Article
Nutrition & Dietetics
Maggie A. Stanislawski, Daniel N. Frank, Sarah J. Borengasser, Danielle M. Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, Liza Wayland, Janet C. Siebert, Daniel H. Bessesen, Paul S. MacLean, Edward L. Melanson, Victoria A. Catenacci
Summary: The ongoing weight loss trial comparing daily caloric restriction to intermittent fasting in overweight or obese adults found significant improvements in clinical health measures and altered composition and diversity of fecal microbiota in the first three months. Significant associations were observed between gut microbiota features and clinical measures such as weight and waist circumference. Differences in the relative abundance of Akkermansia were also seen between the intervention groups.
Review
Nutrition & Dietetics
Valentina Alvarez-Arrano, Sandra Martin-Pelaez
Summary: Intestinal microbiota plays a potential role in obesity development. Probiotics and synbiotics intake can lead to significant weight loss, with specific strains like Lactobacillus and Bifidobacterium showing the best results. These findings suggest that probiotics and synbiotics have the potential to aid in weight reduction in overweight and obese populations.
Review
Nutrition & Dietetics
Malgorzata Moszak, Marta Pelczynska, Agnieszka Wesolek, Dominika Stenclik, Pawel Bogdanski
Summary: Obesity is a chronic condition characterized by the accumulation of excessive fat in the body, and is often accompanied by health consequences. The treatment of obesity involves a comprehensive approach that includes diet, exercise, medication, surgery, and psychological support. The effectiveness of probiotics, prebiotics, and synbiotics in weight control has been studied, but the findings are inconclusive due to the heterogeneity of the studies.
Article
Immunology
Mariusz Kaczmarczyk, Monika Szulinska, Igor Loniewski, Matylda Kregielska-Narozna, Karolina Skonieczna-Zydecka, Tomasz Kosciolek, Valentyn Bezshapkin, Pawel Bogdanski
Summary: Probiotic intervention alters the influence of microbiota on biochemical, physiological, and immunological parameters, but does not affect diversity and taxonomic composition of the microbiota. Baseline microbiota is not a predictor of therapeutic response to a multispecies probiotic.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Sevag Hamamah, Arman Amin, Abdul Latif Al-Kassir, Judith Chuang, Mihai Covasa
Summary: Obesity is a complex disease that is becoming more prevalent worldwide. Recent research suggests that changes in gut microbiota, influenced by the consumption of dietary fats, play a key role in the development of obesity. These alterations in gut microbiota can affect important satiation signals, leading to hyperphagia and obesity. This review discusses the mechanisms by which gut microbiota influences satiation signals, the effects of dietary interventions on gut microbiota and satiety signals, and microbiota optimizing therapies to combat obesity.
Article
Nutrition & Dietetics
Stephan C. Bischoff, Nguyen K. Nguyen, Benjamin Seethaler, Julia Beisner, Philipp Kuegler, Thorsten Stefan
Summary: This study found that gut microbiota patterns can predict the long-term success of weight loss in individuals. The prediction accuracy is high, but further confirmation is needed through larger prospective trials.
Review
Nutrition & Dietetics
Simone Perna, Zahra Ilyas, Attilio Giacosa, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Chiara Rigon, Maurizio Naso, Antonella Riva, Giovanna Petrangolini, Ali A. Redha, Mariangela Rondanelli
Summary: This meta-analysis study found that probiotic supplementation can significantly reduce BMI, waist circumference, and hip circumference in overweight and obese patients, but the effect on body weight is not significant. Although there is a positive trend, further research is needed before recommending probiotics as a therapeutic strategy for these patients.
Review
Immunology
Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu, Huaxiang Wu
Summary: This article summarizes the role of gut microbiota in the onset and progression of gout, discusses its importance in the diagnosis and treatment of gout, and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Susana Lauw, Nelson Kei, Po Lam Chan, Tsz Kwan Yau, Ka Lee Ma, Carol Ying Ying Szeto, Janice Su-Chuen Lin, Sunny Hei Wong, Peter Chi Keung Cheung, Hoi Shan Kwan
Summary: Increasing dietary fiber consumption from fruits and vegetables combined with synbiotic supplementation is more effective in tackling obesity by modulation of the gut microbiota and improving metabolic syndrome traits.
Article
Food Science & Technology
Yung-Tsung Chen, Shiou-Yun Chiou, Ai-Hua Hsu, Yu-Chun Lin, Jin-Seng Lin
Summary: The study found that LRH05 significantly reduces body weight gain and WAT weight in mice, as well as improving hepatic steatosis and glucose intolerance. LRH05 can ameliorate the pro-inflammatory process by regulating gene expression and reducing inflammatory macrophage infiltration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Mijra Koning, Hilde Herrema, Max Nieuwdorp, Abraham S. Meijnikman
Summary: Humans have a diverse gut microbiome, consisting of bacteria, fungi, viruses, and archaea. Patients with NAFLD have an altered gut microbiome and compromised gut barrier function. Preclinical studies suggest that adjusting the gut microbiome could be a promising therapeutic strategy for NAFLD. This overview summarizes the current information on both untargeted techniques (such as probiotics and fecal microbiota transplantation) and targeted microbiome-focused therapies (including engineered bacteria, prebiotics, postbiotics, and phages) for the treatment of NAFLD.
Article
Endocrinology & Metabolism
Eun-Ji Song, Eun-Sook Lee, Young In Kim, Dong-Uk Shin, Ji-Eun Eom, Hee Soon Shin, So-Young Lee, Young-Do Nam
Summary: L. paracasei AO356 has been found to have an anti-obesity effect and can modify the gut microbiota and metabolic pathways associated with obesity. Its safety has also been confirmed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhuye Jie, Xinlei Yu, Yinghua Liu, Lijun Sun, Peishan Chen, Qiuxia Ding, Yuan Gao, Xukai Zhang, Maomao Yuye, Yuan Liu, Yong Zhang, Karsten Kristiansen, Huijue Jia, Susanne Brix, Kaiye Cai
Summary: The baseline gut microbiota plays a crucial role in individual weight loss trajectories and can predict the relationship between dietary factors and weight loss. Changes in abundances of certain bacterial species during weight loss are associated with changes in body weight.
Review
Immunology
Rui Qin, Gengren Tian, Junbao Liu, Lu Cao
Summary: Endometriosis is a common gynecological disease that is associated with an imbalance of sex hormones, immune inflammation, and tumor characteristics. Recent studies have shown an association between the gut microbiota and endometriosis, suggesting that regulating gut microbiota may be beneficial for the treatment of endometriosis patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Shuyi Fan, Suyun Chen, Lin Lin
Summary: Obesity is a chronic metabolic disorder caused by an energy imbalance and is becoming increasingly prevalent, posing a global health concern. The multifactorial etiology of obesity includes genetics, high-fat diet, gut microbiota, and other factors. Among these factors, the implication of gut microbiota in the development of obesity has been widely recognized. This study aims to investigate the potential contribution of gut microbiota to high-fat diet induced obesity and the current state of probiotic intervention therapy research, providing novel insights for obesity prevention and management.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)