期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 34, 期 7, 页码 627-630出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2017.1423467
关键词
Leptin; kisspeptin; neurokinin B; precocious puberty; obesity
This study investigated the relationships of circulating leptin, kisspeptin, and neurokinin B (NKB) levels with precocious puberty (PP) in overweight/obese girls and evaluated the usefulness of these markers in the initiation of puberty. One hundred and twenty-eight girls aged 7.0-8.9years with PP (group A, normal-weight; group B, overweight/obese) and 30 age-matched normal controls (NC) were enrolled. Serum levels of leptin, kisspeptin, and NKB were measured by commercial kits. Serum leptin levels were higher in group A (4.21ng/mL) and B (5.64ng/mL) compared to the NC (2.35ng/mL, p<.001). Serum kisspeptin levels were lower in group A (0.59ng/mL) than in group B (0.66ng/mL, p=.018). Serum NKB levels were not different among the three groups. The predictive value of leptin (AUC =0.791) was lower than that of IGF-1 (AUC =0.917, p=.009), although both were significant markers for PP in the regression analysis. BMI z-score (AUC =0.806) was a predictive factor of PP. In conclusion, a higher level of leptin, IGF-1, and fatness in overweight/obese girls with PP compared to the NC confirms their roles in the regulation of puberty. Further research is needed if the effects of kisspeptin and NKB on puberty are limited at the levels of neurons or target tissue.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据