Article
Immunology
Yufei Huang, Shumin Yan, Xiaoyu Dong, Xue Jiao, Shuang Wang, Dong Li, Guoyun Wang
Summary: Changes in peritoneal macrophages contribute to the homeostasis of the peritoneal immune microenvironment in endometriosis. MST1 deficient macrophages may accelerate the autophagy of ectopic endometrium via IL-10 regulated by miR-887-5p.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Chieh Chen, Yung-Che Chou, Chia-Yi Hsu, Eing-Mei Tsai, Tze-Kiong Er
Summary: In this study, RNA sequencing analysis was used to identify a potential pathogenic gene of endometriosis. The differentially expressed genes were found to be enriched in several signaling pathways, providing new insights into the underlying mechanisms of endometriosis.
Article
Biochemistry & Molecular Biology
Liansuo Zhang, Wei Shao, Mingqing Li, Songping Liu
Summary: ITGB3 is upregulated in ectopic endometrial stromal cells (ESCs) and interacts with ITCH, which regulates cell proliferation and invasion abilities through ubiquitination.
Article
Endocrinology & Metabolism
Lili Dong, Gaiwen Liu, Huiying Xiao
Summary: The DLK1/IGF-2 axis is potentially involved in the pathogenesis of endometriosis, regulating the viability, migration, and adhesion of endometrial stromal cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Obstetrics & Gynecology
Yanqing Ren, Xinru Wang, Jinyu Guo, Di Wang, Xinhua Li, Xiumei Cheng, Xinguo Wang
Summary: Increased expression of CHCHD2 in endometriotic tissues may contribute to the pathogenesis of endometriosis via regulating mitochondrial function and apoptosis, and CHCHD2 may be a potential target for interrupting the development of endometriosis.
REPRODUCTIVE SCIENCES
(2022)
Article
Immunology
Laihua Hu, Jinghe Zhang, Yichen Lu, Binqing Fu, Weiping Hu
Summary: This study reveals the significant role of estrogen receptor beta (ER beta) in the progression of endometriosis. The binding of ER beta to the CD47 promoter promotes its expression, highlighting the importance of the ER beta-CD47 axis in the pathogenesis of endometriosis. Targeting CD47 may provide a novel therapeutic approach for treating endometriosis and other ER beta-associated diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Meng Wei, Fang Wang, Lihong Shang, Ting Hao, Chunfang Ha
Summary: This study found that NF-KBp65 is regulated by the RAS/MEK/ERK signaling pathway to promote the proliferation and invasion of endometrial stromal cells. These results provide multiple potential targets for non-hormonal therapy for endometriosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Alina M. Gamisonia, Marina N. Yushina, Irina A. Fedorova-Gogolina, Mikhail G. Akimov, Chupalav M. Eldarov, Stanislav Pavlovich, Vladimir V. Bezuglov, Natalia M. Gretskaya, Gennady T. Sukhikh, Mikhail Yu. Bobrov
Summary: The study found that N-arachidonoyldopamine, N-docosahexaenoyldopamine, and N-oleoyldopamine have a higher selective cytotoxic effect on endometrioid stromal cells, possibly inducing apoptosis through an intrinsic pathway, which provides hope for further research of these compounds as potential therapeutic agents against endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Fengyuan Qian, Tianjin Tang, Shiquan Wang, Bin Wang, Lei Wang, Hengliang Shi
Summary: The study revealed that CacyBP/SIP promotes the degradation of p53 by interacting with p53 and Mdm2, disrupting normal regulation in p53 mutant cells. In wildtype cells, CacyBP/SIP did not have a promoting effect on cell proliferation.
Article
Endocrinology & Metabolism
Xi Wang, Mengmeng Zhang, Liaofei Jiang, Xiaoling Fang, Tingting Zhang
Summary: In this study, the clinical implications of actin filament associated protein 1-antisense RNA 1 (AFAP1-AS1) in endometriosis (EMS) were investigated. It was found that high expression of AFAP1-AS1 and BCL9, as well as low expression of miR-15a-5p, were observed in EMS. Exosomes derived from endometrial stromal cells (ESCs) were found to deliver AFAP1-AS1 to ESCs, promoting their proliferation, migration, and invasion. AFAP1-AS1 bound to BCL9, which was targeted by miR-15a-5p in EMS. Inhibition of exosomal AFAP1-AS1 suppressed migration and invasion of ESCs through miR-15a-5p/BCL9. These findings suggest that ESCs-derived exosomes carrying AFAP1-AS1 contribute to the pathogenesis of EMS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Li, Xiaolin Lv, Mei Jiang, Zhili Jin
Summary: This study demonstrates that Sitagliptin possesses a protective effect against hypoxia-induced damages in endometrial stromal cells by suppressing inflammation and oxidative stress.
Article
Cell Biology
Guojing Li, Yu Lin, Yili Zhang, Nihao Gu, Bingxin Yang, Shan Shan, Na Liu, Jing Ouyang, Yisai Yang, Feng Sun, Hong Xu
Summary: Endometriosis, a chronic disorder characterized by abnormal distribution of tissue, can cause iron overload and oxidative stress. The study found that ferroptosis of endometrial stromal cells can trigger the secretion of cytokines, promoting angiogenesis in adjacent lesions. VEGFA and IL8, important angiogenic factors, are upregulated in ectopic lesions. These findings provide a rationale for clinical practice and drug development for endometriosis.
CELL DEATH DISCOVERY
(2022)
Article
Endocrinology & Metabolism
Ziyu Zhang, Yaoqing Wang, Liqin Zeng, Kaihui Yu, Yuanqin Wang, Yong Luo, Faying Liu, Bicheng Yang, Yang Zou, Liqun Wang, Ouping Huang
Summary: miR-218-5p inhibits the migration of ectopic endometrial stromal cells by inhibiting LASP1 expression in the endometrial microenvironment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Immunology
Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang, Yongdong Dai
Summary: This study suggests that the occurrence of endometriosis may be associated with the interaction between macrophages and endometrial stromal cells, promoting the development of endometriotic lesions by activating the NLRP3 inflammasome.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Jinggang Li, Xiaofei Guan, Chongyun Xu, Jingyun Jia, Ling Zhang, Hui Han
Summary: This study found that miR-206 is downregulated in EM and miR-206 mimic inhibits cell proliferation, migration, and invasion while promoting cell apoptosis in EM. Furthermore, miR-206 inhibits tumor growth in vivo. Additionally, MALAT1 is upregulated in EM and is indicated to be a target of miR-206.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
