Article
Pediatrics
Yakun Liu, Chunhui Peng, Kai Wang, Dongyang Wu, Jun Yan, Wenjun Tu, Yajun Chen
Summary: Liver stiffness measurement by SWE and serum GGT level showed the best discriminative utility in differentiating BA from non-BA patients within 45 days. The change in serum direct bilirubin (DB) level was associated with the need for liver transplantation in later life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Peace N. Dike, Nadia Mahmood, Sanjiv Harpavat
Summary: Biliary atresia (BA) is a common cause of chronic liver disease in children and often leads to liver transplantation. Ultrasound (US) and elastography techniques are important tools in diagnosing BA and predicting outcomes after treatment, including the development of portal hypertension and the need for liver transplant. Future studies will further explore the utility of these techniques in monitoring and predicting disease outcomes in BA patients.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Yin-Ann Boo, Mei-Hwei Chang, Yung-Ming Jeng, Shinn-Forng Peng, Wen-Ming Hsu, Wen-Hsi Lin, Huey-Ling Chen, Yen-Hsuan Ni, Hong-Yuan Hsu, Jia-Feng Wu
Summary: The study evaluated the diagnostic performance of transient elastography (TE) with liver stiffness measurement (LSM) greater than 7.7 kPa for biliary atresia (BA) in different age groups, showing high diagnostic power across all age groups. LSM was positively correlated with the percentage of collagen fibers in liver specimens stained by picrosirius red.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Dongying Zhao, Yahui Li, Wei Xie, Wenjie Wu, Yan Chen, Yongjun Zhang
Summary: This study aimed to investigate the longitudinal changes and predictive value of acoustic radiation force impulse elastography and other parameters within three months after hepatoportoenterostomy (HPE) for 2-year outcomes of biliary atresia (BA) patients. The results showed that early postoperative bilirubin levels and SWS changes were reliable predictors of 2-year BA outcomes.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Pediatrics
Jin-qiao Liu, Wen-juan Chen, Meng-jie Zhou, Wen-feng Li, Ju Tang, Qi-chang Zhou
Summary: A nomogram was established to predict the prognosis of children with biliary atresia within 2 years after Kasai portoenterostomy. Independent predictors such as age at surgery, METAVIR score, liver stiffness measurement at 3 months, first onset of cholangitis within 3 months, and jaundice clearance time were identified. The nomogram showed good discrimination and calibration in internal and external validation, outperforming individual predictors in predicting the prognosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Ana M. Calinescu, Omid Madadi-Sanjani, Cara Mack, Richard A. Schreiber, Riccardo Superina, Deirdre Kelly, Claus Petersen, Barbara E. Wildhaber
Summary: For the first time, there is an international consensus on guidelines for the definition, treatment, and prophylaxis of cholangitis during the first year after Kasai HPE. The study used the Delphi method, literature review, surveys, and expert panel discussions to establish these guidelines. The experts agreed on the elements to define cholangitis, the durations for prophylaxis and treatment, and the addition of positive blood culture to the definition of confirmed cholangitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Lee M. Bass, Wen Ye, Kieran Hawthorne, Daniel H. Leung, Karen F. Murray, Jean P. Molleston, Rene Romero, Saul Karpen, Philip Rosenthal, Kathleen M. Loomes, Kasper S. Wang, Robert H. Squires, Alexander Miethke, Vicky L. Ng, Simon Horslen, M. Kyle Jensen, Ronald J. Sokol, John C. Magee, Benjamin L. Shneider
Summary: The incidence of gastroesophageal variceal hemorrhage (VH) in biliary atresia (BA) patients is low and associated with features of portal hypertension and clinical parameters. The mortality rate of VH in this population is also relatively low. These findings should be considered in screening for varices and primary prophylaxis of VH.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haesung Yoon, Kyong Ihn, Jisoo Kim, Hyun Ji Lim, Sowon Park, Seok Joo Han, Kyunghwa Han, Hong Koh, Mi-Jung Lee
Summary: This study aimed to evaluate the feasibility of ultrasound shear wave elastography (SWE) for predicting hepatic fibrosis and native liver outcomes in patients with biliary atresia. The results showed that preoperative liver SWE can predict advanced hepatic fibrosis, and immediate postoperative liver SWE can predict poor native liver outcomes.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fatima Safira Alatas, Glen Lazarus, Michelle Clarissa Junaidi, Hanifah Oswari
Summary: This study aimed to assess the value of prophylactic antibiotics in reducing the risk of cholangitis following the Kasai hepatoportoenterostomy (HPE) procedure. The meta-analysis results showed that prophylactic antibiotics did not significantly reduce the incidence of cholangitis after Kasai HPE. There is conflicting evidence on their efficacy in prolonging native liver survival.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Pediatrics
Sindhu Pandurangi, Seung Kim, Akihiro Asai, Alexander Bondoc, William Balistreri, Kathleen Campbell, Alexander Miethke, Anna Peters, Michael Rogers, Amy Taylor, Suzanna Labib Attia, Troy Gibbons, Bhargava Mullapudi, Rachel Sheridan, Greg Tiao, Jorge A. Bezerra
Summary: This study aimed to evaluate the efficacy of personalized use of antibiotics and corticosteroids in patients with biliary atresia after surgery. The results showed that the personalized medication group had a significantly higher success rate of bile drainage compared to the conventional treatment group, and also maintained more native livers at 2 years. Therefore, personalized medication may help improve postoperative bile drainage.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Bingtian Dong, Zongjie Weng, Guorong Lyu, Xiaocen Yang, Huaming Wang
Summary: Ultrasound elastography shows good diagnostic accuracy for BA and can serve as a non-invasive tool to facilitate the differential diagnosis of BA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harim Kim, So-Young Yoo, Ji Hye Kim, Min-Ji Kim, Sanghoon Lee, Tae Yeon Jeon
Summary: The feasibility of using preoperative imaging indices to predict 2-year native liver survival after the Kasai procedure in patients with biliary atresia (BA) was investigated. The study found that preoperative ultrasound and/or MRI can enhance the prediction accuracy of native liver survival in BA patients after the Kasai procedure.
EUROPEAN RADIOLOGY
(2023)
Article
Pediatrics
Lyan H. Rodijk, Ruben J. de Kleine, Henkjan Z. Verkade, Behrooz J. Alizadeh, Marieke J. Witvliet, Jan B. F. Hulscher, Janneke L. M. Bruggnik
Summary: This study aimed to investigate anxiety, stress, and quality of life in parents of children diagnosed with biliary atresia (BA). The results showed that mothers of infants diagnosed with BA reported higher levels of anxiety, which decreased over time. Fathers did not significantly differ in anxiety or stress levels compared to reference values. The overall quality of life for parents was relatively unaffected after the diagnosis of BA in their child.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Cristina Mihaela Cepeha, Corina Paul, Andreea Borlea, Renata Bende, Monica Simina Mihuta, Dana Stoian
Summary: This study examined the elastographic differences between healthy thyroid parenchyma and those affected by chronic autoimmune thyroiditis (CAT) in children. The findings suggest that strain elastography can be used as a useful examination technique for diagnosing CAT in children, with good sensitivity and specificity.
APPLIED SCIENCES-BASEL
(2022)
Article
Pediatrics
Fanny Yeung, Adrian C. H. Fung, Patrick H. Y. Chung, Y. Y. Chu, W. K. Seto, Kenneth K. Y. Wong
Summary: This study found a strong correlation between the FibroScan (R) fibrosis score and the biochemical changes of liver fibrosis as well as the clinical development of portal hypertensive complications.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jia-Feng Wu, Chi -San Tai, Kai -Chi Chang, Huey -Ling Chen, Yen-Hsuan Ni, Hong-Yuan Hsu, Mei-Hwei Chang
Summary: This study found a close relationship between HBsAg titers in childhood and the development of advanced fibrosis in adulthood. Higher HBsAg titers in childhood were associated with a higher risk of advanced fibrosis in adulthood.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Hong-Yuan Hsu, Huey Ling Chen, Cheng Lun Chiang, Ming Wei Lai, Shu Chi Mu, Wan Hsin Wen, Shao Wen Cheng, Jen Jan Hu, Kai Chi Chang, Chien Nan Lee, Chun Jen Liu, Jia Feng Wu, Yen Hsuan Ni, Mei Hwei Chang
Summary: Maternal TDF therapy during late pregnancy can reduce the risk of HBV mother-to-infant transmission. Maternal genotype C and pre-S1 wild-type sequence at delivery are associated with infant IPF.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Surgery
Chu-Kuang Chou, Chien-Chuan Chen, Chieh-Chang Chen, Jia-Feng Wu, Wei-Chih Liao, Han-Mo Chiu, Hsiu-Po Wang, Ming-Shiang Wu, Ping-Huei Tseng
Summary: The study found that anti-reflux mucosal intervention is an effective and safe endoscopic treatment for PPI-dependent GERD, but there may be negative effects in some patients. Further research is needed to evaluate treatment response and avoid the detrimental effect of PPI discontinuation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Huey-Huey Chua, Mei-Hwei Chang, Ya-Hui Chen, Daw-Jen Tsuei, Yung-Ming Jeng, Po-Huang Lee, Yen-Hsuan Ni
Summary: We identified RBMY as a predictive biomarker for hepatocellular carcinoma metastasis. Provirus integration phosphorylates RBMY, leading to stabilized and translocated RBMY that promotes epithelial-mesenchymal transition and mitochondrial dysregulation in hepatocellular carcinoma, resulting in distant metastasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Chih-Hsiang Yu, Shiann-Tarng Jou, Ying-Hui Su, Elane Coustan-Smith, Gang Wu, Chao-Neng Cheng, Meng-Yao Lu, Kai-Hsin Lin, Kang-Hsi Wu, Shu-Huey Chen, Fang-Liang Huang, Hsiu-Hao Chang, Jinn-Li Wang, Hsiu-Ju Yen, Meng-Ju Li, Shu-Wei Chou, Wan-Ling Ho, Yen-Lin Liu, Chia-Ching Chang, Ze-Shiang Lin, Chien-Yu Lin, Hsuan-Yu Chen, Yu-Ling Ni, Dong-Tsamn Lin, Shu-Wha Lin, Jun J. Yang, Yen-Hsuan Ni, Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang
Summary: This study analyzed data from two consecutive protocols to determine the clinical impact of minimal/measurable residual disease (MRD) and tumor genetic subtypes in newly diagnosed pediatric acute lymphoblastic leukemia (ALL) patients. The results showed that MRD-directed therapy improved outcomes for pediatric ALL, especially for standard-risk patients. This study provides important data to inform the design of future clinical trials in Taiwan.
Article
Gastroenterology & Hepatology
Wei-Chen Lin, Wei-Chen Tai, Chung-Hsin Chang, Chia-Hung Tu, I-Che Feng, Ming-Jium Shieh, Chen-Shuan Chung, Hsu-Heng Yen, Jen-Wei Chou, Jau-Min Wong, Yu-Hwa Liu, Tien-Yu Huang, Chiao-Hsiung Chuang, Tzung-Jiun Tsai, Feng-Fan Chiang, Chien-Yu Lu, Wen-Hung Hsu, Fang-Jung Yu, Te-Hsin Chao, Deng-Chyang Wu, Ai-Sheng Ho, Hung-Hsin Lin, Chun-Lung Feng, Keng-Liang Wu, Ming-Wun Wong, Chien-Chih Tung, Chun-Chi Lin, Chia-Chang Chen, Huang-Ming Hu, Lung-Sheng Lu, Huann-Sheng Wang, I-Chen Wu, Hsin-Yu Kuo, Jia-Feng Wu, Hsiang Yao Shih, Yen-Hsuan Ni, Shu-Lun Tang, Peng-Hsu Chen, Shu-Chen Wei
Summary: This nationwide prospective registry study investigated the real-world effectiveness, safety, and persistence of vedolizumab (VDZ) in inflammatory bowel disease (IBD) patients in Taiwan. Disease relapse rates after VDZ discontinuation due to reimbursement restriction were assessed.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Way Seah Lee, Katsuhiro Arai, George Alex, Suporn Treepongkaruna, Kyung Mo Kim, Chee Liang Choong, Karen S. C. Mercado, Andy Darma, Anshu Srivastava, Marion M. Aw
Summary: Pediatric inflammatory bowel disease (PIBD) is increasing rapidly in the Asia-Pacific region, and current guidelines may not be applicable in this region. This position paper aims to provide an evidence-based approach to PIBD in the Asia-Pacific region, considering the unique disease characteristics and regional resources. Extensive literature search was performed to cover epidemiology, disease characteristics, management, and monitoring. Gastrointestinal infections, including tuberculosis, should be ruled out before diagnosing IBD, and the NUD15 gene may be a better predictor of leukopenia compared to TPMT in some Asian populations. The main considerations in using biologics in this region are high cost, access, and infectious risk, particularly tuberculosis. This position paper serves as a useful guide for clinicians in managing PIBD in the Asia-Pacific region.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chia-Chu Yeh, Chieh-Chang Chen, Chien-Chuan Chen, Ming-Lun Han, Jia-Feng Wu, Hsiu-Po Wang, Ming-Shiang Wu, Ping-Huei Tseng
Summary: This study aimed to evaluate the characteristics of the esophageal microbiome in achalasia patients and the changes before and after peroral endoscopic myotomy (POEM). The study found that there were distinct microbiome differences in achalasia patients, with an abundance of Lactobacillus. After POEM, the abundance of Lactobacillus decreased, and Neisseria increased. Further studies are needed to understand the long-term effects of these microbial changes.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chee-Seng Lee, Yen-Hsuan Ni, Huey-Ling Chen, Jia-Feng Wu, Hong-Yuan Hsu, Yin-Hsiu Chien, Ni-Chung Lee, Wuh-Liang Hwu, Ting-An Yen, Huey-Huey Chua, Yu-Ju Chen, Yu-Lin Wang, Mei-Hwei Chang
Summary: This study aimed to evaluate the potential of matrix metalloproteinase-7 (MMP-7) levels measured using the dried blood spot (DBS) method within 3 days of birth as a screening tool for biliary atresia (BA) patients. MMP-7 levels were significantly higher in BA patients compared to non-BA patients. DBS MMP-7 analysis can be used to distinguish BA from other conditions as early as 3 days of age.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Pediatrics
Chi -Bo Chen, Jacob Shujui Hsu, Pei-Lung Chen, Jia-Feng Wu, Huei-Ying Li, Bang -Yu Liou, Mei-Hwei Chang, Yen-Hsuan Ni, Wuh-Liang Hwu, Yin-Hsiu Chien, Yen -Yin Chou, Yao-Jong Yang, Ni-Chung Lee, Huey-Ling Chen
Summary: This study used advanced genetic analysis methods to assist in the clinical diagnosis of genetic liver diseases. A combined panel-WES approach was found to be efficient, with a diagnostic yield of 27.8% for 352 patients.
JOURNAL OF PEDIATRICS
(2023)
Letter
Medicine, General & Internal
Yu-Cheng Lin, Pi-Feng Chang, Yen-Hsuan Ni
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Pediatrics
Cheng-Yu Chen, Mei-Hwei Chang, Huey-Ling Chen, Yin-Hsiu Chien, Jia-Feng Wu
Summary: Compared with patients identified later based on the presence of cholestasis/hepatitis, patients identified early by newborn screening have less severe cholestasis and are cholestasis-free at a significantly younger age. A timely diagnosis is needed, along with follow-up examinations that assess metabolic profile and body weight, to improve the long-term prognosis of NICCD patients.
PEDIATRIC RESEARCH
(2023)