Article
Nutrition & Dietetics
Natalia Yeste, Jorge Perez-Valle, Ana Heras-Molina, Jose Luis Pesantez-Pacheco, Esteban Porrini, Antonio Gonzalez-Bulnes, Anna Bassols
Summary: Intrauterine Growth Restriction (IUGR) affects the normal growth of the fetus during pregnancy and can lead to neurological and cognitive deficits. A high-fat diet has harmful effects on brain function. Research using a pig model of IUGR found that the susceptibility to a high-fat diet may differ between animals with IUGR and normal birth-weight animals in adulthood, with the high-fat diet affecting the serotoninergic pathway. However, the morphology of the hippocampus was not significantly changed.
Article
Geriatrics & Gerontology
Jeremy Ebersole, Gregory Rose, Tore Eid, Kevin Behar, Peter Patrylo
Summary: The age-related decrease in hippocampal metabolism is correlated with cognitive decline. However, the resting state neural metabolism and GLU-GLN cycling may be preserved during aging. Enhanced astroglial metabolism observed in aged cognitively-unimpaired rats may serve as a compensatory change to maintain hippocampus-dependent cognitive function.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Chen-Hua Huang, Yi-Long Huang, Zhao-Qing Shen, Chao-Hsiung Lin, Ting-Fen Tsai
Summary: Cisd2 protects the liver from age-related fat accumulation, ameliorates dysregulation of lipid metabolism and protein homeostasis, and is considered a novel molecular target for therapies targeting fatty liver diseases. It is likely to prevent malignant progression to cirrhosis and hepatocellular carcinoma.
Article
Chemistry, Multidisciplinary
Ayano Kato, Iori Sakakibara, Taku Fukushima, Kosuke Sugiura, Tomoya Fukawa, Takeshi Nikawa, Takayuki Uchida
Summary: This study analyzed the effect of different glucose concentrations on protein expression in muscle cells and found that low and medium glucose concentrations can enhance glucose utilization and induce myosin expression.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Giulio E. Brancati, Chahinaz Rawas, Antoine Ghestem, Christophe Bernard, Anton I. Ivanov
Summary: The hippocampus in control mice shows spatial and time-dependent differences in energy metabolism along the dorsoventral axis, with changes in metabolic activity between morning and afternoon. In an epilepsy model, this spatiotemporal organization is significantly altered, with enhanced aerobic glycolysis in both dorsal and ventral parts in the afternoon when seizure probability is high. This suggests that energy metabolism is tailored to the functions performed by brain networks and alterations in pathological conditions may contribute to network dysfunctions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Rongrong Lu, Xu Wang, Wenting Zhao, Pan Wang, Shuang Zhao, Xiaoyan Zhao, Dan Wang
Summary: This study investigated the regulatory mechanism of low temperature on garlic greening using transcriptome and proteome analysis. The results showed that low temperature storage promoted metabolic processes and energy metabolism, helping garlic to respond to oxidative stress and prepare for pigment synthesis.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Mingsheng Zhu, Weiwei Shen, Jiemei Li, Nan Jia, Yabing Xiong, Jinhua Miao, Chao Xie, Qiyan Chen, Kunyu Shen, Ping Meng, Xiaolong Li, Qinyu Wu, Shan Zhou, Maosheng Wang, Yaozhong Kong, Lili Zhou
Summary: Aging is a risk factor for kidney injury, and energy homeostasis and mitochondria play important roles in delaying aging. AMPK, a serine/threonine kinase, regulates energy and mitochondrial homeostasis as well as autophagy. In this study, the direct AMPK activator O304 was found to protect against cellular senescence and aged-related fibrosis in the kidneys, while restoring energy metabolism, promoting autophagy, and preserving mitochondrial homeostasis. Transcriptomic sequencing confirmed that O304 induced beneficial pathways and downregulated aging-related processes. This suggests that O304 has potential as a therapeutic approach to delay kidney aging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Turner H. Swartz, Uzi Moallem, Hadar Kamer, Gitit Kra, Yishai Levin, Laman K. Mamedova, Barry J. Bradford, Maya Zachut
Summary: Negative energy balance in early lactation dairy cows is associated with metabolic disorders, leading to altered liver proteome characterized by shifts in hepatic protein abundance involved in fatty acid uptake, impaired anti-inflammatory responses, and mitochondrial dysfunction. Differentially abundant proteins identified in this study may serve as potential biological markers for disease or targets for improving metabolic adaptations in postpartum dairy cattle.
JOURNAL OF PROTEOMICS
(2021)
Article
Rehabilitation
Alice S. Ryan, Maria Novitskaya, Alice L. Treuth
Summary: This study compared the resting metabolic rate (RMR) of stroke survivors with predicted RMR values using equations developed for adults without stroke. The results showed that the predicted RMR values were significantly higher than the measured RMR, suggesting that the existing equations are not suitable for the stroke population. The study highlights the need for the development of more accurate predictive equations and provides support for modifying nutritional intake guidelines for patients with muscle atrophy conditions.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Neurosciences
Yujuan Zhou, Xu Wang, Yingying Liu, Yulu Gu, Renjun Gu, Geng Zhang, Qing Lin
Summary: Alzheimer's disease (AD) is a degenerative disease of the central nervous system that causes progressive loss of cognitive functions and impacts the daily life of patients. Adult hippocampal neurogenesis (AHN) in the dentate gyrus of the hippocampus plays a crucial role in learning and memory functions. In AD, AHN is affected to different extents at different times, and understanding its molecular mechanisms can contribute to the research for better diagnostics and treatments for AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biology
Stefanny Villalobos-Cantor, Ruth M. Barrett, Alec F. Condon, Alicia Arreola-Bustos, Kelsie M. Rodriguez, Michael S. Cohen, Ian Martin
Summary: Controlled protein synthesis is crucial for regulating gene expression in a cell type-specific manner. We developed a new method to specifically label and visualize newly-synthesized proteins in targeted cell populations in the fly brain, allowing for quantitative analysis of protein synthesis states in vivo.
Article
Biochemistry & Molecular Biology
Alyssa Tidmore, Sucharita M. Dutta, Arriyam S. Fesshaye, William K. Russell, Vania D. Duncan, Richard A. Britten
Summary: Exposure to space radiation can impair spatial memory in rodents, with individual susceptibility to this impairment varying. Proteomic profiling revealed unique protein signatures associated with spatial memory performance, and exposure to radiation resulted in changes in protein ubiquitination levels in the hippocampal proteome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Minghao Yuan, Yangyang Wang, Shengyuan Wang, Zhenting Huang, Feng Jin, Qian Zou, Jing Li, Yinshuang Pu, Zhiyou Cai
Summary: The neuro-glia-vascular unit (NGVU) plays a crucial role in neurodegenerative diseases, particularly in relation to aging, offering new directions for future research.
Article
Environmental Sciences
Claudia Raposo de Magalhaes, Denise Schrama, Chatsirin Nakharuthai, Surintorn Boonanuntanasarn, Dominique Revets, Sebastien Planchon, Annette Kuehn, Marco Cerqueira, Raquel Carrilho, Ana Paula Farinha, Pedro M. Rodrigues
Summary: Hepatic metabolic adjustments in fish are crucial in enhancing energy availability to combat stressors. Teleosts display a diversity of metabolic responses based on species biology and individual experiences. Prolonged stress triggers complex molecular responses, impacting various metabolic pathways in the liver.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Neurosciences
Junke Jia, Wanjiang Tao, Ting Chen, Qi Zhong, Jiahui Sun, Yutong Xu, Xiaokai Sui, Chang Chen, Zongze Zhang
Summary: This study investigates the role of SIRT6 in modulating hippocampal neurogenesis and energy metabolism following sleep deprivation. The findings suggest that sleep deprivation inhibits hippocampal neurogenesis, reduces dendritic spine density, impairs memory, and disrupts energy metabolism. Furthermore, the study demonstrates that SIRT6 overexpression in the dentate gyrus alleviates the neurogenic and memory impairments caused by sleep deprivation by restoring energy metabolism homeostasis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kinga Gostomska-Pampuch, Dominika Drulis-Fajdasz, Agnieszka Gizak, Jacek R. Wisniewski, Dariusz Rakus
Summary: The decline in cognitive functions in aging may be related to changes in energy metabolism. Quantitative analysis of protein levels in brain structures of young and aged mice revealed significant differences in proteins involved in energy metabolism pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Izabela Figiel, Ewa Baczynska, Tomasz Wojtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Wlodarczyk
Summary: This study reveals that the deletion of DG in rat hippocampal cell cultures leads to significant changes in the density and morphology of dendritic spines, accompanied by a decrease in laminin and aquaporin 4. However, silencing of DG does not affect synaptic transmission or Psd-95 protein expression, suggesting the existence of unknown mechanisms to maintain proper synaptic signaling despite impaired structure of dendritic spines. Presumably, astrocytes are involved in these processes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
James Andrew McCubrey, Stephen L. Abrams, Linda S. Steelman, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Paolo Lombardi, Agnieszka Gizak, Przemyslaw Duda
Summary: The study indicates that TP53 reactivator APR-246 can increase the therapeutic potential of many modified berberine compounds, which is of significance for pancreatic ductal adenocarcinoma.
Article
Cell Biology
Stephen L. Abrams, Przemyslaw Duda, Shaw M. Akula, Linda S. Steelman, Matilde L. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Maria Rita Emma, Melchiorre Cervello, Dariusz Rakus, Agnieszka Gizak, James A. McCubrey
Summary: TP53 mutation is common in pancreatic cancer and promotes tumor growth and metastasis. APR-246, a molecule that restores wildtype TP53 function, can increase the sensitivity of PDAC cells to chemotherapy. Introduction of WT-TP53 enhances sensitivity to TP53 reactivators, chemotherapeutic drugs, and signal transduction inhibitors in PDAC cells.
Article
Cell Biology
Lukasz Pietras, Ewa Stefanik, Dariusz Rakus, Agnieszka Gizak
Summary: This study demonstrates that the oligomeric state of the multifunctional protein FBP2 is crucial for its physiological roles in cardiomyocytes. By chemically inducing a reduction in the FBP2 dimer-tetramer ratio, the interaction between FBP2 and mitochondria is restricted, leading to increased Tau phosphorylation, enhanced FBP2-Tau and FBP2-MAP1B interactions, disturbance of tubulin network, slowed mitochondrial trafficking, and increased mitophagy.
Article
Chemistry, Analytical
Natalia Pudelko-Malik, Jerzy Wisniewski, Dominika Drulis-Fajdasz, Piotr Mlynarz
Summary: A liquid chromatography-mass spectrometry method was developed to quantitatively analyze the presence of a chemical compound in mouse tissues. The study found that the compound is not only present in the liver, heart, and skeletal muscle, but also in different regions of the brain.
JOURNAL OF SEPARATION SCIENCE
(2022)
Review
Cell Biology
Anna Buszka, Agata Pytys, Domnic Colvin, Jakub Wlodarczyk, Tomasz Wojtowicz
Summary: Protein lipidation, specifically S-palmitoylation, is a common post-translational modification that regulates protein trafficking in membranes and has essential roles in human physiology and brain function. Recent experimental studies have shed light on the discrete molecular switch function of protein S-palmitoylation within minutes to hours, expanding protein functions and subcellular localization. This review focuses on the impact of protein palmitoylation on functional changes in synapses associated with neuronal activity and plasticity, highlighting its crucial role in learning, memory, and cognitive functions.
Editorial Material
Cell Biology
Agnieszka Gizak
Article
Cell Biology
Dominika Drulis-Fajdasz, Adam Krzystyniak, Alicja Puscian, Agata Pytys, Kinga Gostomska-Pampuch, Natalia Pudelko-Malik, Jerzy L. Wisniewski, Piotr Mlynarz, Arkadiusz Miazek, Tomasz Wojtowicz, Jakub Wlodarczyk, Kamila Dus-Szachniewicz, Agnieszka Gizak, Jacek R. Wisniewski, Dariusz Rakus
Summary: Inhibition of glycogen breakdown improves memory formation in old mice by stimulating neuroplasticity and affecting hippocampal proteome. However, in young animals, inhibition of glycogen degradation impairs memory formation without significant effects on cortical dendritic spines.
Meeting Abstract
Biochemistry & Molecular Biology
D. Drulis-Fajdasz, A. Krzystyniak, K. Gostomska-Pampuch, J. R. Wisniewski, N. Pudelko-Malik, J. L. Wisniewski, P. Mlynarz, D. Rakus
Article
Cell Biology
James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemyslaw Duda, Agnieszka Gizak
Summary: TP53 plays a crucial role in regulating signaling and apoptotic pathways in pancreatic cancer, impacting drug sensitivity and metabolism.
