Article
Clinical Neurology
Woo-Jin Lee, Jun-Sang Sunwoo, Jung-Ick Byun, Han-Joon Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho H. Kim, Sang Kun Lee, Carlos H. Schenck, Ki-Young Jung
Summary: This study evaluated the frequency of symptom improvement in isolated REM sleep behavior disorder (iRBD) patients with coexisting obstructive sleep apnea (OSA) after positive airway pressure (PAP) treatment. The results suggest that respiratory events that co-occur with REM without atonia (RWA) may predict improvement in RBD symptoms after PAP treatment.
Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Rong Ren, Ye Zhang, Linghui Yang, Yuan Shi, Naima Covassin, Xiangdong Tang
Summary: This study aimed to quantify the independent association between arousals during REM/NREM sleep and prevalent hypertension. The results showed a significant dose-response relationship between arousal index during REM sleep and hypertension, while arousal index during NREM sleep was not a significant predictor of hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Hwa-Yen Chiu, Yung-Yang Liu, Tsu-Hui Shiao, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen
Summary: This study investigated the clinical features of REM-related obstructive sleep apnea (OSA) in Taiwan. The results showed that OSA patients with high REM-AHI/NREM-AHI ratio are associated with young age, female gender, high BMI, and low AHI. After adjusting for OSA severity, patients with REM-related OSA presented with longer desaturation duration and lower nadir oxygen saturation.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
Tetsuro Hoshino, Ryujiro Sasanabe, Kenta Murotani, Reiko Hori, Mamiko Mano, Atsuhiko Nomura, Noriyuki Konishi, Masayo Baku, Yoshitomo Nishio, Chihiro Kato, Wojciech Kuczynski, Toshiaki Shiomi
Summary: The study compared the proportion of individuals with a low respiratory arousal threshold between patients with REM and non-REM OSA, finding significantly higher rates in those with REM-predominant OSA and REM-isolated OSA. This suggests that a low respiratory arousal threshold may play a role in the pathogenesis of REM OSA, particularly in REM-isolated OSA.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Chun-Chao Chen, Cheng-Hsin Lin, Tsung Yeh Yang, Ta-Jung Wang, Shao-Jung Li, Yu-Ann Fang, Tzu-Jung Chen, Huey-En Tzeng, Chun-Chih Chiu, Wen-Rui Hao, Meng-Ying Lu, Ju-Chi Liu
Summary: This study found a strong relationship between sleep disorders and the risk of developing atrial fibrillation, with insomnia having a higher impact compared to other sleep disorders.
Article
Cardiac & Cardiovascular Systems
Michiel Delesie, Lieselotte Knaepen, Johan Verbraecken, Karolien Weytjens, Paul Dendale, Hein Heidbuchel, Lien Desteghe
Summary: This study demonstrates that home-worn PGs with an automated AHI algorithm can serve as OSA screening tools in AF patients. Different devices showed varying success rates in home monitoring, but all performed well in detecting clinically relevant OSA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raquel Lopez-Galvez, Jose Miguel Rivera-Caravaca, Dario Mandaglio-Collados, Esteban Orenes-Pinero, Alvaro Lahoz, Diana Hernandez-Romero, Carlos M. M. Martinez, Marina Carpes, Jose Maria Arribas, Sergio Canovas, Gregory Y. H. Lip, Francisco Marin
Summary: Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). In this study, the pathophysiological mechanisms of AF in patients with OSA were investigated. Biomarkers reflective of AF pathophysiology and miRNAs involved in AF were assessed. OSA patients exhibited a higher incidence of postoperative AF, dysregulated biomarkers and miRNAs, and increased interstitial fibrosis, all of which contribute to the development of a substrate that increases the AF risk.
Article
Clinical Neurology
Le Wang, Donghui Wei, Jing Zhang, Jie Cao, Xinxin Zhang
Summary: This cross-sectional study found a significant positive association between REM AHI and hypertension in OSA patients, with a more pronounced effect in female patients.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
So Young Lee, Soo Jeong Kim, Hyo Jae Kim, Sang-Ahm Lee
Summary: Obstructive sleep apnea (OSA) can lead to misdiagnosis of rapid eye movement (REM) sleep behavior disorder (RBD) on video-polysomnography (video-PSG). This study found that OSA was associated with lower diagnostic accuracy of RBD on video-PSG. Patients who underwent continuous positive airway pressure (CPAP) studies were more likely to be diagnosed with RBD compared to their initial video-PSG diagnosis.
Article
Medicine, General & Internal
Hajime Kumagai, Hiroyuki Sawatari, Tetsuro Hoshino, Noriyuki Konishi, Yuka Kiyohara, Kengo Kawaguchi, Hiroko Tsuda, Yoko Haseda, Ryujiro Sasanabe, Toshiaki Shiomi
Summary: This study focused on 27 patients with REM-related OSA and found that males had greater nocturnal blood pressure fluctuations compared to females. A high proportion of patients exhibited a non-dipping pattern in nocturnal blood pressure fluctuations. Despite slightly more severe clinical symptoms in females, nocturnal SBP fluctuations should be considered in male patients with REM-related OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jiasuoer Xiaokereti, Yan-Kai Guo, Zhen-Yu Dong, Mei Ma, Yan-Mei Lu, Yao-Dong Li, Xian-Hui Zhou, Ling Zhang, Bao-Peng Tang
Summary: Autonomic imbalance in obstructive sleep apnea plays a crucial role in atrial fibrillation. The study found that OSA significantly enhanced neural remodeling in the left stellate ganglion and left atrium, leading to increased AF inducibility.
Article
Oncology
Juanjuan Zou, Yupu Liu, Huajun Xu, Lili Meng, Jianyin Zou, Yingjun Qian, Bin Chen, Hongliang Yi, Jian Guan, Shankai Yin
Summary: This study found that the frequency of respiratory events during REM sleep is associated with insulin resistance in adults with suspected OSA, and REM sleep duration is independently associated with hyperinsulinemia.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Patrick L. Stafford, Evan Harmon, Paras Patel, McCall Walker, Nazem Akoum, Seung-Jung Park, Yeilim Cho, Kenneth Bilchick, Nishaki Mehta, Sula Mazimba, Yoonsik Cho, Younghoon Kwon
Summary: This study investigated the prevalence and associated factors of positional obstructive sleep apnea (POSA) in patients with atrial fibrillation (AF). The results showed that POSA prevalence was similar between patients with and without AF. Obesity and severe OSA were associated with lower odds of POSA, while male sex was associated with higher odds of POSA in patients with AF.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Vincent Mysliwiec, Matthew S. Brock, Kristi E. Pruiksma, Casey L. Straud, Daniel J. Taylor, Shana Hansen, Shannon N. Foster, Sara Mithani, Sarah Zwetzig, Kelsi Gerwell, Stacey Young-McCaughan, Tyler Powell, John A. Blue Star, Daniel G. Cassidy, Jim Mintz, Alan L. Peterson
Summary: This study aimed to characterize the sleep disorders of insomnia, obstructive sleep apnea (OSA), and comorbid insomnia and OSA (COMISA) in active duty military personnel. The results showed that military personnel with insomnia only and COMISA had more severe symptoms of sleep disorders, sleep-related impairment, fatigue, and psychiatric disorders compared to those with OSA alone. These findings highlight the importance of comprehensive assessment for sleep-related impairment, sleep, and comorbid disorders in military personnel with clinically significant sleep disturbances.
Article
Cardiac & Cardiovascular Systems
Sun Yong Lee, Isabel E. Allen, Celso Diaz, Xiaofan Guo, Cara Pellegrini, Ramin Beygui, Ricardo Cardona-Guarache, Gregory M. Marcus, Byron K. Lee
Summary: A meta-analysis compared the success and mortality rates of rotating and laser sheaths in transvenous lead extraction. The study found that laser sheaths had lower success rates and a 9.3-fold higher risk of death.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Nursing
Sukardi Suba, Thomas J. Hoffmann, Kirsten E. Fleischmann, Hildy Schell-Chaple, Priya Prasad, Gregory M. Marcus, Fabio Badilini, Xiao Hu, Michele M. Pelter
Summary: This study aims to examine the occurrence rate of specific types of PVC alarms and the association with patient demographic and clinical characteristics. Isolated PVCs were the most frequent type, while R-on-T was the least common. Age, gender, and presence of PVCs on the ECG were associated with higher alarm rates. Hyperkalaemia at ICU admission was associated with a lower occurrence of R-on-T PVCs. Further research is needed to explore the association of PVCs with adverse outcomes.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, John S. Gottdiener, Gregory M. Marcus
Summary: Cardiac conduction disease can lead to serious complications, but there are no established prevention strategies. A study found that older age, male sex, higher BMI, hypertension, and coronary heart disease were associated with a higher prevalence of conduction disease, while White race and more physical activity were associated with a lower prevalence. More physical activity was also associated with a reduced risk of incident conduction disease.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Valerie J. Block, Shuiting Cheng, Jeremy Juwono, Richard Cuneo, Gina Kirkish, Amber M. Alexander, Mahir Khan, Amit Akula, Eduardo Caverzasi, Nico Papinutto, William A. Stern, Mark J. Pletcher, Gregory M. Marcus, Jeffrey E. Olgin, Stephen L. Hauser, Jeffrey M. Gelfand, Riley Bove, Bruce A. C. Cree, Roland G. Henry
Summary: Remote activity monitoring has the potential to evaluate real-world, motor function, and disability at home. The relationships of daily physical activity with spinal cord white matter and gray matter areas, multiple sclerosis (MS) disability and leg function, are unknown.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Sarah E. E. Stern, Matthew A. A. Christensen, McKenna R. R. Nevers, Jian Ying, Caroline McKenna, Shannon Munro, Chanu Rhee, Matthew H. H. Samore, Michael Klompas, Barbara E. E. Jones
Summary: Comparing electronic surveillance criteria with manual assessments and diagnoses, we found that automated surveillance of non-ventilator-associated hospital-acquired pneumonia (NV-HAP) using electronic health record data is feasible and correlated moderately with manual surveillance criteria. The use of electronic surveillance allows for increased consistency and efficiency in monitoring NV-HAP.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Nursing
Sukardi Suba, Thomas J. Hoffmann, Kirsten E. Fleischmann, Hildy Schell-Chaple, Gregory M. Marcus, Priya Prasad, Xiao Hu, Fabio Badilini, Michele M. Pelter
Summary: In-hospital ECG monitors are commonly set to alarm for PVCs, but the association with VT is unknown. This study analyzed a large PVC alarm dataset to determine the correlation between PVCs identified during continuous monitoring and VT, IHCA, and death in ICU patients. The results suggest that there is no significant association between PVCs and VT or death, and the clinical relevance of activating PVC alarms as a forewarning of VT should be questioned.
RESEARCH IN NURSING & HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, Eric Vittinghoff, Gurbani Kaur, Tor Biering-Sorensen, Elsayed Z. Soliman, Gregory M. Marcus
Summary: This post hoc analysis found that targeting intensive blood pressure control was associated with a lower risk of developing left ventricular conduction disease.
Editorial Material
Cardiac & Cardiovascular Systems
Krishna Pundi, Gregory M. Marcus, Mintu Turakhia
Editorial Material
Cardiac & Cardiovascular Systems
Gregory M. Marcus
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Oncology
Gregory M. Marcus
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Judith A. Hahn, Robin Fatch, Nancy P. Barnett, Gregory M. Marcus
Summary: This study determined the optimal cutoff for phosphatidylethanol (PEth) in middle-age and older adults to detect heavy alcohol consumption, providing a reference for clinical diagnosis.
Article
Respiratory System
Scott A. Sands, Raichel M. Alex, Dwayne Mann, Daniel Vena, Philip Terrill, Laura K. Gell, Andrey Zinchuk, Tamar Sofer, Sanjay R. Patel, Luigi Taranto-Montemurro, Ali Azarbarzin, Michael Rueschman, David P. White, Andrew Wellman, Susan Redline
Summary: This study investigates the impact of obesity, age, sex, and race/ethnicity on the severity of sleep apnea. The study finds that obesity, male sex, older age, and Chinese ancestry are associated with increased severity of sleep apnea. Different subgroups exhibit different underlying pathophysiological pathways, providing multiple targets for intervention.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Computer Science, Information Systems
Jesse O. Wrenn, Matthew A. Christensen, Michael J. Ward
Summary: This study investigated the accuracy of measuring the Glasgow Coma Scale (GCS) in determining altered mentation in electronic health records (EHR). The results showed that there was modest agreement between eConfusion and provider documentation, but eConfusion had low sensitivity, making it unsuitable as a measure for altered mentation in clinical decision support tools in the emergency department (ED).
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Nhung Nguyen, Noah D. Peyser, Jeffrey E. Olgin, Mark J. Pletcher, Alexis L. Beatty, Madelaine F. Modrow, Thomas W. Carton, Rasha Khatib, Djeneba Audrey Djibo, Pamela M. Ling, Gregory M. Marcus
Summary: The study found that people who co-use tobacco and cannabis are more likely to suffer from anxiety and depression compared to single substance users or non-users. In particular, co-use of both substances was associated with the highest risk of poor mental health outcomes.
Meeting Abstract
Clinical Neurology
Valerie Block, Shuiting Cheng, Jeremy Juwono, Richard Cuneo, Gina Kirkish, Amber Alexander, Mahir Khan, Amit Akula, Eduardo Caverzasi, Nico Papinutto, William Stern, Mark Pletcher, Gregory Marcus, Jeffrey Olgin, Stephen Hauser, Jeffrey Gelfand, Riley Bove, Bruce Cree, Roland Henry