期刊
HUMAN IMMUNOLOGY
卷 79, 期 6, 页码 485-490出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2018.03.007
关键词
Ankylosing spondylitis (AS); Clonotypes; Diversity; T cell receptor (TCR); TCR repertoire
类别
资金
- National Natural Science Foundation of China [81402255]
- Guangdong Province Natural Science Funds for Distinguished Young Scholar [2016A030306050]
- Guangdong Province Natural Science Funds [2014A030313803]
- Science and technology innovation platform in Foshan city [2015AG10002]
- Guangdong Te Zhi program youth science and technology talent of project [2015TQ01R462]
- Science and Technology Planning Project of Guangdong Province [2017A020215185]
Ankylosing spondylitis (AS) is a chronic and progressive autoimmune disease affecting the invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the underlying pathogenesis of AS, which mediated autoimmune and inflammatory responses via specific recognition of autoantigen peptides presented by susceptibility HLA. Antigen-specific T cells triggered by HLA/antigen complexes will undergo a massive expansion that forming an uneven T cell repertoire. To enhance our understanding of T-cell-mediated autoimmune in AS, we applied TCR beta chains high-throughput sequencing to AS patients for in-depth TCR repertoire analysis. A significantly lower TCR repertoire diversity was observed in peripheral blood of AS patients relative to controls. And severe patients in our AS cohort have a more restricted TCR repertoire than mild patients, suggesting that the TCR repertoire diversity might be associated with the clinical severity of disease. No V, J and VJ pairs with significant biased usage were identified, which indicated that the usage frequency deviation of certain V/J/V-J genes in AS patients is little. This is a pilot study with potentially interesting observation on reduced diversity of T cells repertoire in peripheral blood of AS patients and further studies are needed.
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