Article
Multidisciplinary Sciences
Denesh Selvarajah, Alexander Lam, Mitali Fadia, David McDowell
Summary: Pilomyxoid astrocytoma (PMA) is a rare variant of astrocytoma that is usually found in the hypothalamic and chiasmatic areas in children. PMA shares many histopathological features with Pilocytic astrocytoma (PA), but has notable differences in radiological and histopathological findings, and is known to exhibit more aggressive clinical progression. We report a rare case of PMA in a 25-year-old female involving the temporal lobe, presenting with recurrent partial seizures. This case is unique due to the uncommon location, unusual age group, and distinctive radiological features.
Article
Clinical Neurology
Alice Metais, Yassine Bouchoucha, Thomas Kergrohen, Volodia Dangouloff-Ros, Xavier Maynadier, Yassine Ajlil, Matthieu Carton, Wael Yacoub, Raphael Saffroy, Dominique Figarella-Branger, Emmanuelle Uro-Coste, Annick Sevely, Delphine Larrieu-Ciron, Maxime Faisant, Marie-Christine Machet, Ellen Wahler, Alexandre Roux, Sandro Benichi, Kevin Beccaria, Thomas Blauwblomme, Nathalie Boddaert, Fabrice Chretien, Francois Doz, Christelle Dufour, Jacques Grill, Marie Anne Debily, Pascale Varlet, Arnault Tauziede-Espariat
Summary: A retrospective study examined 28 cases of pediatric spinal low-grade glioma (LGG) and glioneuronal tumors. It was found that 25% of spinal pilocytic astrocytomas (PA) were reclassified as diffuse leptomeningeal glioneuronal tumors (DLGNT). Histopathology and radiology are not sufficient to differentiate PA and DLGNT, but molecular data can accurately classify these tumors.
ACTA NEUROPATHOLOGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Jihwan Eom, Dain Kim, Sung Soo Ahn, Eui Hyun Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study developed a fully automatic radiomics model to differentiate adult pilocytic astrocytomas from high-grade gliomas. The model showed superior performance compared to both clinical and radiomics models, and outperformed human judgement. The model explanation suggested that intratumoural heterogeneity from T2-weighted images was highly associated with the diagnosis of pilocytic astrocytomas.
EUROPEAN RADIOLOGY
(2022)
Article
Veterinary Sciences
Kelly Muller, Eunbee Kim, Abbie Lebowitz, Heather Daverio
Summary: Dogs are valuable models for studying spontaneous intracranial neoplasia in humans, with meningioma being the most common intracranial tumor in dogs. This report presents a rare case of a 23-week-old American Bulldog with a high-grade astrocytoma, a type of glioma, with pilocytic morphology.
VETERINARY SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Dain Kim, Jihwan Eom, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study developed a DTA model based on demographical information and MRI findings for the differential diagnosis of adult PAs and HGGs. The results indicated that tumor location, characteristics, and size are significant predictors for the differential diagnosis of adult PAs and HGGs.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Clinical Neurology
Joo Whan Kim, Ji Hoon Phi, Ji Yeoun Lee, Eun Jung Koh, Kyung Hyun Kim, Hyoung Jin Kang, Jung Yoon Choi, Sung-Hye Park, Kyu-Chang Wang, Seung-Ki Kim
Summary: This study updated the clinical outcomes of optic pathway and hypothalamic gliomas (OPHGs) and found that using less invasive operations and chemotherapy as the first-line treatment for OPHGs is feasible. The study showed that debulking surgery may be considered in cases with cerebrospinal fluid pathway obstruction, progression despite chemotherapy or radiation, and refractory shunt-related ascites in OPHG patients.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Natalia Voronina, Christian Aichmueller, Thorsten Kolb, Andrey Korshunov, Marina Ryzhova, Jill Barnholtz-Sloan, Gino Cioffi, Martin Sill, Andreas von Deimling, Stefan M. Pfister, Jan Gronych, David T. W. Jones, Jonas Frisen, Marc Zapatka, Aurelie Ernst
Summary: Adult and pediatric pilocytic astrocytomas show similarities in terms of genome-wide expression and methylation patterns, potentially originating from early life. There may be differences in PAs of different anatomic locations.
Article
Oncology
Konstantin Okonechnikov, Piyush Joshi, Mari Sepp, Kevin Leiss, Ioannis Sarropoulos, Florent Murat, Martin Sill, Pengbo Beck, Kenneth Chun-Ho Chan, Andrey Korshunov, Felix Sah, Maximilian Y. Deng, Dominik Sturm, John DeSisto, Andrew M. Donson, Nicholas K. Foreman, Adam L. Green, Giles Robinson, Brent A. Orr, Qingsong Gao, Emily Darrow, Jennifer L. Hadley, Paul A. Northcott, Johannes Gojo, Daisuke Kawauchi, Volker Hovestadt, Mariella G. Filbin, Andreas von Deimling, Marc Zuckermann, Kristian W. Pajtler, Marcel Kool, David T. W. Jones, Natalie Jaeger, Lena M. Kutscher, Henrik Kaessmann, Stefan M. Pfister
Summary: This study successfully identified the cellular origins of the three most common pediatric brain tumors and identified potential therapeutic targets based on the tumor-specific genes expressed in these cellular origins.
Editorial Material
Ophthalmology
Katherine J. Williams, Richard C. Allen
Summary: A 17-year-old girl presented with 3 months of decreased vision and throbbing eye pain in the right eye. MRI revealed fusiform expansion of the right optic nerve and enhancement of orbital, canalicular, and prechiasmatic segments of the right optic nerve.
JAMA OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Megan M. J. Bauman, Daniel Jeremiah Harrison, Max B. Giesken, David J. Daniels
Summary: This study provides an overview of the current literature on pilocytic astrocytomas through a bibliometric analysis of the top 100 most cited publications. The research shows an increase in studies on pilocytic astrocytomas over the past three decades, with future directions focusing on targeted therapies and discovering additional cellular pathways contributing to disease pathogenesis.
CHILDS NERVOUS SYSTEM
(2022)
Article
Oncology
Amanda De Andrade Costa, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne Scheaffer, Xiaofan Guo, Sonika Dahiya, David H. Gutmann
Summary: The study identified ITGAL/CD11A as a critical microglia regulator of LGG biology, with implications for future stroma-targeted brain tumor treatment strategies.
Article
Oncology
Thara Tunthanathip
Summary: Malignant transformation of low-grade astrocytoma has a poor prognosis. This study identified supratentorial tumor, midline shift greater than 5mm, and non-total resection as risk factors for malignant transformation.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Guanyi Wang, Yibin Jia, Yuqin Ye, Enming Kang, Huijun Chen, Jiayou Wang, Xiaosheng He
Summary: This study retrospectively analyzed the clinical and epidemiological characteristics of pediatric brain tumors in Northwest China, identifying pilocytic astrocytoma as the most common subtype. Through bioinformatics analysis, potential diagnostic biomarkers were identified.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Pathology
Ida Schwartz Bobach, Magnus Stougaard
Summary: This study presents a novel approach for identifying KIAA1549-BRAF fusion using SNP analysis and NGS, which was tested in a retrospective cohort. The results demonstrate that this method can accurately identify fusions in PA samples, while no fusions were found in other tumor types.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Clinical Neurology
Sasan Darius Adib, Martin U. Schuhmann, Johann-Martin Hempel, Antje Bornemann, Rocio Evangelista Zamora, Marcos Tatagiba
Summary: Glial tumors in the cerebellopontine angle (CPA) are rare, with less than 1% being pilocytic astrocytoma (PA-CPA). This study presented four cases of PA-CPA treated surgically, with good long-term facial nerve function and low recurrence rate postoperatively.
NEUROSURGICAL REVIEW
(2021)
