期刊
GENES BRAIN AND BEHAVIOR
卷 17, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/gbb.12444
关键词
epitranscriptomics; neuropsychiatric disorders; RNA modifications
资金
- Intramural NIH HHS [Z01 AA000280-18] Funding Source: Medline
Much progress in our understanding of RNA metabolism has been made since the first RNA nucleoside modification was identified in 1957. Many of these modifications are found in noncoding RNAs but recent interest has focused on coding RNAs. Here, we summarize current knowledge of cellular consequences of RNA modifications, with a special emphasis on neuropsychiatric disorders. We present evidence for the existence of an RNA code, similar to the histone code, that fine-tunes gene expression in the nervous system by using combinations of different RNA modifications. Unlike the relatively stable genetic code, this combinatorial RNA epigenetic code, or epitranscriptome, may be dynamically reprogrammed as a cause or consequence of psychiatric disorders. We discuss potential mechanisms linking disregulation of the epitranscriptome with brain disorders and identify potential new avenues of research.
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