Article
Immunology
Jesica Hayon, Sofia Lupo, Cristina Poveda, Kathryn M. Jones, Qian Qian, Hulin Wu, Thomas P. Giordano, Charles J. Fleischmann, Caryn Bern, Jeffrey D. Whitman, Eva H. Clark
Summary: This article reports the results of a Chagas disease screening strategy applied at a large HIV clinic, emphasizing the importance of improving screening strategies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Hui Li, Shuyi Wang, Fang-Hua Lee, Ryan S. Roark, Alex Murphy, Jessica Smith, Chengyan Zhao, Juliette Rando, Neha Chohan, Yu Ding, Eunlim Kim, Emily Lindemuth, Katharine J. Bar, Ivona Pandrea, Cristian Apetrei, Brandon F. Keele, Jeffrey D. Lifson, Mark G. Lewis, Thomas N. Denny, Barton F. Haynes, Beatrice H. Hahn, George M. Shaw
Summary: The study demonstrates the successful construction of SHIVs with bulky aromatic substitutions at residue 375, allowing efficient replication in rhesus macaques and effective transmission across rectal, vaginal, penile, oral, or intravenous routes. These SHIVs can serve as a model for HIV-1 infection studies in preclinical monkey trials.
JOURNAL OF VIROLOGY
(2021)
Article
Oncology
Carole Metekoua, Yann Ruffieux, Victor Olago, Tafadzwa Dhokotera, Matthias Egger, Julia Bohlius, Eliane Rohner, Mazvita Muchengeti
Summary: The main risk factors for squamous cell carcinoma of the conjunctiva (SCCC) among people with HIV (PWH) in South Africa are immunodeficiency and exposure to ultraviolet radiation. The incidence rate of SCCC decreased between 2004 and 2014, and PWH residing within latitudes 30°S to 34°S had a lower SCCC risk. Other risk factors for SCCC were lower CD4 counts and middle age, while there was no evidence for an association of sex or settlement type with SCCC risk.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Immunology
Rodrigue Garcia, Peder Emil Warming, Carl Johann Hansen, Deepthi Rajan, Christian Torp-Pedersen, Thomas Benfield, Fredrik Folke, Jacob Tfelt-Hansen
Summary: People with HIV have a higher risk of out-of-hospital cardiac arrest and are younger than those without HIV. The incidence rate of OHCA is higher in individuals with HIV, but the 30-day mortality rate is similar to those without HIV.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Ke Zhuang, Yongxi Zhang, Pingzheng Mo, Liping Deng, Yong Jiang, Lei Yu, Fanghua Mei, Shaoxin Huang, Xi Chen, Yajun Yan, Hongbin Tang, Xiangdong Li, Yong Xiong, Shuwen Wu, Hengning Ke, Xien Gui, Ke Lan
Summary: The identification of differentially expressed proteins in the plasma of patients with AIDS-NHL may lead to the development of biomarkers for screening, diagnosis, treatment, and prognosis. Immunoglobulin and complement components were found to be common proteins in this study. These proteins play a role in the pathogenesis of AIDS-NHL.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Infectious Diseases
Maha Al-Mozaini, Tahani Alrahbeni, Qais Dirar, Jawaher Alotibi, Abdulrahman Alrajhi
Summary: The first reported case of acquired immunodeficiency syndrome (AIDS) in the Kingdom of Saudi Arabia (KSA) was in 1984, with increasing number of patients diagnosed with HIV despite proper medical care. Surveillance of HIV in KSA faces challenges, with the need for targeted treatment and preventive strategies to control HIV co-infections. The progress towards meeting WHO 90-90-90 goals for HIV is not systematically monitored, with differences in common co-infections and the need for new resilient methods of treatment and preventive measures.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Immunology
Namrata M. Nilavar, Sathees C. Raghavan
Summary: Inhibitors targeting HIV integrase can interfere with the binding and cleavage of RAG, hindering its physiological functions, providing a new avenue for HIV treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Boyoung Park, Kyoung Hwan Ahn, Yunsu Choi, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Jun Young Choi, Joon Young Song, Eunjung Lee, Yoon Hee Jun, Young Kyung Yoon, Won Suk Choi, Myungsun Lee, Jaehyun Seong, Shin-Woo Kim
Summary: This study examined the cancer incidence and risk among HIV-infected individuals in Korea compared to the general population. The findings showed an increased risk of cancer, particularly AIDS-defining and virus-related cancers, in people with HIV. Efforts to improve cancer prevention, screening, and healthcare accessibility for HIV-infected individuals are necessary.
Article
Infectious Diseases
Eduardo Mastrangelo Falcao, Priscila Marques de Macedo, Dayvison Francis Saraiva Freitas, Andrea d'Avila Freitas, Beatriz Grinsztejn, Valdilea Goncalves Veloso, Rodrigo Almeida-Paes, Antonio Carlos Francesconi do Valle
Summary: Paracoccidioidomycosis (PCM) is an endemic systemic mycosis in Latin America, and when it occurs in individuals with immunosuppressive conditions, it can present as an opportunistic disease. A study conducted in a Brazilian reference center found a low occurrence of PCM in people living with HIV/AIDS (PLWHA), but PCM diagnosis helped identify HIV infection in some atypical and severe cases. Therefore, HIV investigation is recommended in PCM patients.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Geriatrics & Gerontology
SeyedAhmad SeyedAlinaghi, Morteza Ghayomzadeh, Pegah Mirzapour, Seyed Farzad Maroufi, Zahra Pashaei, Zoha Ali, Marcarious M. Tantuoyir, Narjes Aghaie, Farzin Vahedi, Roghayeh Salmani, Mehrzad MohsseniPour, Kowsar Qaderi, Ramin Shahidi, Akram Peyman, Sanaz Varshochi, Arian Afzalian, Seyede Parmis Maroufi, Esmaeil Mehraeen, Omid Dadras, Daniel Hackett
Summary: People living with HIV are at a higher risk of sarcopenia, which can significantly impact their quality of life and ultimately lead to death. This systematic review explored the prevalence of sarcopenia in this population and identified several factors associated with its development. The findings indicate that age, gender, time since HIV diagnosis, vertebral fractures, drug use, and gamma-glutamyl transferase level are promoting factors, while higher education, employment, physical exercise, calf circumference, and gait speed are protective factors against sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Psychology, Multidisciplinary
Xiaoyu Du, Qian Zhang, Jiaqi Hao, Xilong Gong, Jing Liu, Jia Chen
Summary: This study utilizes bibliometric analysis to investigate the research on depression related to HIV/AIDS. The findings reveal that HIV-related depression significantly affects the quality of life and treatment outcomes of individuals living with HIV. Key contributors in this field include the United States, South Africa, and the United Kingdom, and major topics of research include adherence to antiretroviral therapy, mental health, substance abuse, stigma, and the situation in Sub-Saharan Africa.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Dermatology
Eduardo Vinicius Grego Uemura, Luana Rossato
Summary: This systematic review focuses on sporotrichosis co-infection with HIV/AIDS, revealing high prevalence in Brazil and systemic dissemination as the most frequent clinical presentation, which requires prolonged systemic antifungal therapy.
Article
Biotechnology & Applied Microbiology
Hamza Sher, Hafsa Sharif, Tahreem Zaheer, Sarmad Ahmad Khan, Amjad Ali, Hasnain Javed, Aneela Javed
Summary: In this study, two potential HIV vaccines were designed using immunoinformatic approaches. Through analysis and simulation, these vaccines demonstrated potential immune responses, with HIV-1b showing more promise. Experimental validation and animal model studies can further confirm the efficacy and safety of these vaccines.
Review
Immunology
George Siopis
Summary: The link between obesity and the severity of COVID-19 is emphasized by accumulating data. Obesity affects multiple components of the immune system, leading to a reduced defense against harmful microorganisms. Severe acute respiratory syndrome coronavirus 2 takes advantage of the weakened immune system in obese individuals, precipitating COVID-19 and, in some cases, death. Therefore, obesity should be regarded as another form of acquired immunodeficiency syndrome and treated seriously. Unlike AIDS caused by HIV, obesity is a comorbidity-acquired immunodeficiency syndrome. It is important to recognize obesity as a risk factor for COVID-19 mortality. Obesity is a modifiable condition, and lifestyle modifications can reverse it. Strong public health actions are needed to promote lifestyle measures and reduce the burden of overweight and obesity, which currently affect more than one-third of the global population and are projected to increase to 55-80% in the next thirty years.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Immunology
Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Adam Rupert, Jeanette Higgins, Ornella Sortino, Ana M. Ortega-Villa, Virginia Sheikh, Gregg Roby, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti
Summary: Severe mycobacterial IRIS in HIV can cause secondary HLH driven by pathologic IFN gamma production and T-cell activation, leading to worse outcomes. Increased ferritin, anemia, CXCL9, and sCD25 associate with this phenotype and may be used for risk stratification and treatment optimization.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Rheumatology
Ali Mert, Haluk Vahaboglu, Ferhat Arslan, Ayse Batirel, Kemal Tolga Saracoglu, Aliye Bastug, Atahan Cagatay, Ilim Irmak, Gulcin Telli Dizman, Ihsan Ertenli, Lutfiye Nilsun Altunal, Buket Erturk Sengel, Mehmet Bayram, Ahmet Omma, Shirkhan Amikishiyev, Adalet Aypak, Cemal Bes, Sibel Bolukcu, Sacit Icten, Arzu Topeli, Murat Bektas, Birsen Yigit Arslan, Sinan Ozturk, Senol Comoglu, Selda Aydin, Orhan Kucuksahin, Ozan Cemal Icacan, Burak Ince, Sarvan Aghamuradov, Melek Yalcin Mutlu, Funda Simsek, Salih Emre, Cemal Ustun, Pinar Ergen, Ozlem Aydin, Meliha Meric Koc, Omur Gokmen Sevindik, Zekaver Odabasi, Volkan Korten, Hurrem Bodur, Rahmet Guner, Serhat Unal, Mehmet Kocak, Ahmet Gul
Summary: While tocilizumab users showed more frequent intubation or death, PS-matched analyses based on gender, ferritin, and procalcitonin levels revealed that tocilizumab may be effective in a subset of patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Clinical Neurology
Gorkem Tutal Gursoy, Hatice Yuksel, Inci Mulkem Simsek, Saniye Oral, Fadime Erdogan Kucukdagli, Ayberk Karaman, Esragul Akinci, Aliye Bastug, Hatice Rahmet Guner, Hesna Bektas
Summary: This study investigated the neurological presentations in patients with COVID-19 cytokine storm (CS). The most common neurological symptom in the CS group was altered level of consciousness, and the presence of CS was associated with a higher mortality rate.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Letter
Public, Environmental & Occupational Health
Rahmet Guner, Imran Hasanoglu, Bircan Kayaaslan, Adalet Aypak, Esragul Akinci, Hurrem Bodur, Fatma Eser, Ayse Kaya Kalem, Orhan Kucuksahin, Ihsan Ates, Aliye Bastug, Yasemin Tezer Tekce, Zeynep Bilgic, Fahriye Melis Gursoy, Hatice Nisa Akca, Seval Izdes, Deniz Erdem, Emra Asfuroglu, Habibe Hezer, Hatice Kilic, Musa Civak, Sibel Aydogan, Turan Buzgan
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Sumeyye Kazancioglu, Aliye Bastug, Bircan Kayaaslan, Nevzat Mehmet Mutlu, Esin Calci, Turan Turhan, Ipek Mumcuoglu, Esragul Akinci, Hurrem Bodur
Summary: This study compared the diagnostic value of Candida score, colonization index, serum BDG detection, and routine laboratory parameters in ICU patients. The findings suggest that serum BDG may be useful for predicting candidemia in ICU, and combining BDG with CRP could be a stronger predictor for candidemia.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Medicine, General & Internal
Belgin Coskun, Muge Ayhan, Elif Mukime Saricaoglu, Rahmet Guner, Esragul Akinci, Turan Buzgan, Bircan Kayaaslan, Adalet Altunsoy, Ayse Yasemin Tezer Tekce, Imran Hasanoglu, Ayse Kaya Kalem, Fatma Eser, Yesim Aybar Bilir, Burcu Ozdemir
Summary: Early diagnosis is crucial for severe diseases in COVID-19. This study found a relationship between MHR and disease severity, suggesting that MHR could serve as an inflammatory marker in COVID-19.
KONURALP TIP DERGISI
(2022)
Article
Public, Environmental & Occupational Health
Sumeyye Kazancioglu, Aliye Bastug, Burcu Ozdemir, Esragul Akinci, Hurrem Bodur
VECTOR-BORNE AND ZOONOTIC DISEASES
(2022)
Article
Medicine, General & Internal
Hatice Kilic, Emine Arguder, Aysegul Karalezli, Ebru Unsal, Rahmet Guner, Bircan Kayaslan, Imran Hasanoglu, Ihsan Ates, Musa Civak, Esmehan Akpinar, Ebru Parlak, Filiz Sadi, Yasin Kocaman, Sibel Gunay, Esra Metan, Mukremin Er, Aynil Dalkiran, Habibe Hezer, Hulya Erguden, Zeynep Hancioglu, Ayse Kalem, Fatma Eser, Adalet Aypak, Esragul Akinci, Selma Karahmetoglu, Emin Gemcioglu, Emra Kalkan, Osman Inan, Abdulrezzak Yilmaz, Bagdagul Guler, Esra Copuroglu, Isil Turan, Derya Gokmen, Serhat Hayme, Aziz Ahmet Surel
Summary: The study aimed to assess the impact of chronic lung disease on mortality in patients hospitalized with prevariant COVID-19 pneumonia. It was found that patients with chronic lung disease had a higher mortality rate, particularly those with chronic obstructive pulmonary disease, lung cancer, and interstitial lung diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Burcu Ozdemir, Esragul Akinci, Ayse But, Sumeyye Kazancioglu, Ahmet Cinar Yasti, Yunus Nadi Yuksek, Isa Sozen, Hurrem Bodur
Summary: Detection of BSI in burn patients is crucial for reducing mortality rates. High TBSA and thrombocytopenia are significant factors associated with mortality risk.
MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS
(2022)
Article
Medicine, General & Internal
Burcu Ozdemir, Ali Atay, Meral Akdogan Kayhan, Yasemin Ozderin Ozin, Dilara Turan Gokce, Adalet Altunsoy, Rahmet Guner
Summary: The study found that tissue CMV-DNA PCR testing is more useful for diagnosing CMV colitis and enables rapid and appropriate treatment.
Article
Pharmacology & Pharmacy
B. Ozdemir, E. Akinci, M. Koksal, E. Rodoplu, A. Altunsoy, R. Guner, B. Kayaaslan, A. K. Kalem, I. Hasanoglu, F. Eser, M. Ayhan, E. M. Saricaoglu, Y. A. Bilir, B. Coskun
Summary: It is possible to diagnose COVID-19 faster and more accurately with chest X-ray and chest CT than with RT-PCR tests. This study aimed to verify the possibility of reducing the use of CT in the diagnosis and follow-up of COVID-19 by using CXR. The results showed that CXR can help detect moderate and severe cases of COVID-19 and assist clinicians in patient management and treatment planning.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Orhan Kucuksahin, Abdulsamet Erden, Ozlem Karakas, Serdar Can Guven, Berkan Armagan, Enes Seyda Sahiner, Osman Inan, Ali Can Kurtipek, Emin Gemcioglu, Selma Karaahmetoglu, Sema Turan, Seval Izdes, Deniz Erdem, Adalet Aypak, Muge Ayhan, Esragul Akinci, Hurrem Bodur, Rahmet Guner, Ahmet Omma, Ihsan Ates
Summary: This retrospective study compared outcomes of hospitalized COVID-19 patients who received anakinra or tocilizumab, showing that anakinra administration was associated with better survival and clinical improvement compared to tocilizumab.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sevilay Sezer, Ceylan Bal, Ayse Kaya Kalem, Bircan Kayaaslan, Fatma Eser, Imran Hasanoglu, Esragul Akinci, Rahmet Guner, Ozcan Erel, Gulsen Yilmaz
Summary: This study reveals a correlation between alteration in steroid hormone levels and disease severity in COVID-19 patients, suggesting the importance of monitoring steroid hormone levels during disease management.
Article
Biochemistry & Molecular Biology
Aliye Bastug, Hurrem Bodur, Urartu Ozgur Safak Seker, Nazlican Filazi, Omer Aydos, Ebru Sahin Kehribar, Ali Reza Hanifehnezhad, Sumeyye Kazancioglu, Recep Erdem Ahan, Volkan Aslan, Banu Cakir, Ahmet Sertcelik, Aykut Ozkul
Summary: Factors affecting the presence and titers of neutralizing antibodies in COVID-19 recovered patients were studied. Higher titers of neutralizing antibodies were found in severe patients. The presence of antibody response is not the only determinative factor for recovery.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
