期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 266, 期 -, 页码 110-118出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2018.05.003
关键词
Mollusc; Neuropeptide; Tachykinin signalling; Feeding
资金
- ANR project NEMO [ANR 14CE020020]
- NEMO project
- European Union
- European Research Council (ERC grant) [340318]
- Research Foundation - Flanders (FWO grant) [G069713N, G0C0618N]
- European Research Council (ERC) [340318] Funding Source: European Research Council (ERC)
Although tachykinin-like neuropeptides have been identified in molluscs more than two decades ago, knowledge on their function and signalling has so far remained largely elusive. We developed a cell-based assay to address the functionality of the tachykinin G-protein coupled receptor (Cragi-TKR) in the oyster Crassostrea gigas. The oyster tachykinin neuropeptides that are derived from the tachykinin precursor gene Cragi-TK activate the Cragi-TKR in nanomolar concentrations. Receptor activation is sensitive to Ala-substitution of critical Cragi-TK amino acid residues. The Cragi-TKR gene is expressed in a variety of tissues, albeit at higher levels in the visceral ganglia (VG) of the nervous system. Fluctuations of Cragi-TKR expression is in line with a role for TK signalling in C. gigas reproduction. The expression level of the Cragi-TK gene in the VG depends on the nutritional status of the oyster, suggesting a role for TK signalling in the complex regulation of feeding in C. gigas.
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