期刊
FUTURE VIROLOGY
卷 10, 期 1, 页码 27-39出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fvl.14.99
关键词
cancer; E5; growth factor receptor; HPV; oncogene; signaling
类别
资金
- UK Medical Research Council [MR/K012665/1]
- Yorkshire Cancer Research [L001PhD]
- Medical Research Council [MR/K012665/1] Funding Source: researchfish
- MRC [MR/K012665/1] Funding Source: UKRI
Mucosal human papillomaviruses express a small, hydrophobic, protein called E5, which plays an important role in the HPV life cycle by delaying normal epithelial cell differentiation while maintaining cell cycle progression. In addition, E5 exhibits transforming abilities in a number of cell culture systems and transgenic mouse models. Lacking any described enzymatic activity, E5 is thought to function by binding to host proteins and modulating their activities. In particular, members of the growth factor receptor family are known targets for subversion. This review article summarizes our latest understanding of this enigmatic oncoprotein, including its role in the HPV life cycle, interactions with host proteins and contribution toward tumorigenesis.
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