Article
Gastroenterology & Hepatology
Lili Tian, Majid Mufaqam Syed-Abdul, Priska Stahel, Gary F. Lewis
Summary: This study found that oral glucose must be absorbed and metabolized to enhance intestinal lipid mobilization, and the effects on high-fat-fed rats were similar to those on chow-fed rats.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jonathan Trujillo-Viera, Rabih El-Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza-Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E. Mayer, Mona C. Loeffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara
Summary: The study reveals the significant role of protein kinase D2 in lipid absorption, where its activity promotes TG transfer within enterocytes, affecting the development of obesity and diabetes. This finding suggests that targeting PKD2 may hold promise as a therapeutic approach for obesity.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Darby W. Kozan, Joshua T. Derrick, William B. Ludington, Steven A. Farber
Summary: This review provides a comprehensive overview of how intestinal enterocytes absorb dietary lipid and secrete chylomicrons to meet the unique needs of each animal. The putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus, is discussed. Understanding the molecular response of intestinal cells to dietary lipid has the potential to uncover novel therapies to combat metabolic syndrome.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Physiology
Emile Levy, Jean Francois Beaulieu, Schohraya Spahis
Summary: Over the past two decades, extensive research has been carried out on the digestion and absorption of intestinal fat, with a focus on the critical players and mechanisms involved in the process. Through experiments and animal models, the relationship between disease-causing factors and clinical manifestations has been revealed, contributing to a better understanding and treatment of the pathological condition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Yu He, Ning Liu, Yun Ji, Patrick Tso, Zhenlong Wu
Summary: Weaning stress in piglets reduces intestinal fat absorption and affects the morphology and expression of proteins related to fat absorption.
JOURNAL OF NUTRITION
(2022)
Review
Endocrinology & Metabolism
Bruno Verges
Summary: Postprandial hyperlipidaemia, characterized by increased chylomicron production and delayed catabolism, is an important factor in the development of cardiovascular disease in individuals with type 2 diabetes. Insulin resistance and reduced GLP-1 secretion contribute to the pathophysiology of postprandial hyperlipidaemia. Multiple factors, including increased expression of microsomal triglyceride transfer protein and enhanced stability of apolipoprotein B-48, are involved in the overproduction of chylomicrons. These metabolic abnormalities can be influenced by glucose-lowering treatments, such as metformin, pioglitazone, alpha-glucosidase inhibitors, dipeptidyl peptidase 4 inhibitors, and GLP-1 agonists.
Review
Biochemistry & Molecular Biology
Joshua R. Cook, Alison B. Kohan, Rebecca A. Haeusler
Summary: The small intestinal epithelium plays a larger and more dynamic role in lipid metabolism, with enterocytes treating fat differently based on its absorption across the apical versus the basolateral membrane. This dual-track model of enterocyte fat metabolism integrates lipid flux along both the apical and basolateral tracks to calibrate the overall program of lipid metabolism.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Luis Garcia-Villarreal, Andrea Hernandez-Ortega, Ana Sanchez-Monteagudo, Luis Pena-Quintana, Teresa Ramirez-Lorenzo, Marta Riano, Raquel Moreno-Perez, Alberto Monescillo, Daniel Gonzalez-Santana, Ildefonso Quinones, Almudena Sanchez-Villegas, Vicente Olmo-Quintana, Paloma Garay-Sanchez, Carmen Espinos, Jesus M. Gonzalez, Antonio Tugores
Summary: Wilson disease is a genetic disorder caused by mutations in the ATP7B gene, which affects copper metabolism. Early diagnosis is crucial to prevent disease progression, and serum ceruloplasmin levels, along with genetic analysis, are key diagnostic tools. This study emphasizes the importance of population screening and highlights the significance of genetic testing for accurate diagnosis and management of Wilson disease.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Cell Biology
Som Dev, Robert L. Kruse, James P. Hamilton, Svetlana Lutsenko
Summary: This review summarizes recent advances in the characterization of Wilson disease pathophysiology and discusses emerging targets for improving diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Jie Lin, Yexiang Zheng, Ying Liu, Yi Lin, Qiqi Wang, Xiao-Hong Lin, Wenli Zhu, Wei-Hong Lin, Ning Wang, Wan-Jin Chen, Ying Fu
Summary: This study suggests that plasma glial fibrillary acidic protein could serve as a biomarker for distinguishing neurological involvement in patients with Wilson disease.
MOVEMENT DISORDERS
(2021)
Review
Medicine, General & Internal
Ana Lucena-Valera, Pilar Ruz-Zafra, Javier Ampuero
Summary: Wilson's disease is a rare hereditary disorder caused by a deficiency in the ATP7B transporter. It results in copper accumulation primarily in the liver, and secondarily in other organs such as the central nervous system. The disease has a wide spectrum of symptoms, ranging from asymptomatic to acute liver failure. Diagnosis requires a combination of clinical signs, symptoms, and diagnostic tests. Treatment involves lifelong maintenance with chelating agents and copper absorption inhibitors, and liver transplant may be an option for end-stage liver disease patients.
Article
Multidisciplinary Sciences
Baozhen Zhang, Hong Pan, Ze Chen, Ting Yin, Mingbin Zheng, Lintao Cai
Summary: A twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling and self-adaptive capabilities has been developed for targeted gastrointestinal inflammation therapy. The TBY-robot uses an enzyme-macrophage switching mechanism to autonomously navigate to inflamed sites. It successfully overcomes barriers in the gastrointestinal tract and enhances drug accumulation at the diseased site, demonstrating its potential for precision treatment of inflammatory diseases.
Review
Engineering, Biomedical
Rebecca Donahue, Jugal Kishore Sahoo, Sara Rudolph, Ying Chen, David L. Kaplan
Summary: Mucus is a hydrogel that protects the body's surfaces and plays a role in defense against pathogens. Dysfunction of the gut mucus barrier is associated with diseases. Current methods for studying mucus have limitations. Therefore, there is a need for mucus-mimetic hydrogels that accurately reflect the human epithelial environment for research on disease and microbiome interactions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, General & Internal
Xiali Xiong, Hong Wei, Yunxia Zhu, Xin Zhou, Zhiqiang Zhao, Qiang Chen
Summary: Pregnancy combined with Wilson disease is extremely harmful, with high rates of miscarriage, premature birth, and perinatal mortality. The cases of 4 pregnant women with Wilson disease have shown that comprehensive monitoring and multidisciplinary management before and after pregnancy can lead to better pregnancy outcomes and improved quality of life for these patients.
Article
Medicine, General & Internal
Minmin Chen, Chenyan Li, Shiqiao Peng, Mengyuan Liu, Yiling Li, Mingjun Sun, Xuren Sun
Summary: This article reports the first case of Wilson disease complicated by Crohn disease. The patient presented with repeated low fever, elevated C-reactive protein for 3 years, and anal fistula for 6 months. Ustekinumab was found to be safe and effective in the treatment. The study suggests that copper metabolism and oxidative stress play key roles in both Wilson disease and Crohn disease.
Article
Biochemistry & Molecular Biology
Samuel Jayakanthan, Lelita T. Braiterman, Nesrin M. Hasan, Vinzenz M. Unger, Svetlana Lutsenko
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Katharina Schmidt, Martina Ralle, Thomas Schaffer, Samuel Jayakanthan, Bilal Bari, Abigael Muchenditsi, Svetlana Lutsenko
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Dawn Hayward, Valentina L. Kouznetsova, Hannah E. Pierson, Nesrin M. Hasan, Estefany R. Guzman, Igor F. Tsigelny, Svetlana Lutsenko
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Cell Biology
Svetlana Lutsenko
Summary: Copper homeostasis is crucial for the development and function of organisms, with misbalance leading to serious pathologies. Mammalian Cu(I) transporters play a key role in regulating intracellular copper fluxes, with various regulatory proteins contributing to the dynamic and cell-specific nature of the copper transport networks. The comparison of copper transport mechanisms in the liver and intestine highlights the distinct composition and regulatory responses of their transporters to changing copper levels.
JOURNAL OF CELL SCIENCE
(2021)