Article
Gastroenterology & Hepatology
Jessica L. Petrick, Ruth M. Pfeiffer, Linda M. Liao, Christian C. Abnet, Xiaolin Wu, Marilie D. Gammon, Thomas L. Vaughan, Michael B. Cook
Summary: This study found that certain circulating miRNAs may be associated with the diagnosis and survival of esophageal adenocarcinoma, showing potential as predictive biomarkers.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Shao-Hua Xie, Eivind Ness-Jensen, Hilde Langseth, Randi E. Gislefoss, Fredrik Mattsson, Jesper Lagergren
Summary: The study suggests that higher levels of SHBG and lower levels of FSH may increase survival in EAC, while the other examined sex hormone measures may not influence survival.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Michal Eid, Paraskevi Karousi, Lumir Kunovsky, Stepan Tucek, Dagmar Brancikova, Zdenek Kala, Ondrej Slaby, Jiri Mayer, Christos K. Kontos, Jan Trna
Summary: PDAC is increasing in incidence and associated with high mortality rates. Radical surgery is the only potential curative procedure, but only a minority of patients achieve radicality. miRNAs play an important role in PDAC, potentially serving as non-invasive diagnostic and prognostic biomarkers.
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Summary: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Worsening TP53 dysfunction is directly correlated with worse treatment outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
A. Justin Rucker, Vignesh Raman, Oliver K. Jawitz, Kristen E. Rhodin, Betty C. Tong, David H. Harpole, Thomas A. D'Amico
Summary: This study found that delaying endoscopic resection for up to 180 days from diagnosis does not worsen survival or increase the likelihood of margin-positive resection in patients with stage I esophageal adenocarcinoma.
ANNALS OF THORACIC SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Tetiana Pozniak, Dzmitry Shcharbin, Maria Bryszewska
Summary: Circulating microRNAs serve as sensitive biomarkers for diagnosing and treating various diseases, playing a significant role in monitoring diseases and evaluating treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Irina Robinson, Alexandra Bertsch, Katharina Leithner, Philipp Stiegler, Horst Olschewski, Andelko Hrzenjak
Summary: The study found significant differences in the expression of miRNAs between lung adenocarcinoma cells and healthy donor cells. Four miRNAs were found to be deregulated in plasma samples of lung adenocarcinoma patients, and their target genes are closely related to the mechanisms of tumor development and progression.
Article
Geriatrics & Gerontology
Jonas Mengel-From, Katrine Egebjerg Nielsen, Signe Bedsted Clemmensen, Soren Feddersen, Kaare Christensen, Jacob V. B. Hjelmborg, Qihua Tan, Marianne Nygaard
Summary: The study found that miRNAs may play an important role in the variation of old age mortality, with some miRNAs associated with individuals who have shorter lifespans. Pathway analysis results indicate that these miRNAs are involved in lipid metabolism, tissue maintenance, and morphology.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Surgery
Carlos S. Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q. Wong, Bonnie Z. Zhang, Kenji M. Fujihara, Lynn Chong, Michael W. Hii, Sarah-Jane Dawson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons
Summary: The study demonstrates the clinical utility of ctDNA in predicting disease status and treatment response in esophageal adenocarcinoma patients. It shows that ctDNA can provide additional prognostication over conventional staging investigations and may be a useful biomarker for surveillance of recurrent disease.
Article
Cardiac & Cardiovascular Systems
Andreas Bouckaert, Johnny Moons, Toni Lerut, Willy Coosemans, Lieven Depypere, Hans Van Veer, Philippe Nafteux
Summary: A retrospective cohort study showed that primary surgery performed through transthoracic approach can yield comparable overall and disease-free survival after 5 years in locally advanced esophageal adenocarcinoma, with potentially fewer postoperative complications and shorter hospital and intensive care unit stay compared with neoadjuvant chemoradiotherapy followed by surgery.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Noel E. Donlon, Brendan Moran, Anitha Kamilli, Maria Davern, Andrew Sheppard, Sinead King, Claire L. Donohoe, Maeve Lowery, Moya Cunningham, Narayanasamy Ravi, Carmen Mueller, Jonathan Cools-Lartigue, Lorenzo Ferri, John V. Reynolds
Summary: This study compared the effects of two different regimens in the treatment of locally advanced esophageal adenocarcinoma and evaluated factors such as tolerance, toxicity, sarcopenia, and pulmonary function. The results showed that both regimens had similar survival rates and operative outcomes, but the CROSS regimen increased the risk of respiratory failure and atrial fibrillation.
Review
Oncology
Masahisa Ohtsuka, Kazuya Iwamoto, Atsushi Naito, Mitsunobu Imasato, Satoshi Hyuga, Yujiro Nakahara, Manabu Mikamori, Kenta Furukawa, Jeongho Moon, Tadafumi Asaoka, Kentaro Kishi, Awad Shamma, Hiroki Akamatsu, Tsunekazu Mizushima, Hirofumi Yamamoto
Summary: MicroRNAs (miRNAs) show potential as noninvasive biomarkers for gastrointestinal cancer (GIC) due to their stability in blood and association with GIC status. Research on miRNAs is crucial for early detection and treatment improvement in GIC patients.
Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Emeric Chalchat, Keyne Charlot, Sebastian Garcia-Vicencio, Pierre Hertert, Stephane Bauge, Stephanie Bourdon, Julie Bompard, Cedric Farges, Vincent Martin, Cyprien Bourrilhon, Julien Siracusa
Summary: Ultra-endurance sports can lead to exercise-induced muscle damage and exertional rhabdomyolysis, with circulating miRNAs potentially useful in assessing the degree of muscle damage. Following a 24-h run, significant increases in muscle damage markers were observed, with elevated levels of myomiRs correlating with reduced muscle height and a diagnosis of exertional rhabdomyolysis in elite ultramarathon runners.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Gastroenterology & Hepatology
Calvin X. Geng, Anuragh R. Gudur, Mark Radlinski, Ross C. D. Buerlein, Daniel S. Strand, Bryan G. Sauer, Vanessa M. Shami, Andrew Y. Wang, Alexander Podboy
Summary: Lower socioeconomic status is associated with higher cancer-specific mortality and lower rates of endoscopic resection in early esophageal adenocarcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)