期刊
GENOME
卷 61, 期 5, 页码 337-347出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/gen-2017-0114
关键词
lncRNA; RNA-Seq; chicken; muscle development
资金
- China Post-doctoral Science Foundation [2014 M552004]
- Program for Innovation Research Team of Ministry of Education [IRT16R23]
- National Natural Science Foundation of China [31372330]
- Key Science and Technology Research Project of Henan Province [151100110800]
Chicken muscle quality is one of the most important factors determining the economic value of poultry, and muscle development and growth are affected by genetics, environment, and nutrition. However, little is known about the molecular regulatory mechanisms of long non-coding RNAs (lncRNAs) in chicken skeletal muscle development. Our study aimed to better understand muscle development in chickens and thereby improve meat quality. In this study, Ribo-Zero RNA-Seq was used to investigate differences in the expression profiles of muscle development related genes and associated pathways between Gushi (GS) and Arbor Acres (AA) chickens. We identified two muscle tissue specific expression lncRNAs. In addition, the target genes of these lncRNAs were significantly enriched in certain biological processes and molecular functions, as demonstrated by Gene Ontology (GO) analysis, and these target genes participate in five signaling pathway, as revealed by an analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Taken together, these data suggest that different lncRNAs might be involved in regulating chicken muscle development and growth and provide new insight into the molecular mechanisms of lncRNAs.
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