期刊
GUT AND LIVER
卷 12, 期 2, 页码 158-164出版社
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl17063
关键词
Gastric juice; Helicobacter pylori; Gastritis; atrophic; Intestinal metaplasia
资金
- National Research Foundation of Korea (NRF) - Korean Government [2012R1A1B5002680]
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1 beta levels were measured. Results: The mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH <3 (n=28) and pH >= 3 (n=18) groups, H. pylori was lower in the pH <3 group (21.4%) than in the pH >= 3 group (61.1%) (p=0.007). The pH >= 3 group demonstrated AG and IM more frequently than the pH <3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1 beta levels between the two groups. Conclusions: There is a relationship between chronic H. pylori infection and gastric juice pH >= 3, which may originate from AG and IM in the body.
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