Tomoyuki Yokota, Nobuaki Azemoto, Kazuhiro Uesugi, Yoshiyasu Kisaka, Yoshinori Tanaka, Naozumi Shibata, Hideki Miyata, Teruki Miyake, Yoichi Hiasa
Summary: Patients with viral hepatitis-related chronic liver disease are often diagnosed with pancreatic cancer at an early stage, allowing for a higher chance of surgical resection and favorable long-term outcomes.
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Mitchell L. Shiffman, Aliya Gulamhusein, Kris Kowdley, John M. Vierling, Cynthia Levy, Andreas E. Kremer, Ehud Zigmond, Pietro Andreone, Stuart C. Gordon, Christopher L. Bowlus, Eric J. Lawitz, Richard J. Aspinall, Daniel S. Pratt, Karina Raikhelson, Maria S. Gonzalez-Huezo, Michael A. Heneghan, Sook-Hyang Jeong, Alma L. Ladron de Guevara, Marlyn J. Mayo, George N. Dalekos, Joost P. H. Drenth, Ewa Janczewska, Barbara A. Leggett, Frederik Nevens, Victor Vargas, Eli Zuckerman, Christophe Corpechot, Eduardo Fassio, Holger Hinrichsen, Pietro Invernizzi, Palak J. Trivedi, Lisa Forman, David E. J. Jones, Stephen D. Ryder, Mark G. Swain, Alexandra Steinberg, Pol F. Boudes, Yun-Jung Choi, Charles A. McWherter
Summary: This study evaluated the efficacy and safety of seladelpar in patients with primary biliary cholangitis who had inadequate response or intolerance to ursodeoxycholic acid. The results showed that seladelpar significantly improved liver biochemistry and pruritus in these patients, and it was well tolerated.
Article
Gastroenterology & Hepatology
Amanda Ricciuto, Binita M. Kamath, Gideon M. Hirschfield, Palak J. Trivedi
Summary: Autoimmune liver diseases are classified into three syndromes, but they are challenging due to variant presentations and lack of definable disease aetiologies. This article argues that "autoimmune sclerosing cholangitis" and "PSC/AIH-overlap" in young patients represent inflammatory phases of primary sclerosing cholangitis and should be considered as the same entity to facilitate unified care and collaborative studies.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Albert Pares, Nuria Guanabens
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
C. Fiorella Murillo Perez, Stephanie Ioannou, Iman Hassanally, Palak J. Trivedi, Christophe Corpechot, Adriaan J. van der Meer, Willem J. Lammers, Pier Maria Battezzati, Keith D. Lindor, Frederik Nevens, Kris Kowdley, Tony Bruns, Nora Cazzagon, Annarosa Floreani, Andrew L. Mason, Aliya Gulamhusein, Cyriel Y. Ponsioen, Marco Carbone, Ana Lleo, Marlyn J. Mayo, George N. Dalekos, Nikolaos K. Gatselis, Douglas Thorburn, Xavier Verhelst, Albert Pares, Maria-Carlota Londono, Harry L. A. Janssen, Pietro Invernizzi, Raj M. Vuppalanchi, Gideon M. Hirschfield, Bettina E. Hansen, Cynthia Levy
Summary: This study aimed to assess the POISE criteria for treatment response evaluation in patients with primary biliary cholangitis (PBC) and evaluate the utility of alkaline phosphatase (ALP) at six months as a predictor of insufficient response. The results showed that an ALP threshold of 1.9 x ULN at six months accurately identified non-responders.
LIVER INTERNATIONAL
(2023)
Article
Microbiology
Heather Armstrong, Mandana Rahbari, Heekuk Park, David Sharon, Aducio Thiesen, Naomi Hotte, Ning Sun, Hussain Syed, Hiatem Abofayed, Weiwei Wang, Karen Madsen, Eytan Wine, Andrew Mason
Summary: Genetically manipulated mice lacking IL-10 have increased MMTV expression, which may contribute to the development of colitis. Antiviral therapy targeting MMTV reduces colonic MMTV RNA and improves colitis symptoms in these mice.
Article
Gastroenterology & Hepatology
Laura Martinez-Gili, Alexandros Pechlivanis, Julie A. K. McDonald, Sofina Begum, Jonathan Badrock, Jessica K. Dyson, Rebecca Jones, Gideon Hirschfield, Stephen D. Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor-Robinson, Mary M. E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Summary: A study on patients with primary biliary cholangitis (PBC) showed that there is variation in response to ursodeoxycholic acid (UDCA) treatment. Responders exhibited high levels of secondary and tertiary bile acids, while non-responders had lower urinary bile acid levels and higher levels of 12-dehydrocholic acid. Additionally, non-responders showed lower gut microbiota diversity and lower capacity for bile acid deconjugation.
Article
Biochemistry & Molecular Biology
Charmaine van Eeden, Desiree Redmond, Naima Mohazab, Maggie J. J. Larche, Andrew L. L. Mason, Jan Willem Cohen Tervaert, Mohammed S. S. Osman
Summary: This study aimed to assess the prevalence of ME/CFS in early limited cutaneous systemic sclerosis (lcSSc) patients and determine if alterations in mitochondrial gene expression and mtDNA integrity could be used to distinguish between fatigued and non-fatigued patients. ME/CFS-related symptoms were assessed through questionnaires, and the expression of mitochondrial gene transcripts and mtDNA integrity were quantified. The study found that SSc patients with ME/CFS could be differentiated from non-fatigued patients through mitochondrial gene analysis, specifically with reduced expression of ND4 and CyB and increased expression of Cox7C. ND4 and CyB expression were also correlated with disease severity indicators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Infectious Diseases
Nicola Pugliese, Davide Polverini, Ivan Arcari, Stella De Nicola, Francesca Colapietro, Chiara Masetti, Monica Ormas, Roberto Ceriani, Ana Lleo, Alessio Aghemo
Summary: The efficacy and safety of DAAs in the elderly population appear to be similar to that of the general population, but further research is needed to confirm this evidence.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)