Article
Endocrinology & Metabolism
Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li
Summary: A retrospective cohort study on 110 patients with deep ovarian suppression found that a modified GnRH antagonist protocol based on LH levels during the second ovarian stimulation cycle resulted in significantly better reproductive outcomes compared to continuing with GnRH agonist long protocol. The use of modified protocol led to higher ongoing pregnancy and live birth rates, and lower cancellation rate, suggesting that patients may benefit from adjusting their treatment based on LH levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Kevin K. W. Kuan, Sean Omoseni, Javier A. Tello
Summary: This study compared the outcomes of assisted reproductive technology (ART) in women with endometriosis following the long GnRH-agonist protocol and the GnRH-antagonist protocol. The results showed that both protocols generally yielded similar pregnancy outcomes, but the long GnRH-agonist protocol may be associated with a higher cumulative pregnancy rate.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mu Lv, Juanjuan Yu, Peiqin Chen, Qimeng Xiao, Liqun Lou, Yifan Luo, Mu Yuan, Yuan Xu, Youji Feng, Mingzhu Bai, Zhenbo Zhang, Linxia Li
Summary: This study compares the efficacy of GnRH-ant protocol and GnRH-a protocol in IVF therapy for patients with severe male infertility factors. The results show that the GnRH-a protocol has a higher live birth rate and ongoing pregnancy rate, especially in single embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Erkan Kalafat, Engin Turkgeldi, Sule Yildiz, Merve Dizdar, Ipek Keles, Baris Ata
Summary: This study compared the use of GnRH agonist trigger after PPOS and GnRH antagonist ovarian stimulation cycles. The results showed that PPOS cycles had higher yields of mature oocytes and remaining blastocysts, but the cumulative ongoing pregnancy or live birth rates were similar between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Depeng Zhao, Rui Xie, Xuemei Li
Summary: This study aimed to compare the pregnancy outcomes after fresh embryo transfer in patients with thin endometrium using GnRH antagonist and GnRH agonist regimens. The results showed that in patients with thin endometrium, the rates of clinical pregnancy and live birth were significantly lower in the GnRH antagonist group compared to the GnRH agonist group. Multivariable regression analysis demonstrated that the GnRH agonist regimen was associated with a higher live birth rate compared to the GnRH antagonist protocol.
FRONTIERS IN MEDICINE
(2023)
Article
Genetics & Heredity
Jun Wang, Jing Zhang, Nan Zhao, Yuan Ma, Xiyi Wang, Xingqing Gou, Ying Ju, Hengde Zhang, Shuqiang Chen, Xiaohong Wang
Summary: This study compares the aneuploidy rates in early aborted tissues or blastocysts between IVF cycles using the GnRH antagonist protocol and the GnRH agonist long protocol. The results show a significantly higher aneuploidy rate in the GnRH antagonist group, especially in young and normal ovarian responders.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
Hoon Kim, Soo Jin Han, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim
Summary: The optimal number of oocytes for maximizing the rate of clinical pregnancy varies depending on the method of pituitary suppression. Too many oocytes may not lead to better clinical outcomes.
REPRODUCTIVE SCIENCES
(2021)
Review
Obstetrics & Gynecology
Baris Ata, Martina Capuzzo, Engin Turkgeldi, Sule Yildiz, Antonio La Marca
Summary: This review provides a comprehensive analysis of the mechanism, effectiveness, and cost-effectiveness of progestins for pituitary suppression in assisted reproductive technology (ART). Future research priorities have been identified to further explore the use of progestins in ART.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Medicine, General & Internal
Rihab Abbas Ali, Maher Abood Mukheef, Hind Hadi Majeed, Bahaa ALdeen Abdulrahman Hadi
Summary: The study compared two stimulation protocols for ICSI in good prognosis patients and found that the GnRH-antagonist protocol resulted in higher oocyte retrieval, lower risk of OHSS, and higher pregnancy rates compared to the GnRH-agonist protocol without significant differences.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2021)
Article
Genetics & Heredity
Jacob Christ, Christopher N. Herndon, Bo Yu
Summary: This study reported three cases of severe OHSS among oncofertility patients. Despite measures such as freezing embryos, patients still developed severe symptoms of OHSS. Therefore, caution should be exercised when deciding on treatment strategies for such patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Medicine, General & Internal
Michail Papapanou, Kalliopi Syristatidi, Maria Gazouli, Makarios Eleftheriades, Nikolaos Vlahos, Charalampos Siristatidis
Summary: Controlled ovarian hyperstimulation (COH) is crucial for successful in vitro fertilization (IVF). Personalized approaches to study patients' responses to different COH protocols are necessary. The mTOR and Hippo signaling pathways play important roles in follicular homeostasis and oocyte quality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ming-Xing Chen, Xiang-Qian Meng, Zhao-Hui Zhong, Xiao-Jun Tang, Tian Li, Qian Feng, Enoch Appiah Adu-Gyamfi, Yan Jia, Xing-Yu Lv, Li-Hong Geng, Lin Zhu, Wei He, Qi Wan, Yu-Bin Ding
Summary: The GnRH agonist long-acting protocol results in higher live birth rates for IVF/ICSI patients with different ages, ovarian reserves, and body mass indexes (BMI). However, the suitability of this protocol depends on the specific biological characteristics of the patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Oliver Pohl, Kyle Baron, Matthew Riggs, Jonathan French, Ramon Garcia, Jean-Pierre Gotteland
Summary: This study aimed to identify the appropriate dosage range of linzagolix to relieve endometriosis-related pelvic pain and protect bone health. The results suggested that a daily dose of 75-125 mg linzagolix may achieve the targets of pain relief, efficacy, and bone mineral density loss in Caucasian patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Tolga Atakul, Ahter Tanay Tayyar, Ozgur Deniz Turan, Serkan Yasar Celik, Mustafa Yilmaz, Mert Kucuk, Hasan Yuksel, Buket Demirci
Summary: This study evaluated the effect of GnRH agonist or GnRH antagonist therapy on bleomycin-administered rats by examining ovarian follicle counts and AMH levels. The results showed that the simultaneous administration of GnRH agonist or GnRH antagonist can reduce the harmful effects of bleomycin on ovarian reserve.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Lanlin Yang, Keli Luo, Guangxiu Lu, Ge Lin, Fei Gong
Summary: This study aimed to compare the euploidy rates in PGT-A cycles using oral dydrogesterone or GnRH antagonist protocol. In a retrospective cohort study, no significant differences were found between the two groups after propensity matching based on age, BMI, and AMH. Additionally, there were no significant differences in the number of oocytes retrieved, embryos biopsied, and embryo testing.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Obstetrics & Gynecology
Ana Raquel Neves, Pedro Montoya-Botero, Noemie Sachs-Guedj, Nikolaos P. Polyzos
Summary: The literature regarding the association between the number of oocytes retrieved and the cumulative live birth rate (CLBR) is conflicting. Some studies suggest a continuous increase in CLBR with more oocytes retrieved, while others find a plateau. The association between oocyte number and CLBR varies according to patients' age.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Panagiotis Drakopoulos, Yakoub Khalaf, Sandro C. Esteves, Nikolaos P. Polyzos, Sesh K. Sunkara, Daniel Shapiro, Botros Rizk, Hong Ye, Michael Costello, Yulia Koloda, Bruno Salle, Monica Lispi, Thomas D'Hooghe, Antonio La Marca
Summary: A high ovarian response refers to a greater number of follicles and/or oocytes compared to a normal response. It can be diagnosed before oocyte pick-up when there are >18-20 follicles ≥11-12 mm, or after oocyte pick-up when >18-20 oocytes have been retrieved. Women with a high response are at high risk of ovarian hyperstimulation syndrome (OHSS). Appropriate management strategies, such as individualized gonadotropin dosing, monitoring, and choice of protocols, can greatly reduce the risk of high response.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Milena Alec, Antonella Martino, Patrick Dallenbach, Jean-Marie Wenger, Nicola Pluchino
Summary: The study aims to demonstrate the feasibility of managing large endometriomas through a 2-step laparoscopic procedure. The first step involves ethanol sclerotherapy, followed by CO2 laser ablation and a 6-month follow-up. This approach helps preserve ovarian reserve, but further research is needed to evaluate its long-term effects.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Filipa Rafael, Maria Dias Rodrigues, Jose Bellver, Mariana Canelas-Pais, Nicolas Garrido, Juan A. Garcia-Velasco, Sergio Reis Soares, Samuel Santos-Ribeiro
Summary: For women with infertility and overweight/obesity, delaying infertility treatment to promote weight loss should consider female age. Substantial weight loss in a short period of time (3 months) seems to provide any benefit, particularly for women over 38 years old.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
F. Blavier, D. Grobet, C. Duflos, R. Rayssiguier, N. Ranisavljevic, M. Duport Percier, A. Rodriguez, C. Blockeel, S. Santos-Ribeiro, G. Faron, L. Gucciardo, F. Fuchs
Summary: Compared to the standard clinical approach, retrospective implementation of the new medical software in a gynaecological emergency unit was correlated with more accurate diagnosis and more cost-effective management.
HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Arnaud Zuber, Adriana Peric, Nicola Pluchino, David Baud, Milos Stojanov
Summary: The human body is colonised by microorganisms, including the genital tract which has been linked to male infertility and pathological conditions like prostate cancer. However, research on the microbiota of the male genital tract remains lacking due to difficulties in sampling and low abundance of microbiota. This narrative review aims to present the results of studies using next-generation sequencing to examine bacterial colonisation patterns in different anatomical compartments of the male genital tract and highlight their findings and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Shari Mackens, Francisca Pais, Panagiotis Drakopoulos, Samah Amghizar, Caroline Roelens, Lisbet Van Landuyt, Herman Tournaye, Michel De Vos, Christophe Blockeel
Summary: This retrospective cohort study aimed to investigate whether additional oral dydrogesterone supplementation improves reproductive outcomes in patients with low serum progesterone concentrations during frozen embryo transfer (FET) after artificial endometrial preparation. The study found that the live birth rate was comparable between patients who received additional oral dydrogesterone supplementation and those who continued with the routine protocol.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Medicine, General & Internal
Valeria Donno, Sandra Garcia-Martinez, Nikolaos P. Polyzos
Summary: This retrospective observational study analyzed 5190 ovarian stimulation cycles and found no association between patients' BMI or weight and the efficiency of different types of triggers to induce final oocyte maturation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
K. Lundin, J. G. ESHRE Addons Working Grp, J. G. Bentzen, G. Bozdag, T. Ebner, J. Harper, N. Le Clef, A. Moffett, S. Norcross, N. P. Polyzos, S. Rautakallio-Hokkanen, I Sfontouris, K. Sermon, N. Vermeulen, A. Pinborg
Summary: This study focused on the safety and efficacy of add-ons used in ART treatment. The study formulated 42 recommendations covering various aspects such as diagnosis, laboratory tests, and clinical management. However, most of the recommendations were based on low-quality evidence.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Mina Popovic, Lorena Borot, Aline R. Lorenzon, Ana Luiza Rossi de Castro Lopes, Denny Sakkas, Belen Lledo, Ruth Morales, Jose Antonio Ortiz, Nikolaos P. Polyzos, Monica Parriego, Felicitas Azpiroz, Micaela Galain, Aida Pujol, Bjorn Menten, Lien Dhaenens, Frauke Vanden Meerschaut, Dominic Stoop, Maria Rodriguez, Enrique Perez de la Blanca, Amelia Rodriguez, Rita Vassena
Summary: The diagnosis of mosaicism affects the ploidy rates across different providers offering preimplantation genetic testing for aneuploidies (PGT-A), with providers reporting low rates of mosaicism having significantly higher euploidy rates.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
P. Verdyck, G. Altarescu, S. Santos-Ribeiro, C. Vrettou, U. Koehler, G. Griesinger, V Goossens, C. Magli, C. Albanese, M. Parriego, L. Coll, R. Ron-El, K. Sermon, J. Traeger-Synodinos
Summary: The study found that known chromosome segregation errors accounted for 90.4% of abnormal chromosome copy numbers in polar bodies of oocytes from women of advanced maternal age. These errors were associated with impaired embryo development.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Noemie Sachs-Guedj, Buenaventura Coroleu, Maria Angela Pascual, Ignacio Rodriguez, Nikolaos Polyzos
Summary: The presence of adenomyosis has a significant negative impact on the clinical outcomes of patients undergoing frozen embryo transfer (FET), leading to higher miscarriage rates, lower clinical pregnancy rates, and lower live birth rates. The use of GnRH agonist pre-treatment does not appear to improve clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Samuel Santos-Ribeiro, Catarina M. Godinho, Sergio Reis-Soares
Summary: Frozen embryo transfers (FET) are gaining popularity in assisted reproductive technology (ART) due to advancements in cryopreservation techniques and the 'freeze-all' strategy. The debate between artificial or natural cycles for FET preparation continues, but natural cycle FETs offer promising outcomes and increased convenience for patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Biology
Romualdo Sciorio, Nicola Pluchino, Barry J. Fuller
Summary: The use of oocyte cryopreservation has significantly increased in recent years, with advancements in vitrification techniques and cryoprotectants improving clinical infertility treatment. Biosafety concerns arise due to potential contamination from liquid nitrogen, and research suggests the need to further understand the impact of vitrification-induced stress on epigenetic modifications. It is important to explore the benefits, efficiency, and potential long-term consequences of human oocyte vitrification for offspring health.