Article
Oncology
Detlef Bartkowiak, Reinhard Thamm, Alessandra Siegmann, Dirk Boehmer, Volker Budach, Thomas Wiegel
Summary: In prostate cancer patients, a pre-SRT PSA <0.4 ng/ml is a significant predictor for biochemical progression (BCR), progression-free survival (PFS), and overall survival (OS), contradicting the hypothesis that the advantage of early salvage radiotherapy (SRT) is mainly due to lead-time bias.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Zelin Ma, Zezhou Wang, Yuan Li, Yang Zhang, Haiquan Chen
Summary: This study investigates whether lead-time bias contributes to the excellent survival of AIS and MIA. The results show that resecting lung adenocarcinoma at pre-/minimally invasive stage can improve life expectancy after adjustment for the lead time.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
James Hugh McVittie, Masoud Asgharian
Summary: The paper focuses on testing for differences in survival medians when collected data are not representative samples and subject to right censoring. The authors propose a large-sample test using the nonparametric maximum likelihood estimator of the survivor function in the target population and examine its small sample performance through simulation. The method is applied to test for differences in survival medians of Alzheimer's disease and dementia groups.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Oncology
Bradford E. Jackson, Rachel A. Greenup, Paula D. Strassle, Allison M. Deal, Chris D. Baggett, Jennifer L. Lund, Katie E. Reeder-Hayes
Summary: Research shows that immortal-time bias may lead to overestimation of treatment effect, researchers should identify and address this issue in design and analysis. By guiding researchers on how to deal with immortal-time bias, treatment benefits can be more accurately assessed.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Corey K. Gentle, Hemasat Alkhatib, Stephanie A. Valente, Chao Tu, Debra A. Pratt
Summary: This study evaluated the incidence and consequences of continuing screening mammography in patients with stage IV non-breast cancer. The results showed that despite low survival rates, 14% of patients underwent screening, but no new breast cancers were identified.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
David N. Anderson, Elisa R. Port
Summary: The article discusses the utility of locoregional treatment in de novo Stage IV breast cancer and aims to help readers understand how to apply key study results, including those published in the Journal of Clinical Oncology, to their own clinical practice through case presentations and literature reviews.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Mahdi Sheikh, Anush Mukeriya, Oxana Shangina, Paul Brennan, David Zaridze
Summary: Smoking cessation after diagnosis of early-stage lung cancer was associated with significantly improved overall survival, progression-free survival, and decreased risks for all-cause mortality, cancer-specific mortality, and disease progression among current smokers. Effects were consistent across different smoking levels and cancer stages.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Surgery
Andrew Tang, Usman Ahmad, Siva Raja, Alejandro C. Bribriesco, Monisha Sudarshan, Jesse Rappaport, Alok Khorana, Eugene H. Blackstone, Sudish C. Murthy, Daniel P. Raymond
Summary: This study aimed to identify factors influencing the time from diagnosis to treatment (TTT) of surgically resected early stage non-small cell lung cancer (NSCLC) and to determine the impact of TTT on post-resection survival. Large database studies have shown that longer TTT is associated with worse overall survival. The results of this study suggest that preoperative physiologic workup and multidisciplinary evaluation are the major factors contributing to longer TTT.
Article
Oncology
Benjamin J. Matthews, Muhammad Mustafa Qureshi, Stephen J. Fiascone, Caroline C. Nitschmann, Oluwadamilola T. Oladeru, Minh-Tam Truong, Ariel E. Hirsch, Kimberley S. Mak, M. A. Dyer
Summary: This study aimed to identify patient factors associated with not receiving a recommendation for adjuvant chemotherapy after primary surgery for ovarian cancer. Results showed that age, comorbidity scores, and race were independent predictors for not receiving a recommendation for adjuvant chemotherapy. Black patients were more likely to not be recommended for chemotherapy, which was associated with lower survival rates.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Min-Yi Lv, Xi-Jie Chen, Jun-Guo Chen, Bin Zhang, Yan-Yun Lin, Tian-Ze Huang, De-Gao He, Kai Wang, Zeng-Jie Chi, Jian-Cong Hu, Xiao-Sheng He
Summary: In this study, a robust prognostic nomogram was developed to predict the overall survival of stage IV colorectal cancer patients. The nomogram showed superior predictive ability compared to the traditional TNM staging system, as demonstrated by various evaluation methods and external validation.
GASTROENTEROLOGY REPORT
(2022)
Article
Agronomy
Yanning Wang, Liping Chen, Guiting Song, Tao Huang, Guangliang Wu, Jingai Tan, Peng Wang, Qin Cheng, Caijing Li, Qi Zhong, Shiying Huang, Mengmeng Yang, Haohua He, Jianmin Bian
Summary: This study aimed to identify the quantitative trait loci (QTL) related to salt tolerance in rice, focusing on traits such as root length, bud length, and survival percent under different salinity conditions. Through the use of chromosome segment substitution lines (CSSLs) derived from the varieties Nipponbare and 9311, a total of 18 QTLs were identified, with 13 of them being detected under salt stress conditions. These QTLs were classified into two categories, based on their expression under control and salt stress conditions. Furthermore, several QTLs were reported for the first time to be associated with salt stress in rice. The identification of these QTLs under salt stress conditions provides valuable genetic factors for improving salt tolerance in rice through the use of molecular marker technology, and contributes to a better understanding of the genetic mechanism underlying salt tolerance in rice.
Article
Cardiac & Cardiovascular Systems
A. Justin Rucker, Vignesh Raman, Oliver K. Jawitz, Kristen E. Rhodin, Betty C. Tong, David H. Harpole, Thomas A. D'Amico
Summary: This study found that delaying endoscopic resection for up to 180 days from diagnosis does not worsen survival or increase the likelihood of margin-positive resection in patients with stage I esophageal adenocarcinoma.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Yifan Feng, Ye Wang, Yangqin Xie, Shuwei Wu, Yuyang Li, Min Li
Summary: Factors affecting the prognosis of patients with stage IIIC1 cervical cancer were analyzed to establish nomogram models for predicting overall survival (OS) and cancer-specific survival (CSS). Tumor size was identified as the most important prognostic factor in these models.
Article
Oncology
Frans Emland, Helena Taflin, Goran Carlsson, David Ljungman, Elinor Bexe Lindskog
Summary: Prolonged postoperative length of stay (LOS) is associated with increased risk of recurrence and shorter disease-free survival (DFS) in patients with stage III colon cancer, regardless of whether adjuvant chemotherapy is given. Factors such as age, comorbidity, complications, and tumor features also play a role in this correlation.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jingxuan Zhao, Xuesong Han, Leticia Nogueira, Stacey A. Fedewa, Ahmedin Jemal, Michael T. Halpern, K. Robin Yabroff
Summary: Previous studies have shown that uninsured patients in the United States are more likely to be diagnosed with late-stage cancer and have worse survival rates. This report provides comprehensive data on the association between health insurance coverage type and stage at diagnosis and long-term survival in individuals diagnosed with common cancers between 2010 and 2013.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Gastroenterology & Hepatology
Robert J. Huang, Meira Epplein, Chisato Hamashima, Il Ju Choi, Eunjung Lee, Dennis Deapen, Yanghee Woo, Thuy Tran, Shailja C. Shah, John M. Inadomi, David A. Greenwald, Joo Ha Hwang
Summary: This study shows that the burden of GC is unequally distributed in the US, predominantly affecting Asian, African American, Hispanic, and American Indian/Alaskan Native populations. International studies have provided substantial evidence supporting the effectiveness of strategies such as H. pylori testing and treatment, as well as endoscopic screening in reducing GC-specific mortality. However, there is a lack of data from US sources. Therefore, there is an urgent need for cancer prevention trials targeting high-risk immigrant and minority populations in the US, and for the development of national strategies for GC prevention.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Amnon Sonnenberg, John M. Inadomi
Editorial Material
Gastroenterology & Hepatology
Sachin Wani, Rena Yadlapati, Siddharth Singh, Tarek Sawas, David A. Katzka, Matthew Hall, Jacques Bergman, Marcia I. Canto, Amitabh Chak, Douglas A. Corley, Gary W. Falk, Rebecca C. Fitzgerald, Rehan Haidry, John M. Inadomi, Prasad G. Iyer, Jennifer Kolb, Srinadh Komanduri, Vani Konda, Elizabeth A. Montgomery, V. Raman Muthusamy, Joel H. Rubenstein, Felice Schnoll-Sussman, Nicholas J. Shaheen, Michael Smith, Stuart Spechler, Ravy Vajravelu
Article
Public, Environmental & Occupational Health
Carolyn M. Rutter, John M. Inadomi, Christopher E. Maerzluft
Summary: Systematic delays in the screening process can significantly reduce the effectiveness of colorectal cancer screening, especially with longer delays. Screening delays may result in variations in colorectal cancer incidence among different patient groups.
JOURNAL OF MEDICAL SCREENING
(2022)
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Amir-Houshang Omidvari, Brianna N. Lauren, William D. Hazelton, Francesca Lim, Sarah Xinhui Tan, Chung Yin Kong, Minyi Lee, Ayman Ali, Chin Hur, John M. Inadomi, Georg Luebeck, Iris Lansdorp-Vogelaar
Summary: The optimal strategy for screening esophageal adenocarcinoma varies by race and sex. White men with GERD symptoms can potentially be screened more intensely than is currently recommended, while screening women may not be cost-effective and could even cause net harm for black women.
Editorial Material
Gastroenterology & Hepatology
John M. Inadomi
Article
Environmental Sciences
Charles R. Rogers, David G. Perdue, Kenneth Boucher, Kevin M. Korous, Ellen Brooks, Ethan Petersen, John M. Inadomi, Fa Tuuhetaufa, Ronald F. Levant, Electra D. Paskett
Summary: There is an association between masculinity barriers and lower rates of CRC screening completion, with negative attitudes towards medical professionals and exams as well as a strong masculine identity being significant factors. This association is more pronounced among Black men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Meeting Abstract
Oncology
S. Hardikar, B. Krick, R. Benson, M. Winn, C. Winterton, P. A. Newcomb, J. M. Inadomi, C. M. Ulrich
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Ming Yu, Helen R. Moinova, Amber Willbanks, Victoria K. Cannon, Ting Wang, Kelly Carter, Andrew Kaz, Deepti Reddi, John Inadomi, Georg Luebeck, Prasad G. Iyer, Marcia Canto, Jean S. Wang, Nicholas J. Shaheen, Prashanti N. Thota, Joseph E. Willis, Thomas LaFramboise, Amitabh Chak, Sanford D. Markowitz, William M. Grady
Summary: This study identifies methylation markers that can distinguish esophageal adenocarcinoma (EAC) and high-grade dysplasia (HGD) from normal squamous epithelium (SQ) or nondysplastic Barrett's esophagus (NDBE). The results demonstrate the potential of DNA methylation-based molecular assays for the early detection of EAC using esophageal brushing samples.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Joan M. Griffin, Lila J. Finney Rutten, Xuan Zhu, Ziding Feng, Charles R. Rogers, Tracey L. Marsh, John M. Inadomi
Summary: This study aims to test the effectiveness of an evidence-based video intervention in improving colorectal cancer screening. The study is divided into three groups, with participants watching different types of videos, and the adherence to screening guidelines will be assessed using medical record data and surveys. This will provide evidence for integrating informational and motivational videos into clinical practice to encourage colorectal cancer screening.
CONTEMPORARY CLINICAL TRIALS
(2022)
Editorial Material
Gastroenterology & Hepatology
Beth A. Mccormick, John M. Inadomi
Article
Public, Environmental & Occupational Health
Rachel B. Issaka, Ari Bell-Brown, Jason Kao, Cyndy Snyder, Dana L. Atkins, Lisa D. Chew, Bryan J. Weiner, Lisa Strate, John M. Inadomi, Scott D. Ramsey
Summary: In safety-net healthcare systems, completion of colonoscopy within one year after an abnormal FIT result is often below 50%. This study found a discordance between documented reasons in electronic health records (EHR) and patient-reported reasons for lack of colonoscopy. Patient-related factors were the most common reasons for lack of follow-up.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Medicine, General & Internal
Aruna Kamineni, V. Paul Doria-Rose, Jessica Chubak, John M. Inadomi, Douglas A. Corley, Jennifer S. Haas, Sarah C. Kobrin, Rachel L. Winer, Jennifer Elston Lafata, Elisabeth F. Beaber, Joshua S. Yudkin, Yingye Zheng, Celette Sugg Skinner, Joanne E. Schottinger, Debra P. Ritzwoller, Jennifer M. Croswell, Andrea N. Burnett-Hartman
Summary: This review evaluates the reporting of harms in U.S. cancer screening guidelines and identifies inconsistencies and opportunities for improvement. The guidelines do not fully report harms for any specific organ type or category across organ types. Reporting of harms is most complete for prostate cancer screening and least complete for colorectal cancer screening. Future work should consider nuances of each organ-specific screening process and explore optimal ways to determine net screening benefit. Improved harms reporting can aid decision making and improve cancer screening outcomes.
ANNALS OF INTERNAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Ji Yoon Yoon, Julian A. Abrams, Joel H. Rubenstein, Shailja Shah, Jake Kim, John M. Inadomi, David A. Katzka, Michelle K. Kim, Chin Hur
Meeting Abstract
Gastroenterology & Hepatology
Joel H. Rubenstein, Amir-Houshang Omidvari, Brianna Lauren, William D. Hazelton, Francesca Lim, Sarah Xinhui Tan, Chung Yin Kong, Minyi Lee, Ayman Ali, Chin Hur, John M. Inadomi, Georg Luebeck, Iris Lansdorp-Vogelaar