期刊
GENOMICS
卷 111, 期 3, 页码 310-319出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2018.02.005
关键词
SVs; NGS; Xiang pig; Litter size
资金
- National High Technology Research and Development Program of China (863 Program) [2013AA102503]
- National Natural Science Foundation of China [31672390, 31401091]
- Guizhou Province Hundred Innovative Talents Project [2016-4012]
- Guizhou Agriculture Research program [QKHZC[2017]2585, QKHZC[2017]2587, NY.[2013]3073]
To gain a better knowledge of structural variations (SVs) in Xiang pig, we used next-generation sequencing to analyze the Xiang pigs with larger (XL) or smaller litter sizes (XS). Our analysis yielded 28,040 putative SVs in the Xiang pig. These SVs distributed throughout all of chromosomes. Some functional regions including exons and untranslated regions were less varied than introns and intergenic regions. We detected 4637 and 4119 specific SVs, which contained 1697 and 1582 genes in XL and XS group, respectively. These genes were mainly enriched in the well-known pathways involved in development and reproduction processes. Population validation was carried out on 50 SVs candidates using PCR method in 144 Xiang pig crowds. All of 50 SVs were confirmed by PCR method and 14 SVs were associated with the litter size of Xiang pigs. These results may be helpful for the elucidation of growth and reproduction regulation in Xiang pig.
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