Article
Cell Biology
Sina Dadafarin, Tomas C. Rodriguez, Michelle A. Carnazza, Raj K. Tiwari, Augustine Moscatello, Jan Geliebter
Summary: In this study, analysis of RNA-sequencing data revealed that MEG3 is highly associated with lymph node metastasis in thyroid cancer and may be a driver of aggressive disease.
Article
Endocrinology & Metabolism
Wenlong Wang, Ying Ding, Wei Jiang, Xinying Li
Summary: This study aimed to evaluate the impact of N stage subclassification on different distant metastasis sites based on age stratification, especially for patients with papillary thyroid microcarcinoma (PTMC). The results showed that the risk of distant metastasis increased with the progress of N disease, and N1b disease had a higher risk of lung metastasis in younger patients and an increased risk of both lung and bone metastasis in older patients. N1a disease did not increase the risk of distant metastasis in PTMC patients. Combining N stage with risk stratification can be beneficial for predicting distant metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Yunfei Yan, Yu Wang, Na Liu, Yuansheng Duan, Xiaohan Chen, Beibei Ye, Rong Yang, Wenchao Zhang, Xudong Wang
Summary: DLNM serves as a predictive indicator for cervical lymph node metastasis in PTC patients, highlighting the importance of DLN detection in guiding the extent of surgery.
Article
Endocrinology & Metabolism
Luying Gao, Xiaoyi Li, Yu Xia, Ruifeng Liu, Chunhao Liu, Xinlong Shi, Yanjiao Wu, Liyuan Ma, Yuxin Jiang
Summary: This study evaluated the relevance of large-volume lateral lymph node metastases (LLNMs) and recurrent/persistent risk in papillary thyroid carcinoma (PTC) patients. The study found that patients with large-volume LLNM had a significantly higher risk of recurrence/persistence compared to those with low-volume LLNM. Multilevel suspected LLNMs and loss of fatty hilum were identified as preoperative indicative factors of large-volume LLNM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yubo Sun, Wei Sun, Jingzhe Xiang, Hao Zhang
Summary: This study aimed to construct a nomogram that predicts central lymph node metastasis (CLNM) in T1-T2 papillary thyroid carcinoma (PTC) patients without lateral lymph node metastases (LLNM). The nomogram showed good accuracy and applicability in predicting CLNM in both internal and external validation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Juerong Lu, Jintang Liao, Yunhao Chen, Jie Li, Xinyue Huang, Huajun Zhang, Bo Zhang
Summary: By analyzing ultrasound characteristics and clinical data, we identified clinical factors associated with lymph node metastasis in patients with papillary thyroid carcinoma (PTC), and developed a personalized nomogram for predicting lymph node metastasis. The nomogram showed excellent discrimination, calibration, and clinical practicability, and may assist clinicians in predicting lymph node metastasis prior to surgery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Qiang Chen, Yang Liu, Wei Lu, Lingyun Zhang, Anping Su, Feng Liu, Jingqiang Zhu
Summary: The clinical value of pretracheal lymph node subdivision in identifying contralateral central lymph node metastasis and risk factors for occult contralateral metastasis in unilateral papillary thyroid carcinoma (PTC) were assessed in this study. The results showed that prelaryngeal lymph node metastasis and contralateral pretracheal lymph node metastasis were identified as risk factors for contralateral central lymph node metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zipeng Wang, Qungang Chang, Hanyin Zhang, Gongbo Du, Shuo Li, Yihao Liu, Hanlin Sun, Detao Yin
Summary: This study aimed to explore the risk factors and develop a predictive model for central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). The analysis of collected data revealed that age, gender, multifocality, BRAF, and tumor size were associated with CLNM. The predictive model was shown to be practical and convenient for clinicians to predict CLNM in PTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao
Summary: This study identified TM4SF1 as a potential diagnostic marker of LNM and TSPAN2 as a prognostic factor for patients with PTC. Additionally, a predictive model was established to assess prognosis in PTC patients, providing a novel strategy for predicting effective treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Peng Li, Wei Jiang, Ying Ding, Ruixin Zhou, Baizhao Li, Xinying Li, Wenlong Wang
Summary: This study found that multifocality in papillary thyroid carcinoma is strongly associated with lateral lymph node metastasis, especially for patients with four or more tumor foci. Age is also a factor that affects the risk of lateral lymph node metastasis in patients with multifocality.
Article
Endocrinology & Metabolism
Lingqian Zhao, Tianhan Zhou, Wenhao Zhang, Fan Wu, Kecheng Jiang, Bei Lin, Siqi Zhan, Tao Hu, Tian Tang, Yu Zhang, Dingcun Luo
Summary: The study revealed the clinical significance of blood immune indexes in predicting lateral lymph node metastasis (LLNM) of thyroid papillary carcinoma (PTC). A predictive model combining the systemic immune-inflammation index (SII) and tumor diameter was established to effectively predict the occurrence of LLNM in PTC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Min, Yizhou Huang, Minjie Wei, Xiaoyuan Wei, Hang Chen, Xing Wang, Jialin Chen, Ke Xiang, Yang Feng, Guobing Yin
Summary: High serum thyroglobulin antibody (TgAb) level, lower tumor location, irregular margin of CLN, and micro-calcification in the CLN were significantly associated with CLN metastasis in PTC patients with HT. An individualized nomogram with a favorable C-index of 0.815 was established, which may help surgeons manage the CLN in this subpopulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Peiliang Lin, Faya Liang, Jingliang Ruan, Ping Han, Jianwei Liao, Renhui Chen, Baoming Luo, Nengtai Ouyang, Xiaoming Huang
Summary: A preoperative nomogram was developed to predict HVLNMs in the central compartment of PTC, with age, BRAF V600E mutation, nodule diameter, and calcification identified as independent predictors. The nomogram showed good discrimination with an AUC of 0.821.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Peng, Zhao-Tao Zhang, Tong-Tong Wang, Ya Wang, Chun-Hua Li, Min-Jing Zuo, Hua-Shan Lin, Liang-Geng Gong
Summary: This study aimed to explore the feasibility of using a computed tomography (CT) radiomics signature to predict the pathological central lymph node metastasis (CLNM) status in patients with negative clinical lymph node (cN0) papillary thyroid carcinoma (PTC). The results showed that the radiomics signature had a good ability to distinguish between the pN0 and pN1 groups in both the training and validation sets. The calibration curves and decision curve analysis demonstrated that the model had clinical utility.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Meiwu Zhang, Yan Zhang, Huilin Wei, Liu Yang, Rui Liu, Baisong Zhang, Shuyi Lyu
Summary: This study aimed to evaluate the value of a preoperative ultrasound radiomics nomogram for predicting large-number cervical lymph node metastasis (CLNM) in primary papillary thyroid carcinoma (PTC). Retrospective data of PTC patients were collected and a radiomics signature was established using feature selection methods. A radiomics nomogram combining the radiomics signature and clinical risk factors was developed, and its predictive efficiency and clinical application value were evaluated. The model showed good performance in predicting CLNM.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.