Article
Public, Environmental & Occupational Health
Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Jung Eun Lee, Dong-Hyun Kim
Summary: This study found that alcohol intake increased the risk of colorectal cancer in East Asian populations, and there may be an interaction between ALDH2 gene and methyl diets, where a low methyl diet increased the risk of CRC among individuals with the ALDH2 A allele.
PUBLIC HEALTH NUTRITION
(2021)
Article
Oncology
Chang Kyun Choi, Min-Ho Shin, Sang-Hee Cho, Hye-Yeon Kim, Wei Zheng, Jirong Long, Sun-Seog Kweon
Summary: This study found that the ALDH2 rs671 genotype related to alcohol consumption was associated with a reduced risk of colorectal cancer in men, especially among regular drinkers. However, the ADH1B rs1229984 genotype showed no significant association with colorectal cancer risk. The combined genotype with the highest genetically predicted alcohol consumption was associated with a higher risk for colorectal cancer.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ting-Gang Chang, Ting-Ting Yen, Chia-Yi Wei, Tzu-Hung Hsiao, I-Chieh Chen
Summary: This study aimed to evaluate the associations of ADH1B rs1229984 and ALDH2 rs671 with the risks of alcohol-related disorder and cancer. The results showed significant additive and synergic risks of these genetic variants for alcohol-related disorders and cancer. It is recommended to advise high-risk individuals carrying these variants to reduce alcohol consumption as a preventive measure.
Article
Oncology
Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung, Min-Ho Shin
Summary: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation. The study found that in men, the risk of esophageal cancer was higher with GA and AA genotypes, while in women, the risk was higher with GA and AA genotypes as well. Additionally, in men, the association between ALDH2 polymorphisms and esophageal cancer was influenced by alcohol consumption.
Article
Oncology
Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Lizbeth Lopez-Carrillo, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Reza Malekzadeh, Farhad Pourfarzi, Lina Mu, Zuo-Feng Zhang, Nuno Lunet, Carlo La Vecchia, Paolo Boffetta
Summary: The analysis revealed that there is a super-multiplicative interaction between Hp infection and alcohol drinking, as well as high salt intake, while the interaction with smoking and socioeconomic status is weaker. The interactions were more pronounced in individuals with a history of peptic ulcer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Ayaka Tajiri, Ryu Ishihara, Hirohisa Sakurai, Takahiko Nakamura, Yasuhiro Tani, Takahiro Inoue, Katsunori Matsueda, Muneaki Miyake, Kotaro Waki, Hiromu Fukuda, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Tomoki Michida, Takashi Matsunaga
Summary: The activation patterns of alcohol-metabolizing enzymes are associated with the age at onset of esophageal squamous cell carcinoma, lesion location, and metachronous esophageal squamous cell carcinoma and head and neck squamous cell carcinoma. Different approaches to the prophylaxis and treatment of esophageal cancer should be considered based on the enzyme activity pattern.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Urology & Nephrology
Daniel R. Greenberg, Hriday P. Bhambhvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, Michael L. Eisenberg
Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.
JOURNAL OF UROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Emily Brennan, Danielle A. J. M. Schoenaker, Kimberley Dunstone, Michael D. Slater, Sarah J. Durkin, Helen G. Dixon, Simone Pettigrew, Melanie A. Wakefield
Summary: By integrating low-risk drinking guidelines with alcohol harm reduction advertisements, messages can increase drinkers' intentions to reduce their alcohol consumption and comply with low-risk drinking guidelines.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Genetics & Heredity
Arnold Kukowka, Boguslaw Brzuchalski, Mateusz Kurzawski, Damian Malinowski, Monika Anna Bialecka
Summary: Increasing alcohol consumption by women of childbearing age contributes to more frequent cases of fetal alcohol spectrum disorder. The cause of the syndrome is fetal alcohol exposure, particularly high prenatal alcohol exposure. Genetic background and polymorphisms of genes involved in ethanol metabolism may play a significant role in the pathogenesis of FASD. However, further research is needed to fully understand the genetic background of FASD.
Article
Oncology
Yukihiro Sugimoto, Yuriko N. Koyanagi, Yukino Kawakatsu, Isao Oze, Yukari Taniyama, Yumiko Kasugai, Tsutomu Tanaka, Tetsuya Abe, Masahiro Tajika, Yasuhiro Shimizu, Hidemi Ito, Kenji Wakai, Keitaro Matsuo
Summary: Alcohol is metabolized to acetaldehyde and acetate through the actions of alcohol dehydrogenase and aldehyde dehydrogenase. The ADH1B rs1229984 polymorphism is associated with drinking habits and the risk of esophageal cancer. Mediation analysis showed that this genetic variant increases the risk of esophageal cancer by affecting alcohol metabolism and drinking intensity.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yuriko N. Koyanagi, Isao Oze, Yumiko Kasugai, Yukino Kawakatsu, Yukari Taniyama, Kazuo Hara, Yasuhiro Shimizu, Issei Imoto, Hidemi Ito, Keitaro Matsuo
Summary: A functional variant on ALDH2 rs671 (G>A) protects against alcohol-induced carcinogenesis by decreasing alcohol consumption, but also contributes to the accumulation of carcinogens, resulting in a direct carcinogenic effect. This study quantified the opposing effects of the rs671 A allele on pancreatic cancer risk and explored the impact of the rs671 A allele and alcohol consumption on pancreatic carcinogenesis. The results showed that alcohol consumption was associated with an increased risk of pancreatic cancer, but the effect did not vary by genotype. This study supports the association between alcohol consumption and pancreatic cancer risk and suggests the potential contribution of the rs671 A allele to pancreatic carcinogenesis through impaired metabolism.
Article
Genetics & Heredity
Takashi Sasaki, Yoshinori Nishimoto, Takumi Hirata, Yukiko Abe, Toru Takebayashi, Yasumichi Arai
Summary: The study identified that the ALDH2 p.E504K variation is strongly associated with current and quitting drinking behaviors in the Japanese Oldest Old population. Factors associated with quitting drinking in men included ALDH2 genotype, alcohol-related biomarkers, history of heart or kidney disease, and frailty score, while factors associated with quitting drinking in women included smoking history, walking time, and depression score.
Article
Substance Abuse
Seung Joo Kang, Cheol Min Shin, Joohon Sung, Nayoung Kim
Summary: ALDH2 polymorphism affects the risk of gastric cancer, especially in moderate to heavy drinkers. Individuals with inactive ALDH2 who consume moderate to heavy amounts of alcohol are more susceptible to gastric cancer than non-drinkers or light drinkers.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Oncology
Bokyung Kim, Kyungdo Han, Hyunsoo Chung, Sang Gyun Kim, Soo-Jeong Cho
Summary: This study found that smoking cessation and alcohol abstinence are associated with reduced risk of developing depression in patients with gastric cancer who undergo surgery, while starting regular physical activity is not associated with risk of depression.
Article
Substance Abuse
Sebastian Pena, Pia Makela, Tiina Laatikainen, Tommi Harkanen, Satu Mannisto, Markku Heliovaara, Seppo Koskinen
Summary: The study investigated the relationship between socio-economic status and alcohol-related mortality, as well as the joint effects of alcohol, smoking, and body mass index. The findings suggest that individuals with lower socio-economic status may be more vulnerable to the effects of alcohol and smoking on alcohol-related mortality.
Article
Oncology
Eiji Higaki, Tetsuya Abe, Hironori Fujieda, Takahiro Hosoi, Takuya Nagao, Koji Komori, Seiji Ito, Naoya Itoh, Keitaro Matsuo, Yasuhiro Shimizu
Summary: This study investigated the impact of antimicrobial prophylaxis on the prevention of postoperative pneumonia after esophagectomy. The results showed that ampicillin/sulbactam (ABPC/SBT) was more effective than cefazolin (CEZ) in preventing early-onset pneumonia, with similar incidences of late-onset pneumonia, Clostridioides difficile infections, and multidrug-resistant organisms between the two groups. Multivariate analyses consistently supported the superiority of ABPC/SBT in preventing early-onset pneumonia.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Endocrinology & Metabolism
Takuma Furukawa, Yuichiro Nishida, Megumi Hara, Chisato Shimanoe, Kayoko Koga, Chiharu Iwasaka, Yasuki Higaki, Keitaro Tanaka, Ryoko Nakashima, Hiroaki Ikezaki, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Yasuyuki Nakamura, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai
Summary: This study found an interaction effect between physical activity and carbohydrate intake on HbA1c levels, especially with individuals who have high carbohydrate intake, where the negative correlation between physical activity and HbA1c levels was more pronounced.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Ophthalmology
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki
Summary: This study conducted a Mendelian randomization analysis to assess the causal association between genetically predicted glycemic traits and the risk of primary open-angle glaucoma (POAG). The results did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Hasegawa, Haruyuki Takaki, Hiroshi Kodama, Keitaro Matsuo, Takashi Yamanaka, Atsuhiro Nakatsuka, Motoshi Takao, Hideo Gobara, Sadao Hayashi, Yoshitaka Inaba, Koichiro Yamakado
Summary: The purpose of this study was to explore the impact of ablative margin depicted by CT immediately after RF ablation on reducing LTP for CRC lung metastases. A retrospective study was conducted on 70 patients who underwent RF ablation for CRC lung metastases. The results indicated that an ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Rheumatology
Yu Toyoda, Masahiro Nakatochi, Akiyoshi Nakayama, Yusuke Kawamura, Hirofumi Nakaoka, Kenji Wakai, Keitaro Matsuo, Hirotaka Matsuo
Article
Rheumatology
Ai Yaku, Yuki Ishikawa, Takeshi Iwasaki, Ryosuke Hiwa, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Moritoshi Furu, Hiromu Ito, Takao Fujii, Taira Maekawa, Motomu Hashimoto, Koichiro Ohmura, Tsuneyo Mimori, Chikashi Terao
Summary: Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. However, the genetic architecture underlying IgG-RF, which is associated with rheumatoid vasculitis, is not well understood.
Article
Oncology
Yukari Taniyama, Isao Oze, Yuriko N. Koyanagi, Yukino Kawakatsu, Yuri Ito, Tomohiro Matsuda, Keitaro Matsuo, Tetsuya Mitsudomi, Hidemi Ito
Summary: Introduction of EGFR-TKIs and EGFR mutation testing has led to improved survival in NSCLC patients, particularly in women with adenocarcinoma and at advanced stages.
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki-Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Summary: The ALDH2 enzyme's ability to break down aldehydes is impaired by a specific gene polymorphism, leading to alcohol flushing and an increased risk of esophageal cancer in East Asians. Recent studies suggest that this gene variant may result in higher levels of DNA damage caused by naturally occurring aldehydes. However, in breast epithelial cells, this loss of function does not appear to have an impact on the initiation and development of cancer.
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Oncology
Yoshiaki Usui, Hidemi Ito, Kota Katanoda, Tomohiro Matsuda, Yoshinobu Maeda, Keitaro Matsuo
Summary: The introduction of rituximab has led to a decline in mortality rates of non-Hodgkin lymphoma in both Japan and the United States, despite an increase in incidence. However, the trends in mortality rates have differed between the two countries, with the mortality rate declining continuously in the United States but stopping in Japan.
Article
Multidisciplinary Sciences
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, Kei Muro, Makoto Mark Taketo, Tomoyoshi Soga, Masahiro Aoki
Summary: Cancer cachexia is a metabolic disorder characterized by a decrease in B vitamin-related liver enzymes. The relationship between enzymes and their associated metabolites may depend on protein abundance and cofactor subtype. These metabolic/proteomic changes can be utilized for the diagnosis of cancer cachexia through blood samples.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.
