Article
Chemistry, Multidisciplinary
Rong Hu, Yigao Tao, Xiaofeng Zhang, Weiping Su
Summary: In this study, a copper-catalyzed cascade reaction was reported, which produced novel γ-lactams through 1,2-aryl migration with a broad substrate scope and high yields. Mechanistically, the 1,2-aryl migration may be derived from the intramolecular amide C-N bond formation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Samir Z. Zard
Summary: This brief review discusses various approaches to synthesizing six-membered carbocyclic architectures using the unique radical chemistry of xanthates. These methods include modifying existing cyclohexane building blocks, combining xanthate chemistry with classical ionic reactions, and direct ring closure. The complex structures presented in this review would be challenging to obtain using traditional methods.
JOURNAL OF CHEMICAL RESEARCH
(2022)
Review
Chemistry, Organic
Preeti, Krishna Nand Singh
Summary: This report highlights the progress and advantages of metal-free multicomponent reactions in synthesizing moncyclic six-membered N-heterocycles, including pyridine, pyrimidine, pyrazine, triazine and their hydrogenated derivatives. The literature since 2000 not only offers diverse methods for synthesis of these heterocycles, but also provides new insights into the exploration of metal-free multicomponent chemistry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Thorsten Kinsinger, Uli Kazmaier
Summary: The Matteson homologation is a versatile tool for the synthesis of polyunsaturated alkyl boronic esters, which can be used as precursors for constructing carbocycles. The high diversity of the Matteson reaction allows for the preparation of highly substituted cyclic boronic esters, suitable for further reactions.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Organic
Anup Biswas, Avisek Ghosh, Rajat Shankhdhar, Indranil Chatterjee
Summary: Chiral analogues of squaramides have proved to be efficient asymmetric catalysts in the synthesis of acyclic and cyclic chiral molecules. By utilizing several bifunctional squaramides as catalysts, a wide range of cyclic molecules bearing multiple functionalities and stereocenters have been successfully synthesized.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yulia Volkova, Igor Zavarzin
Summary: Heterocycles functionalized with pentavalent phosphorus are of great importance in various fields. This review focuses on the synthetic strategies towards aromatic monocyclic six-membered N-heterocycles bearing phosphonates and phosphine oxides, which have been reported from 2012 to 2022.
Review
Chemistry, Multidisciplinary
Jiatong Li, Ao Gu, Xiao-Mei Nong, Shuyang Zhai, Zhu-Ying Yue, Meng-Yao Li, Yingbin Liu
Summary: This review provides a comprehensive summary of the synthesis and clinical implications of six-membered aromatic nitrogen heterocyclic anti-tumor agents. It includes the synthesis pathways of pyridine, quinoline, pyrimidine, and quinazoline, as well as the historical progression, targets, mechanisms of action, and clinical effectiveness of small molecule inhibitors possessing these structural features.
Article
Chemistry, Multidisciplinary
Alessandra Lattanzi
Summary: The development of organocatalysis and the use of Michael addition reaction have greatly contributed to the synthesis of quaternary stereocenters and the preparation of functionalized building blocks. In this account, the authors highlight their achievements in accessing novel heterocycles with quaternary stereocenters, particularly focusing on the use of organocatalysis derived from Cinchona alkaloids. The enantioenriched heterocycles obtained were further manipulated to prepare useful compounds for downstream applications.
Article
Chemistry, Applied
Arianna Quintavalla, Ruben Veronesi, Davide Carboni, Ada Martinelli, Nelsi Zaccheroni, Liviana Mummolo, Marco Lombardo
Summary: A new synthetic method has been developed for the generation of 2,3-dihydrofurans or beta,gamma-unsaturated ketones starting from alpha-halo ketones and alkenes catalysed by Ir(ppy)(3) under visible-light irradiation. The redox-neutral nature of the process and mild reaction conditions make it sustainable by avoiding the use of sacrificial reactants and stoichiometric strong oxidants. Detailed mechanistic pathways have been disclosed through experimental investigations and DFT calculations, showing that the synthesis can be directed towards different products depending on the substrates and experimental conditions chosen.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Lu Yang, Xiayu Liang, Yuyang Ding, Xinran Li, Xuefeng Li, Qingle Zeng
Summary: This review presents recent transition metal catalyzed transformations for the synthesis of chiral five- and six-membered benzo oxygen heterocycles and discusses in detail the reaction mechanisms and processes for chirality transfer or control.
Article
Chemistry, Organic
Nicolas Jamey, Laurent Ferrie
Summary: This study reports the ring expansion reaction of cyclobutanols with molecular oxygen and the generalization of ring contraction through a rearrangement reaction. It also reveals the difference in stability between 1,2-dioxane and 1,2-dioxolane against organic bases.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Inorganic & Nuclear
Dewmi A. Ekanayake, Arundhoti Chakraborty, Jeanette A. Krause, Hairong Guan
Summary: This study identified a series of copper borohydride complexes capable of catalyzing the hydrogenation of aldehydes, with some catalyst mixtures showing higher efficiency, although certain functional groups may inhibit the reaction. Modifying the catalyst structure can impact its catalytic activity.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Yan Gao, Qianyi Zhao, Lixin Li, Yan-Na Ma
Summary: The article discusses the synthesis of various N-heterocycles through intramolecular oxidative C-N bond formation as well as the mechanism study, providing new insights for the preparation of N-heterocycles.
Article
Chemistry, Multidisciplinary
Xiaoli Jiang, Feng-Tao Sheng, Yao Zhang, Gao Deng, Shaolin Zhu
Summary: Designing ligands in transition-metal catalyzed reactions is challenging. In this study, researchers applied the concept of combining multiple ligands to enhance catalytic efficiency and selectivity. As a result, they successfully achieved asymmetric remote hydroacylation and migratory acylation reactions to synthesize chiral α-aryl ketones.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Organic
Navjeet Kaur, Pranshu Bhardwaj, Mansi Gupta
Summary: Various diketones and dicarbonyl compounds play significant roles in the synthesis of core heterocyclic compounds and also act as chelating ligands. Organic chemists have focused on the synthesis of nitrogen-containing heterocyclic compounds.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Jagadish Das, Mari Vellakkaran, Debasis Banerjee
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Anitha Alanthadka, Sourajit Bera, Debasis Banerjee
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Jagadish Das, Mari Vellakkaran, Motahar Sk, Debasis Banerjee
Article
Chemistry, Organic
Anitha Alanthadka, Sourajit Bera, Mari Vellakkaran, Debasis Banerjee
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Motahar Sk, Ashish Kumar, Jagadish Das, Debasis Banerjee
Article
Chemistry, Organic
Sourajit Bera, Atanu Bera, Debasis Banerjee
Review
Chemistry, Organic
Mari Vellakkaran, Sungwoo Hong
Summary: Organic photocatalysis has gained attention for generating active radical species under mild conditions. Quinolinones and coumarins are widely distributed and promising organic photosensitizers, leading to the development of highly site-selective synthetic methods. Innovative approaches using light-absorbing quinolinone and coumarin scaffolds have been highlighted for site-selective C-H bond functionalization.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mari Vellakkaran, Taehwan Kim, Sungwoo Hong
Summary: This study presents a general strategy for site-selective C-H functionalization of heteroarenes, specifically achieving high site selectivity at the C4 position of pyridines through visible-light-induced beta-carbonyl alkylation. The method enables the synthesis of valuable beta-pyridylated (aryl)ketones, aldehydes, and esters with broad functional-group tolerance, serving as an effective tool for late-stage functionalization of complex and medicinally relevant molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Lalit Mohan Kabadwal, Sourajit Bera, Debasis Banerjee
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Sourajit Bera, Atanu Bera, Debasis Banerjee
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Jagadish Das, Mari Vellakkaran, Debasis Banerjee
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.